[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"quality-of-recovery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:quality-of-recovery":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,47,67,91,114,143,171,198,234,263,290],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100636916","revised-paravertebral-nerve-blocks-for-enhanced-recovery-after-stoma-closure-100636916",false,"NCT07571902","Revised-Paravertebral Nerve Blocks for Enhanced Recovery After Stoma Closure","Revised-Paravertebral Nerve Blocks for Enhanced Recovery After Stoma Closure: A Randomized Clinical Trial","r-PVB III","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Patients scheduled to undergo elective ileostomy, colostomy, or ileocolostomy reversal surgery.\n\nExclusion Criteria:\n\n* Contraindications to nerve block, including skin infection at the puncture site, increased intracranial pressure, uncorrectable coagulopathy, bridging indication for therapeutic anticoagulation (CHADS-VASc ≥8), sepsis, or allergy to local anesthetics.\n* Expected operative time longer than 150 minutes, or stoma reversal not being the primary surgical procedure.\n* Chronic opioid use.\n* Heart failure, liver failure, renal failure, coagulation disorders, or a history of allergy to local anesthetics.\n* Inability to comply with study procedures, including severe psychiatric illness, refusal to sign informed consent, or anticipated difficulty in completing postoperative follow-up.","ALL","18 Years",{"count":20,"type":21},250,"ESTIMATED","INTERVENTIONAL",[24],"NA","After stoma closure, pain remains an important problem affecting patient recovery. A revised paravertebral block (r-PVB) was developed as a single-shot, large-volume intercostal-space injection performed at the exposed mid-axillary ninth to eleventh intercostal level with the patient kept supine after induction of anesthesia. Rather than puncturing the classical paraspinal target near the transverse process with the patient in a prone or lateral position, the r-PVB technique is designed to exploit retrograde spread of local anesthetic from the intercostal space to the paravertebral space, thereby generating a functional paravertebral block while avoiding direct entry into the paravertebral space and the need for specific body positioning. The r-PVB technique addresses several practical limitations of conventional PVB by eliminating the need to reposition an anesthetized patient, using a more accessible and potentially clearer sonographic window, reducing interference from transverse-process shadowing, and facilitating in-plane needle visualization.",[27,28,29],"Stoma Closure","Postoperative Pain","Quality of Recovery",[27,31,32,28,29,33,34],"Ileostomy Closure","Colostomy Closure","Intercostal Space Block","Paravertebral Nerve Block","NOT_YET_RECRUITING","2026-05-06",{"date":38,"type":39},"2026-05-11","ACTUAL",{"date":41,"type":21},"2026-04-27",{"date":43,"type":21},"2027-12-31",{"name":45,"class":46},"Sixth Affiliated Hospital, Sun Yat-sen University","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":63,"startDateStruct":64,"completionDateStruct":65,"leadSponsor":66,"locationsCount":4},"100636525","revised-paravertebral-nerve-blocks-for-enhanced-recovery-after-laparoscopic-cholecystectomy-100636525","NCT07566819","Revised-Paravertebral Nerve Blocks for Enhanced Recovery After Laparoscopic Cholecystectomy","Revised-Paravertebral Nerve Blocks for Enhanced Recovery After Laparoscopic Cholecystectomy: A Randomized Clinical Trial","REVISED-PVB II","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective laparoscopic cholecystectomy for benign gallbladder disease\n\nExclusion Criteria:\n\n* Contraindications to nerve block, including skin infection at the puncture site, increased intracranial pressure, uncorrectable coagulopathy, bridging indication for therapeutic anticoagulation (CHADS-VASc ≥ 8), sepsis, or allergy to local anesthetics\n* Surgeon-estimated high likelihood of conversion to open surgery\n* Chronic opioid use\n* Heart failure, liver failure, or renal failure\n* Coagulation disorders\n* History of allergy to local anesthetics\n* Inability to comply with the study protocol, including severe psychiatric illness, refusal to provide informed consent, or anticipated difficulty with postoperative follow-up",{"count":20,"type":21},[24],"After laparoscopic cholecystectomy, pain remains an important problem affecting patient recovery. A revised paravertebral block (r-PVB) was developed as a single-shot, large-volume intercostal-space injection performed at the exposed mid-axillary eighth or ninth intercostal level with the patient kept supine after induction of anesthesia. Rather than puncturing the classical paraspinal target near the transverse process with a specific prone or lateral position of the patient, r-PVB is designed to exploit medial spread of local anesthetic along the intercostal-endothoracic-extrapleural continuum, thereby generating a functional paravertebral block while avoiding direct entry into the paravertebral space and specific body positioning. r-PVB addresses several practical limitations of conventional PVB by eliminating the need to reposition an anesthetized patient, using a more accessible and potentially clearer sonographic window, reducing interference from transverse-process shadowing, and facilitating in-plane needle visualization.",[59,60,28,29],"Benign Gallbladder Disease","Laparoscopic Cholecystectomy",[60,28,29,34,62],"intercostal space block",{"date":38,"type":39},{"date":41,"type":21},{"date":43,"type":21},{"name":45,"class":46},{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":22,"phases":78,"briefSummary":79,"conditions":80,"keywords":83,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":89,"leadSponsor":90,"locationsCount":4},"100636612","revised-paravertebral-nerve-blocks-for-enhanced-recovery-after-video-assisted-thoracoscopic-pneumonectomy-100636612","NCT07567950","Revised-Paravertebral Nerve Blocks for Enhanced Recovery After Video-assisted Thoracoscopic Pneumonectomy","Revised-Paravertebral Nerve Blocks for Video-Assisted Thoracoscopic Surgery: A Randomized, Controlled, Observer-masked Noninferiority Trial.","r-PVB-1","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective video-assisted thoracoscopic pneumonectomy for benign or malignant diseases\n\nExclusion Criteria:\n\n* Contraindications to nerve block, including skin infection at the puncture site, increased intracranial pressure, uncorrectable coagulopathy, bridging indication for therapeutic anticoagulation (CHADS-VASc ≥ 8), sepsis, or allergy to local anesthetics\n* Surgeon-estimated high likelihood of conversion to open surgery\n* Chronic opioid use\n* Heart failure, liver failure, or renal failure\n* Coagulation disorders\n* History of allergy to local anesthetics\n* Inability to comply with the study protocol, including severe psychiatric illness, refusal to provide informed consent, or anticipated difficulty with postoperative follow-up",true,{"count":77,"type":21},200,[24],"Revised-Paravertebral Nerve Block (r-PVB) is performed right after induction of general anesthesia and before lateral positioning of surgery. Under ultrasound guidance, an intercostal space between the 6th and 8th ribs at the midaxillary line is identified. Using an in-plane technique, the needle is advanced into the internal intercostal muscle, and 30 mL of 0.5% ropivacaine is injected to achieve the block. Traditional Paravertebral Nerve Block (PVB) is performed right after the lateral positioning of surgery under ultrasound guidance. According to the operator's preference, choose any of the commonly used three traditional paravertebral block approaches. Among these 3 approaches, the axial plane approach is recommended as the first choice: use the convex probe to identify the 6th and 8th transverse processes, then scan cranially to display the superior costotransverse ligament, pleura, and paravertebral space. Under sterile conditions, insert the needle in-plane approximately 2 cm lateral to the probe, ensuring the ultrasound probe remains stable and dynamically visualizing the needle advancement. Stop advancing the needle when the tip passes through the superior costotransverse ligament. Administer 2% lidocaine in pulsatile injections, 1-2 ml per pulse, observing the spread of fluid at the needle tip on ultrasound and depression of the pleura. Repeat pulsatile injections until a total of 5 ml lidocaine is administered, and if necessary, increase with another 5 ml of pulsatile lidocaine. The fluid movement and pleura depression observed on ultrasound confirm proper needle placement. Then, use this needle to inject 30 ml of 0.5% ropivacaine to complete the PVB. The surgical procedure will start right after the intervention blocks.",[81,28,29,82],"Video-assisted Thoracoscopic Surgery (VATS)","Lung Diseases",[84,28,29,34,62],"Video-Assisted Thoracoscopic Surgery","2026-05-05",{"date":87,"type":39},"2026-05-08",{"date":36,"type":21},{"date":43,"type":21},{"name":45,"class":46},{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":98,"targetDuration":4,"studyType":22,"phases":100,"briefSummary":101,"conditions":102,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":109,"leadSponsor":111,"locationsCount":113},"100628186","front-block-for-quality-of-recovery-after-total-hip-arthroplasty-100628186","NCT07458360","FRONT Block for Quality of Recovery After Total Hip Arthroplasty","Effect of Femoral Rami and Obturator Nerve Trunk (FRONT) Block on Postoperative Quality of Recovery After Total Hip Arthroplasty: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Scheduled for total hip arthroplasty under spinal anesthesia\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Ability to understand and complete the QoR-15 questionnaire\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate\n* Contraindication to spinal anesthesia or regional block\n* Allergy to study medications\n* Chronic opioid use (daily use for more than 3 months)\n* Neurological or neuromuscular disorders affecting the lower extremities\n* Infection at the injection site\n* Coagulation disorders\n* Cognitive impairment prevents questionnaire completion",{"count":99,"type":21},80,[24],"This prospective randomized controlled trial evaluates the effect of ultrasound-guided unilateral Femoral Rami and Obturator Nerve Trunk (FRONT) block on postoperative quality of recovery in patients undergoing elective total hip arthroplasty.",[103,28,29],"Osteoarthritis of the Hip","RECRUITING","2026-04-25",{"date":107,"type":39},"2026-04-28",{"date":105,"type":39},{"date":110,"type":21},"2026-07-05",{"name":112,"class":46},"Konya Meram State Hospital",1,{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":121,"targetDuration":4,"studyType":22,"phases":123,"briefSummary":125,"conditions":126,"keywords":131,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":113},"100616680","phase-4-impact-of-perioperative-dexmedetomidine-and-esketamine-on-postoperative-quality-of-recovery-100616680","NCT07308756","Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery","Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery in Patients Undergoing General Anesthesia and Surgery: A 2×2 Factorial Randomized Trial","Inclusion Criteria:\n\n* Aged 18 years or over;\n* Scheduled to undergo surgery under general anesthesia, with an expected surgical duration of at least 1 hour;\n* Required patient-controlled intravenous analgesia after surgery.\n\nExclusion Criteria:\n\n* Unable to communicate preoperatively due to visual, auditory, or verbal barriers or other reasons;\n* Severe bradycardia (heart rate \\\u003C50 bpm), sick sinus syndrome, or grade 2 or higher atrioventricular block without pacemaker;\n* History of hyperthyroidism or pheochromocytoma;\n* History of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or intracranial hypertension;\n* Intracranial tumor or neurosurgery;\n* Severe liver dysfunction (Child-Pugh class C), renal failure (requiring renal replacement therapy), or American Society of Anesthesiologists class IV or higher;\n* Enrolled in other clinical studies.",{"count":122,"type":21},316,[124],"PHASE4","For patients after surgery, quality of recovery has significant impacts on the prognosis, quality of life, and rational allocation of medical resources. Dexmedetomidine and esketamine have each been used during the perioperative period and improved postoperative analgesia and subjective sleep quality. This 2x2 factorial trial is designed to explore the effects of dexmedetomidine, esketamine, and their combination on the quality of recovery in patients recovering from surgery under general anesthesia.",[127,128,129,130,29],"General Anesthesia","Surgery","Dexmedetomidine","Esketamine",[132,128,129,130,133],"General anesthesia","Quality of recovery","2026-04-08",{"date":136,"type":39},"2026-04-13",{"date":138,"type":39},"2026-01-05",{"date":140,"type":21},"2027-04",{"name":142,"class":46},"Peking University First Hospital",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":11,"sex":17,"minAge":151,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":153,"phases":4,"briefSummary":154,"conditions":155,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":113},"100608374","the-role-of-neuroinflammation-on-neurocognitive-outcome-in-cardiac-surgery-100608374","NCT07200726","The Role of Neuroinflammation on Neurocognitive Outcome in Cardiac Surgery","The Role of Neuroinflammation on Neurocognitive Outcome in Cardiac Surgery: INOCS Study","INOCS","Inclusion Criteria:\n\n* aged 60 years or older;\n* scheduled for cardiac surgery.\n\nExclusion Criteria:\n\n* dementia, as diagnosed by a specialist, since this would make detection of PNCD impossible;\n* urgent, not elective surgery.","60 Years",{"count":99,"type":21},"OBSERVATIONAL","RATIONALE: Postoperative cognitive changes are common after cardiac surgery and can be categorised into three main types: postoperative delirium (POD), delayed neurocognitive recovery (DNCR) and postoperative neurocognitive disorder (PNCD). DNCR is diagnosed until postoperative day 30 and PNCD is diagnosed at least 30 days after the operation. Both conditions can be mild or major, and can affect the quality of life of these patients.\n\nThe incidence of PNCD in cardiac surgery is around 40%. Despite this high incidence, screening for PNCD is absent in current postoperative care since the diagnosis of PNCD is difficult and very time intensive. Furthermore, the underlying pathogenesis is incompletely understood.\n\nThe identification of a biomarker and\u002For validated short diagnostic instrument would be of paramount importance to easily identify patients at risk, or to diagnose patients with PNCD in order to identify therapeutical pathways for this disease.\n\nOBJECTIVES: The main objective of this prospective clinical trial is to evaluate the performance of the short NPA and\u002For biochemical markers for the diagnosis of DNCR and PNCD in cardiac surgery patients aged 60 years or older.\n\nSTUDY DESIGN: Single-centre interventional observational study\n\nSTUDY INTERVENTIONS: Patients will undergo a neurophysiological assessment (NPA) pre-operatively and at two timepoints post-operatively, namely 6 (+\u002F-1) days and 40 (+\u002F- 10) days after surgery. During the stay at the intensive care unit, they will be screened daily for delirium, using the CAM-ICU and 3D-CAM.\n\nTo evaluate whether the development of DNCR or POD has an important effect on quality of recovery , the quality of recovery scale 15 (QOR-15), muscle strength (handgrip strength) and the Chalder fatigue score will be scored post-operative (postop day 1, 3 and 5). To evaluate whether PNCD has an effect on quality of live the EQ5D5L score will be measured at 40 (+\u002F- 10) days after surgery, compared to preoperative values.\n\nOn several time points, blood samples will be drawn to measure markers of neuroinflammation. The time points will be preoperatively, at the moment of arrival on ICU, postoperative day 1, 2 and 3, if still on ICU. Two repeat blood sample will be taken at the moment of NPA performed after 6 (+\u002F- 1) days and 40 (+\u002F- 10) days after surgery, if the patient is willing (not obligatory).\n\nSTUDY POPULATION:\n\nPatients aged 60 years or older who are scheduled for cardiac surgery.\n\nInclusion criteria:\n\n* aged 60 years or older;\n* scheduled for cardiac surgery.\n\nExclusion criteria:\n\n* dementia, as diagnosed by a neurologist;\n* urgent, not elective surgery.\n\nMAIN STUDY ENDPOINTS:\n\nPrimary outcome PNCD defined as a decline of \\> 1 SD on \\> 2 tests in one or more cognitive domains or a decline of \\> 1 SD on total cognitive domain score.\n\nSecondary outcomes Postoperative delirium - CAM-ICU will be evaluated twice daily (morning and evening) on every day when the patient is awake (not intubated) on the ICU. This is standard of care and is part of the routine clinical care in the hospital. Furthermore, once daily a 3D-CAM will be performed on day 1, 3 and 5.\n\nQuality of recovery\n\n* QOR-15, a validated measurement of quality of recovery in the short term postoperative recovery, will be evaluated pre-operatively and postoperatively day 1, 3 and 5.\n* EQ5D5L, a validated measurement of quality of recovery in the long term postoperative recovery, will be evaluated preoperatively and at the moment of the third NPA measurement.\n* Postoperative muscle function (upper extremity, by hand grip strength) on day 1, 3 and 5 after surgery and at the moment of the second and third NPA measurement (being day 6 (+\u002F-1) and day 40 (+\u002F-10) postoperatively), as compared to preoperative values.\n* Chalder Fatigue questionnaire on day 1, 3 and day 5 and on the second and third NPA measurement, as compared to preoperative.\n\nBiochemical analysis\n\n\\- Blood samples will be drawn for analysis before induction of anaesthesia (preoperatively), at the end of the operation (immediately postoperatively on arrival in ICU), on day 1, 2 and 3 postoperatively (if still at the ICU) and at the time of the postoperative follow-up visits with the NPA testing (day 6 (+\u002F-1) and day 40 (+\u002F-10) days post-surgery).\n\nAt each time point, markers of neuroinflammation and -degeneration will be determined.\n\nTertiary outcomes\n\n* Length of CPB\n* Duration of mechanical ventilation\n* Administered anaesthetic drugs during surgery\n* Transfusion need\n* Length of ICU stay (days)\n* Length of in-hospital stay (days)\n* Readmission to ICU or hospital within 28 days after surgery\n* Cardiovascular outcome: atrial fibrillation, , thrombo-embolic events, myocardial injury, myocardial infarction, cardiac arrest, cardiac death\n* Pulmonary outcome: postoperative pulmonary complications, postoperative pneumonia, postoperative respiratory failure\n* Postoperative infection within 28 days after surgery",[156,157,158,159,160,161,162,29],"Postoperative Neurocognitive Dysfunction","Postoperative Neurocognitive Disorder","Cardiac Surgery","Major Surgery Under General Anesthesia","Major Surgery in Adult Patients","Postoperative Fatigue","Elderly Patients","2026-04-07",{"date":134,"type":39},{"date":166,"type":39},"2025-10-21",{"date":168,"type":21},"2026-10",{"name":170,"class":46},"Ziekenhuis Oost-Limburg",{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":178,"enrollmentInfo":179,"targetDuration":4,"studyType":22,"phases":181,"briefSummary":182,"conditions":183,"keywords":184,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":113},"100613286","4-point-tap-block-vs-combined-rsb-ostap-block-for-recovery-after-laparoscopic-cholecystectomy-100613286","NCT07264608","4-Point TAP Block vs. Combined RSB-OSTAP Block for Recovery After Laparoscopic Cholecystectomy","Comparison of 4-Point Transversus Abdominis Plane Block and Combined Bilateral Rectus Sheath-Oblique Subcostal TAP Block on Quality of Recovery After Laparoscopic Cholecystectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\nAdults aged 18-65 years\n\nASA physical status I-II\n\nScheduled for elective laparoscopic cholecystectomy\n\nAbility to understand the study and provide written informed consent\n\nExclusion Criteria:\n\nAllergy or hypersensitivity to local anesthetics or study medications\n\nCoagulopathy, anticoagulant therapy, or local infection at block site\n\nSevere pulmonary disease (severe COPD, uncontrolled asthma, respiratory failure)\n\nNYHA class III-IV heart failure\n\nHistory of thoracic or abdominal surgery affecting block area\n\nChronic pain syndrome or regular opioid\u002Fanalgesic use\n\nMorbid obesity (BMI \\> 35 kg\u002Fm²)\n\nPregnancy or breastfeeding\n\nCognitive impairment preventing cooperation\n\nConversion to open cholecystectomy\n\n\\-","65 Years",{"count":180,"type":21},76,[24],"Laparoscopic cholecystectomy is a common keyhole surgery to remove the gallbladder. Although the cuts are small, patients can still have significant pain and nausea after the operation, which may delay recovery and discharge. To improve comfort, doctors often use ultrasound-guided abdominal nerve blocks as part of multimodal pain management.\n\nIn this single-center, randomized controlled trial, adult patients scheduled for elective laparoscopic cholecystectomy will receive standard general anesthesia and be randomly assigned to one of two routinely used block techniques at the end of surgery: (1) a 4-point transversus abdominis plane (TAP) block, or (2) a combined bilateral rectus sheath block plus oblique subcostal TAP block. Both techniques are performed under ultrasound guidance while the patient is still asleep.\n\nThe main aim of the study is to compare the quality of recovery on the first day after surgery between the two groups, using a short questionnaire (QoR-15). Secondary aims are to compare pain scores, the need for additional pain medicine, and the frequency of postoperative nausea and vomiting between the groups during the first 24 hours. All other aspects of anesthesia and surgical care will follow standard hospital practice. Participation is not expected to add significant risk beyond that of routine anesthesia and surgery, as both block techniques are already commonly used in clinical practice.",[28,29],[133,185,186,187,188],"TAP block","Rectus sheath block","OSTAP block","Laparoscopic cholecystectomy","2025-12-03",{"date":191,"type":39},"2025-12-10",{"date":193,"type":21},"2025-12-30",{"date":195,"type":21},"2026-04-30",{"name":197,"class":46},"Konya City Hospital",{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":11,"sex":17,"minAge":205,"maxAge":4,"enrollmentInfo":206,"targetDuration":4,"studyType":22,"phases":208,"briefSummary":209,"conditions":210,"keywords":216,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":230,"leadSponsor":231,"locationsCount":233},"100561028","enhanced-vitals-monitoring-after-major-surgery-trial-100561028","NCT06584825","Enhanced Vitals Monitoring After Major Surgery Trial","The Impact of Enhanced Postoperative Vitals Monitoring In-hospital and at Home vs. Standard Care After Inpatient Abdominal and Vascular Surgery: A Pilot Two-centre Randomized Controlled Study","Inclusion Criteria:\n\n1. Undergoing inpatient major abdominal (general surgery, urology, or gynecology) or vascular surgery at St. Paul's Hospital (SPH) and Mount Saint Joseph (MSJ) Hospital\n2. Length of stay of at least 48 hours (planned by the clinical team, or by the Canadian Institute of Health Information Discharge Abstract Database Expected Length of Stay (ELOS) for the surgical case mix group\n3. Self-reported fluency in reading and speaking in English for patient or home caregiver\n4. Living within British Columbia, Canada and in an area that is covered by Bell cellular network (the Cloud DX Inc. device has cellular Long Term Evolution (LTE) using the Bell network).\n\nExclusion Criteria:\n\n1. Patient refusal\n2. Transplant surgery, since these patients have a unique set of considerations and postoperative course.\n3. Inability to communicate with research personnel, perform self-monitoring of vital signs, or complete study surveys due to cognitive, language, visual, or hearing barriers\n4. Lack of capacity to consent to the study (including under the active influence of sedative medication or having received general anesthetic within the past 24 hours)\n5. Unable to use (or does not have a caregiver who can help put on\u002Ftake off) study monitoring device at home\n6. Preoperatively known planned discharge to a nursing home or rehabilitation facility\n7. Patient with known allergic reactions to any part material of the device\n8. Unable to monitor blood pressure accurately noninvasively using arm blood pressure cuffs, such as due to underlying vascular anatomy or non-pulsatile blood flow physiology\n9. Unlikely to be able to return the home monitoring kit (no fixed address, living too far away from site, etc.)","19 Years",{"count":207,"type":21},110,[24],"The aim of this clinical trial is to examine the feasibility of an enhanced vital sign monitoring solution in-hospital and at-home. This study includes adult patients undergoing inpatient major vascular or abdominal surgery. Researchers will compare the enhanced vitals monitoring group to the standard of care group to see if it may change post-operative management and outcomes. The primary question it aims to answer is if enhanced monitoring of surgical patient vitals can increase the number of days at home alive in the first 30 days after surgery. Participants in the intervention group will test two vitals monitoring devices, one in the hospital and one at home. They will also be asked to complete several questionnaires and a follow up phone call.",[128,211,29,212,213,214,215],"Post Operative Complications","General Surgery","Vascular Surgery","Urology","Gynecology",[217,218,219,220,221,222,223,224,225],"Days alive and at home","DAH30","Quality of Recovery 15","Pilot Randomized Controlled Trial","vitals","blood pressure","heart rate","oxygen saturation","device","2025-11-17",{"date":228,"type":39},"2025-11-21",{"date":226,"type":39},{"date":43,"type":21},{"name":232,"class":46},"University of British Columbia",2,{"id":235,"slug":236,"hasResults":11,"nctId":237,"briefTitle":238,"officialTitle":239,"acronym":4,"eligibilityCriteria":240,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":178,"enrollmentInfo":241,"targetDuration":4,"studyType":22,"phases":243,"briefSummary":244,"conditions":245,"keywords":249,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":254,"lastUpdatePostDateStruct":255,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":261,"locationsCount":4},"100598233","the-effect-of-encouraging-patients-undergoing-obesity-surgery-to-move-on-physical-mobility-recovery-and-negative-effects-of-surgery-100598233","NCT07068828","The Effect of Encouraging Patients Undergoing Obesity Surgery to Move on Physical Mobility, Recovery and Negative Effects of Surgery","The Effect of Mobilization Incentive Protocol Applied to Bariatric Surgery Patients on Physical Mobility, Recovery Quality and Complications","Inclusion Criteria:\n\n* Over 18 years of age,\n* Can speak and understand Turkish,\n* No communication problems,\n* Admitted to the clinic for bariatric surgery,\n* undergoing elective surgery,\n* Who agreed to wear a smartwatch,\n* Smartphone users,\n* Individuals who volunteered to participate in the study and who do not have physical movement disabilities\n\nExclusion Criteria:\n\n* In any of the ASA IV and V groups according to the ASA Physical Condition Classification System,\n* 6-min walk test contraindicated (unstable angina pectoris within the last month, systolic blood pressure above 180 mmHg, diastolic blood pressure above 100 mmHg, resting heart rate above 120),\n* Have any cognitive or neurological impairment that may adversely affect ambulation or cooperation,\n* Using a walking aid such as cane, walker, etc. while walking,\n* Have a disease that requires assistance with physical movement (e.g. after stroke, limb amputation)",{"count":242,"type":21},70,[24],"Early mobilization and physical mobility have a critical role in minimizing complications after surgical procedures. Although there are a limited number of studies in the literature on the step count of bariatric surgery patients, there is no study focusing on interventions that promote mobilization in this patient group. The aim of this study was to determine the effect of a mobilization incentive protocol on physical mobility, quality of recovery and complications in patients undergoing bariatric surgery.\n\nThis single-blind randomized controlled study will include 70 individuals who underwent bariatric surgery in the General Surgery ward of Kayseri City Hospital between July 2025 and June 2026. Patients will be followed up for 3 days after surgery, starting with the hospitalization process in the clinic before surgery. All participating patients will be administered preoperative patient information form, 6-minute walk test and International Physical Activity Questionnaire. Patients in the intervention group will be shown video-based mobilization training after bariatric surgery. The control group will not receive any intervention. Both groups will wear a smart watch at the time of the first mobilization (8th hour after surgery) and a patient follow-up form will be filled out. A reminder brochure will be hung in their rooms on the 1st postoperative day and a reminder text message will be sent to their cell phones on the 1st and 3rd days. The number of steps will be measured from the smart watch for three days postoperatively, complications will be followed according to the clavien dindo classification system and the Quality of Recovery-15 scale will be applied on the 3rd postoperative day. The analysis of the research data will be performed in IBM SPSS Statistics 26.0 package program. When comparisons between groups are made, parametric tests will be used in the analysis of data showing normal distribution in numerical data, and non-parametric tests will be used in the analysis of data not showing normal distribution. Chi-square test will be used in the analysis of categorical variables.\n\nThe lack of protocols to increase mobilization emphasizes the importance and innovativeness of this study. The mobilization promotion protocol is expected to increase the physical activity level (number of steps) of bariatric surgery patients in the postoperative period, improve the quality of recovery and reduce complications. These findings will reveal the importance of mobilization incentive protocol by contributing to postoperative care strategies.",[246,247,29,248],"Physical Activity","Bariatric Surgery","Mobilization",[250,251,252,253],"bariatric surgery","physical activity","quality of recovery","mobilization","2025-07-14",{"date":256,"type":39},"2025-07-16",{"date":258,"type":21},"2025-08-01",{"date":260,"type":21},"2026-08-01",{"name":262,"class":46},"TC Erciyes University",{"id":264,"slug":265,"hasResults":11,"nctId":266,"briefTitle":267,"officialTitle":268,"acronym":4,"eligibilityCriteria":269,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":270,"enrollmentInfo":271,"targetDuration":4,"studyType":22,"phases":273,"briefSummary":274,"conditions":275,"keywords":279,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":289,"locationsCount":113},"100589707","transcutaneous-auricular-vagus-nerve-stimulation-and-quality-of-recovery-after-major-noncardiac-surgery-100589707","NCT06957912","Transcutaneous Auricular Vagus Nerve Stimulation and Quality of Recovery After Major Noncardiac Surgery","Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Quality of Recovery After Major Noncardiac Surgery: A Randomized Trial.","Inclusion Criteria:\n\n1. Aged ≥18 years but \\\u003C85 years.\n2. Scheduled for elective or limited-time noncardiac surgery with expected duration ≥2 hours.\n\nExclusion Criteria:\n\n1. Lesions or infections of the auricle skin.\n2. Recent or long-term use of cholinergic or anticholinergic medications.\n3. Neurosurgery.\n4. Expected mechanical ventilation with intubation for ≥1 day after surgery.\n5. Diagnosed schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis before surgery.\n6. Preoperative left ventricular ejection fraction (LVEF) \\\u003C30%, or those with sick sinus syndrome, sinus bradycardia (heart rate \\\u003C50 beats per minute), atrioventricular block of grade II or above, or implanted pacemaker.\n7. Inability to communicate due to coma, severe dementia, or language barrier before surgery, or unable to cooperate with intervention.\n8. American Society of Anesthesiologists physical status grade \\>IV, or estimated survival \\\u003C24 hours.","85 Years",{"count":272,"type":21},320,[24],"Transcutaneous auricular vagus nerve stimulation (taVNS) is a novel non-invasive neuromodulation technique. Existing evidence suggested that taVNS improves pain management, sleep quality, inflammatory responses, and gastrointestinal recovery after surgery. This study is designed to test the hypothesis that perioperative use of taVNS may improve quality of recovery in patients after major noncardiac surgery.",[276,277,278,29],"Vagus Nerve Stimulation","Transcutaneous Electric Nerve Stimulation","Noncardiac Surgery",[280,281,133],"Transcutaneous auricular vagus nerve stimulation","Noncardiac surgery","2025-06-02",{"date":284,"type":39},"2025-06-03",{"date":286,"type":39},"2025-05-13",{"date":288,"type":21},"2026-09",{"name":142,"class":46},{"id":291,"slug":292,"hasResults":11,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":4,"eligibilityCriteria":296,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":297,"targetDuration":4,"studyType":22,"phases":298,"briefSummary":299,"conditions":300,"keywords":303,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":309,"lastUpdatePostDateStruct":310,"startDateStruct":312,"completionDateStruct":314,"leadSponsor":316,"locationsCount":113},"100453721","phase-4-preoperative-maltodextrins-effect-on-cardiac-function-in-cardiac-surgery-100453721","NCT05188222","Preoperative Maltodextrin's Effect on Cardiac Function in Cardiac Surgery","The Effect of Preoperative Maltodextrin on Cardiac Function in Cardiac Surgery Patients with Reduced Left Ventricular Ejection Fraction: a Randomized, Controlled, Double-blind, Clinical Trial","Inclusion Criteria:\n\n* 18 years of age or older\n* Presenting for coronary artery bypass grafting surgery\n* Preoperative left ventricular ejection fraction \\\u003C 50%\n* First case of the day (7:30am start time)\n\nExclusion Criteria:\n\n* Dysphagia, gastroparesis\n* Cannot tolerate oral intake\n* Celiac disease\n* Type 1 diabetes",{"count":242,"type":21},[124],"A randomized, controlled, double-blinded clinical trial evaluating the effect of the administration of a Maltodextrin solution on cardiac function in patients presenting for coronary artery bypass grafting surgery with a reduced left ventricular ejection fraction.",[301,29,302],"Left Ventricular Dysfunction","Right Ventricular Dysfunction",[304,305,306,307,308],"Cardiac surgery","Insulin","Maltodextrin","Enhanced Recovery After Surgery","Quality of Recovery After Surgery","2025-02-21",{"date":311,"type":39},"2025-02-24",{"date":313,"type":21},"2025-12-01",{"date":315,"type":21},"2027-03-01",{"name":317,"class":46},"Jewish General Hospital"]