[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pupillometry\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pupillometry":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100637724","dynamic-trajectories-of-pupillary-light-reflex-parameters-and-prognosis-in-critically-ill-patients-a-multicenter-prospective-cohort-study-100637724",false,"NCT07616518","Dynamic Trajectories of Pupillary Light Reflex Parameters and Prognosis in Critically Ill Patients: A Multicenter Prospective Cohort Study","PUPIL","Inclusion Criteria:\n\n1. Age 18 years or older.\n2. Admission to the emergency intensive care unit.\n3. Critically ill patients with an expected EICU stay longer than 48 hours.\n4. Written informed consent obtained from the participant or legally authorized representative.\n\nExclusion Criteria:\n\n1. Severe ocular disease, severe ocular trauma, postoperative ocular status, or other conditions that prevent reliable pupillary measurement.\n2. Known neuro-ophthalmic disorders that may affect the pupillary light reflex, such as oculomotor nerve palsy.\n3. Use of topical ophthalmic medications during the study period that may significantly affect pupillary response, when their effects cannot be accurately recorded or evaluated.\n4. Pregnancy or breastfeeding.","ALL","18 Years",{"count":19,"type":20},700,"ESTIMATED","OBSERVATIONAL","This multicenter prospective observational cohort study aims to investigate the association between early dynamic trajectories of pupillary light reflex parameters and clinical outcomes in critically ill patients admitted to emergency intensive care units. Quantitative pupillometry will be performed during the first 7 days after EICU admission. Constriction velocity will be the primary parameter for trajectory analysis, while dilation velocity, pupil diameter, constriction percentage, maximum constriction velocity, and latency will be analyzed as supplementary parameters. The study will evaluate whether these dynamic pupillary trajectories are associated with discharge outcome and 90-day functional outcome assessed by the Glasgow Outcome Scale-Extended.",[24,25,26],"Critical Illness","Pupillometry","Prognosis",[28,29,30,26,31],"Pupillary light reflex","Critically ill patients","Dynamic trajectory","Constriction Velocity","NOT_YET_RECRUITING","2026-05-24",{"date":35,"type":36},"2026-06-01","ACTUAL",{"date":38,"type":20},"2026-06-06",{"date":40,"type":20},"2026-10-13",{"name":42,"class":43},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":54,"conditions":55,"keywords":63,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100591382","early-wake-up-predictors-after-out-of-hospital-cardiac-arrest-100591382","NCT06979700","Early WAKE-up Predictors After Out-of-Hospital Cardiac Arrest","Early Wake-up Predictors After Out-of-hospital Cardiac Arrest - an Observational, Multicenter Substudy of the DANOHCA Trial","WAKE-OHCA","Inclusion Criteria:\n\n* Age ≥18 years\n* OHCA of presumed cardiac cause\n* Sustained ROSC, defined as persistent signs of circulation and no need for chest compressions or mechanical circulatory support for 20 minutes\n* Unconsciousness (GCS \\\u003C9) (patients not able to obey verbal commands) after sustained ROSC at the time of randomization\n\nExclusion Criteria:\n\n* Females of childbearing potential if pregnancy is suspected (unless a negative HCG test can rule out pregnancy within the inclusion window)\n* Known bleeding diathesis (medically induced coagulopathy (e.g. warfarin, NOAC, clopidogrel) does not exclude the patient)\n* Suspected or confirmed acute intracranial bleeding\n* Suspected or confirmed acute stroke\n* Unwitnessed asystole\n* Known limitations in therapy and Do Not Resuscitate-order\n* Known disease making 180 days survival unlikely\n* Known pre-arrest CPC 3 or 4 functional status\n* \\>3 hours (180 minutes) from ROSC to screening\n* Systolic blood pressure \\\u003C80 mm Hg despite fluid loading\u002Fvasopressor and\u002For inotropic medication (If the systolic blood pressure is recovering during the inclusion window of 180 minutes the patient may be included)\n* Use of intra-aortic balloon pump\u002Faxial flow device\u002FECMO (If the patient is weaned and the device is removed during the inclusion window of 180 minutes the patient may be included)\n* Temperature on admission \\\u003C30°C\n* Known allergy for dexamethasone or olanzapine\n* Ongoing (within 48 h) treatment with olanzapine or dexamethasone\n* Known back or hip condition that precluded the patients from being positioned with backrest from 0 to 45-degree angle\n* Known or suspected Long QT Syndrome (LQTS)\n* Known active fungal disease. Localized skin lesions do not exclude patients from inclusion\n* Estimated body weight \\\u003C45kg",{"count":53,"type":20},250,"WAKE-OHCA is a prospective observational substudy of the Danish Out-of-Hospital Cardiac Arrest (DANOHCA) trial, identifier NCT05895838. The aim is to collect early neuromonitoring data to identify key predictors of successful wake-up.",[56,57,58,59,25,60,61,62],"Cardiac Arrest (CA)","Anoxic Brain Injury","Comatose Survivors of Cardiac Arrest","EEG","Optic Nerve Sheath Diameter","Transcranial Doppler Ultrasound","Neurological Outcome",[64,65],"wakeup","sedation","RECRUITING","2025-11-14",{"date":69,"type":36},"2025-11-18",{"date":71,"type":36},"2025-05-13",{"date":73,"type":20},"2027-12",{"name":75,"class":43},"University of Aarhus",2,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":16,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":4},"100586559","stress-evaluation-and-management-using-high-fidelity-simulation-in-medical-education-100586559","NCT06916949","Stress Evaluation and Management Using High Fidelity Simulation in Medical Education","The Role of High-fidelity Medical Simulation in Managing Emotional Components and Stress During Emergency and Urgent Care","STRATAGEM","Inclusion Criteria:\n\n* Medical trainees from the specialties of Emergency Medicine, Anesthesia and Intensive Care, Clinical Toxicology, Pediatrics, and Neonatology.\n* Normal hearing and vision, or corrected to normal.\n\nExclusion Criteria:\n\n* Known history of psychiatric disorders, cognitive impairment, or cardiac arrhythmias.\n* Current treatment with psychoactive, cardio-stimulant, or cardio-inhibitory medications.\n* Significant stressful life events in the past six months (e.g., family bereavement).\n* Previous systematic experience in meditation.",true,"25 Years","40 Years",{"count":89,"type":20},45,"INTERVENTIONAL",[92],"NA","The goal of this interventional study is to collect clinical and neurophysiological information to determine whether high-fidelity simulation can serve as a stress-inducing stimulus in a population of healthy residents (Emergency medicine, Anesthesia and Intensive care medicine, Paediatrics), both male and female, aged between 25 and 40 years. The main questions it aims to answer are:\n\n1. Define in which phase of the simulation the highest level of stress is observed.\n2. Determine the level of stress reached after performing a second high-fidelity simulation after a period of time.\n3. Identify whether specific brain areas are activated during high-fidelity simulation.\n\nParticipants will form teams, consisting of three medical trainees from the same specialty training program, that will undergo two high-fidelity simulations based on a clinical scenario relevant to their residency.\n\n* During the simulation, automatic pupillometry will be performed on all team members at the four time points.\n* Additionally, a two-lead ECG will be recorded for all team members at baseline and end of the debriefing\n* One team member will undergo EEG monitoring throughout the entire simulation. The EEG recordings will be sampled at baseline, during the simulation and end of the debriefing.",[95,25,96,97,98,99],"Stress","High Fidelity Simulation Training","Resident Education","Heart Rate Variability, Biomarker of Stress","Simulation Training","2025-04-01",{"date":102,"type":36},"2025-04-08",{"date":104,"type":20},"2025-04",{"date":106,"type":20},"2025-05",{"name":108,"class":43},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS"]