[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"quality-of-life-outcomes\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:quality-of-life-outcomes":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,91],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100599814","efficacy-and-safety-of-resveratrol-in-patients-with-rheumatoid-arthritis-100599814",false,"NCT07089381","Efficacy and Safety of Resveratrol in Patients With Rheumatoid Arthritis.","Inclusion Criteria:\n\n* Adult patients \\> 18 years old\n* Established diagnosis of RA according to American College of Rheumatology\u002FEuropean league Against Rheumatism (ACR\u002FEULAR) 2010 criteria (Aletaha et al., 2010), presented with moderate to high disease activity identified as disease activity score-28 based on C-reactive protein (CRP) levels (DAS-28-CRP) \\>3.2.\n* Patients receiving stable regimen of one or more csDMARDs for at least the past 3 months.\n* RA Patients with Moderate or high disease activity identified as disease activity score-28 based on C-reactive protein (CRP) levels (DAS-28-CRP) \\>3.2.\n\nExclusion Criteria:\n\n* Patients receiving biologic DMARDs therapy for RA\n* Patients taking any other anti-inflammatory drugs\n* Patients taking any other antioxidants\n* Pregnant and lactating women\n* Other rheumatological, inflammatory diseases or malignancies\n* Smokers\n* Thyroid illnesses\n* Patients with impaired liver functions (liver transaminases level ≥ three times upper normal limits), impaired kidney functions (estimated glomerular filtration rate (eGFR) \\\u003C 30 ml\u002Fmin)","ALL","18 Years",{"count":18,"type":19},118,"ESTIMATED","INTERVENTIONAL",[22],"NA","The aim of the current study is to evaluate the effects of resveratrol on the clinical outcome(s) of patients with moderate rheumatoid arthritis.\n\nObjectives :\n\n1. To investigate the effects of Resveratrol on inflammation and oxidative stress by measuring:\n\n   * Serum Sirtuin 1(SIRT1)\n   * Serum Myeloperoxidase (MPO)\n   * Serum C-reactive protein (CRP)\n2. To investigate the effects of Resveratrol on disease activity by measuring the disease activity (DAS28 score).\n3. To investigate the effect of Resveratrol on improving the quality of life using the Health Assessment Questionnaire Disability index (HAQ-DI).\n4. To assess any adverse effects related to Resveratrol.\n\nPatients:\n\nEligible patients (no=118) will be randomly assigned in a 1:1 ratio to one of two groups:\n\n1. Control group: 59 patients will receive the standard treatment for management of RA for 3 months.\n2. Resveratrol group: 59 patients will receive the standard treatment for management of RA in addition to Resveratrol 1 gm daily, (Organix Egypt) (given as one 1000 mg tablets once daily) for 3 months.",[25,26,27,28,29,30,31,32,33],"Rheumatic Arthritis","Rheumatoid Arthritis (RA) Prevention","Inflamation","Antioxidant","Anti Oxidative Stress","Anti Aging","C Reactive Protein","Methotrexate","Quality of Life Outcomes","RECRUITING","2025-07-21",{"date":37,"type":38},"2025-07-28","ACTUAL",{"date":40,"type":19},"2025-08-01",{"date":42,"type":19},"2026-06-01",{"name":44,"class":45},"Ain Shams University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":55,"targetDuration":57,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":73,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":4},"100587057","survey-of-psychological-well-being-of-health-care-workers-in-the-hospital-setting-100587057","NCT06923436","Survey of Psychological Well-being of Health Care Workers in the Hospital Setting","FROM THE INVISIBLE TO THE VISIBLE: Survey on the Psychological Well-being of Hospital Healthcare Workers","IN-VISIBLE","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Work activity carried out in departments classified as at risk for work-related stress (emergency care, oncology...)\n* Willingness to participate in the study and the ability to understand and sign the informed consent form.\n\nExclusion Criteria:\n\n* Psychological\u002Fpsychiatric comorbidities\n* Inability to sign the informed consent form",{"count":56,"type":19},500,"4 Months","OBSERVATIONAL","The psychological well-being of healthcare workers in hospital settings is a topic of growing interest in the scientific literature, given the crucial importance of their role in ensuring high-quality care. In addition, the Covid-19 pandemic health emergency has further accentuated the relevance of this issue, increasing anxiety and stress levels, testing the resilience and resistance of those working in care settings, revealing and highlighting how the accumulation of work-related stress can result in disabling pathologies for the caregiver, with an inevitable impact on the facility and care in general. Recent studies show that health care workers are particularly vulnerable to work-related stress, which can result from various factors such as high work demands, emotional pressure, irregular shifts, and interactions with critically ill patients. Burnout syndrome, characterized by emotional exhaustion, depersonalization and reduced personal accomplishment, is widely documented among hospital staff. Research indicates that burnout not only compromises the psychological health of healthcare workers, but also negatively affects the quality of care provided by increasing the risk of medical errors.\n\nIn light of these factors, it is crucial to deepen our understanding of the dynamics that influence psychological well-being and work-related stress in health care workers in order to develop effective interventions that can improve their quality of life and consequently the quality of care provided to patients.\n\nPreliminary assessment of the emotional burden and motivational aspects of health care workers (showing what very often eludes a first glance, making visible something that is often invisible), along with effective stress management, would allow for greater ability to remain calm under pressure, reduced frustration, increased ability to make informed decisions, and to communicate effectively with patients and colleagues. These aspects translate into an image of a safer and more caring health care system in promoting better quality of care.\n\nThe aim of this project is to highlight the importance of psychological wellbeing for those working in health care settings and to promote attention to this area, also with a view to identifying possible interventions aimed at identifying preventive and protective factors in relation to health care workers.\n\nThe aim, therefore, is to show what is very often invisible at first sight, to make visible what is invisible: to explore, accommodate and contain areas of criticality and fragility in the context of work in health care settings, working on interventions aimed at the psychological well-being of workers.",[61,62,63,64,65,66,67,68,69,70,71,33,72],"Healthy","Psychological Well Being","Stress Response","Professional Quality of Life","Resilience","Alexithymia","Spirituality","Coping Skills","Job-related Affective Well-being","Burnout, Healthcare Workers","Empathy Skills","Technostress",[74,75,76,77,78,79,80],"Psychological well-being of health care workers in the hospital setting","work-related stress","emotional burden","Motivational aspects of health professionals","occupational well-being","Perceived Stress","Perceived stress from the intensive use of digital technology in work settings","NOT_YET_RECRUITING","2025-04-23",{"date":84,"type":38},"2025-04-27",{"date":86,"type":19},"2025-04",{"date":88,"type":19},"2026-04",{"name":90,"class":45},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":98,"targetDuration":57,"studyType":58,"phases":4,"briefSummary":100,"conditions":101,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":46},"100580988","quality-of-life-and-decisional-regret-in-patients-affected-by-acoustic-neuroma-100580988","NCT06844461","Quality of Life and Decisional Regret in Patients Affected by Acoustic Neuroma","QOL-DR-NEUROMA","Inclusion Criteria:\n\n* Patient with sporadic acoustic neuroma in follow-up with wait and scan protocol or treated with microsurgical resection with any approach\n\nExclusion Criteria:\n\n* Patient with NF2\n* Patient previuosly treated with RT in the head and neck district\n* Patient with pre-treatment facial palsy ipsi and controlateral\n* Patient non native italian speakers\n* Patient with major mental illness already existing before the acoustic neuroma diagnosis\n* Patient with neurological issues such as chronic migraine or postural instability already existing before the acoustic neuroma diagnosis",{"count":99,"type":19},40,"Italian translation and validation study of two different questionnaire (VSQOL and DRS) about quality of life in patient with acoustic schwannoma.",[33,102],"Acoustic Schwannoma","2025-02-24",{"date":105,"type":38},"2025-02-25",{"date":107,"type":38},"2024-01-20",{"date":109,"type":19},"2025-04-30",{"name":111,"class":45},"IRCCS Azienda Ospedaliero-Universitaria di Bologna"]