[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pyelonephritis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pyelonephritis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100637870","diagnosis-of-abdominal-pain-using-rna-levels-the-natural-study-100637870",false,"NCT07579312","Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL Study","Neutrophil Activation Test Using RNA Levels to Assist in the Diagnosis of Abdominal Pain: The NATURAL Study","NATURAL","Inclusion Criteria:\n\nAge \\> 7 yr old Abdominal pain of likely non-traumatic origin Risk of intra-abdominal infection (see IAI signs) Ability to provide informed consent\u002Fassent Potential to order abdominal CT, ultrasound, endoscopy, or surgery for possible IAI\n\nExclusion Criteria:\n\nAny situation where delay could be detrimental Hemodynamically unstable (see age-adjusted criteria) Prisoner or other involuntary detainee Inability to provide informed consent\u002Fassent",true,"ALL","7 Years",{"count":21,"type":22},1000,"ESTIMATED","OBSERVATIONAL","The NATURAL Study is a prospective, observational, pragmatic study of RNA biomarkers of infections to aid in the diagnosis of abdominal pain.\n\nSummary of Research Study:\n\nHypothesis: A genomic-derived panel of 6 RNA biomarkers present in stabilized whole blood will provide diagnostic information about the presence of bacterial, biofilm, and viral infections in the abdomen. We hypothesize that biomarkers will be more than 90% sensitive with a high (\\>90%) negative predictive value for IAI.\n\nResearch Design: The project design is a prospective, pragmatic, observational study. The NATURAL Study will be sponsored by True Bearing Diagnostics, Inc., and performed at 5 or more academic medical centers. Patients with suspected intra-abdominal infections (IAIs), such as appendicitis, diverticulitis, acute cholecystitis, pancreatitis, peritonitis, pyelonephritis, and abscess are candidates for this study. This is a broad category of patients that are defined by the suspicion of an internal abdominal infection, usually involving some type of advanced imaging analysis, such as CT scan or ultrasound. All participants will be consented for this observational, minimal-risk study prior to venipuncture. Ultimately, The NATURAL Study will determine the positive agreement (\\~sensitivity) and negative agreement (\\~specificity) of the TruNAV RNA biomarkers in relation to the clinical diagnosis of the presence or absence of an IAI, based on CT scans and\u002For surgical confirmation, the current standard of care for diagnosis of IAI.\n\nObjective: To validate a novel RNA fingerprint in ED patients with suspected IAIs.\n\nThe NATURAL Study is designed to determine the accuracy of novel RNA biomarkers for diagnosis of IAI in patients suspected of having IAI. Subgroup analysis will analyse RNA biomarker for multiple types of actual and suspected IAIs (appendicitis, diverticulitis, acute cholecystitis, pancreatitis, peritonitis, pyelonephritis, and abscess.)\n\nSubjects: Approximately 1,000 ED patients presenting with abdominal pain that are candidates to receive CT or other confirmatory diagnostics will be enrolled.",[26,27,28,29,30],"Intra Abdominal Infections","Appendicitis Acute","Pyelonephritis","Diverticulitis","Epiploic Appendagitis",[26,32,33,28,29,34,35],"Biomarkers","Appendicitis","Epiploic appendagitis","Gastroenteritis","RECRUITING","2026-05-06",{"date":39,"type":40},"2026-05-12","ACTUAL",{"date":42,"type":40},"2026-04-17",{"date":44,"type":22},"2027-09",{"name":46,"class":47},"True Bearing Diagnostics, Inc.","INDUSTRY",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":18,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":48},"100598331","population-pharmacokinetics-of-temocillin-in-acute-enterobacterial-pyelonephritis-in-children-100598331","NCT07070102","Population Pharmacokinetics of Temocillin in Acute Enterobacterial Pyelonephritis in Children","TEMOKID-POP","Inclusion Criteria:\n\n* Patient aged 0 to 15 years\n* Presenting with a febrile urinary tract infection due to GNR (a febrile urinary tract infection is defined as a urine culture showing significant leukocyturia (≥104) and direct examination showing GNR, in a patient with fever)\n* Requiring hospitalization in the general pediatrics, emergency (short-stay hospitalization unit), nephrology, or intensive care units of the Robert-Debré University Hospital for a presumed period of at least 48 hours.\n* Non-opposition of the legal representatives obtained by one of the investigator\n\nExclusion Criteria:\n\n* Presence of sepsis (Phoenix score ≥ 2)\n* Gram-positive cocci (GPC) urinary tract infection (Urinalysis before antibiotic therapy revealed significant leukocyturia (≥104) and direct examination revealed GPC)\n* Known allergy to beta-lactam antibiotics\n* Severe renal impairment (glomerular filtration rate \\\u003C30 mL\u002Fmin\\*1.73 m2)","1 Day","15 Years",{"count":59,"type":22},50,"Temocillin, a 6-alpha-methoxypenicillin derivative of ticarcillin, is a narrow-spectrum antibiotic, primarily restricted to Enterobacterales. Therefore, its prescription for the treatment of febrile urinary tract infections requiring hospitalization in pediatrics appears interesting.\n\nHowever, and despite marketing authorization in pediatrics for the treatment of complicated urinary tract infections (including acute pyelonephritis), the pharmacokinetic parameters of this antibiotic have not been specifically evaluated in pediatrics, and the optimal dose is not known in this population.\n\nThrough this study, we propose to determine the pharmacokinetic parameters of temocillin in children aged 0-15 years with a febrile urinary tract infection due to Gram-negative rod (GNR), without sepsis but requiring hospitalization. The results will help to establish dose recommendations for temocillin in the pediatric population, based on age and renal function.",[28],[63],"temocillin","NOT_YET_RECRUITING","2025-07-07",{"date":67,"type":40},"2025-07-17",{"date":69,"type":22},"2025-09-01",{"date":71,"type":22},"2027-09-01",{"name":73,"class":74},"Assistance Publique - Hôpitaux de Paris","OTHER",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":18,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":48},"100359368","the-validity-of-the-quick-renal-mri-in-pediatric-kidney-disease-100359368","NCT03959163","The Validity of the Quick Renal MRI in Pediatric Kidney Disease","Inclusion Criteria:\n\n* Aim 1:\n\n  * Patient is admitted to American Family Children's Hospital for a febrile UTI, suspected pyelonephritis, or diagnosed pyelonephritis\n  * Undergoing clinical DMSA scan\n* Aim 2:\n\n  * Undergoing DMSA scans as a part of their routine clinical care\n  * History of more than one UTI in the past year\n\nExclusion Criteria:\n\n* Aim 1:\n\n  * No evidence of pyuria on their urine analysis\n  * Negative urine culture\n  * Not comfortable with having a Quick MRI performed\n* Both aims:\n\n  * Contraindications to MRI","0 Years","21 Years",{"count":84,"type":22},100,"INTERVENTIONAL",[87],"NA","The investigators propose a new imaging method for children born with congenital anomalies of the urinary tract that is a rapid, injection-, sedation-, and radiation-free alternative: the quick renal MRI. This proposal hypothesizes that the quick renal MRI has high validity compared to current radiologic standard for renal infection and scarring, the 99mTechnetium-dimercaptosuccinic acid (99mTc- DMSA) renal scan in the detection of acute renal infections and scars. If the quick renal MRI is accurate, it could potentially replace the DMSA scan for those specific questions and ease the burden of testing for children with chronic renal disease. Findings from these studies will provide preliminary data and rationale for a multi-centered study to further test this new technology.\n\nParticipants will be 0-21 years of age and can expect to be on study for from 1 week (if enrolled in Aim 1) to 6 months (if enrolled in Aim 2).",[28,90,91],"Pyelonephritis Acute","Renal Sclerosis","2024-04-02",{"date":94,"type":40},"2024-04-03",{"date":96,"type":40},"2019-05-07",{"date":98,"type":22},"2025-01",{"name":100,"class":74},"University of Wisconsin, Madison"]