[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"radiation-enteritis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:radiation-enteritis":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100563516","phase-2-efficacy-and-safety-of-thalidomide-combined-with-glutamine-in-the-treatment-of-radiation-intestinal-injury-100563516",false,"NCT06617182","Efficacy and Safety of Thalidomide Combined With Glutamine in the Treatment of Radiation Intestinal Injury.","Efficacy and Safety of Thalidomide Combined With Glutamine in the Treatment of Radiation Intestinal Injury: a Single-center, Open-label, Randomized Controlled Study","Inclusion Criteria:\n\n* Age 18-80 years old, gender is not limited;\n* Patients with hematochezia symptoms of chronic radiation intestinal injury: Due to the lack of diagnostic gold standard for radiation intestinal injury, a comprehensive analysis of clinical, endoscopic, imaging and histopathological findings was mainly performed to make the diagnosis of radiation intestinal injury on the basis of excluding infectious and other non-infectious intestinal injuries. Exposure to radioactive sources is a necessary factor in the diagnosis of radiation intestinal injury, and tumor activity or recurrence should be excluded.\n* The proportion of dominant defecation bleeding in total defecation times in the week before treatment is not less than 20%;\n* ECOG score: 0-2.\n\nExclusion Criteria:\n\n* Patients with hemodynamic instability;\n* Patients with obvious liver and kidney function injury: bilirubin, aminotransferase (ALT, AST) exceeded the upper limit of normal by 2 times; eGFR\\\u003C60ml\u002Fmin or dialysis patients;\n* Patients allergic to thalidomide or glutamine;\n* Patients whose primary disease was gastrointestinal malignancy;\n* Patients currently suffering from serious or uncontrolled underlying diseases of the blood, digestive tract, metabolism, endocrine, lung, heart, nervous system, mental system, etc.;\n* Female patients during pregnancy and breastfeeding (including patients with reproductive needs);\n* Patients infected with HIV;\n* Patients who cannot cooperate with regular follow-up and review of laboratory indicators;\n* any other circumstances which, in the opinion of the investigator, would render the subject unfit for study inclusion.","ALL","18 Years","80 Years",{"count":20,"type":21},150,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","At present, there is still a lack of standard and effective treatment strategies and procedures for radiation intestinal injury. Studies have shown that thalidomide can effectively treat refractory gastrointestinal bleeding caused by vascular malformation. Therefore, The investigators designed a single-center, open-label, randomized controlled study to evaluate the efficacy and safety of thalidomide combined with glutamine in the treatment of radiation intestinal injury.",[27],"Radiation Enteritis","RECRUITING","2026-03-23",{"date":31,"type":32},"2026-03-27","ACTUAL",{"date":34,"type":32},"2024-09-30",{"date":36,"type":21},"2028-11-01",{"name":38,"class":39},"Yongquan Shi","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":53,"conditions":54,"keywords":55,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":40},"100325395","fecal-microbiota-transplantation-for-radiation-enteritis-100325395","NCT03516461","Fecal Microbiota Transplantation for Radiation Enteritis","Efficacy and Safety of Fecal Microbiota Transplantation in Radiation Enteritis","Inclusion Criteria:\n\n1. age ≥18 years old;\n2. Radiation enteritis diagnosed by colonoscopy after finishing radiotherapy.\n\nExclusion Criteria:\n\n1. Patients who were pregnant or nursing;\n2. Patients who were unable or unwilling to undergo a gastroscopy;\n3. Patients who had gastrointestinal infection;\n4. Patients with cardiopulmonary failure.","85 Years",{"count":50,"type":21},70,[52],"NA","Radiation enteritis is one of the most feared complications after abdominal or pelvic radiation therapy.The gut microbiota is considered to constitute a \"microbial organ\" which has pivotal roles in the intestinal diseases and body metabolism. Evidence from animal studies demonstrated the link between intestinal bacteria and radiation enteritis. This clinical trial aims to evaluate the efficacy and safety of fecal microbiota transplantation (FMT) for radiation enteritis.",[27],[56,27,57],"Gut Microbiota","Fecal Microbiota Transplantation","2025-03-27",{"date":60,"type":32},"2025-03-30",{"date":62,"type":32},"2018-01-07",{"date":64,"type":21},"2025-07-01",{"name":66,"class":39},"The Second Hospital of Nanjing Medical University"]