[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pulseless-electrical-activity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pulseless-electrical-activity":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100637044","abdominal-aortic-tourniquet-application-for-non-traumatic-out-of-hospital-cardiac-arrest-100637044",false,"NCT07573566","Abdominal Aortic Tourniquet Application for Non-Traumatic Out-of-Hospital Cardiac Arrest","ATTICA","Inclusion Criteria:\n\n* Cardiac arrest with indication for initiation of resuscitation\n* Age ≥ 18 years\n\nExclusion Criteria:\n\n* Pregnancy (suspected or confirmed)\n* Age \\\u003C 18 years\n* Abdominal circumference does not allow application of the AAJT\n* Traumatic etiology\n* Planned eCPR or other intervention in which study inclusion would delay the standard of care\n* Known abdominal aortic aneurysm","ALL","18 Years",{"count":19,"type":20},5,"ESTIMATED","INTERVENTIONAL",[23],"NA","The aim of the study is to investigate whether occluding the abdominal aorta with an external device could be a potential therapeutic option in cases of non-traumatic cardiac arrest occurring outside of a hospital.\n\nIn cardiac arrest, the heart suddenly stops beating, causing the circulation of blood to collapse. In this situation, vital organs-especially the brain and the heart itself-are no longer adequately supplied with oxygen. Without immediate treatment, severe damage or death occurs within minutes.\n\nThe study therefore examines a specific intervention: the temporary occlusion of the abdominal aorta, which carries blood to the lower regions of the body. If this artery is blocked for a short period, the available blood can be redirected more effectively to the upper parts of the body. In theory, this could improve the oxygen supply to these organs and increase the likelihood that the heart will resume beating or that neurological damage can be reduced.",[26,27,28,29,30],"Cardiac Arrest (CA)","Out-of-hospital Cardiac Arrest (OHCA)","Asystole","Pulseless Electrical Activity","Ventricular Fibrillation",[32,33,34],"AAJT","OHCA","Aortic occlusion","NOT_YET_RECRUITING","2026-04-30",{"date":38,"type":39},"2026-05-07","ACTUAL",{"date":41,"type":20},"2026-08",{"date":43,"type":20},"2027-09",{"name":45,"class":46},"Klinikum Klagenfurt am Wörthersee","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":47},"100521616","emergency-resuscitative-endovascular-balloon-occlusion-of-the-aorta-in-out-of-hospital-cardiac-arrest-100521616","NCT06071910","Emergency Resuscitative Endovascular Balloon Occlusion of the Aorta in Out of Hospital Cardiac Arrest","ERICA-ARREST","Inclusion criteria\n\n* Non-Traumatic OHCA in patients within the East of England area AND with a East Anglian Air Ambulance (EAAA) REBOA team in attendance\n* Patients below or equal to 80yrs of age and above or equal to 18yrs of age, according to available information\u002Festimate at scene\n* No flow \\\u003C10 mins from data available (i.e. total period in OHCA with no CPR)\n* In cardiac arrest (with no sustained ROSC) on arrival of the EAAA REBOA team\n\nExclusion criteria\n\n* Patients aged less than 18 or above 80 years\n* Known terminal illness\n* Multiple severe co-morbidities\n* Traumatic Cardiac Arrest (TCA)\n* Inability to deploy mechanical CPR (e.g. LUCAS Device)\n* Pregnancy, obvious or suspected","80 Years",{"count":57,"type":20},40,[23],"This study will assess the feasibility of performing pre-hospital resuscitative endovascular balloon occlusion of the aorta (REBOA) as an adjunct to conventional Advanced Life Support (ALS) in patients suffering from non-traumatic out of hospital cardiac arrest (OHCA). As well as providing valuable insights into the technical feasibility of performing this procedure as part of a resuscitation attempt, the study will also document the beneficial physiological effects of REBOA in this group of patients.",[61,62,63,30,64,29],"Out-Of-Hospital Cardiac Arrest","Cardiac Arrest","Cardiac Arrhythmia","Ventricular Arrythmia","RECRUITING","2026-02-26",{"date":68,"type":39},"2026-03-02",{"date":70,"type":39},"2024-06-04",{"date":72,"type":20},"2026-12-31",{"name":74,"class":46},"Queen Mary University of London",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":85,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":47},"100461070","phase-2-surviving-pea-in-roanoke-spear-study-100461070","NCT05283850","Surviving PEA in Roanoke (SPEAR) Study","A Prospective, Pre-Hospital Comparison of Normal Saline Versus Half-Normal Saline, After Universal Calcium Chloride Administration, to Improve Outcomes in Pulseless Electrical Activity Patients","SPEAR","Inclusion Criteria:\n\n* All patients who present with PEA at any time during the patients' treatment by Roanoke Fire-EMS, Botetourt County Department of Fire \\& EMS and\u002For Salem Fire-EMS. This study defines a PEA presentation as any patient who is unconscious, presenting without a carotid pulse and with non-(VT\u002FVF) ventricular tachycardia\u002Fventricular fibrillation electrical activity.\n\nExclusion Criteria:\n\n* Patient less than 18 years old\n* Known pregnancy\n* Duration of untreated cardiac arrest of more than 30 minutes\n* Traumatic cardiac arrest\n* Known (LVAD) Left Ventricular Assist Device\n* Rapidly fatal underlying disease\n* Known or suspected digitalis toxicity\n* A physical, durable (DNR) Do Not Resuscitate (or durable DNR medical jewelry) presented to EMS before treatment with asserting a preference not to be enrolled\n* Prisoners and other populations with involuntary consent",{"count":84,"type":20},342,[86,87],"PHASE2","PHASE3","The Carilion Clinic and Virginia Tech Carilion School of Medicine, in conjunction with Roanoke Fire-EMS, Botetourt County Department of Fire \\& EMS and Salem Fire-EMS, are studying the outcomes of patients experiencing Pulseless Electrical Activity (PEA). PEA refers to a type of cardiac arrest in which there is normal electrical activity in the heart however the heart still fails to contract to generate a pulse. Without heart contractions, which normally generates a pulse, the brain and other important organs fail to receive blood and oxygen. Unfortunately, the majority (97.3%) of patients that experience this rhythm do not survive and most don't even make it to the hospital. This study is trying to determine if the administration of a High Calcium, Low Sodium (HCLS) fluid in pre-hospital care will improve the chances of survival.\n\nGenerally, a sodium (salt) solution is provided to patients experiencing cardiac arrest. Studies have shown that lower sodium and higher calcium content may activate certain parts of the heart cells required to generate a pulse under PEA conditions.\n\nThis study is a double-blind, prospective, clinical trial. PEA patients will randomly receive either routine fluid therapy (salt solution) or a HCLS solution. While HCLS solution is not the standard fluid used by EMS providers responding to PEA, it is composed of FDA approved components and is occasionally used by EMS providers at their discretion in treating PEA. It is predicted that HCLS will either improve PEA survival or deliver similar outcomes as routine treatment. All patients will receive standard, high quality cardiac arrest and post-cardiac arrest care regardless of assigned treatment group.",[62,29],[91,92,93,94,95,96,97,98,99,100],"Crystalloid Fluids","Emergency Medical Services (EMS)","Pre-Hospital Medicine","Sodium Chloride","Calcium Chloride","Normal Saline","Half-Normal Saline","Waiver of Informed Consent","Paramedic","Electrolyte","2022-03-08",{"date":103,"type":39},"2022-03-17",{"date":105,"type":39},"2022-02-16",{"date":107,"type":20},"2027-02",{"name":109,"class":46},"Carol Bernier"]