[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pulpotomy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pulpotomy":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,49,76,103,137,161,184,207],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100639316","r-officinalis-as-pulpotomy-agent-in-permanent-teeth-with-irreversible-pulpitis-100639316",false,"NCT07610057","R. Officinalis as Pulpotomy Agent in Permanent Teeth With Irreversible Pulpitis","Comparative Clinical and Radiographic Evaluation of Rosmarinus Officinalis Versus Mineral Trioxide Aggregate as Pulpotomy Medicament in Vital Mature Permanent Teeth With Irreversible Pulpitis","Inclusion Criteria\n\n* Healthy patients (ASA classification 1 and 2) of age range of 18-40 of both sexes would be included.\n* Vital mature permanent posterior teeth with deep caries approaching the pulp as seen on periapical x-ray.\n* Pain indicative of irreversible pulpitis (spontaneous pain or pain exacerbated by a cold stimulus which could last from a few seconds to hours), which a cold test could reproduce.\n* Tooth will be selected on the basis of working diagnosis i.e. successful hemostasis within 5 minutes after removal of coronal pulp.\n* Absence of clinical signs or symptoms suggesting a non-vital tooth such as tenderness to percussion or palpation, mobility, presence of abscess, soft tissue swelling or suppurating sinus.\n* Absence of radiographic changes as; furcation or periapical pathology, internal or external root resorption or calcification in the canals.\n* The tooth structure of selected teeth should be restorable after completion of the treatment\n\nExclusion Criteria:\n\n* Patients with ASA classification 3, 4 ,5 and 6 would be\n* Patients taking antibiotics within last 2 weeks.\n* Teeth with pulp necrosis, cracked tooth, internal or external resorption, calcified canals, acute or chronic apical periodontitis with an associated sinus tract or periapical radiolucency.\n* Periodontally compromised tooth.\n* Uncooperative patients or failure to obtain authorization from patients.","ALL","18 Years","40 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study evaluates and compares the clinical and radiographic outcomes of Rosmarinus officinalis and Mineral Trioxide Aggregate (MTA) when used as pulpotomy medicaments in vital mature permanent teeth with irreversible pulpitis. The aim is to determine the effectiveness of both materials in terms of pain reduction and periapical healing. While MTA is considered a gold standard, it has limitations such as high cost, long setting time, and potential discoloration. Therefore, this study investigates Rosmarinus officinalis as a natural, cost-effective alternative with comparable therapeutic potential. This study also provide an alternative to RCT in teeth with irreversible pulpitis",[27,28,29],"Irreversible Pulpitis","Pulpotomy","MTA Vital Tooth Pulpotomy",[31,32,33,34,35],"pulpotomy","rosemarinus officinalis","MTA","permanent teeth with irreversible pulpitis","Vital pulp theray","NOT_YET_RECRUITING","2026-05-21",{"date":39,"type":40},"2026-05-27","ACTUAL",{"date":42,"type":21},"2026-06-01",{"date":44,"type":21},"2026-12-31",{"name":46,"class":47},"University of Health Sciences Lahore","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":16,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":48},"100428758","phase-4-clinical-and-radiographic-success-of-mta-vs-biodentine-100428758","NCT04863222","Clinical and Radiographic Success of MTA vs Biodentine","Clinical and Radiographic Success of Mineral Trioxide Aggregate (MTA) vs Septodont Biodentine in Primary Molars in Pulpotomy and Indirect Pulp Cap Treatments","Inclusion Criteria:\n\n* Male or female patients ages of 2 to ≤12 years.\n* Bilateral symptomatic or asymptomatic vital primary molars with caries approximating or into the pulp.\n* Patient who need a pulpotomy and\u002For indirect pulp cap treatments in two or more quadrants.\n* Parents of patients who can provide consent in English.\n* Patients who need treatment in an operating room setting at Geisinger.\n\nExclusion Criteria:\n\n* Pre-operative radiographic or clinical symptoms associated with irreversible pulpitis or necrotic pulp.\n* Radiographs not displaying furcation region of the tooth.\n* Patients with cardiac conditions who need prophylaxis for infective Endocarditis.\n* Patients with any type of cancer in the past or present.\n* Non-restorable molars.",true,"2 Years","12 Years",{"count":60,"type":21},646,[62],"PHASE4","The purpose of this prospective study is to compare the clinical and radiographic success of MTA and Biodentine as a medicament in vital pulp therapy in maxillary and mandibular primary molars in a pediatric population. There is limited research currently on Biodentine since it's a novel product. Biodentine is less expensive than MTA and does not cause discoloration like MTA. Biodentine may be an alternative medicament used for vital pulp therapy in primary molars.",[65,28],"Indirect Pulp Cap","RECRUITING","2025-12-22",{"date":69,"type":40},"2025-12-23",{"date":71,"type":40},"2021-11-12",{"date":73,"type":21},"2026-12-01",{"name":75,"class":47},"Geisinger Clinic",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":56,"sex":16,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":48},"100568777","comparison-of-clinical-success-of-stainless-steel-crowns-and-zirconia-crowns-in-primary-molars-100568777","NCT06685640","Comparison of Clinical Success of Stainless Steel Crowns and Zirconia Crowns in Primary Molars","Evaluation of Clinical Success and Parental Satisfaction of Prefabricated Stainless Steel Crowns and Zirconia Crowns Applied to Primary Molar Teeth","Inclusion Criteria:\n\n* Age range of children from 4 to 5 years.\n* Systemically healthy.\n* Children who are positive and extremely positive according to the Frankl behavior scale.\n* Asymptomatic primary mandibular second molars with multi-surface deep caries requiring pulpotomy treatment.\n* No history of spontaneous pain.\n* Primary mandibular second molars where bleeding at the pulpotomy site can be controlled within 3 to 5 minutes.\n* Having opposing teeth in occlusal contact.\n* Patients without any periodontal-related attachment loss.\n* Patients without abscesses or fistulas on primary second molars.\n* Children who verbally and in writing agree to participate in the study and are willing to attend regular follow-up appointments will be included.\n\nExclusion Criteria:\n\n* Having a systemic disease.\n* Periapical infection, abscess, or mobility in primary second molars.\n* Those with active periodontal disease.\n* Malocclusion or missing opposing tooth.\n* Primary second molars with pathological internal or external resorption.\n* Physiological root resorption exceeding 1\u002F3 of the root.\n* Children with bruxism or unilateral chewing habits will not be included in the study.","4 Years","5 Years",{"count":86,"type":21},10,[24],"Evaluation and understanding of clinical success, parental satisfaction and effects on periodontal tissues are the main expected benefits of prefabricated zirconia crowns and prefabricated stainless steel crowns. For a long time, stainless steel crowns have been the restorative material of choice for children's primary and permanent posterior teeth. Today, prefabricated zirconia crowns are more popular than other options because they meet aesthetic expectations and have high mechanical strength. The aim of this study is to evaluate and compare the periodontal health, plaque accumulation, opposing tooth wear, parental satisfaction, and clinical performance (color match, retention, marginal integrity, marginal discoloration, anatomic form, secondary caries, surface roughness, surface gloss and postoperative sensitivity) of pediatric prefabricated stainless steel and zirconia crowns applied after pulpotomy to asymptomatic, multifaceted, deep carious primary mandibular second molars.",[90,28],"Dental Caries",[92,93,94],"primary molars","stainless steel crowns","zirconia","2025-12-18",{"date":67,"type":40},{"date":98,"type":40},"2024-07-30",{"date":100,"type":21},"2027-04-30",{"name":102,"class":47},"Aydin Adnan Menderes University",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":56,"sex":16,"minAge":83,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":22,"phases":113,"briefSummary":114,"conditions":115,"keywords":120,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":48},"100583083","clinical-and-radiographic-evaluation-of-potassium-nitrate-in-polycarboxylate-versus-mineral-trioxide-aggregate-in-vital-pulpotomy-in-primary-molars-100583083","NCT06871709","Clinical and Radiographic Evaluation of Potassium Nitrate in Polycarboxylate Versus Mineral Trioxide Aggregate in Vital Pulpotomy in Primary Molars","Clinical and Radiographic Evaluation of Potassium Nitrate in Polycarboxylate Versus Mineral Trioxide Aggregate in Vital Pulpotomy in Primary Molars: a Randomized Clinical Trial","❖ Inclusion Criteria:\n\n1. Children aged 4 to 7 years, in good general health.\n2. Children with vital, deeply carious primary molars.\n3. No history of spontaneous pain, pathological mobility, draining sinus tract, redness or swelling of the vestibule.\n4. Normal gingival and periodontal condition, with no sensitivity to vestibular palpation, and no pain on percussion test.\n5. No sign of radiolucency in periapical or furcation area.\n6. No widening of PDL space or loss of lamina dura continuity.\n7. No evidence of internal\u002Fexternal pathological root resorption.\n\nExclusion Criteria:\n\n1. Children with a physical disability or medical disability.\n2. Unrestorable molars.\n3. Uncooperative patient.\n4. Parent unable to attend Follow- up visits.\n5. Parents refuse to give written informed consent.\n6. If the access was opened and irreversible pulpitis was evident.","7 Years",{"count":112,"type":21},50,[24],"The purpose of this RCT is to compare the clinical\u002Fradiographic outcomes of Potassium nitrate in polycarboxylate cement and MTA as pulpotomy biomaterials used for asymptomatic vital primary lower second molar and this will help to clinically evaluate the use of alternative material in vital pulpotomy in primary molars with deep carious cavities.\n\nEmphasis is set on avoiding total pupectomy and maintaining radicular pulp vitality therefore maintain the tooth in a viable condition till it's shedding and eruption of the permanent successor.",[116,28,117,118,119],"Vital Pulp Therapies","Pulp Disease, Dental","Pulpotomies Primary Teeth","Pulp Therapy",[121,122,33,28,123,124,125,126,127],"Mineral Trioxide Aggregate","Potassium Nitrate","Vital Pulpotomy","Vital Pulp therapy","Primary Molars","pulp therapy","Pulp disease","2025-03-06",{"date":130,"type":40},"2025-03-12",{"date":132,"type":21},"2025-05-30",{"date":134,"type":21},"2026-12-30",{"name":136,"class":47},"Cairo University",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":56,"sex":16,"minAge":83,"maxAge":144,"enrollmentInfo":145,"targetDuration":4,"studyType":22,"phases":146,"briefSummary":147,"conditions":148,"keywords":150,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":48},"100578298","clinical-and-radiographic-evaluation-of-chitosan-versus-formocresol-after-vital-pulpotomy-of-primary-molars-100578298","NCT06809478","Clinical and Radiographic Evaluation of Chitosan Versus Formocresol After Vital Pulpotomy of Primary Molars","Clinical and Radiographic Evaluation of Chitosan Versus Formocresol After Vital Pulpotomy of Primary Molars: a Randomized Clinical Study","Inclusion Criteria:\n\n* Healthy cooperative children with at least one deep carious mandibular primary molar indicated for vital pulpotomy.\n* In age range from 4 to 8 years old.\n* Both sexes will be included.\n* Patients with provoked pain.\n* Restorable teeth.\n\nExclusion Criteria:\n\n* Excessive haemorrhage that cannot be stopped by a damp cotton pellet after several minutes.\n* With congenital anomalies in teeth e.g., taurodontism, concrescence or fusion.\n* Patients who show allergic reaction to any material will be used in this trial.\n* Will not be able to stick to follow up protocol in the trial and refuse to give communication data.\n* Patient's guardians refuse to sign up an informed consent before participating in this trial.","8 Years",{"count":112,"type":21},[24],"The goal of this clinical trial is to evaluate whether Chitosan liquid will show similar clinical and radiographical success rate compared to Formocresol when used in vital pulp therapy in primary molars.\n\nThe main question it aims to answer is:\n\n* Will Chitosan liquid, in comparison to Formocresol, show similar clinical outcomes in relation to presence\u002Fabsence of post-operative pain, swelling, sinus and\u002For fistula formation when used in vital pulpotomy in primary molars?\n* Will Chitosan liquid, in comparison to Formocresol, show similar radiographical outcomes in relation to presence\u002Fabsence of furcal involvement, periapical lesion, pathological root resorption and\u002For widening of periodontal membrane space when used in vital pulpotomy in primary molars?\n\nFollowing conventional pulpotomy procedure, the primary investigator will evaluate the effect of placing a cotton pellet damp with Chitosan liquid directly on radicular vital pulp compared to that of placing a cotton pellet damp with Formocresol on radicular vital pulp.\n\nPrimary teeth included in both arms of the study will be restored by zinc oxide and eugenol and covered by a stainless steel crown as final restoration.\n\nThe clinical trail will be followed up for 1 year. Clinical outcomes will be evaluated every 3 months. Radiographic outcomes will be evaluated every 6 months.",[149,28],"Pulpitis - Reversible",[31,151,152,92],"formocresol","chitosan","2025-02-01",{"date":155,"type":40},"2025-02-05",{"date":157,"type":21},"2025-04",{"date":159,"type":21},"2026-07",{"name":136,"class":47},{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":56,"sex":16,"minAge":83,"maxAge":168,"enrollmentInfo":169,"targetDuration":4,"studyType":22,"phases":171,"briefSummary":172,"conditions":173,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":182,"locationsCount":48},"100538257","clinical-and-radiographic-evaluation-of-vital-pulpotomy-techniques-in-primary-molars-using-of-premixed-bioactive-bioceramic-mta-neo-putty-as-a-novel-pulpotomy-medication-versus-formocresol-100538257","NCT06288477","Clinical and Radiographic Evaluation of Vital Pulpotomy Techniques in Primary Molars Using of Premixed Bioactive Bioceramic MTA (Neo-putty) as a Novel Pulpotomy Medication Versus Formocresol","Clinical and Radiographic Evaluation of Vital Pulpotomy Techniques in Primary Molars Using of Premixed Bioactive Bioceramic MTA (Neo-putty) as a Novel Pulpotomy Medication Versus Formocresol: A Randomized Clinical Trial.","Criteria The eligibility criteria were set according to the guidelines of AAPD, 2020. (4)\n\nInclusion Criteria:\n\n1. 4 -9 years old\n2. Primary molars with no spontaneous or provoked pain\n3. Primary molars with at least two-thirds of the root length were still present.\n4. Primary molars with no sign of internal or other kinds of root or bone resorption.\n\nExclusion Criteria:\n\n1. Patients with systemic diseases (congenital or rheumatic heart disease, hepatitis, nephritis, tumor, cyclic neutropenia, leukemia, and children on long-term corticosteroid therapy).\n2. Un-cooperative patients.\n3. Un-restorable primary molars (Grossly broken-down primary molars that have decay extending way under the gingiva and tooth with root caries).","9 Years",{"count":170,"type":21},44,[24],"Despite the benefit of formocresol, there are toxic effects allergic reactions and local soft and hard tissue necrosis have been reported when such formaldehyde compounds were used clinically, however, the adverse effect of the clinically used of this compound are not widely reported. It has been stated that it has a side effect on the permanent successor although it results as a successful technique for the treatment of the primary teeth",[174,28,175],"Vital","Techniques","2024-12-18",{"date":178,"type":40},"2024-12-20",{"date":180,"type":40},"2024-03-20",{"date":153,"type":21},{"name":183,"class":47},"October University for Modern Sciences and Arts",{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":56,"sex":16,"minAge":191,"maxAge":192,"enrollmentInfo":193,"targetDuration":4,"studyType":22,"phases":195,"briefSummary":196,"conditions":197,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":48},"100565286","assessment-of-i-prf-versus-nano-mta-combined-with-i-prf-scaffold-in-vital-pulp-therapy-in-mature-mandibular-first-molars-100565286","NCT06640205","Assessment of I-PRF Versus Nano MTA Combined with I-PRF Scaffold in Vital Pulp Therapy in Mature Mandibular First Molars","Clinical and Radiographic Assessment of I-PRF Versus Nano Mineral Trioxide Aggregate Combined with I-PRF Scaffold in Vital Pulp Therapy in Mandibular First Molars with Closed Apices: \"Randomized Controlled Trial\"","Inclusion Criteria:\n\n* Patients suffering from Symptomatic irreversible pulpitis in mature mandibular molars only will be involved.\n\n  * Patients of either gender aged from 15-30.\n  * Tooth should give positive response to cold test.\n  * The tooth is restorable\n  * Patients should be free from any systemic disease that may affect normal healing and predictable outcome.\n  * Patients who will agree to the consent and will commit to follow-up period.\n  * Patients with mature root.\n  * Patients with no internal or external resorption and no periapical lesions.\n  * Soft tissues around the tooth are normal with no swelling or sinus tract.\n\nExclusion Criteria:\n\n* Patients with immature roots.\n\n  * Haemostasias after 10 minutes can not be controlled after total pulpotomy\n  * Patients with periapical lesions or infections.\n  * Pregnant females.\n  * Patients with fistula or swelling\n  * Patients with necrotic pulp.","15 Years","30 Years",{"count":194,"type":21},51,[24],"Assessment of I-PRF versus Nano Mineral trioxide aggregate Combined with I-PRF in pulpotomy in mature Mandibular First Molars",[28],"2024-10-10",{"date":200,"type":40},"2024-10-15",{"date":202,"type":40},"2023-09-03",{"date":204,"type":21},"2025-09-02",{"name":206,"class":47},"Future University in Egypt",{"id":208,"slug":209,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":212,"acronym":33,"eligibilityCriteria":213,"healthyVolunteers":56,"sex":16,"minAge":214,"maxAge":144,"enrollmentInfo":215,"targetDuration":4,"studyType":22,"phases":217,"briefSummary":219,"conditions":220,"keywords":222,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":48},"100532977","phase-3-clinical-and-radiographic-evaluation-of-bioceramic-putty-mta-versus-mta-in-pulpotomy-of-immature-permanent-molars-100532977","NCT06219824","Clinical and Radiographic Evaluation of Bioceramic Putty MTA Versus MTA in Pulpotomy of Immature Permanent Molars","Clinical and Radiographic Evaluation of Bioceramic Putty Mineral Trioxide Aggregate Versus Mineral Trioxide Aggregate in Pulpotomy of Immature Permanent Molars: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients aged from 6-8 years of both sexes have immature permanent molars\n* with deep carious lesions indicated for pulpotomy.\n* Restorable young permanent molars with no clinical symptoms of irreversible pulpitis.\n* Permanent molars without any clinical sign of pulp necrosis including swelling, fistula, pain on percussion, and pathologic tooth mobility.\n* Permanent molars without any adverse radiographic findings including thickening of the periodontal ligament space, radiolucency at the interradicular or periapical regions\n* permanent molars without internal and external root resorption, or calcification in pulp tissue.\n\nExclusion Criteria:\n\n* Medically compromised patients who have systemic disease.\n* Uncooperative patients who refuse treatment.\n* Permanent molars that were previously restored.","6 Years",{"count":216,"type":21},40,[218],"PHASE3","The present study aims to evaluate the clinical and radiographic success of bioceramics putty MTA versus MTA in the pulpotomy of immature permanent molars\n\nThe main question it aims to answer is:\n\nWill the biocermaics putty MTA have higher clinical and radiographic success rates than MTA in pulpotomy of immature permanent molars?",[28,221],"Deep Caries",[223,224,31,225,226,227,228],"Immature permanent molars,","young permenent molars","vital pulp therapy","deep caries","Putty MTA","bioceramic MTA","2024-07-22",{"date":231,"type":40},"2024-07-23",{"date":233,"type":21},"2024-11-01",{"date":235,"type":21},"2025-11-30",{"name":136,"class":47}]