[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"racial-disparities\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:racial-disparities":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,81],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100572056","effect-of-the-hcc-liver-link-intervention-100572056",false,"NCT06728293","Effect of the HCC Liver-Link Intervention","Inclusion Criteria\n\n• Within UCSF criteria:\n\nCandidates are eligible or a standardized MELD or PELD exception if, before completing locoregional therapy, they have lesions that meet one of the following criteria:\n\n* One Class 5 lesion greater than 5 cm and less than or equal to 8 cm\n* two or three Class 5 lesions that meeting all of the following\n\n  * At least one lesion greater than 3cm\n  * Each lesion less than or equal to 5 cm, and\n  * A total diameter of all lesions less than or equal to 8cm\n* Four or five Class 5 lesions each less than 3 cm, and a total diameter of all lesions less than or equal to 8 cm.\n* Between 18-75 years old\n* Have no more than two visits with an HCC-related provider\n* Able to read, write, and speak English\n* Any 1 of the following:\n\n  * Self-report as Black race (can be multiple races as long as 1 is Black)\n  * Self-report as insured by Medicaid (+\u002F- Medicare)\n  * SVI (Social vulnerability index) \\>= .75\n  * Unmarried\n\nExclusion Criteria\n\n* Lacks capacity to provide informed consent, including those with stage 2 HE or higher at the time of consent.\n* Age over 75\n* Last transthoracic echocardiogram with EF\\\u003C40% (OK if no prior echo)\n* BMI over 50\n* Patients who, in the investigator's judgment, are unlikely to ever be eligible for liver transplantation or resection at the time of enrollment, with reason documented\n* Prior history of any solid organ transplant\n* Non-skin cancer malignancies other than hepatocellular carcinoma in past 2 years unless approved by PI (i.e. cervical cancer, early prostate cancer)\n* Patients who have undergone resection or waitlisted\n* Patients near completion of transplant evaluation, PI to determine utility of intervention.","ALL","18 Years","75 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study is a pilot, multi-center randomized controlled trial testing the HCC Liver-Link intervention, a culturally tailored, multi-level program designed to reduce racial disparities in hepatocellular carcinoma (HCC) care. The intervention combines: (1) patient education to improve HCC-related disease and treatment knowledge, (2) social needs and substance use screening with referral to social work and community resources, and (3) facilitated access to subspecialty cancer care through a multidisciplinary HCC tumor board.\n\nA total of 40 Black patients with Barcelona Clinic Liver Cancer (BCLC) stage 0, A, or downstaged B disease will be randomized to receive either the HCC Liver-Link intervention or usual care and followed for 6 months or until liver transplant waitlisting. Primary outcomes are time to receipt of curative therapies (liver transplantation or resection) and change in HCC-related knowledge. Findings will inform development of larger interventions to eliminate racial disparities in HCC outcomes.",[26,27],"HCC","Racial Disparities","RECRUITING","2026-06-03",{"date":31,"type":32},"2026-06-05","ACTUAL",{"date":34,"type":32},"2025-06-10",{"date":36,"type":20},"2027-01",{"name":38,"class":39},"Indiana University","OTHER",2,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":15,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":55,"conditions":56,"keywords":65,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100580635","phase-2-family-acceptance-project-online-pilot-rct-100580635","NCT06839859","Family Acceptance Project Online (Pilot RCT)","An Online Family-based Program to Reduce Inequity Among Sexual and Gender Minority Youth of Color (Pilot RCT)","FAP-O","Inclusion Criteria (youth):\n\n1. Identify as a sexual\u002Fgender minority (including youth questioning their sexual orientation and\u002For gender identity AND their identity must be known to their participating caregiver).\n2. Identify as a person of color\u002Fbelonging to a minority racial and\u002For ethnic group.\n3. Be between the ages of 14 and 25 years\n4. Read and speak English\n5. Live in the United States\n6. Report consistent access to a phone, tablet, and\u002For computer with high-speed internet access\n7. Report an ability to attend eight, two-hour online sessions at pre-determined times\n8. Report moderate to high levels of caregiver\u002Ffamily rejection\n9. Not be at high-risk for suicide\n10. Not be actively psychotic\n\nInclusion Criteria (caregivers):\n\n1. Be a caregiver (biological parent, stepparent, grandparent, aunt\u002Funcle, or another adult who provides care) to an SGMY of color between the ages of 14 to 25\n2. Be over the age of 18\n3. Read and speak English\n4. Live in the United States\n5. Report consistent access to a phone, tablet, and\u002For computer with high-speed internet access.\n6. Report an ability to attend nine, two-hour online sessions at pre-determined times.\n7. Be aware of the SGM youth's minority identity\n8. NOT identify as SGM\n9. Report spending time with participating youth at least 5 waking hours per week\n10. Not be at high-risk for suicide\n11. Not be actively psychotic",true,"14 Years",{"count":52,"type":20},180,[54],"PHASE2","Research shows that sexual and gender minority youth (SGMY) experience high rates of mental health problems and other challenges (e.g., social, academic). A major factor that leads to these challenges is family rejection (family behaviors and reactions that minimize, deny, ridicule and attempt to prevent or change a child's sexual orientation, gender identity and gender expression). Racial and ethnic minority youth experience the highest rates of family rejection and related health risks.\n\nThe Family Acceptance Project (FAP) is a research, education, and intervention initiative that was founded more than 20 years ago to help diverse families learn to support and affirm their SGMY. FAP's Family Support Model is grounded in the lived experiences of diverse SGMY and families and uses a culture-based family support framework that enables parents and caregivers to change rejecting behaviors that FAP's research has shown contribute to health risks and increase supportive and accepting behaviors that promote well-being for SGMY.\n\nThe overall goal of this research project is to evaluate a nine-week online version of FAP's Family Support Model (FAP-O). The investigators will specifically study how FAP-O:\n\n1. Promotes parent\u002Fcaregiver acceptance and support of their sexual and gender minority youth.\n2. Increases family bonding and communication.\n3. Increases SGMYs' feelings of pride in being LGBTQ+ and more hopeful about the future.\n4. Leads to reductions in mental health problems reported by SGMY who experience family rejection.\n\nBefore receiving FAP-O's family support services, racial and ethnic minority SGMY (ages 14 to 25) and their caregivers will complete an initial pre-test survey. After completing this initial (baseline) survey, half of the families will participate in program sessions. Following the first round of sessions, all participants will complete an immediate follow-up survey, with an additional survey conducted six months after this. These surveys help us learn if FAP-O impacts the project's goals above. After the final survey, the other half of the families will attend program sessions. The investigators will also ask SGMY and caregivers to share what they liked about the program and their guidance for enhancing it.",[57,27,58,59,60,61,62,63,64],"LGBTQ","Family Relationships","Minority Stress","Depression","Anxiety","Drug Use","Teen Dating Violence","Sexual Risk Reduction",[57,66,67,68,69,70],"Family Support","Parents of LGBTQ Youth","Racial\u002FEthnic Minority","Health Equity","Family Acceptance","2026-02-08",{"date":73,"type":32},"2026-02-11",{"date":75,"type":32},"2025-04-24",{"date":77,"type":20},"2026-12",{"name":79,"class":39},"University of Michigan",1,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":49,"sex":15,"minAge":89,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":21,"phases":92,"briefSummary":93,"conditions":94,"keywords":95,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":40},"100618063","lakota-family-acceptance-project-100618063","NCT07326748","Lakota Family Acceptance Project","Development and Evaluation of an Indigenized Family Acceptance Project for Lakota LGBTQ2S+ Youth","L-FAP","Youth Inclusion Criteria:\n\n* Identify as 2SLGBTQ+ (and their identity must be known to their participating caregiver)\n* Identify as Indigenous (multiracial youth who are also Indigenous are eligible)\n* Youth should be between the ages of 13 and 18 years\n* Read and speak English\n* Report moderate to high levels of caregiver\u002Ffamily rejection (as evidenced by agreement on items that assess the presence and frequency of specific family rejecting behaviors \\[includes ambivalent and moderately and highly rejecting caregivers\\]\n* Report an ability and commitment to attending eight sessions at two hours a week over eight weeks with their caregiver\n\nParticipating Caregiver Inclusion Criteria:\n\n* Caregivers are broadly defined and may include a biological parent, stepparent, grandparent, aunt\u002Funcle, or other adult who provides care to the Indigenous 2SLGBTQ+ youth\n* Must be over the age of 18\n* Read and speak English\n* Be aware of the SGM identity of their Indigenous 2SLGBTQ+ youth\n* report an ability and commitment to attending eight sessions at two hours a week over eight weeks with their teen\n\nExclusion Criteria:\n\n* We will exclude Indigenous 2SLGBTQ+ youth and caregivers at imminent risk for suicide and\u002For who are experiencing current psychosis symptoms as determined by results on the safety items screener.","13 Years",{"count":91,"type":20},28,[23],"The goal of this open pilot trial (OPT) is to develop a Lakota-adapted Family Acceptance Project (LFAP) for Indigenous 2SLGBTQ+ youth and their caregivers. The OPT is specifically focused on acceptability, feasibility, and safety of programming and research protocols. The investigators will also examine pre- to post- changes on outcomes for the sole purposes of making sure scores on measures are changing in the hypothesized direction (e.g., depression scores are going from moderate to minimal as opposed to no change or depression scores increasing). Once enrolled in the study, participants complete a baseline survey. Then participants will engage in LFAP which is an 8-session group intervention; sessions will be scheduled once a week for eight weeks (at 2 hours per session). Participants will complete survey instruments before and immediately after the program sessions, in addition to post-program surveys and an exit interview.",[57,27,58,59,60,61,62,63,64],[96,57,97,98,99,100,68,101,102,103],"family acceptance","2SLGBTQ+","youth","family support","parents of LGBTQ youth","health equity","Native American\u002FIndigenous","Two Spirit","2026-01-23",{"date":106,"type":32},"2026-01-26",{"date":108,"type":32},"2026-01-20",{"date":110,"type":20},"2027-01-31",{"name":79,"class":39}]