[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"quality-of-life-qol\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:quality-of-life-qol":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,42,0,25,[9,45,68,101,143,174,207,240,275,301,332,360,390,418,451,486,512,542,571,597,627,660,688,713,742],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100592097","compassion-strikes-back-100592097",false,"NCT06988995","Compassion Strikes Back","Compassion Strikes Back: Improving Dyadic Quality of Life for LVAD Patients and Caregivers","Inclusion Criteria:\n\n* LVAD implantation or caregiver or patient with LVAD; over 18 years old; primary caregiver is a family member\n\nExclusion Criteria:\n\n* Currently or in the past 3 months received psychotherapy or psychosocial or peer support; hospitalized for psychiatric reasons in the past 6 months; current, active suicidal thoughts or a reported suicide attempt within the past year; a current alcohol\u002Fsubstance use disorder that required immediate treatment; or a current or past thought disorder, psychosis, or unmanaged bipolar disorder; enrolled in another investigational research\u002Fclinical trial; toxic\u002Fnegative dynamic between pt and caregiver; extended post-LVAD implantation course (i.e., more than 2 months in the hospital).","ALL","18 Years","80 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","Research has shown that LVAD patients and their caregivers typically experience increased mental health concerns and decreased quality of life following LVAD implantation and hospital discharge. The purpose of this study is to explore how to improve quality of life for LVAD patients and their caregivers in the initial transition from hospital to home after LVAD implantation.\n\nOver the course of the study, participants will complete 2 surveys: one when participants are in the hospital and one at a 2-month post-hospital follow-up appointment with the participants' cardiologist. Participants may be contacted if there is data missing from surveys.\n\nParticipants may also be provided with information on improving mental health in the form of handouts or a brief meeting with a psychology provider.",[28,29,30,31],"LVAD Caregivers","LVAD (Left Ventricular Assist Device)","Quality of Life (QOL)","Self-Compassion","RECRUITING","2026-06-25",{"date":35,"type":36},"2026-06-29","ACTUAL",{"date":38,"type":36},"2025-12-01",{"date":40,"type":22},"2026-12",{"name":42,"class":43},"University of Florida","OTHER",1,{"id":46,"slug":47,"hasResults":12,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":44},"100642074","the-effects-of-strength-training-on-muscle-mass-and-mental-health-in-adults-taking-obesity-medication-100642074","NCT07652333","The Effects of Strength Training on Muscle Mass and Mental Health in Adults Taking Obesity Medication","The Effects of Strength Training on Muscle Mass and Mental Health in Adults Taking Obesity Medication: A Pilot Study","STRONG","Inclusion Criteria:\n\n* Initiating GLP-1 RAs prescribed by physician or advanced practice practitioner and willing to withhold the start of the drug until baseline assessment completed\n* Non-Smoker\n* ≥18 years old\n* Obese: Body Mass Index 30-45 kg\u002Fm² or BMI ≥27 + ≥1 weight related comorbidity; either hypertension or sleep apnea confirmed by participant self-report\n* Inactive: not meeting the current US exercise guidelines over the past 6 months\n* Capable of performing the required exercise training\n\nExclusion Criteria:\n\n* A serious heart condition, such as unstable heart disease or heart failure, irregular heartbeats that are not well controlled, severe narrowing of the heart valves, or any recent inflammation of the heart or its lining\n* Cancer requiring treatment in the past 5 years\n* Hypothyroidism\u002Fhyperthyroidism\n* Personal or family history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia Syndrome type 2 (MEN2)\n* Gastroparesis\n* Chronic\u002Fidiopathic acute pancreatitis\n* Hepatic disease or cirrhosis\n* Struggle with alcohol or other substance abuse (heavy drinking (≥4 drinks\u002Fday or ≥8 drinks\u002Fweek for women; ≥5 drinks\u002Fday or ≥15 drinks\u002Fweek for men), or who score ≥3 on the Drug Abuse Screening Test (DAST-10))\n* Diabetes (Type 1 or 2)\n* Major risk factors for coronary heart disease such as uncontrolled high blood pressure (≥160 mm Hg systolic or ≥100 mm Hg diastolic)\n* Problems with your muscles or bones that limit your ability to exercise\n* Any other medical condition that is life-threatening, can interfere with or be aggravated by the exercise training\n* Plans to be away ≥2 weeks in the next 3 months\n* Participation in any other concurrent interventional clinical trial\n* History of eating disorders or weight-loss surgery, unstable weight (±5% change in past 6 months), or use of obesity medication (e.g., such as Wegovy, Ozempic, Saxenda, Zepbound, Mounjaro) in the last 3 months\n* Inability to give informed consent\n* History of major depression or other severe psychiatric disorders (e.g., who answer \"yes\" to question 9 on PHQ-9 in the Psych\\_QoL\\_Sleep questionnaires.)\n* Pregnant or plan to become pregnant during study",{"count":21,"type":22},[25],"The purpose of this study is to examine the effects of resistance exercise, such as weightlifting, on retention of muscle mass and mental health in individuals taking GLP-1 RAs (an obesity medication). Resistance exercise is focused on increasing the strength of participants' muscles, such as how much participant can lift.\n\n•The duration of this study is 3 months. This includes:\n\n* Orientation session to explain study protocol, exercise program, and complete questionnaire about participants' medical history and lifestyle.\n* Two health assessments at baseline and at 3 months. These assessments include body composition, resting blood pressure, cardiovascular function, and muscular strength. Both the resistance exercise group and the control group will complete assessments at baseline and again at 3 months. After the 3-month period, individuals in the control group may choose to participate in the exercise training and complete the optional 6-month assessments.\n* Personalized resistance exercise sessions for 60 minutes per session, twice per week, for 3 months.",[57,58,30],"Muscle Composition","Obesity","2026-06-21",{"date":61,"type":36},"2026-06-24",{"date":63,"type":36},"2026-05-25",{"date":65,"type":22},"2027-05-31",{"name":67,"class":43},"University of Pittsburgh",{"id":69,"slug":70,"hasResults":12,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":12,"sex":17,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":23,"phases":80,"briefSummary":81,"conditions":82,"keywords":88,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":44},"100582242","acupuncture-for-adhd-acupoint-data-mining-clinical-effectiveness-and-interviews-to-explore-treatment-outcomes-100582242","NCT06860763","Acupuncture for ADHD: Acupoint Data Mining, Clinical Effectiveness, and Interviews to Explore Treatment Outcomes.","Clinical Study on Acupuncture Treatment for Attention Deficit Hyperactivity Disorder.","ACU-ADHD","Inclusion Criteria:\n\nPatients will be considered for enrolment if they meet the criteria of:\n\n* A confirmed diagnosis of ADHD based on the DSM-5 criteria for ADHD (Western medical diagnosis) and in accordance with the ADHD Chinese Medicine Clinical Trial Design and Evaluation Technical Guidelines.\n* Aged between 6 and 12 years.\n* No use of any other pharmacological treatments (both Western and traditional Chinese medicine) within the two weeks prior to the start of the study.\n* An IQ score of greater than 80, as determined by the Raven's Progressive Matrices test.\n* The participant has not participated in any other clinical trials.\n\nExclusion Criteria:\n\nPatients will be excluded from the study if they meet any of the following criteria:\n\n* Do not meet the inclusion criteria\n* Have comorbid psychiatric disorders, severe medical or psychiatric conditions that may interfere with the study (e.g., epilepsy, severe anxiety), pervasive developmental disorders, intellectual disability, or a history of suicidal or self-harming behavior\n* Have participated in any other drug clinical trials within the past 3 months.\n* Have severe comorbid conditions such as cardiovascular, hepatic, renal, or hematologic diseases.\n* Have any other conditions that the researchers believe may interfere with the assessment of treatment efficacy or safety.","6 Years","12 Years",{"count":79,"type":22},120,[25],"This study aims to evaluate the efficacy of acupuncture as a treatment for Attention Deficit Hyperactivity Disorder (ADHD) in children aged 6-12 years. Using a mixed-methods approach, the research will triangulate data from acupoint data mining, treatment outcomes assessment, and patient perspectives to provide a comprehensive analysis of acupuncture's potential therapeutic benefits for ADHD.\n\nThis prospective cohort study will recruit children diagnosed with ADHD, assigning them to receive either acupuncture combined with traditional Chinese herbal treatment or herbal treatment alone. Quantitative assessments using the the SNAP-IV, Conners 3-P, BRIEF-2, PedsQL™ 4.0 Generic Core Scales, PSQI and CGI that will be complemented by qualitative interviews to capture nuanced patient experiences and treatment outcomes.\n\nThe study will span 12 months, commencing on March 1st, 2025 with an expected completion by February 28th, 2026. By integrating quantitative assessments with qualitative insights, it aims to provide comprehensive evidence on acupuncture's role in ADHD management. Findings may inform clinical guidelines and enhance patient-centered care approaches.",[83,84,85,86,87,30],"Acupuncture","ADHD - Attention Deficit Disorder With Hyperactivity","Children","Interview","Executive Functioning",[83,89,90,86,91,92],"ADHD","Executive functioning","TCM","PedsQL",{"date":94,"type":36},"2026-06-23",{"date":96,"type":36},"2024-10-15",{"date":98,"type":22},"2027-01-31",{"name":100,"class":43},"The Third Affiliated Hospital of Beijing University of Chinese Medicine",{"id":102,"slug":103,"hasResults":12,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":23,"phases":111,"briefSummary":112,"conditions":113,"keywords":123,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":142},"100603978","early-exercise-based-rehabilitation-in-patients-hospitalized-for-acute-pulmonary-embolism-100603978","NCT07143539","Early Exercise-Based Rehabilitation in Patients Hospitalized for Acute Pulmonary Embolism","Early Exercise-based Rehabilitation in High-risk Patients Hospitalized for Acute Pulmonary Embolism: a Pragmatic Multicenter Randomized Partially Blinded Superiority Trial","RehabPE","Inclusion Criteria:\n\n1. Age ≥18 years\n2. Hospitalization for objectively confirmed acute symptomatic PE, defined as intraluminal filling defect of a segmental or more proximal pulmonary artery on computed tomography pulmonary angiography (CTPA) or a high-probability ventilation-perfusion scintigraphy, and admission within the past 7 days\n3. Increased risk for post-PE syndrome, defined as simplified Pulmonary Embolism Severity Index (sPESI) ≥1 point at the time of admission\n4. Written informed consent\n\nExclusion Criteria:\n\n1. Contraindication to EBR (known unstable cardiac conditions like angina pectoris, severe valvular heart disease, or severe resting pulmonary hypertension)\n2. Medical condition that clearly precludes participation in EBR (e.g., inability to walk, unstable joints, severe neurological impairment)\n3. Recently completed (i.e., \\\u003C6 months), ongoing, or planned in- or outpatient EBR, or planned supervised outpatient physiotherapy for any indication\n4. Planned hospitalization during follow-up (e.g., elective surgery or inpatient chemotherapy)\n5. Contraindication to anticoagulation\n6. Life expectancy \\\u003C1 year based on the treating physician's clinical judgement\n7. Known pregnancy\n8. Inability to speak German or French\n9. Participation in another study that prohibits concurrent participation in RehabPE\n10. Unable to provide informed consent (e.g., due to dementia)\n11. Unwilling to provide informed consent\n12. Prior enrollment in this study",{"count":110,"type":22},160,[25],"Up to half of patients with pulmonary embolism (PE) suffer from impaired quality of life, reduced physical capacity, and symptoms like shortness of breath even three months after diagnosis, despite standard treatment with anticoagulation (blood thinners). The randomized RehabPE trial investigates whether an early, structured rehabilitation program with physical training and patient education can prevent such long-term effects.\n\nThe study includes hospitalized patients with acute symptomatic PE who are at increased risk of impaired quality of life three months after diagnosis. After informed consent, patients are randomly assigned to one of two groups: one receives an early 6-8-week, center-based rehabilitation program; the other receives standard follow-up care without rehabilitation. The intervention group completes 16-18 outpatient sessions of endurance and strength training, along with two education sessions covering the condition, treatment, and symptom management.\n\nOver 180 days, changes in quality of life, physical exercise capacity, breathlessness, and psychological symptoms, and the time to return to work \u002F usual daily activities will be monitored and compared between groups.",[114,115,30,116,117,118,119,120,121,122],"Venous Thromboembolism (VTE)","Exercise Therapy","Anxiety Depression","Humans","Exercise Tolerance","Rehabilitation Exercise","Dyspnea","Functional Status","Pulmonary Embolism (Diagnosis)",[124,125,126,127,128,129,130,131,132],"pulmonary embolism","deep vein thrombosis","excercise-based rehabilitation","post-PE syndrome","health-related quality of life","anxiety","depression","dyspnea","impact of early excercise-based rehabilitation","2026-06-11",{"date":135,"type":36},"2026-06-12",{"date":137,"type":36},"2025-12-17",{"date":139,"type":22},"2028-06",{"name":141,"class":43},"Insel Gruppe AG, University Hospital Bern",6,{"id":144,"slug":145,"hasResults":12,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":150,"sex":151,"minAge":152,"maxAge":153,"enrollmentInfo":154,"targetDuration":4,"studyType":156,"phases":4,"briefSummary":157,"conditions":158,"keywords":4,"overallStatus":164,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":4},"100642517","balance-fall-risk-and-gait-in-women-with-total-knee-arthroplasty-100642517","NCT07650175","Balance, Fall Risk, and Gait in Women With Total Knee Arthroplasty","Investigation of Balance, Fall Risk, Gait Performance, and Quality of Life in Postmenopausal Women Undergoing Total Knee Arthroplasty","Inclusion Criteria:\n\n* Volunteering to participate in the study.\n* Being 60 years of age or older.\n* Having a Mini Mental Test score of 24 or higher.\n* Not having undergone previous arthroplasty surgery on the knee where surgery is planned.\n* Having experienced unilateral TDA.\n* Being a postmenopausal woman\n\nExclusion Criteria:\n\n* Individuals whose vital signs are unstable after surgery, or who develop any major complications such as deep vein thrombosis, pulmonary embolism, wound infection, or prolonged anesthesia side effects.\n* Presence of any neurological, vestibular, visual, cardiopulmonary, auditory, or cognitive deficits that may affect measurements.\n* Individuals diagnosed with diabetes.",true,"FEMALE","60 Years","85 Years",{"count":155,"type":22},30,"OBSERVATIONAL","Total knee arthroplasty (TKA) is a commonly performed surgical procedure aimed at reducing pain, restoring joint function, and improving quality of life, particularly among older women. Despite improvements in pain and functional outcomes following TKA, findings regarding balance, fall risk, and gait performance remain inconsistent. Impairments in these parameters may adversely affect daily activities, independence, and overall quality of life.\n\nUnlike previous studies that have primarily focused on one or two outcomes, this study will comprehensively evaluate balance, fall risk, gait performance, and quality of life in postmenopausal women who have undergone TKA. The findings are expected to provide a more holistic understanding of long-term functional outcomes following TKA and contribute to the planning of rehabilitation programs. Therefore, the aim of this study is to compare balance, fall risk, gait performance, and quality of life between postmenopausal women who have undergone TKA and healthy postmenopausal women.",[159,160,30,161,162,163],"Total Knee Arthroplasty","Postmenopausal Women","Balance","Risk of Falling","Walking","NOT_YET_RECRUITING","2026-06-10",{"date":167,"type":36},"2026-06-16",{"date":169,"type":22},"2026-06-20",{"date":171,"type":22},"2026-07-22",{"name":173,"class":43},"Karabuk University",{"id":175,"slug":176,"hasResults":12,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":181,"targetDuration":4,"studyType":23,"phases":183,"briefSummary":184,"conditions":185,"keywords":190,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":206},"100643035","efficacy-and-safety-of-transcutaneous-posterior-tibial-nerve-stimulation-on-fecal-continence-in-patients-undergoing-surgery-for-rectal-neoplasia-100643035","NCT07632196","Efficacy and Safety of Transcutaneous Posterior Tibial Nerve Stimulation on Fecal Continence in Patients Undergoing Surgery for Rectal Neoplasia","Randomized Clinical Trial Assessing the Efficacy and Safety of Transcutaneous Posterior Tibial Nerve Stimulation on Fecal Continence in Patients Undergoing Surgery for Rectal Neoplasia","Inclusion Criteria:\n\n\\- Adult patients diagnosed with rectal neoplasia and who have undergone a high anterior rectal resection regardless of the surgical approach (open, laparoscopic, laparoscopic+TaTME or robotic+TaTME).\n\nExclusion Criteria:\n\n* Patients not operated or within active surveillance strategy programs (watch \\& wait)\n* Patients with ostomy\n* Patients with contraindications to the use of the neurostimulator:\n\n  * Pacemaker \u002F Defibrillator \u002F Other electronic devices\n  * History of heart problems\n  * Propensity to excessive bleeding (coagulopathies)\n  * Damage to the nervous system (epilepsy)\n  * Current pregnancy\n  * Infections or skin lesions\n  * Severe vascular disorders\n  * Active neoplasms.",{"count":182,"type":22},84,[25],"Rectal neoplasia is one of the most prevalent cancers in Spain, and the treatment of choice is total mesorectal excision (TME), as it has demonstrated significant oncological improvements. However, mesorectal excision is not without complications, and patients often experience altered bowel function in the form of low anterior resection syndrome (LARS), as well as erectile dysfunction. However, few studies evaluate faecal incontinence, as most focus on oncological outcomes.\n\nThe aim of our study is to evaluate the efficacy and safety of posterior tibial nerve stimulation on fecal incontinence, sexual dysfunction, and quality of life in patients who underwent to rectal surgery for rectal neoplasia.\n\nIt will be conducted a randomized clinical trial (1:1) with two arms: half of the patients will receive posterior tibial nerve stimulation, while the other half will undergo stimulation with subtherapeutic doses. Faecal incontinence will be assessed using the LARS and Wexner questionnaires, and quality of life and sexual function will be assessed using the Fecal Incontinence Quality of Life Scale (FIQLS) and the Colorectal Cancer Quality of Life Questionnaire (QLQ-CR38), at one month, six months and one year after surgery.",[186,187,30,188,189],"Low Anterior Resection Syndrome (LARS)","Rectal Neoplasm Malignant","Fecal Incontinence (FI)","Disorder of Ejaculation",[191,192,193,194,195,196,188],"total mesorectum excision","rectal neoplasm","randomised clinical trial","posterior tibial nerve stimulation","low anterior resection syndrome (LARS)","life quality","2026-06-02",{"date":199,"type":36},"2026-06-08",{"date":201,"type":36},"2026-02-06",{"date":203,"type":22},"2028-12-31",{"name":205,"class":43},"Althaia Xarxa Assistencial Universitària de Manresa",2,{"id":208,"slug":209,"hasResults":12,"nctId":210,"briefTitle":211,"officialTitle":212,"acronym":213,"eligibilityCriteria":214,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":215,"targetDuration":4,"studyType":23,"phases":217,"briefSummary":219,"conditions":220,"keywords":224,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":235,"leadSponsor":237,"locationsCount":239},"100588083","phase-3-improving-functional-outcomes-and-quality-of-life-in-patients-with-rectal-cancer-after-surgery-with-intensified-follow-up--surveillance-100588083","NCT06936774","Improving Functional Outcomes and Quality of Life in Patients With Rectal Cancer After Surgery With Intensified Follow-up & Surveillance","Improving Functional Outcomes and Quality of Life in Patients With Rectal Cancer After Surgery With Intensified Follow-up & Surveillance - a Randomized Controlled Trial (iRECOVER)","iRECOVER","Inclusion Criteria:\n\n* patients older than 18 years\n* patients with rectal cancer in the middle and lower third of the rectum in stages I to IV who underwent LAR with TME and protective ileostomy\n* able to give informed consent as documented by signature\n\nExclusion Criteria:\n\n* dementia or other psychiatric disorder that would prevent the patients from answering the questionnaires and experiencing sustainable training effects\n* impossibility of stoma reversal due to persistent anastomotic leak and\u002For local recurrence",{"count":216,"type":22},140,[218],"PHASE3","The goal of this clinical study is to gain further insights into the treatment of patients with Low Anterior Resection Syndrome (LARS) symptoms after rectal resection. The main question is: Can LARS symptoms and quality of life be improved by implementing an intensified follow-up program? Researchers will compare the results of the intervention group with the results of a control group in which patients do not receive an intensified follow-up program to determine whether the intervention works. Participants will undergo an intensified follow-up program which consists of several follow-up visits and medical treatment, pelvic floor muscle training and gynaecological and urological co-treatment in case of LARS symptoms and urinary or sexual complaints.",[221,222,223,30],"LARS - Low Anterior Resection Syndrome","Rectal Cancer Surgery","Rectal Cancer",[225,226,227,228,229,230],"LARS","Low Anterior Resection Syndrome","Intensified follow-up","Rectal cancer","Rectal resection","Low anterior resection","2026-04-30",{"date":233,"type":36},"2026-05-06",{"date":38,"type":36},{"date":236,"type":22},"2028-07-01",{"name":238,"class":43},"University Hospital, Basel, Switzerland",5,{"id":241,"slug":242,"hasResults":12,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":246,"eligibilityCriteria":247,"healthyVolunteers":12,"sex":17,"minAge":248,"maxAge":249,"enrollmentInfo":250,"targetDuration":252,"studyType":156,"phases":4,"briefSummary":253,"conditions":254,"keywords":262,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":44},"100600102","rehabilitation-practices-in-critically-ill-patients-receiving-invasive-mechanical-ventilation-in-the-intensive-care-unit-100600102","NCT07093125","Rehabilitation Practices in Critically Ill Patients Receiving Invasive Mechanical Ventilation in the Intensive Care Unit.","An Observational Study on Rehabilitation Practices in the ICU for Critically Ill Patients Undergoing Invasive Mechanical Ventilation - Report (REPOrt)","REPOrt","Inclusion Criteria:\n\n* Patients admitted to a participating ICU\n* Adult patients (aged 16 years or older, depending on local regulations for the definition of \"adults\")\n* Patients who have received invasive ventilation for at least 48 hours\n* Patients who have obtained written informed consent from the patient or next of kin (if local legislation demands so)\n\nExclusion Criteria:\n\n• Patients admitted for withdrawn of life sustain therapy","16 Years","100 Years",{"count":251,"type":22},2400,"28 Days","This international, multicenter, observational study aims to describe rehabilitation practices in Intensive Care Units (ICUs) worldwide.\n\nThe primary objective is to provide an overview of current rehabilitation strategies used in ICUs globally.\n\nSecondary objectives include assessing the relationship between rehabilitation and key ICU outcomes such as ICU and hospital mortality, length of stay, duration of invasive ventilation, extubation failures, and long-term outcomes including quality of life and functional performance 28 days post-ICU discharge.\n\nThe study will also compare rehabilitation practices across different geographic and economic regions to identify potential disparities. The study is structured into three modules, with participation contingent on local resources and feasibility.\n\nThe BASIC Module (mandatory for all centers) gathers fundamental data on rehabilitation practices and their association with patient outcomes.\n\nThe EXTENDED Module (optional) collects more detailed information on the type, timing, duration, and safety of rehabilitation interventions, including passive exercises, active mobilization, respiratory therapies, dysphagia training, occupational therapy, and cognitive support.\n\nThe EXTENDED FOLLOW-UP Module (optional) evaluates the patient's quality of life and functional recovery 28 days after ICU discharge. By examining global rehabilitation practices and their impact on patient outcomes, this study aims to improve rehabilitation strategies in ICUs, contributing to better patient care, recovery, and long-term health outcomes.",[255,256,257,30,258,259,260,261],"Mechanical Ventilation","Pulmonary Rehabilitation","Intensive Care Units (ICUs)","Outcome Assessment","Extubation Failure","Mortality","Critical Care",[263,255,264,265],"Pulmonary rehabilitation","Intensive Care Unit (ICU)","Rehabilitation Outcomes","2026-04-27",{"date":268,"type":36},"2026-05-04",{"date":270,"type":36},"2025-10-01",{"date":272,"type":22},"2029-10-01",{"name":274,"class":43},"Universita degli Studi di Genova",{"id":276,"slug":277,"hasResults":12,"nctId":278,"briefTitle":279,"officialTitle":280,"acronym":281,"eligibilityCriteria":282,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":283,"targetDuration":284,"studyType":156,"phases":4,"briefSummary":285,"conditions":286,"keywords":4,"overallStatus":164,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":4},"100617607","quality-of-life-and-functional-outcomes-in-laryngeal-cancer-patients-100617607","NCT07320820","Quality of Life and Functional Outcomes in Laryngeal Cancer Patients","Assessment of Quality of Life, Patient Satisfaction, Swallowing Function, Voice Outcomes, Pain, and Anxiety-Depression at Baseline and at 3-, 6-, and 12-Month Follow-Up in Patients Diagnosed With Laryngeal Squamous Cell Carcinoma: A Prospective Questionnaire-Based Study","QoL in LSSC","Inclusion Criteria:\n\n* Age ≥ 18 years at the time of enrollment.\n* Histopathologically confirmed diagnosis of laryngeal squamous cell carcinoma.\n* Planned to undergo surgical treatment or radiotherapy\u002Fchemoradiotherapy as part of standard oncological care.\n* Willing and able to participate in the study and to provide written informed consent.\n* No history of psychiatric or neurological disorders that could impair comprehension, questionnaire completion, or study participation.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years.\n* Presence of comorbid conditions that may independently affect swallowing or voice functions.\n* Patients who withdraw consent or request to discontinue participation during or after the treatment period.\n* History of psychiatric disorders or use of psychiatric medications that may interfere with study participation or completion of patient-reported outcome measures.",{"count":79,"type":22},"12 Months","Laryngeal squamous cell carcinomas are head and neck malignancies that directly affect both swallowing and voice functions and are associated with a significant deterioration in patients' quality of life throughout the treatment process.\n\nThe aim of this study is to evaluate quality of life, voice and swallowing functions, pain, anxiety-depression levels, and patient satisfaction at the pre-treatment period and at the 3rd, 6th, and 12th months post-treatment in patients with laryngeal malignancies, using validated questionnaires, in order to:\n\nElucidate the course of functional recovery following treatment,\n\nIndividualize rehabilitation and follow-up strategies, and\n\nExamine the relationship between functional outcomes and oncological survival.",[287,30,288,289,290,291,116],"Laryngeal Carcinoma","Patient Satisfaction","Voice Quality","Swallowing Function","Pain Management","2026-04-21",{"date":294,"type":36},"2026-04-22",{"date":296,"type":22},"2026-04-02",{"date":298,"type":22},"2027-12-31",{"name":300,"class":43},"Saglik Bilimleri Universitesi",{"id":302,"slug":303,"hasResults":12,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":4,"eligibilityCriteria":307,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":308,"targetDuration":4,"studyType":23,"phases":310,"briefSummary":312,"conditions":313,"keywords":316,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":324,"startDateStruct":326,"completionDateStruct":328,"leadSponsor":330,"locationsCount":44},"100566459","phase-2-supplemental-postoperative-bupivacaine-following-non-surgical-endodontic-treatment-100566459","NCT06655454","Supplemental Postoperative Bupivacaine Following Non-Surgical Endodontic Treatment","The Effects of Supplemental Postoperative 0.5% Bupivacaine With 1:200,000 Epinephrine Following Non-Surgical Endodontic Treatment on Patients' Quality of Life, Pain, and Analgesic Consumption","Inclusion Criteria:\n\n1. Medical ASA Class I or II\n2. Patients above 18 years old\n3. Patients with a blood pressure below 160\u002F100\n4. Patients who are treatment planned and have agreed to have emergency endodontic therapy or non-surgical root canal therapy with a pulpal diagnosis of symptomatic irreversible pulpitis according to the AAE Glossary of Endodontic Terms.\n5. Patients must be able to comprehend and complete all study protocols, written consent, and questionnaires in English.\n\nExclusion Criteria:\n\n1. Medical ASA III or above\n2. Patients who reported the use of tobacco or nicotine-containing products such as vapes, e-cigarettes, gums, or pouches and will not in the 48 hours following treatment\n3. Patients who reported the use of any marijuana products or illicit drugs in the 48 hours prior to treatment and will not in the next 48 hours.\n4. Patients who have taken opioids to control pain.\n5. Pregnant patients\n6. Patients with a blood pressure of 160\u002F100 or greater\n7. Patients with a known hypersensitivity or allergy to any local anesthetic agent of the amide group, or any other components of the two anesthetic solutions such as epinephrine, sodium metabisulfite used in the study.\n8. Patients who have more than one tooth with odontogenic pain at the time of the screening.\n9. Patients who are unable to consent and do not understand or are unable to read the questionnaires.\n10. Patients who have had 4 1.7 ml carpules or more of anesthetic (Lidocaine and\u002F or Septocaine, 1:100,000) during standard care of treatment.",{"count":309,"type":22},150,[311],"PHASE2","The study will investigate the impact of an additional injection of long-acting anesthetic on pain level, quality of life, and use of pain medication after a nonsurgical endodontic treatment. The long-acting anesthetic will be compared to a mock injection group and a group with no additional anesthetic to determine any differences in effects.",[314,30,315],"Pain Assessment","Analgesic Use",[317,318,319,320,321,322],"bupivacaine","nonsurgical endodontic treatment","root canal therapy","irreversible pulpitis","pain management","anesthetic use","2026-04-08",{"date":325,"type":36},"2026-04-13",{"date":327,"type":36},"2024-11-01",{"date":329,"type":22},"2026-12-31",{"name":331,"class":43},"New York University",{"id":333,"slug":334,"hasResults":12,"nctId":335,"briefTitle":336,"officialTitle":337,"acronym":4,"eligibilityCriteria":338,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":339,"targetDuration":4,"studyType":23,"phases":341,"briefSummary":342,"conditions":343,"keywords":346,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":352,"startDateStruct":354,"completionDateStruct":356,"leadSponsor":358,"locationsCount":44},"100584216","vomiting-prevention-in-children-with-cancer-100584216","NCT06886451","Vomiting Prevention in Children With Cancer","Prevention of Vomiting in Pediatric Oncology Inpatients Using Machine Learning","Inclusion Criteria:\n\n* All pediatric patients admitted to the oncology service at SickKids\n\nExclusion Criteria:\n\n* Pediatric patients admitted to the oncology service at SickKids that are discharged prior to prediction time",{"count":340,"type":22},1332,[25],"The goal of this single arm trial is to learn if a machine learning (ML) model predicting the risk of vomiting within the next 96 hours will impact vomiting outcomes in inpatient cancer pediatric patients.\n\nThe main questions it aims to answer are whether an ML model predicting the risk of vomiting within the next 96 hours will:\n\nPrimary\n\n1\\. Reduce the proportion with any vomiting within the 96-hour window\n\nSecondary\n\n1. Reduce the number of vomiting episodes\n2. Increase the proportion receiving care pathway-consistent care\n3. Impact on number of administrations and costs of antiemetic medications\n\nNewly admitted participants will have a ML model predict the risk of vomiting within the next 96 hours according to their medical admission information. The prediction will be made at 8:30 AM following admission. Pharmacists will be charged with bringing information about patients' vomiting risk to the attention of the medical team and implementing interventions.",[344,30,345],"Chemotherapy Induced Nausea and Vomiting","Pediatric Cancer",[347,348,349,350],"Vomiting","Machine learning","Quality of life","Pediatric oncology","2026-03-03",{"date":353,"type":36},"2026-03-05",{"date":355,"type":36},"2025-03-18",{"date":357,"type":22},"2027-03-18",{"name":359,"class":43},"The Hospital for Sick Children",{"id":361,"slug":362,"hasResults":12,"nctId":363,"briefTitle":364,"officialTitle":364,"acronym":4,"eligibilityCriteria":365,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":366,"targetDuration":4,"studyType":156,"phases":4,"briefSummary":368,"conditions":369,"keywords":375,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":381,"lastUpdatePostDateStruct":382,"startDateStruct":384,"completionDateStruct":386,"leadSponsor":388,"locationsCount":206},"100584753","feeding-difficulties-and-quality-of-life-in-children-with-tracheal-cannula-100584753","NCT06893458","Feeding Difficulties and Quality of Life in Children With Tracheal Cannula","Inclusion Criteria: Children below the age of 18 with tracheostomy undergoing follow-up through the Long term Intensive Care Unit at Karolinska University Hospital in Stockholm Sweden between march 2025 and march 2027.\n\nExclusion criteria: Patients that can not undergo full evaluations\u002Fexaminations will not be included.",{"count":367,"type":22},80,"The over all goal of this observational study is to study if there is an association between the presence of feeding difficulties and self-assessed quality of life in children with tracheal cannula.\n\nThe main questions it aims to answer are\n\n1. What is the incidence of feeding difficulties in children with tracheostomy and what type of feeding difficulties affect these children?\n2. How do children with a tracheal tube and their parents assess their quality of life measured through PedsQL?\n3. Is there an association between the presence of feeding difficulties and self-assessed quality of life in children with tracheal cannula?\n\nQuality of life will be assessed in an interview using the PedsQL instrument generic module 4.0. Swallowing difficulties will be assessed through evaluations based on The Montreal Children's Hospital Feeding Scale.",[30,370,371,372,373,374],"Tracheostomy","Children in the Pediatric Intensive Care Unit or General Pediatric Care Unit Requiring a Central Venous Catheter","Feeding Difficulties","Swallowing Difficulties","Caregiver Quality of Life",[376,377,378,379,380],"pediatric quality of life","caregiver quality of life","swallowing related quality of life","feeding difficulties","pediatric tracheostomy","2026-02-12",{"date":383,"type":36},"2026-02-13",{"date":385,"type":36},"2025-03-17",{"date":387,"type":22},"2027-03-17",{"name":389,"class":43},"Karolinska Institutet",{"id":391,"slug":392,"hasResults":12,"nctId":393,"briefTitle":394,"officialTitle":394,"acronym":4,"eligibilityCriteria":395,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":396,"enrollmentInfo":397,"targetDuration":4,"studyType":23,"phases":399,"briefSummary":400,"conditions":401,"keywords":406,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":411,"lastUpdatePostDateStruct":412,"startDateStruct":413,"completionDateStruct":415,"leadSponsor":416,"locationsCount":44},"100562319","study-on-the-impact-of-electroacupuncture-combined-with-self-acupressure-on-the-quality-of-life-of-patients-with-early-stage-breast-cancer-undergoing-chemotherapy-100562319","NCT06601621","Study on the Impact of Electroacupuncture Combined With Self-Acupressure on the Quality of Life of Patients With Early-Stage Breast Cancer Undergoing Chemotherapy","Inclusion Criteria:\n\n1. Aged 18 years or older and aged 75 years or younger, inclusive. with an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2;\n2. Patients who have not received prior chemotherapy and are scheduled to receive at least 4 cycles of adjuvant or neoadjuvant chemotherapy or combination targeted therapy;\n3. Normal organ function with platelets ≥ 100\\*10\\^9\u002F L, hemoglobin ≥ 90 g\u002FL, serum creatinine ≤ 1.5 mg\u002Fdl (133 mmol\u002FL), or creatinine clearance ≥ 60 ml\u002Fmin, total bilirubin ≤ 1.5 times the upper limit of normal (ULN), alanine aminotransferase ≤ 2.5 times ULN, and aspartate aminotransferase ≤ 2.5 times ULN;\n4. Premenopausal women need appropriate contraception;\n5. Ability to understand the study well and complete the study questionnaire.\n\nExclusion Criteria:\n\n1. Patients with needle phobia or allergy to stainless steel needles; and\n2. Current diagnosis of mental illness (e.g., major depression, obsessive-compulsive disorder, or schizophrenia);\n3. History of autoimmune diseases, blood disorders, or organ transplantation, or long-term use of hormones or immunosuppressants;\n4. Comorbid bleeding disorders or thyroid dysfunction;\n5. Implantation of a pacemaker; pregnancy or breastfeeding;\n6. A plan for adjuvant radiotherapy in the upcoming chemotherapy cycle;\n7. Current active infection;\n8. Acupuncture treatment within the last four weeks;\n9. Patients who are allergic to the drugs used;\n10. Use of other Traditional Chinese Medicine (TCM) techniques such as Chinese herbs in the next chemotherapy cycle.","75 Years",{"count":398,"type":22},192,[25],"This randomized controlled clinical trial aims to evaluate the effect of electroacupuncture combined with self-acupressure on the quality of life of early-stage breast cancer patients receiving chemotherapy.",[402,30,403,404,405],"Electroacupuncture","Acupressure","Breast Cancer","Chemotherapy",[407,408,409,410],"electroacupuncture","self-acupressure","Quality of life (QOL)","breast cancer","2026-02-11",{"date":381,"type":36},{"date":414,"type":36},"2024-10-19",{"date":231,"type":22},{"name":417,"class":43},"Jiuda Zhao",{"id":419,"slug":420,"hasResults":12,"nctId":421,"briefTitle":422,"officialTitle":423,"acronym":4,"eligibilityCriteria":424,"healthyVolunteers":12,"sex":151,"minAge":18,"maxAge":4,"enrollmentInfo":425,"targetDuration":4,"studyType":23,"phases":426,"briefSummary":427,"conditions":428,"keywords":436,"overallStatus":164,"whyStopped":4,"lastUpdateSubmitDate":443,"lastUpdatePostDateStruct":444,"startDateStruct":446,"completionDateStruct":448,"leadSponsor":449,"locationsCount":44},"100624916","the-effect-of-a-four-week-hatha-yoga-intervention-to-improve-quality-of-life-anxiety-and-depressive-symptoms-in-individuals-undergoing-assisted-reproductive-technology-art-treatment-100624916","NCT07415850","The Effect of a Four-Week Hatha Yoga Intervention to Improve Quality of Life, Anxiety, and Depressive Symptoms in Individuals Undergoing Assisted Reproductive Technology (ART) Treatment","The Effect of a Four-Week Hatha Yoga Intervention to Improve Quality of Life, Anxiety, and Depressive Symptoms in Individuals Undergoing Assisted Reproductive Technology (ART) Treatment: A Randomized Controlled Trial","Inclusion Criteria:\n\n* 18 years of age or older\n* Understand English\n* Scheduled for or currently undergoing an IVF cycle\n* Access to smartphone\u002Fcomputer\u002Ftablet and internet\n* Have a valid working email address\n\nExclusion Criteria:\n\n* Individuals who are Pregnant, or who become Pregnant during the study\n* Individuals undergoing non-IVF cycles (i.e. intrauterine insemination)\n* Individuals undergoing a frozen embryo transfer (FET) cycle\n* Individuals who are currently regularly practicing yoga\n* Individuals who score in the \"severe depression\" classification on the PHQ-9 (PHQ-9 score of 20-27)\n* Individuals endorsing suicidal ideation (answering yes on #9 of PHQ-9).",{"count":367,"type":22},[25],"The goal of this clinical trial is to learn if a four-week yoga program works to improve quality of life in people undergoing IVF (In Vitro Fertilization). It will also learn if a four-week yoga program decreases anxiety and depression symptoms in people undergoing IVF.\n\nThe main questions it aims to answer are:\n\n* Does a four-week yoga program effect quality of life, anxiety, and depression symptoms in people undergoing IVF?\n* Do the effects vary by individual characteristics of the people in the study?\n\nResearchers will compare the yoga intervention group to routine care as usual.\n\nParticipants will:\n\n* Participate in a weekly virtual yoga class for four weeks (total of four yoga classes), or follow routine care as usual while undergoing IVF.\n* Take three online surveys every 4 weeks.\n* Be involved in the study for 8 weeks.",[429,430,30,431,432,433,434,435],"IVF","In Vitro Fertilization","Anxiety","Depression and Anxiety Symptom","Assisted Reproduction Technologies","Yoga","Mental Health",[437,438,439,440,434,441,442],"Fertilization in Vitro","Reproductive Techniques, Assisted","Quality of Life","Psychological Well-Being","Mind-Body Therapies","Complementary Therapies","2026-02-09",{"date":445,"type":36},"2026-02-17",{"date":447,"type":22},"2026-01-21",{"date":98,"type":22},{"name":450,"class":43},"Villanova University",{"id":452,"slug":453,"hasResults":12,"nctId":454,"briefTitle":455,"officialTitle":455,"acronym":456,"eligibilityCriteria":457,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":458,"targetDuration":4,"studyType":23,"phases":460,"briefSummary":461,"conditions":462,"keywords":468,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":477,"lastUpdatePostDateStruct":478,"startDateStruct":480,"completionDateStruct":482,"leadSponsor":484,"locationsCount":44},"100598506","nutritional-prehabilitation-to-improve-cancer-outcomes-n-pico-100598506","NCT07072377","Nutritional Prehabilitation to Improve Cancer Outcomes (N-PICO)","N-PICO","Inclusion Criteria:\n\n* Diagnosis of invasive cancer with plans to initiate chemo-, immune-, targeted-, or hormonal therapy for treatment of their malignancy, or within one month of starting treatment.\n* Age ≥ 18 years of age.\n* Patients must be able to read, write, and speak English as study material and virtual nutrition consultation calls are only available in English.\n* Patients receiving treatment at a participating ambulatory medical oncology site.\n* Willingness to have a remote nutritional consultation and complete questionnaires\u002Fsurveys.\n* Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines.\n\nExclusion Criteria:\n\n* Diagnosis of acute leukemia (these patients generally receive predominantly inpatient care).\n* Diagnosis of head \\& neck cancer, esophageal cancer, gastric cancer, patients presenting with recognized cachexia or severe malnutrition, or patients with PEG tubes for enteral feeding.\n\nRationale: These patients would normally be referred for dietary consultation and may need ongoing clinical intervention from an on-site dietitian beyond the period of the proposed study",{"count":459,"type":22},240,[25],"Brief Summary\n\nThe goal of this clinical trial is to evaluate the acceptability and adherence of low- and high-intensity remote nutritional interventions for cancer patients in rural and urban areas, specifically focusing on those with invasive cancer who are about to start treatment. The main question\\[s\\] it aims to answer are:\n\nCan low- and high-intensity remote nutritional interventions improve adherence to cancer treatment and quality of life? What is the impact of nutritional support on treatment delays, unplanned healthcare utilization, and dietary modifications? Researchers will compare the low-intensity arm (initial nutritional consultation plus written materials) to the high-intensity arm (1-hour consultation, monthly follow-ups, and written materials) to see if higher intensity interventions lead to better outcomes in terms of adherence, quality of life, and healthcare utilization.\n\nParticipants will:\n\nReceive either a low- or high-intensity nutritional consultation. Complete surveys assessing quality of life, dietary habits, treatment delays, and unplanned healthcare use.\n\nBe asked to participate in monthly follow-up consultations (for the high-intensity group) to track progress and provide additional support.",[463,464,30,465,466,467],"Malnutrition","Cancer-related Malnutrition","Nutritional Support","Nutritional Interventions","Rural Health",[469,470,471,472,473,474,475,476],"Cancer Nutrition Intervention","Malnutrition in Cancer Patients","Nutritional Support for Cancer","Prehabilitation Program for Cancer","Rural Cancer Nutrition","Quality of Life and Cancer Nutrition","Remote Nutritional Consultations","Cancer Treatment Outcomes and Nutrition","2026-02-02",{"date":479,"type":36},"2026-02-05",{"date":481,"type":36},"2025-09-10",{"date":483,"type":22},"2028-09",{"name":485,"class":43},"University of Vermont Medical Center",{"id":487,"slug":488,"hasResults":12,"nctId":489,"briefTitle":490,"officialTitle":490,"acronym":4,"eligibilityCriteria":491,"healthyVolunteers":12,"sex":17,"minAge":492,"maxAge":4,"enrollmentInfo":493,"targetDuration":4,"studyType":23,"phases":495,"briefSummary":496,"conditions":497,"keywords":501,"overallStatus":164,"whyStopped":4,"lastUpdateSubmitDate":504,"lastUpdatePostDateStruct":505,"startDateStruct":507,"completionDateStruct":509,"leadSponsor":510,"locationsCount":44},"100619580","exploring-the-effects-of-magnesium-ions-on-peripheral-neuropathy-serum-magnesium-ion-concentrationsleep-quality-and-quality-of-life-in-patients-with-colorectal-cancer-receiving-chemotherapy-100619580","NCT07346469","Exploring the Effects of Magnesium Ions on Peripheral Neuropathy, Serum Magnesium Ion Concentration,Sleep Quality, and Quality of Life in Patients With Colorectal Cancer Receiving Chemotherapy.","Inclusion Criteria:\n\n* a. Patients diagnosed with colorectal cancer by pathology.\n* b. Age ≥ 20 years.\n* c. Conscious.\n* d. Able to communicate fluently in Mandarin and Taiwanese.\n* e. Patients who have received or are expected to begin chemotherapy (Oxaliplatin).\n\nExclusion Criteria:\n\n* a. ECOG (Eastern Cooperative Oncology Group) ≥2 points.\n* b. Patients receiving intravenous nutrition.\n* c. Patients with pre-existing neuropathy.\n* d. Patients with skin wounds.\n* e. Patients with implanted pacemakers.\n* f. Patients with phenylketonuria.\n* g. Patients with diarrhea.\n* h. Patients with renal insufficiency.\n* i. Patients with hypermagnesemia.\n* j. Patients allergic to any of the ingredients","20 Years",{"count":494,"type":22},75,[25],"Chemotherapy for colorectal cancer (CRC) is frequently complicated by chemotherapy-induced peripheral neuropathy (CIPN) and impaired sleep quality, significantly impacting patient quality of life. Low magnesium levels have been implicated in peripheral nerve dysfunction. This interventional study aims to investigate the effects of magnesium supplementation on serum magnesium concentration, CIPN severity, and sleep quality in CRC patients undergoing chemotherapy.\n\nStudy Design and Methods\n\nThis is a prospective, parallel-group, randomized controlled trial (RCT) utilizing a longitudinal design. Participants (CRC patients undergoing chemotherapy) will be randomly allocated to one of three groups:\n\n* Experimental Group 1: Oral magnesium (400mg) supplementation.\n* Experimental Group 2: Oral magnesium (400mg}) supplementation and magnesium solution foot baths.\n* Control Group: Standard care.\n\nMeasurements will be collected using structured questionnaires and blood samples during each chemotherapy cycle. The primary outcomes will be assessed using:\n\n* Serum Magnesium Concentration\n* CIPN Severity: Functional Assessment of Cancer Therapy\u002FGynecologic Oncology Group-neurotoxicity (FACT\u002FGOG-Ntx) scale.\n* Sleep Quality: Verran and Snyder-Halpern Sleep Scale (VSH). Primary Research Questions (Hypotheses)\n\n  1. Can the magnesium intervention (oral and\u002For foot baths) effectively increase the serum magnesium concentration in CRC patients?\n  2. Can the magnesium intervention alleviate or improve the severity of CIPN?\n  3. Can the magnesium intervention improve the sleep quality of CRC patients during chemotherapy? The intervention groups will be compared against the control group to determine if the magnesium interventions lead to superior improvement in the measured outcomes.",[498,499,500,30],"Colorectal Cancer (CRC)","Chemotherapy Induced Peripheral Neuropathy (CIPN)","Sleep Quality",[502,503,500,409],"Colorectal cancer (CRC)","Chemotherapy induced peripheral neuropathy (CIPN)","2026-01-07",{"date":506,"type":36},"2026-01-16",{"date":508,"type":22},"2026-01-01",{"date":203,"type":22},{"name":511,"class":43},"Kaohsiung Medical University Chung-Ho Memorial Hospital",{"id":513,"slug":514,"hasResults":12,"nctId":515,"briefTitle":516,"officialTitle":517,"acronym":518,"eligibilityCriteria":519,"healthyVolunteers":150,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":520,"targetDuration":4,"studyType":156,"phases":4,"briefSummary":522,"conditions":523,"keywords":527,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":533,"lastUpdatePostDateStruct":534,"startDateStruct":536,"completionDateStruct":538,"leadSponsor":540,"locationsCount":44},"100576502","societal-burden-associated-with-type-1-diabetes-in-canada-100576502","NCT06786130","Societal Burden Associated With Type 1 Diabetes in Canada","Burden and (Dis)Utility of Caregivers of Children With T1D","T1D","Inclusion Criteria:\n\n1. Parental caregiver of a child recently diagnosed (\\\u003C= 2 years) with T1D before study inclusion;\n2. Age ≥18 ;\n3. Residence in the Canada;\n4. Willingess to complete a 20-minute survey\n5. Ability to read and understand French or English;\n6. Signature of informed consent form (ICF)\n\nExclusion Criteria:\n\n1\\. Participation in a clinical trial.",{"count":521,"type":22},100,"The purpose of this observational study is to estimate the burden of T1D on caregivers of patient with T1D in terms of work productivity, healthcare resource utilization and quality of life.",[524,30,525,526],"Type 1 Diabetes Mellitus","Work Productivity","Caregiver Subjective Burden",[528,529,530,531,532],"observational","quality of life","caregiver","work productivity","real-world","2025-12-22",{"date":535,"type":36},"2025-12-23",{"date":537,"type":36},"2025-01-09",{"date":539,"type":22},"2025-12",{"name":541,"class":43},"PeriPharm",{"id":543,"slug":544,"hasResults":12,"nctId":545,"briefTitle":546,"officialTitle":547,"acronym":4,"eligibilityCriteria":548,"healthyVolunteers":12,"sex":151,"minAge":18,"maxAge":4,"enrollmentInfo":549,"targetDuration":4,"studyType":23,"phases":551,"briefSummary":552,"conditions":553,"keywords":559,"overallStatus":164,"whyStopped":4,"lastUpdateSubmitDate":563,"lastUpdatePostDateStruct":564,"startDateStruct":566,"completionDateStruct":567,"leadSponsor":569,"locationsCount":44},"100616643","longitudinal-evaluation-of-direct-neurotization-technique-in-breast-reconstruction-with-fully-autologous-components-100616643","NCT07308275","Longitudinal Evaluation of Direct Neurotization Technique in Breast Reconstruction With Fully Autologous Components","Longitudinal Evaluation of Direct Neurotization Technique in Breast Reconstruction With Fully Autologous Components: An Assessment of BREAST-Q Sensation Module, Cutaneous Pressure Threshold, Neuregulin 1 (NRG1) Expression, Nerve Fiber Cross-sectional Area, Intraepidermal Nerve Fiber Density (IENFD), and Breast Morphometry","Inclusion Criteria:\n\n* Female patients aged ≥18 years.\n* Patients with unilateral breast cancer who have undergone or will undergo unilateral mastectomy.\n* Patients undergoing breast reconstruction.\n* Patients with unilateral breast cancer regardless of adjuvant therapy status (receiving radiotherapy and\u002For chemotherapy or receiving no adjuvant therapy).\n* Willing to comply with all scheduled examinations and tissue sampling procedures.\n* Able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* History of peripheral neuropathy (e.g., diabetes mellitus with neuropathic complications).\n* Bilateral mastectomy.\n* Presence of skin or soft-tissue conditions of the breast that may interfere with sensory assessment.\n* Active smokers (use of tobacco, vape, or other nicotine products within 14 days prior to neurotization).\n* Refusal or inability to attend follow-up evaluations.",{"count":550,"type":22},28,[25],"This clinical trial aims to evaluate whether direct neurotization using fully autologous components during autologous breast reconstruction improves postoperative breast sensation and sensory-related quality of life in women undergoing unilateral mastectomy. Direct neurotization involves coapting the recipient intercostal nerve to an autologous nerve graft placed within the flap to facilitate reinnervation.\n\nThe study's primary questions are:\n\n1. Does direct neurotization using fully autologous nerve grafts improve cutaneous sensory recovery, as assessed by Semmes-Weinstein monofilament thresholds measured at standardized breast locations?\n2. Does neurotization enhance patient-reported sensory outcomes and quality of life, as assessed by the BREAST-Q Sensation Module?\n\nAs secondary objectives, the study will assess whether biological predictors of nerve regeneration correlate with sensory outcomes. These include:\n\n1. Neuregulin-1 (NRG1) expression in flap tissue biopsy;\n2. Cross-sectional area of the recipient nerve fibres;\n3. Breast morphometry measured at baseline and follow-up;\n4. Intraepidermal nerve fibre density (IENFD) on skin biopsy.\n\nParticipants will be randomly assigned to receive either:\n\n1. Neurotized autologous breast reconstruction using fully autologous graft components, or\n2. Standard (non-neurotized) autologous breast reconstruction.\n\nThe study will compare these groups to determine whether neurotization accelerates or enhances the return of breast sensation over a 6-month follow-up period, with evaluations at 1 month, 3 months, and 6 months after surgery.\n\nParticipants will undergo:\n\n1. Autologous breast reconstruction with or without direct neurotization as part of their planned cancer surgery.\n2. Sensory testing using Semmes-Weinstein monofilaments at baseline, 1, 3, and 6 months.\n3. Completion of BREAST-Q questionnaires evaluating breast sensation, symptoms, and quality of life at each follow-up visit.\n\n3\\. Intraoperative tissue sampling for NRG1 analysis and nerve morphometry. 4. Skin biopsy (if applicable) to assess intraepidermal nerve fibre density. 5. Breast morphometry assessment using a breast morphometry measurement software tool.\n\nThis study seeks to provide high-quality evidence on the effectiveness of direct neurotization using fully autologous components in restoring breast sensation and to explore biological predictors that may influence sensory recovery after autologous breast reconstruction.",[554,555,556,557,558,30],"Breast Reconstruction After Mastectomy","Neurotization","Mastectomy and Breast Reconstruction","Peripheral Nerve Regeneration","Sensory Function",[560,561,562,529],"breast neurotization","mastectomy","breast sensory","2025-12-15",{"date":565,"type":36},"2025-12-29",{"date":563,"type":22},{"date":568,"type":22},"2027-04-15",{"name":570,"class":43},"Fakultas Kedokteran Universitas Indonesia",{"id":572,"slug":573,"hasResults":12,"nctId":574,"briefTitle":575,"officialTitle":576,"acronym":4,"eligibilityCriteria":577,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":396,"enrollmentInfo":578,"targetDuration":4,"studyType":23,"phases":580,"briefSummary":581,"conditions":582,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":588,"lastUpdatePostDateStruct":589,"startDateStruct":591,"completionDateStruct":593,"leadSponsor":595,"locationsCount":44},"100606693","psychosocial-teleassistance-programme-for-adults-with-spina-bifida-100606693","NCT07178873","Psychosocial Teleassistance Programme for Adults With Spina Bifida","Effects of a Psychosocial Teleassistance Programme for Adults With Spina Bifida","Inclusion Criteria:\n\n* To be diagnosed with spina bifida by a specialist.\n* Being between 18 and 75 years old.\n* Having their informed consent or the informed consent of their legal guardians.\n* Having Spanish as one of their main languages.\n* Having access to a computer (with a camera, microphone and speakers integrated) and Internet connection to take part in the videoconferences.\n\nExclusion Criteria:\n\n* Age that is inconsistent with the established range.\n* The presence of any comorbid diagnosis or sensory deficit that would impede the effective execution of the intervention's activities.",{"count":579,"type":22},35,[25],"This clinical trial assesses the effect of a telecare psychosocial intervention designed for adults with spina bifida. The intervention consists of 10 weekly 1.5-hour group sessions, followed by two 3-month follow-up sessions. Each group will consist of 6 to 7 individuals. The intervention is aimed at strengthening aspects of self-concept, self-esteem, social skills and aims at a reduction of symptomatology and a general improvement of psychological well-being.",[583,584,30,585,431,586,587],"Spina Bifida","Self Esteem","Self Concept","Depression","Interpersonal Needs","2025-12-02",{"date":590,"type":36},"2025-12-10",{"date":592,"type":36},"2024-06-25",{"date":594,"type":22},"2027-01",{"name":596,"class":43},"University of Deusto",{"id":598,"slug":599,"hasResults":12,"nctId":600,"briefTitle":601,"officialTitle":602,"acronym":603,"eligibilityCriteria":604,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":605,"targetDuration":4,"studyType":156,"phases":4,"briefSummary":607,"conditions":608,"keywords":612,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":619,"startDateStruct":621,"completionDateStruct":623,"leadSponsor":625,"locationsCount":239},"100604336","quality-of-life-and-medical-care-of-long-term-sarcoma-survivors-in-germany-prosa-100604336","NCT07148193","Quality of Life and Medical Care of Long-term Sarcoma Survivors in Germany (PROSa+)","Understanding Long-Term Sarcoma Survivorship: Risk Profiles, Outcomes and Unmet Needs - A Joint Project of Research, Sarcoma Centres and Patient Experts (PROSa+)","PROSa+","Inclusion Criteria:\n\n* Diagnosis of sarcoma according to the International Classification of Diseases for Oncology (ICD-O) and World Health Organization (WHO) classification, including soft tissue sarcoma, bone sarcoma, and GIST\n* At least 5 years since initial sarcoma diagnosis\n* With or without active disease\n* Age ≥18 years at the time of study participation\n\nExclusion Criteria:\n\n* Diagnosis of Desmoid tumors\n* Inability to complete a structured questionnaire (e.g., due to insufficient German language skills, cognitive impairment, dementia)",{"count":606,"type":22},1600,"The study PROSa+ aims to assess patient-reported outcomes (PROs), patient-reported experiences (PREs), and the socioeconomic situation of long-term sarcoma survivors (≥ 5 years post-diagnosis, with or without active disease) in Germany. The mixed-methods research design includes a multicenter observational study with a cross-sectional questionnaire survey involving 1,600 participants (paper, online), qualitative interviews with up to 60 participants, and longitudinal analyses combining data from existing sarcoma registries and the previous PROSa study conducted between 2017 and 2020.",[609,610,30,611],"Sarcoma","Survivorship","Medical Care",[609,613,614,615,611,439,616,617,618],"Neoplasms","Patient-Reported Outcomes","Patient-Reported Experiences","Unmet Health Needs","Oncology","Psycho-Oncology",{"date":620,"type":36},"2025-12-08",{"date":622,"type":36},"2025-11-28",{"date":624,"type":22},"2027-09",{"name":626,"class":43},"Technische Universität Dresden",{"id":628,"slug":629,"hasResults":12,"nctId":630,"briefTitle":631,"officialTitle":632,"acronym":633,"eligibilityCriteria":634,"healthyVolunteers":12,"sex":151,"minAge":18,"maxAge":153,"enrollmentInfo":635,"targetDuration":4,"studyType":23,"phases":636,"briefSummary":637,"conditions":638,"keywords":649,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":652,"lastUpdatePostDateStruct":653,"startDateStruct":655,"completionDateStruct":656,"leadSponsor":658,"locationsCount":44},"100609100","pre-habilitation-within-eras-protocol-for-gynecologic-oncology-surgery-the-preeras-study-100609100","NCT07210164","Pre-habilitation Within ERAS Protocol for Gynecologic Oncology Surgery: The Pre_ERAS Study","Prehabilitation With Exercise and Immunonutrition (Ocoxin®) in the Perioperative Management of Gynecologic Malignancies Under ERAS Protocol.","Pre_ERAS","Inclusion Criteria:\n\n* Type of gynecological malignancy: endometrial cancer, ovarian cancer, cervical cancer, treated with laparotomy after the decision of the gynecological-oncology unit (positive opinion of the Multidisciplinary Tumor Board - MDT)\n* Patient age: 18 to 85 years\n* General condition of the patient: ASA score I-III\n* Consent to implement the accelerated recovery protocol - Enhanced recovery after surgery (ERAS)\n* Sufficient understanding of the Greek language\n* Provision of signed, after thorough information, consent to participate in the study\n\nExclusion Criteria:\n\n* Women with performance status: ECOG \\>2 and ASA score \\>III\n* Women who have not been informed and have given written consent",{"count":521,"type":22},[25],"ERAS (Enhanced Recovery After Surgery) protocols are step-by-step care plans that help patients recover faster after surgery. They focus on keeping the body's normal functions, lowering stress from surgery, and supporting a quicker recovery. In gynecologic cancer surgeries, ERAS has been shown to help patients do better, have fewer problems, and leave the hospital sooner.\n\nA prehabilitation program, in combination with ERAS protocols, aims to optimize patients' physical and psychological condition prior to surgery for gynecological cancers. Interventions may include tailored exercise, nutritional support, respiratory training, and psychological preparation. By enhancing baseline fitness and resilience, prehabilitation improves the body's ability to tolerate surgical stress, reduces complications, and facilitates a faster, smoother recovery within the ERAS framework.",[639,640,30,641,642,643,644,645,646,647,648],"ERAS","Compliance","Excercise","Immunonutrition","Post Operative Pain","Laparotomy Patients","Surgical Complication","Gynaecological Malignancies","Gynaecologic Cancer","Gynaecological Oncology",[650,639,651,642],"Prehabilitation","Gynecologic Cancers","2025-09-29",{"date":654,"type":36},"2025-10-07",{"date":38,"type":22},{"date":657,"type":22},"2029-12-30",{"name":659,"class":43},"Aristotle University Of Thessaloniki",{"id":661,"slug":662,"hasResults":12,"nctId":663,"briefTitle":664,"officialTitle":665,"acronym":666,"eligibilityCriteria":667,"healthyVolunteers":150,"sex":151,"minAge":18,"maxAge":4,"enrollmentInfo":668,"targetDuration":670,"studyType":156,"phases":4,"briefSummary":671,"conditions":672,"keywords":676,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":679,"lastUpdatePostDateStruct":680,"startDateStruct":682,"completionDateStruct":684,"leadSponsor":685,"locationsCount":687},"100593784","a-study-of-treatment-related-toxicities-and-quality-of-life-after-local-therapy-in-chinese-breast-cancer-patients-100593784","NCT07010939","A Study of Treatment-Related Toxicities and Quality of Life After Local Therapy in Chinese Breast Cancer Patients","A Prospective Multi-modal Cohort Study of Local Treatment-related Toxicities and Quality of Life in Chinese Breast Cancer Patients (PERSEVERE)","PERSEVERE","Inclusion Criteria:\n\n* Women aged 18 years or older\n* Diagnosed with stage I, II, or III invasive breast cancer confirmed by pathology or cytology\n* No signs of metastatic disease (cancer that has spread to other parts of the body)\n* Scheduled to receive local treatment, including:\n\nSurgery\n\nAnd\u002For neoadjuvant or adjuvant therapy such as chemotherapy, radiation, hormone therapy, or targeted therapy\n\n* Willing and able to complete health questionnaires and attend follow-up visits\n* Has given written informed consent to join the study\n\nExclusion Criteria:\n\n* Have metastatic breast cancer or local recurrence\n* Have already received curative treatment (surgery, chemo, etc.) for the current breast cancer before joining the study\n* Are currently pregnant or breastfeeding\n* Have a history of another cancer within the past 5 years (except for non-melanoma skin cancer or in-situ cervical cancer)\n* Are unable to participate in the study due to mental, physical, or legal reasons (for example, under legal guardianship or imprisonment)",{"count":669,"type":22},3000,"5 Years","This study, called PERSEVERE, examines how local treatment for early breast cancer affects people's health and daily lives over time.\n\nPeople who join the study will have early-stage breast cancer and receive treatment such as surgery and other therapies that are used before or after surgery. The study does not include people with late-stage (metastatic) breast cancer.\n\nResearchers want to learn about short- and long-term side effects that can happen during or after treatment. These may include tiredness, trouble sleeping, emotional distress, pain, or changes in heart or lung function. The study also looks at how these effects impact participants' quality of life.\n\nParticipants will be asked to complete surveys about how they feel. They will also have health checks, such as heart tests, lung function tests, and blood samples. Tissue samples from surgery will also be collected.\n\nThe goal is to understand better how different people respond to breast cancer treatment and find ways to support long-term recovery.",[673,30,674,675],"Breast Neoplasms","Toxicities","Breast Diseases",[673,677,439,614,678],"Treatment-Related Toxicities","Prospective Study","2025-09-08",{"date":681,"type":36},"2025-09-12",{"date":683,"type":36},"2025-04-07",{"date":203,"type":22},{"name":686,"class":43},"FangYi",3,{"id":689,"slug":690,"hasResults":12,"nctId":691,"briefTitle":692,"officialTitle":693,"acronym":4,"eligibilityCriteria":694,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":695,"targetDuration":4,"studyType":23,"phases":697,"briefSummary":698,"conditions":699,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":704,"lastUpdatePostDateStruct":705,"startDateStruct":707,"completionDateStruct":709,"leadSponsor":711,"locationsCount":206},"100569860","impact-of-mindful-self-compassion-therapy-on-self-harm-behaviors-emotional-regulation-and-quality-of-life-among-patients-with-borderline-personality-disorder-100569860","NCT06699732","Impact of Mindful Self-Compassion Therapy on Self Harm Behaviors, Emotional Regulation and Quality of Life Among Patients With Borderline Personality Disorder","Impact of Mindful Self-Compassion Therapy on Self Harm Behaviors, Emotional Regulation and Quality of Life Among Patients With Borderline Personality Disorder: A Randomized Controlled Trial","Inclusion Criteria:\n\n* 1\\. First time diagnosed non-hospitalized patients of Borderline Personality Disorder.\n\n  2\\. Patients of Borderline Personality Disorder experiencing psychological distress,low level of quality of life, social support, emotional dysregulation would be included.\n\n  3\\. Borderline Personality Disorder patients with age 18 years and above (both gender) from outpatient department (OPD) 4. Borderline personality patients who would be able to understand Urdu language and can give the informed consent\n* Exclusion criteria\n\nThe study would have the following exclusion criteria:\n\n1. Hospitalized patients of Borderline Personality\n2. Patients with Borderline Personality having other chronic co-morbid diseases such as cancer, cognitive deficits, and other chronic psychological disorders.\n3. Patients with Borderline Personality younger than 18 years of age",{"count":696,"type":22},60,[25],"The primary purpose of the study is to investigate whether Mindful Self-Compassion (MSC) therapy can significantly reduce self-harm behaviors, improve emotional regulation, and enhance the quality of life in individuals diagnosed with Borderline Personality Disorder (BPD). The study aims to contribute to the existing literature by providing robust evidence on the efficacy of MSC therapy for BPD, which could inform clinical practices and improve treatment outcomes",[700,701,702,30,703],"Psychological Distress","Emotional Regulation","Self Harm","Borderline Personality Disorder (BPD)","2025-08-29",{"date":706,"type":36},"2025-09-02",{"date":708,"type":36},"2024-09-21",{"date":710,"type":22},"2025-12-30",{"name":712,"class":43},"Fatima Jinnah Women University",{"id":714,"slug":715,"hasResults":12,"nctId":716,"briefTitle":717,"officialTitle":718,"acronym":719,"eligibilityCriteria":720,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":721,"targetDuration":4,"studyType":23,"phases":722,"briefSummary":723,"conditions":724,"keywords":727,"overallStatus":164,"whyStopped":4,"lastUpdateSubmitDate":734,"lastUpdatePostDateStruct":735,"startDateStruct":736,"completionDateStruct":738,"leadSponsor":740,"locationsCount":44},"100603540","virtual-reality-and-cranial-nerve-non-invasive-neuromodulation-to-improve-quality-of-life-for-veterans-100603540","NCT07137845","Virtual Reality and Cranial Nerve Non-invasive Neuromodulation to Improve Quality of Life for Veterans","Virtual Reality and Cranial Nerve Non-invasive Neuromodulation to Improve Quality of Life for Veterans Living With Post-traumatic Stress Disorder and Chronic Pain","VR & CN-NINM","Inclusion Criteria:\n\n1. Be a veteran;\n2. Be ≥18 years old;\n3. Have a diagnosis of chronic musculoskeletal pain (pain \\> 6 months);\n4. Have been diagnosed with PTSD by a health professional and\u002For have a PTSD Checklist for DSM-5 (PCL-5) score \\> 30\u002F80 and\n5. Speak English or French.\n\nExclusion Criteria:\n\n1. Bipolar disorder, psychosis;\n2. Neuropathic pain (based on the Neuropathic Pain Diagnosis and Questionnaire (DN4));\n3. Visual disorders or photosensitivity, color blindness;\n4. Epilepsy, motion sickness and\n5. Any containdications to CN-NINM.",{"count":155,"type":22},[25],"Veterans in Canada are twice as likely as the general population to experience chronic pain. This pain is often linked to post-traumatic stress disorder (PTSD), and both have a major impact on their quality of life. The autonomic nervous system (ANS) plays a key role in these pathologies, making its modulation a promising therapeutic target. Veterans are already experiencing pain and PTSD relief via virtual reality (VR), mostly through ANS reactivity modulation. Long-term exposure (desensitization) and the calming effect are the two forms of VR; the latter is more tolerable and more suited for ANS rebalance. Its benefits on pain, however, are still mild and transient. In order to further enhance these benefits, cranial nerve non-invasive neuromodulation (CN-NINM), a novel technology that enables the direct flow of neuronal impulses through tongue stimulation, is suggested to be combined with virtual reality (VR). The goal of this project is to document the feasibility of an intervention combining virtual reality (VR) with real and sham cranial nerve non-invasive neuromodulation (CN-NINM) in veterans with post-traumatic stress disorder and chronic pain.\n\nThe secondary objectives are: 1) to explore and compare the effect of the two interventions (VR + real CN-NINM vs. VR + sham CN-NINM) on various clinical measures, and 2) to explore and compare the effect of these two interventions on autonomic nervous system (ANS) activity.\n\nEach intervention will be applied for 20 minutes. Their painful condition (whether diagnosed or not, type, location, intensity, and unpleasant aspects of the pain) as well as their PTSD-related symptoms will be assessed before and after the intervention.\n\nAt the end of this study, it is expected that the CN-NINM could become a complementary treatment option for relieving pain and PTSD symptoms in PVs and, ultimately, improving their quality of life.",[725,726,30],"Chronic Pain","PTSD - Post Traumatic Stress Disorder",[728,729,730,731,732,733,349],"Chronic pain","PTSD","Veterans","Autonomic nervous system","Virtual reality (VR)","Cranial nerve non-invasive neuromodulation (CN-NINM)","2025-08-22",{"date":704,"type":36},{"date":737,"type":22},"2025-09",{"date":739,"type":22},"2027-08",{"name":741,"class":43},"Université de Sherbrooke",{"id":743,"slug":744,"hasResults":12,"nctId":745,"briefTitle":746,"officialTitle":747,"acronym":4,"eligibilityCriteria":748,"healthyVolunteers":150,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":749,"targetDuration":4,"studyType":23,"phases":750,"briefSummary":751,"conditions":752,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":757,"lastUpdatePostDateStruct":758,"startDateStruct":760,"completionDateStruct":762,"leadSponsor":764,"locationsCount":44},"100588286","music-therapy-and-humanization-in-ed-healthcare-professionals-100588286","NCT06939426","Music Therapy and Humanization in ED Healthcare Professionals","Impact of a Short Music Therapy Program on Intra- and Interpersonal Factors of Humanized Care in a Group of Emergency Nursing Staff at the University Hospital Fundación Santa Fe de Bogotá: a Mixed-methods Pilot and Feasibility Study","Inclusion Criteria:\n\n* Be a member of the emergency department nursing staff at the FSFB for a minimum of 6 months.\n* Be able to commit to participating in eight music therapy sessions over a four-week period.\n* Have the minimum reading skills to understand the questionnaires\n\nExclusion Criteria:\n\n\\- Staff with untreated mental health disorders.",{"count":7,"type":22},[25],"Background: Healthcare professionals in emergency departments frequently experience stressful situations that could jeopardize their mental health, sense of purpose, and ability to empathize with patients, families, and colleagues.\n\nResearch question: What is the impact of a short music therapy program on the intra- and interpersonal factors of humanized care among emergency nursing staff at the University Hospital Fundación Santa Fe de Bogotá (FSFB)? Methodology: This research is a mixed-methods pilot and feasibility study. For the quantitative component, we will apply the HUMAS (Healthcare Professional Humanization Scale) and ProQOL (Professional Quality of Life) measure at the start and at the end of the music therapy program. For the qualitative component, focus group interviews will be conducted and analyzed via thematic analysis.\n\nDiscussion: This study seeks to support the nursing staff of the FSFB emergency department through an interactive, creative, and participatory music therapy self-care program focused on one of the most important pillars of the institution: the humanization of care.",[753,754,30,755,756],"Stress","Burnout","Music Therapy","Humanization of Care","2025-08-07",{"date":759,"type":36},"2025-08-12",{"date":761,"type":36},"2025-06-12",{"date":763,"type":22},"2026-05-01",{"name":765,"class":43},"Fundación Santa Fe de Bogota"]