[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"quadriceps-muscle-atrophy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:quadriceps-muscle-atrophy":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,72,98],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100592535","clinimetric-properties-of-muscle-mass-and-stiffness-measurements-of-the-quadriceps-in-patients-with-copd-100592535",false,"NCT06994689","Clinimetric Properties of Muscle Mass and Stiffness Measurements of the Quadriceps in Patients With COPD","Clinimetric Properties Assessment of Quadriceps Muscle Mass and Stiffness Using Perimetry and ShearWave Elastography in Patients With COPD : a Prospective Observational Study","Metriquad","Inclusion Criteria:\n\n* COPD patients\n* Adults (\\>18 years old)\n* Patients starting a pulmonary rehabilitation (PR) programme\n\nExclusion Criteria:\n\n* Patients included in other research protocol\n* Minors or under guardianship\n* Pregnancy\n* Patients with lower limb amputation or history of neuromuscular disease\n* Cardiovascular contradications for PR","ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","OBSERVATIONAL","A large amount of patients with COPD suffer from muscle dysfunction characterized by losses of muscle mass and strength. Studies have shown an association between a loss of quadriceps muscle mass and premature death.\n\nThis study aims to investigate the clinimetric properties of a simple quadriceps perimetry and ShearWave elastography to improve the monitoring of skeletal muscle function in patients with COPD.",[25,26],"COPD","Quadriceps Muscle Atrophy",[28,29,30],"Clinimetric properties","Muscle mass","Muscle strength","RECRUITING","2026-01-19",{"date":34,"type":35},"2026-01-21","ACTUAL",{"date":37,"type":35},"2025-05-30",{"date":39,"type":21},"2026-12-01",{"name":41,"class":42},"Groupe Hospitalier du Havre","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":18,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":43},"100497237","the-impact-of-blood-flow-restriction-training-in-adolescents-after-acl-reconstruction-a-randomized-controlled-trial-100497237","NCT05754632","The Impact of Blood Flow Restriction Training in Adolescents After ACL Reconstruction: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Prior to surgery participated in \\>50 hours\u002Fyear of level I or II sports as defined by Noyes et al and planned to return to prior level.\n\nLevel I Sports (4-7 days\u002Fweek) Jumping, hard pivoting, cutting (basketball, volleyball,football, soccer, gymnastics, skiing. wrestling)\n\n* Level II sports (1-3 days\u002Fweek) Jumping, hard pivoting, cutting (basketball, volleyball,football, soccer, gymnastics, skiing. wrestling)\n* Completion of postoperative rehabilitation following standard protocols\n* Orthopedic surgical intervention and physical therapy completed at Connecticut Children's.\n\nExclusion Criteria:\n\n* An additional lower extremity injury at time of knee injury or previous surgical intervention on the knee (ipsilateral and contralateral)\n* Multiple ligament ruptures or trauma\n* Weight bearing restrictions for greater than 4 weeks after surgery due to concomitant pathology such as meniscal root\u002Fradial repair, chondral pathology, or multi-ligament pathology\n* Follow-up surgical procedures including, but not limited to, post-operative arthrofibrosis Inability to attend regular physical therapy sessions (≥80% of patient treatment sessions and all assessment visits\n* Contraindications to performing BFRT including known history of central or peripheral neurologic impairments, cardiac or metabolic condition or history of deep vein thrombosis (DVT).","12 Years",{"count":52,"type":21},40,"INTERVENTIONAL",[55],"NA","While there are a number studies that have reported on the use of blood flow restriction training (BFRT) in the adult population, there is limited information about the use of BFRT in the adolescent population. This study aims to evaluate the use of BFRT in conjunction with traditional anterior ligament reconstruction (ACLR) rehabilitation in adolescents.\n\nThe purpose of this study is to compare the addition of a BFRT based exercise protocol to a standard ACL rehabilitation protocol in adolescents. Does the addition of BFRT-based exercise improve strength, hypertrophy, and patient reported outcomes after ACLR in the adolescent population?",[58,59,26],"Anterior Cruciate Ligament Injuries","Knee Injuries",[61,62],"physical therapy","rehabilitation","2026-01-05",{"date":65,"type":35},"2026-01-07",{"date":67,"type":35},"2023-06-08",{"date":69,"type":21},"2029-05-01",{"name":71,"class":42},"Connecticut Children's Medical Center",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":53,"phases":83,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":97},"100429667","vibration-and-post-traumatic-osteoarthritis-risk-following-acl-injury-100429667","NCT04875052","Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury","The Effects of Vibratory Stimuli on Joint Health and Post-traumatic Osteoarthritis Risk Following Anterior Cruciate Ligament Injury","Inclusion Criteria:\n\n* Age 16 to 35 years\n* Unilateral, primary ACLR with bone-patellar tendon-bone autograft\n\nExclusion Criteria:\n\n* History of prior ACL injury or revision ACLR\n* History of prior knee surgery\n* Requirement of multiple ligament surgery at time of ACLR\n* Concomitant injuries or surgical procedures at the time of ACLR that would delay early post-operative weight bearing based on surgeon recommendations (e.g. lower extremity fracture, intra-articular fracture, microfracture procedure)\n* Removal of more than 1\u002F3 of the medial or lateral meniscus at the time of ACLR\n* Articular cartilage damage greater than 3A on the International Cartilage Repair Society Criteria at the time of ACLR\n* History of musculoskeletal injury to either leg in the 3 months prior to participation other than primary ACL injury\n* Prior diagnosis of radiographic OA in any joint of the lower extremity\n* History of neurological disorder (e.g. stroke, multiple sclerosis, etc.)\n* Contraindications for MRI (e.g. extreme claustrophobia, cardiac pacemaker, cochlear implant, metal foreign bodies, aneurism clip, etc.)\n* Pregnant or planning to become pregnant","16 Years","35 Years",{"count":82,"type":21},114,[55],"The goal of this randomized clinical trial is to evaluate the effects of vibration on factors related to the risks of post-traumatic knee osteoarthritis and secondary anterior cruciate ligament (ACL) injury in individuals who have undergone anterior cruciate ligament reconstruction surgery (ACLR). The main objectives are to compare the effects of Standard rehabilitation vs. rehabilitation that includes whole body vibration (WBV) or local muscle vibration (LMV) on:\n\n* Quadriceps muscle function\n* Gait biomechanics linked to post-traumatic knee osteoarthritis development\n* Patient self-report outcomes\n* MRI indicators of knee joint health and muscle quality\n* Landing biomechanics linked to secondary ACL injury risk\n* Evidence-based return-to-physical-activity criteria\n\nParticipants will be assigned to 1 of 3 groups (standard rehabilitation, standard rehabilitation + WBV, or standard rehabilitation + LMV) and will complete assessments of quadriceps function, gait biomechanics, landing biomechanics, functional ability, patient-report outcomes, and MRI 1, 6, and 12 months after ACLR. Researchers will compare the groups to see if vibration embedded in ACLR rehabilitation improves joint health outcomes.",[86,58,87,26],"Osteoarthritis, Knee","Post-traumatic Osteoarthritis","2025-05-27",{"date":90,"type":35},"2025-05-31",{"date":92,"type":35},"2021-01-11",{"date":94,"type":21},"2026-08",{"name":96,"class":42},"University of North Carolina, Chapel Hill",2,{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":53,"phases":108,"briefSummary":110,"conditions":111,"keywords":114,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":123,"leadSponsor":125,"locationsCount":43},"100452676","phase-2-vitamin-d-to-improve-quadricep-muscle-strength-100452676","NCT05174611","Vitamin D to Improve Quadricep Muscle Strength","Vitamin D as an Intervention for Improving Quadricep Muscle Strength in Patients After Anterior Cruciate Ligament Reconstruction: A Randomized Double-Blinded, Placebo-Controlled Clinical Trial","Inclusion Criteria:\n\n1. Aged 18-40 with unilateral ACL injury\n2. Sporting injury with a Tegner score of 7\n3. Pre-op serum vitamin D level \\\u003C20 ng\u002Fml\n4. 4 months post-ACLR with serum Vitamin D level remained \\\u003C20ng\u002Fml\n5. LSI for quadriceps strength \\\u003C70% of contralateral leg at 4-month isokinetic assessment\n6. Both knees without history of injury\u002Fprior surgery\n\nExclusion Criteria:\n\n1. Concomitant bone fracture, major meniscus injury or full-thickness chondral injuries requiring altered rehabilitation program post-operatively\n2. Pre-operative radiographic signs of arthritis\n3. Metal implants that would cause interference on MRI\n4. Non-HS graft for ACLR\n5. Patient non-compliant to the rehabilitation program\n6. Regular sunbed users","40 Years",{"count":107,"type":21},60,[109],"PHASE2","Quadriceps muscle strength is one of the key determinants for patients to fulfill the Return-to-Play (RTP) criteria after an anterior cruciate ligament reconstruction (ACLR), in which the muscle size is directly linked to muscle strength. Quadriceps muscle atrophy is unavoidable after ACLR, but the rehabilitation program should increase quadriceps muscle mass. However, despite good rehabilitation compliance, some patient's progress is sub-par and fail to regain muscle mass. Quadriceps muscle atrophy can persist beyond the completion of the rehabilitation program in almost half the patients and the reason behind this is still unknown. This represents an area that requires significant investigation, as quadriceps muscle atrophy and weakness have been shown to be determinants of poor knee function, decreased performance in sports and increased risk of reinjury.\n\nQuadriceps muscle atrophy after ACLR is well documented. This can be due to a decreased ability to regain muscle mass with rehabilitation. Athletes are one of the high-risk groups for vitamin D insufficiencies. Vitamin D deficiency can potentially result in decreased hypertrophy when exercising the muscle, leading to a poorer outcome in rehabilitation. Vitamin D has long been recognized for its effect on musculoskeletal health. It can have a direct effect on muscle hypertrophy by acting on specific vitamin D receptors (VDRs) on myocytes, and sufficient or increased levels of vitamin D in patients have been found to correlate with an increase in the size, number, and strength of muscle fibres. Quadriceps muscle hypertrophy after ACLR is triggered by exercise training, facilitated by diet and a number of intrinsic factors. As the rehabilitation programs and diets are similar in patients with varying extents of quadriceps muscle atrophy, individual responses (intrinsic factors) to exercise training may account for the resulting persistent quadriceps muscle atrophy. In this study, the investigators hypothesize that the deficiency of vitamin D may contribute to persistent quadriceps atrophy and weakness.\n\nWith a stringent double-blinded randomized-controlled-trial (RCT) research design, our proposal will then address the research questions: 'Does vitamin D supplements improve the vitamin D deficiency status in patients after ACL reconstruction?', and 'Does vitamin D supplements improve quadriceps muscle strength for patients after ACLR?'",[58,26,112,113],"Anterior Cruciate Ligament Rupture","Anterior Cruciate Ligament Tear",[115,116,117,118],"ACL Reconstruction","Vitamin D","Quadricep muscle strength","Quadricep muscle atrophy","2025-03-17",{"date":121,"type":35},"2025-03-18",{"date":119,"type":35},{"date":124,"type":21},"2029-09-17",{"name":126,"class":42},"Chinese University of Hong Kong"]