[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"purging-eating-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:purging-eating-disorders":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,58,94],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":36,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":57},"100531301","targeting-social-function-in-anxiety-and-eating-disorders-100531301",false,"NCT06198023","Targeting Social Function in Anxiety and Eating Disorders","Targeting Social Function to Improve Outcomes in Anxiety and Eating Disorders","SF","Inclusion Criteria:\n\n* In the past 12 months, has met DSM-5 criteria met for an eating disorder (Anorexia Nervosa, Atypical Anorexia Nervosa, Bulimia Nervosa, Avoidant-Restrictive Food Intake Disorder, or Other Specified Feeding or Eating Disorder) and\u002For an anxiety disorder (Generalized Anxiety Disorder, Social Anxiety Disorder)\n* Between the ages of 18-30\n\nExclusion Criteria:\n\n* Current inpatient or residential treatment\n* Medical instability or safety\u002Fsuicide risk as determined by the PI","ALL","18 Years","30 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","Social processing and cognition are often altered in patients with eating disorders. The goal of this clinical trial is to assess two different social therapeutic interventions -- one educational, one interactive -- for their effectiveness in improving clinical outcomes in patients with eating disorders. Patients in both interventions will receive education about social function in eating disorders, but those in the interactive treatment group will complete an additional collaborative art task.\n\nParticipants will:\n\n* attend a baseline study visit to complete clinical interviews, cognitive testing, and behavioral tasks\n* complete a pre-intervention assessment with questionnaires\n* attend eight sessions of their assigned treatment group over the course of 12 weeks\n* complete three virtual follow-up assessments 4, 8, and 12 months from their baseline\n* attend a final study visit to repeat some clinical interviews, cognitive testing, and behavioral tasks\n\nResearchers will compare changes in eating disorder, mood, and anxiety symptoms as well as test results from baseline and final study visits for each group to see if\n\n* patients can be treated effectively with education alone or if an interactive group component produces additional benefits\n* cognitive and behavioral task performance are associated with recovery or illness state.",[28,29,30,31,32,33,34,35],"Eating Disorders","Anorexia Nervosa","Bulimia Nervosa","Atypical Anorexia Nervosa","Purging (Eating Disorders)","Other Specified Feeding or Eating Disorder","Social Anxiety Disorder","Generalized Anxiety Disorder (GAD)",[37,38,39,40,41,42,43,44],"social function","social cognition","social processing","psychoeducation","group therapy","group intervention","art therapy","social anxiety","RECRUITING","2026-04-28",{"date":48,"type":49},"2026-05-05","ACTUAL",{"date":51,"type":49},"2024-02-28",{"date":53,"type":22},"2028-09",{"name":55,"class":56},"University of Texas Southwestern Medical Center","OTHER",1,{"id":59,"slug":60,"hasResults":11,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":4,"eligibilityCriteria":64,"healthyVolunteers":11,"sex":17,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":4,"studyType":23,"phases":69,"briefSummary":70,"conditions":71,"keywords":75,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":93},"100480801","study-comparing-acceptance-and-commitment-therapy-to-supportive-diabetes-counseling-and-a-waitlist-control-for-eating-disorders-in-type-1-diabetes-100480801","NCT05540704","Study Comparing Acceptance and Commitment Therapy to Supportive Diabetes Counseling and a Waitlist Control for Eating Disorders in Type 1 Diabetes","Changing the T1DE (Type 1 Diabetes Eating Disorders): A Randomized Controlled Trial Comparing Acceptance and Commitment Therapy (ACT) to Supportive Diabetes Counseling and a Waitlist Control","Primary Cohort\n\nInclusion Criteria:\n\n* 16-50 years of age\n* Diagnosis of Type 1 diabetes\n* Eating disorder characterized by binge eating and\u002For problematic weight control behaviors, including withholding insulin (Bulimia Nervosa, Binge Eating and Purging Disorder spectrum diagnoses)\n* Independently manages diabetes (not reliant on a caregiver)\n\nExpansion Cohort\n\nInclusion Criteria:\n\n* 16-50 years of age\n* Diagnosis of Type 1 diabetes\n* DEPR-R score \\>=20 but does not meet criteria for the primary cohort\n\nPrimary and Expansion Cohort\n\nExclusion Criteria:\n\n* Active suicidal ideation\n* Diagnosis of Avoidant Restrictive Food Intake Disorder or Anorexia Nervosa spectrum diagnoses\n* Hypoglycemic unawareness as assessed by the Gold Method and multiple severe episodes of hypoglycemia requiring 3rd party assistance in the last 2 years\n* Current substance abuse disorder or current or past psychotic disorder\n* NonEnglish speaking","16 Years","50 Years",{"count":68,"type":22},235,[25],"The goal of this clinical trial is to test whether a new intervention works to treat eating disorders in type 1 diabetes. Participants are assigned to one of the following: (1) Acceptance and Commitment Therapy (ACT), (2) Supportive Diabetes Counseling, or (3) a 6-month Waitlist Control. Participants in the ACT and Supportive Diabetes Counseling conditions complete 12 sessions over 12-16 weeks and use their mobile phone between sessions to increase engagement and reinforce learning.\n\nThe main questions are:\n\nDoes treatment improve glycemic levels, eating disorder symptoms, diabetes management and diabetes distress?\n\nDoes one treatment do better than the other?\n\nHow do the treatments work, if they work, and for whom?\n\nParticipants complete assessments that include wearing a continuous glucose sensor and activity watch, and get a blood draw to determine HbA1c. They also complete diagnostic interviews, surveys and computer tests of attention and things like heart rate and reaction time. These assessments help us better understand the types of changes that are happening and how they might influence health and well-being.",[72,28,73,32,74],"Type 1 Diabetes","Disordered Eating Behaviors","Binge-Eating Disorder",[76,77,78,79,80,81,82,83],"glycemic control","disordered eating behavior","eating disorders","type 1 diabetes","acceptance and commitment therapy","diabetes counseling","mhealth","psychological flexibility","2026-02-23",{"date":86,"type":49},"2026-02-25",{"date":88,"type":49},"2023-04-04",{"date":90,"type":22},"2027-09",{"name":92,"class":56},"Duke University",2,{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":17,"minAge":102,"maxAge":103,"enrollmentInfo":104,"targetDuration":4,"studyType":23,"phases":105,"briefSummary":107,"conditions":108,"keywords":111,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":57},"100478383","early-phase-1-naltrexone-neuroimaging-in-teens-with-eating-disorders-100478383","NCT05509257","Naltrexone Neuroimaging in Teens With Eating Disorders","Development of a Pharmacodynamic Biomarker of Opioid Antagonism in Adolescents With Eating Disorders","NN-RCT","Inclusion Criteria:\n\n* Adolescents and young adults aged 13-21 years\n* Eating disorder diagnosis characterized by binge eating and\u002For purging (eg, Anorexia Nervosa-Binge\u002FPurge, Bulimia Nervosa, Binge Eating Disorder, Other Specified Feeding\u002FEating Disorder) using Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-V) criteria.\n* Stable medication regimen (no dose or drug changes in the past 4 weeks)\n* Participant and parent\u002Flegal guardian (if under 18 years) are willing and able to provide informed permission\u002Fassent\u002Fconsent for the study\n\nExclusion Criteria:\n\n* Pregnant (via UCG)\n* Prior hypersensitivity reaction to naltrexone (e.g., anaphylaxis)\n* Non-removable metal in the body that is magnetic resonance imaging incompatible\n* Current naltrexone use\n* Self-reported opioid use in the past 7 days\n* A language barrier (e.g., non-English speaking) for the participant that precludes communication and\u002For ability to complete all study-related requirements.","13 Years","21 Years",{"count":21,"type":22},[106],"EARLY_PHASE1","Using a randomized, placebo-controlled, crossover study, this study will evaluate functional magnetic resonance imaging (fMRI) as a pharmacodynamic biomarker of opioid antagonism in adolescents with eating disorders. The hypothesis is that fMRI will be able to detect acute reward pathway modulation by naltrexone (an opioid antagonist) in pre-defined regions of interest (anterior cingulate cortex, nucleus accumbens, dorsolateral prefrontal cortex).",[28,109,32,30,110],"Binge Eating","Anorexia Nervosa, Atypical",[112,113,114,115,116,117],"Pediatric","Adolescent","Eating Disorder","Neuroimaging","Naltrexone","Pharmacodynamic Biomarker","2025-11-20",{"date":120,"type":49},"2025-11-25",{"date":122,"type":49},"2022-09-17",{"date":124,"type":22},"2027-06",{"name":126,"class":56},"Children's Mercy Hospital Kansas City"]