[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"quadrantanopia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:quadrantanopia":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,55,90,127,165,186],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":36,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100642991","home-based-vision-rehabilitation-guided-by-brain-imaging-100642991",false,"NCT07635329","Home-based Vision Rehabilitation Guided by Brain Imaging","Behavioral Rehabilitation Through Image-Guided Home-based Training","BRIGHT","Inclusion Criteria:\n\n1. At least 18 years of age.\n2. Capable of providing informed consent and complying with study procedures.\n3. Unilateral or bilateral focal brain damage causing visual field loss.\n4. At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year.\n5. Eligible for MRI based on standard safety screening.\n\nExclusion Criteria:\n\n1. Severe neurological or psychiatric conditions unrelated to the focal lesion that may interfere with study participation or data interpretation.\n2. Current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by DSM-5.\n3. Ocular disease or disorder.","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual field loss.\n\nUsing a prospective, crossover design, BRIGHT combines visual behavioral testing, neuroimaging, and a home-based intervention. It aims to 1) identify neural pathways that support training-induced visual plasticity; and 2) compare the efficacy of different types of visual training delivered in a home-based setting.",[27,28,29,30,31,32,33,34,35],"Visual Field Defect","Stroke","Hemianopia Homonymous","Quadrantanopia","Cortical Blindness","Visual Field Defect, Peripheral","Visual Field Loss","Traumatic Brain Injury","Brain Tumor",[37,38,39,40,41],"neuroplasticity","stroke","vision","TBI","brain tumor","RECRUITING","2026-06-03",{"date":45,"type":46},"2026-06-09","ACTUAL",{"date":48,"type":21},"2026-07-01",{"date":50,"type":21},"2030-03-31",{"name":52,"class":53},"Georgetown University","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":64,"briefSummary":65,"conditions":66,"keywords":71,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":54},"100583352","visual-restoration-using-focused-ultrasound-stimulation-and-immersive-virtual-reality-after-stroke-100583352","NCT06875206","Visual Restoration Using Focused Ultrasound Stimulation and Immersive Virtual Reality After Stroke","LIFU-IVR","Inclusion Criteria:\n\n* ≥ 18 years old of any gender and race\n* Clinical ischemic stroke or hemorrhagic (confirmed by CT or MRI) that occurred \\>= 6-24 months ago\n* Partial or complete homonymous hemianopsia on clinical exam\n\nExclusion Criteria:\n\n* Documented history of severe dementia with or without medication before stroke that affect subject's ability to participate in and be compliant to study protocol\n* Significant upper motor deficits and the subject cannot do IVR sessions at the baseline\n* History of seizures\n* Inability to get a new MRI\n* Presence of any ultrasonic stimulation risk factors: an electrically, magnetically, or mechanically activated metal or nonmetal implant including cardiac pacemaker, intracerebral vascular clips, or any other electrically sensitive support system; non-fixed metal in any part of the body; pregnancy (the effect of ultrasonic stimulation on the fetus is unknown); preexisting scalp lesion or wound or bone defect or hemicraniectomy.\n* Patients will be excluded if they have a previous diagnosis of hemianopsia, a new diagnosis of central retinal ischemic injury, or visual blindness or a history of any other ocular disease.\n* Concerns about the inability to complete study visits\u002Fprocedures by the PI.",{"count":63,"type":21},28,[24],"This research will explore if brain stimulation combined with virtual reality therapy improves visual impairment. The stimulation technique is called low-intensity focused ultrasound stimulation (LIFUS). The treatment uses ultrasound to stimulate vision specific parts of the brain. Before this therapy, the participants will get structural brain imaging. Functional brain imaging will be performed before and after the study's completion to measure brain activity response to therapy.\n\nThe purpose of this research study is to evaluate patients who have had a stroke between 6 and 24 months ago with a visual field impairment. The duration of active participation in the study is 1.5 months.",[28,27,67,68,30,69,70],"Visual Field Defect Following Cerebrovascular Accident","Hemianopia","Occipital Lobe Infarct","Visual Fields Hemianopsia",[72,38,73,74,75,76,77,78,79],"virtual reality","visual deficit","chronic stroke","ultrasound stimulation","neuromodulation","stroke recovery","visual field defect","funcational imaging","NOT_YET_RECRUITING","2026-05-19",{"date":83,"type":46},"2026-05-22",{"date":85,"type":21},"2026-12-01",{"date":87,"type":21},"2027-04",{"name":89,"class":53},"Duke University",{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":97,"enrollmentInfo":98,"targetDuration":4,"studyType":22,"phases":100,"briefSummary":101,"conditions":102,"keywords":106,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":54},"100445805","improving-visual-field-deficits-with-noninvasive-brain-stimulation-100445805","NCT05085210","Improving Visual Field Deficits With Noninvasive Brain Stimulation","Visual Restoration of Losses Caused by Cortical Damage: a New Protocol to Promote Fast Recovery","Inclusion Criteria:\n\n1. 18 years of age or older.\n2. Presence of some intact visual cortical areas (other than primary visual cortex) in the damaged brain hemisphere. This assessment will be made from MRI or CT scans of the subject's head, which will be obtained via standard release from their neurologist.\n3. First ever ischemic or hemorrhagic stroke with damage to primary visual cortex, and rendered blind over a portion of their visual field.\n\n   * Ischemic stroke patients will be either subacute (within 6 months of their stroke) or chronic (more than 6 months)\n   * Hemorrhagic stroke patients will be chronic only (greater than 6 months)\n4. Must demonstrate a clear deficit in either simple or complex visual perception in portions of their visual field as measured by visual perimetry.\n5. Imaging evidence that the stroke is primarily affecting the visual cortex.\n6. Willing and able to participate in the study protocol and to comply with study procedures.\n\nExclusion Criteria:\n\n1. No evidence of damage to the primary visual cortex.\n2. Visual cortex damage as a result of a subsequent stroke (not primary).\n3. Total cortical blindness, covering both left and right visual fields.\n4. Unable to fixate visual targets precisely or unable to perform the visual training exercises as directed.\n5. Complete loss of reading abilities.\n6. Current or prior history of any neurological disorder other than stroke, such as epilepsy, a progressive neurologic disease (e.g. multiple sclerosis) or intracranial brain lesions other than the qualifying stroke lesion.\n7. Current history of poorly controlled migraines including chronic medication for migraine prevention.\n8. History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or immediate (1st degree relative) family history of epilepsy; with the exception of a single seizure of benign etiology (e.g. febrile seizure) in the judgment of the investigator.\n9. History of fainting spells of unknown or undetermined etiology that might constitute seizures.\n10. Past or current history of major depression, bipolar disorder or psychotic disorders, or any other major psychiatric condition.\n11. Participants who are suffering from one-sided attentional neglect as determined by standard neuropsychological tests: figure cancellation and line bisection tasks.\n12. Contraindication for receiving tRNS.\n13. Chronic (particularly) uncontrolled medical conditions that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.).\n14. Any complex, uncontrolled\u002Funstable or terminal medical illness.\n15. Substance abuse or dependence within the past six months.\n16. Medications will be reviewed by the responsible MD (Drs. Sandeep Kumar or Dan Press) and a decision about inclusion will be made based on the following: The patient's past medical history, drug dose, history of recent medication changes or duration of treatment, and combination of CNS active drugs.\n17. All female participants that are pre-menopausal will be required to have a pregnancy test; any participant who is pregnant or breastfeeding will not be enrolled in the study.\n18. Subjects who, in the investigator's opinion, might not be suitable for the study.\n19. A hair style or head dress that prevents electrode contact with the scalp or would interfere with the stimulation (for example: thick braids, hair weave, afro, wig).\n20. Additional criteria for Group 1b only: Contraindication for using VR technology, specifically an implanted medical device such as a pacemaker, implanted defibrillator, deep brain or vagal nerve stimulator. Participants with a history of seizures are already excluded per the above criteria.","80 Years",{"count":99,"type":21},24,[24],"This is a randomized, pilot interventional study in participants with visual field deficit (VFD) caused by cortical lesion. Damage to the primary visual cortex (V1) causes a contra-lesional, homonymous loss of conscious vision termed hemianopsia, the loss of one half of the visual field. The goal of this project is to elaborate and refine a rehabilitation protocol for VFD participants. It is hypothesized that visual restoration training using moving stimuli coupled with noninvasive current stimulation on the visual cortex will promote and speed up recovery of visual abilities within the blind field in VFD participants. Moreover, it is expected that visual recovery positively correlates with reduction of the blind field, as measured with traditional visual perimetry: the Humphrey visual field test or an eye-tracker based visual perimetry implemented in a virtual reality (VR) headset. Finally, although results will vary among participants depending on the extent and severity of the cortical lesion, it is expected that a bigger increase in neural response to moving stimuli in the blind visual field in cortical motion area, for those participants who will show the largest behavioral improvement after training. The overarching goals for the study are as follows: Group 1a will test the basic effects of transcranial random noise stimulation (tRNS) coupled with visual training in stroke cohorts, including (i) both chronic\u002Fsubacute ischemic and chronic hemorrhagic VFD stroke participants, and (ii) longitudinal testing up to 6 months post-treatment. Group 1b will test the effects of transcranial tRNS coupled with visual training on a Virtual Reality (VR) device in stroke cohorts, including both chronic\u002Fsubacute ischemic and chronic hemorrhagic VFD stroke participants. Group 2 will examine the effects of tRNS alone, without visual training, also including chronic and subacute VFD stroke participants and longitudinal testing.",[32,28,103,104,30,31,105,69,70],"Visual Impairment","Hemianopsia","Visual Field Defect Homonymous Bilateral",[107,108,109,110,111,112,113,114,115,116,117],"Visual Field defects","Occipital Stroke","Ischemic Stroke","visual cortex","noninvasive brain stimulation","transcranial direct current stimulation","visual training","visual recovery","vision loss","quadrantanopia","Hemorrhagic stroke","2026-03-03",{"date":120,"type":46},"2026-03-04",{"date":122,"type":46},"2022-01-25",{"date":124,"type":21},"2026-06",{"name":126,"class":53},"Beth Israel Deaconess Medical Center",{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":134,"sex":17,"minAge":135,"maxAge":136,"enrollmentInfo":137,"targetDuration":4,"studyType":22,"phases":139,"briefSummary":140,"conditions":141,"keywords":148,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":54},"100519758","vision-loss-impact-on-navigation-in-virtual-reality-100519758","NCT06047717","Vision Loss Impact on Navigation in Virtual Reality","The Impact of Vision Loss on Naturalistic Behavior and Navigation in Virtual Reality","Cortically Blind Group:\n\nInclusion Criteria:\n\n* Residents of the United States or Canada\n* Presence of one-sided stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range of 21 - 75 years (verified by MRI and\u002For CT scans)\n* Reliable visual field defects in both eyes (homonymous defects) as measured by Humphrey or equivalent perimetry.\n* Willing, able, and competent to provide their own informed consent\n* Cognitively able, responsible to understand written and oral instructions in English\n* Emmetropic or else wear corrective contact lenses inside the virtual reality headset\n\nExclusion Criteria:\n\n* Those who have never driven or earned a drivers' license\n* Past or present ocular disease interfering with visual acuity\n* Best corrected visual acuity (BCVA) worse than 20\u002F40 in either eye\n* Sustained damage to the dorsal lateral geniculate nucleus\n* Presence of diffuse, whole-brain degenerative processes\n* Presence of brain damage deemed by study staff to potentially interfere with outcome measures\n* History of traumatic brain injury\n* Documented history of drug\u002Falcohol abuse\n* Diagnosis of cognitive or seizure disorders\n* Diagnosis of one-sided attentional neglect\n\nControl Group:\n\nInclusion Criteria:\n\n* Normal or corrected-to-normal vision, who are between the ages of 21 and 75 years of age, roughly matched to the age of CB subjects enrolled above\n* Competent and responsible, as determined by the Principal Investigator\n* Willing, able, and competent to provide their own informed consent\n* Normal cognitive abilities, be able to understand written and oral instructions in English\n* Emmetropic or else wear corrective contact lenses inside the virtual reality headset\n\nExclusion Criteria:\n\n* Subjects who have never driven or earned a drivers' license\n* BCVA worse than 20\u002F40 in either eye\n* Presence of vision loss from ocular diseases or disorders\n* Presence of a visual field defect\n* Inability to wear corrective contact lenses inside the virtual reality helmet if required to see clearly\n* Subjects with a history of neurological disorders\n* Subjects with a history of TBI\n* Persons who lack the competence or are otherwise unable to perform the visual testing as directed.",true,"21 Years","75 Years",{"count":138,"type":21},40,[24],"The purpose of this research is to better understand the impact of cortically-induced blindness (CB) and the compensatory strategies subjects with this condition may develop on naturalistic behaviors, specifically, driving. Using a novel Virtual Reality (VR) program, the researchers will gather data on steering behavior in a variety of simulated naturalistic environments. Through the combined use of computer vision, deep learning, and gaze-contingent manipulations of the visual field, this work will test the central hypothesis that changes to visually guided steering behaviors in CB are a consequence of changes to the visual sampling and processing of task-related motion information (i.e., optic flow).",[142,30,143,144,68,104,69,32,145,146,147],"Stroke, Ischemic","Hemianopsia, Homonymous","Hemianopia, Homonymous","Vision Loss Partial","Quadrantanopsia","Stroke Hemorrhagic",[149,150,151,152,153,154,155,38],"Occipital stroke","Vision loss after stroke","Vision recovery","Vision restoration","Partial vision loss","Homonymous quadrantanopsia","Homonymous quadrantanopia","2026-01-07",{"date":158,"type":46},"2026-01-09",{"date":160,"type":46},"2023-11-28",{"date":162,"type":21},"2028-10",{"name":164,"class":53},"University of Rochester",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":173,"targetDuration":4,"studyType":22,"phases":175,"briefSummary":176,"conditions":177,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":54},"100601043","visual-plasticity-following-brain-lesions-100601043","NCT07105358","Visual Plasticity Following Brain Lesions","Vision Improvement Through Behavioral Rehabilitation And Neuroplasticity Training","VIBRANT","A. Stroke, brain tumor, or traumatic brain injury patients\n\nInclusion Criteria:\n\n1. At least 18 years of age.\n2. Capable of providing informed consent and complying with study procedures.\n3. Unilateral or bilateral focal brain damage causing loss of vision.\n4. At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year.\n\nExclusion Criteria:\n\n1. Severe CNS diseases or disorders unrelated to the focal lesion, which could interfere with study results.\n2. Severe mental health challenges that could interfere with study results, or current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by DSM-5.\n3. Vision loss resulting from ocular disease or disorder.\n\nB. Healthy volunteers (age-matched controls):\n\nInclusion Criteria:\n\n1. At least 18 years of age.\n2. Capable of providing informed consent and complying with study procedures.\n\nExclusion Criteria:\n\n1. Any CNS diseases or psychiatric disorders (e.g., epilepsy, schizophrenia) that would interfere with study results.\n2. Previous head injury.\n3. Present or past (within past 6 months) drug or alcohol abuse or addiction based on DSM-5.",{"count":174,"type":21},30,[24],"The VIBRANT (Vision Improvement through Behavioral Rehabilitation And Neuroplasticity Training) study is a prospective, double-blind, crossover design (within-subject) in participants with homonymous hemianopia-a type of visual field loss resulting from damage to the post-chiasmatic visual pathways. It aims to investigate whether transcranial random noise stimulation (tRNS) combined with perceptual learning-based training has potential for improving visual impairments.",[27,28,68,30,31,35,34,32],"2025-07-29",{"date":180,"type":46},"2025-08-05",{"date":182,"type":46},"2025-07-17",{"date":184,"type":21},"2028-06-30",{"name":52,"class":53},{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":192,"eligibilityCriteria":193,"healthyVolunteers":134,"sex":17,"minAge":135,"maxAge":97,"enrollmentInfo":194,"targetDuration":4,"studyType":22,"phases":195,"briefSummary":196,"conditions":197,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":54},"100525398","effect-of-visual-retraining-after-stroke-100525398","NCT06121219","Effect of Visual Retraining After Stroke","Effect of Visual Retraining on Visual Loss Following Cortical Damage","urochester","Cortically Blind Subjects\n\nInclusion:\n\n* Between 21 and 80 years of age\n* Residents of the United States or Canada\n* Unilateral stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range (21-75 years)\n* Reliable visual field defects in both eyes as measured by Humphrey, MAIA, Goldmann, and\u002For equivalent perimetry, large enough to enclose a 5-deg diameter visual stimulus.\n* Able to fixate on visual targets reliably for 1000ms\n* Must have a home computer (desktop or laptop) and reliable internet access\n* Willing, able, and competent to provide informed consent\n* Normal cognitive abilities, able to understand written and oral instructions in English, and competent and responsible adults in order to complete the visual training at home, independently, as instructed, for several months.\n\nExclusion:\n\n* Past or present eye disease interfering with visual acuity\n* BCVA worse than 20\u002F40 in either eye\n* Damage to the dorsal Lateral Geniculate Nucleus\n* Diffuse whole brain degenerative processes\n* History of traumatic brain injury\n* Any other brain damage deemed by study staff to potentially interfere with training ability or outcome measures\n* Documented history of drug\u002Falcohol abuse\n* Currently taking neuroactive medications which would impact training, as determined by PI\n* Presence of cognitive or seizure disorders\n* One-sided attentional neglect\n* Subjects who lack the competence or are otherwise unable to perform the visual training exercises as directed.\n\nControl Subjects (n = 50)\n\nInclusion:\n\n* Between 21 and 80 years of age\n* Report no history of neurological disorder.\n* Competent and responsible, as determined by the Principal Investigator.\n\nExclusion:\n\n* Presence of damage to the visual system\n* Presence of an active disease process involving their nervous system.\n* Cognitive or seizure disorders\n* Best corrected visual acuity worse than 20\u002F40 in either eye\n* Presence of vision field loss from ocular disease or disorder",{"count":20,"type":21},[24],"This project is intended to collect data using standard clinical tests and psychophysics to quantify the effect of visual cortical damage on the structure of the residual visual system, visual perception, spatial awareness, and brain function. The investigators will also assess the effect of intensive visual retraining on the residual visual system, processing of visual information and the use of such information in real-world situations following damage. This research is intended to improve our understanding of the consequences of permanent visual system damage in humans, of methods that can be used to reverse visual loss, and of brain mechanisms by which visual recovery is achieved.",[145,198,29,68,30,142,199,31],"Vision; Loss, Both Eyes","Stroke - Occipital Infarction","2025-07-10",{"date":202,"type":46},"2025-07-16",{"date":204,"type":46},"2024-09-05",{"date":206,"type":21},"2032-01",{"name":164,"class":53}]