[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"radiculopathy-lumbar\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:radiculopathy-lumbar":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,43,82,114,143,181,206,235,263,289,311],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100610069","post-market-safety-and-effectiveness-of-the-corus-lx-system-in-improving-lumbar-interbody-fusion-outcomes-100610069",false,"NCT07222787","Post-market Safety and Effectiveness of the CORUS-LX System in Improving Lumbar Interbody Fusion Outcomes","Post-market Safety and Effectiveness of the CORUS-LX System in Improving Lumbar Interbody Fusion Outcomes for the Treatment of Degenerative Lumbosacral Disc Disease.","ILIF","Inclusion Criteria:\n\n1. Age 18-80 years (Skeletally Mature)\n2. Indicated for lumbar interbody fusion for treatment of degenerative lumbosacral disease at two contiguous disc levels between L4-S1 as determined by the following:\n\n   a) Diagnosis of radiculopathy of the lumbar spine, with pain, including at least one of the following: i) Leg and\u002For buttock pain, weakness, numbness, or paresthesia ii) Low back pain iii) Neurogenic claudication b) Radiographically determined pathology (CT, MRI, X-rays) at the levels to be treated correlating to primary symptoms including at least one of the following: i) Decreased disc height in comparison to a normal adjacent disc. ii) Degenerative instability ≤ grade 1 spondylolisthesis (\\\u003C25% slip). iii) Recurrent disc herniation. iv) Central and\u002For foraminal stenosis.\n3. Oswestry Disability Index Score of \\> 40\u002F100 (Severe Disability).\n4. Unresponsive to non-operative, conservative treatment (rest, heat, electrotherapy, physical therapy, chiropractic care and\u002For analgesics) for:\n\n   1. At least six weeks from symptom onset; or\n   2. Have the presence of progressive symptoms or signs of nerve root\u002F spinal cord compression despite continued non-operative conservative treatment.\n5. Reported to be medically cleared for surgery.\n6. Physically and mentally able and willing to comply with the Protocol, including the ability to read and complete required forms\n7. Willing and able to adhere to the scheduled follow-up visits and requirements of the Protocol.\n8. Written informed consent provided by subject.\n\nExclusion Criteria:\n\n1. Any disease or condition that, in the investigator's opinion, would preclude accurate radiographic evaluation of any treated vertebrae (e.g. morbid obesity).\n2. Any anatomy or condition that makes posterior fusion treatment infeasible (e.g. fused facets).\n3. Has, in the Investigator's opinion, any disease or condition that would preclude accurate clinical evaluation (e.g. neuromuscular disorders).\n4. Active systemic infection or infection at the operative site.\n5. Anticipated treatment for active systemic infection, including HIV or Hepatitis C.\n6. Previous trauma to any of the L3 to S1 levels resulting in significant bony or disco-ligamentous lumbar spine injury that may prevent device placements.\n7. Prior instrumented surgery or pseudoarthrosis at the operative or adjacent levels.\n8. Indicated for or history of laminectomy at any of the index or adjacent levels\n9. Fixed or permanent neurologic deficit related to the target treatment levels that cannot be improved with surgery\n10. Leg, buttocks, or back pain in the absence of other symptoms of radiculopathy or myeloradiculopathy justifying the need for surgical intervention.\n11. Symptomatic disc degeneration requiring surgical intervention at more or less than two levels.\n12. Diagnosis of spondylolisthesis, grade \\>1.\n13. Diagnosis of lytic spondylolisthesis\n14. Diagnosis of iatrogenic, traumatic, or dysplastic spondylolisthesis\n15. Congenital bony and\u002For spinal cord abnormalities affecting spinal stability.\n16. Diagnosis of Paget's disease, osteomalacia or any other metabolic bone disease other than osteopenia.\n17. Diagnosis of osteoporosis, defined as a previous DEXA bone density T-score of ≤-2.5.\n18. Active malignancy or a history of any invasive malignancy (except non-melanoma skin cancer), unless treated with curative intent and without clinical signs or symptoms of the malignancy for at least five years.\n19. Has an uncontrolled seizure disorder.\n20. Cauda equina syndrome or neurogenic bowel\u002Fbladder dysfunction;\n21. Use of epidural steroids within 14 days prior to surgery.\n22. A concomitant condition requiring daily, high-dose oral steroids.\n\n    High dose steroid use is defined as:\n    1. Daily, chronic use of oral steroids of 5 mg\u002Fday or greater (steroid inhalers are not exclusionary).\n    2. Use of short-term (less than 10 days) oral steroids at a daily dose greater than 40 mg within one month of the study procedure.\n23. Long-term use (\\>6 months) of opioids \\>120 mg morphine equivalents.\n24. Known allergy to titanium (Ti)\n25. A current or recent history (≤1 year prior to screening) of substance abuse that required medical treatment.\n26. Is pregnant, nursing, or interested in becoming pregnant within the next 3 years from the time of screening.\n27. Participation as a subject in any other clinical studies involving medical devices or drugs in the last 30 days prior to surgery\n28. A pending personal litigation relating to spinal injury (worker's compensation is not exclusionary).\n29. Anticipated or potential relocation greater than 50 miles that may interfere with completion of follow-up examinations.\n30. A mental illness or belongs to a vulnerable population, as determined by the investigator (e.g., prisoner or developmentally disabled), that would compromise ability to provide informed consent or compliance with follow-up requirements.","ALL","18 Years","80 Years",{"count":21,"type":22},250,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to assess the safety and effectiveness of the study device, CORUS-LX, as an adjunct to lumbar interbody fusion, when used in combination with pedicle screw and rod constructs for the treatment of lumbosacral degenerative disease in patients requiring 2 level (L4-S1) lumbar fusion, for the treatment of symptomatic degenerative lumbosacral disc disease. The main questions it aims to answer are:\n\nIs there fusion success at the treated posterior anatomy of each level? Is there an absence of major adverse device related events? Is there an absence of injections (steroid, facet joint, nerve block) or subsequent revision surgery at index levels for symptoms related to back or leg pain?\n\nResearchers will compare a control arm to the treatment arm to see if research results vary from standard minimally invasive supplemental posterior fusion.\n\nEligible participants will undergo one of the below interventions:\n\n* Two-level lumbar interbody fusion at L4-L5 \\& L5-S1 segments, with supplemental posterior fusion performed using the study device, including pedicle screw and rod fixation.\n* Two-level lumbar interbody fusion at L4-L5 \\& L5-S1 segments, with standard minimally invasive supplemental posterior fusion including pedicle screw and rod fixation.\n\nParticipants will also be asked to read, understand, and sign the informed consent, attend a Screening\u002FBaseline visit, undergo surgery for their designated intervention, and participate in 5 additional study visits where they will complete surveys for patient reported outcomes and SOC procedures. These visits will occur at the below intervals (based upon surgery day as day 0):\n\n* 6 weeks\n* 3 months\n* 6 months\n* 12 months\n* 24 months",[28,29],"Radiculopathy Lumbar","Degenerative Lumbar Disc Disease","RECRUITING","2026-05-27",{"date":33,"type":34},"2026-05-29","ACTUAL",{"date":36,"type":34},"2025-12-01",{"date":38,"type":22},"2029-07-01",{"name":40,"class":41},"Providence Medical Technology, Inc.","INDUSTRY",9,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":54,"conditions":55,"keywords":59,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":81},"100635923","mirror-image-spine-correction-exercises-versus-conservative-physiotherapy-for-lumbar-radiculopathy-100635923","NCT07558993","Mirror Image Spine Correction Exercises Versus Conservative Physiotherapy for Lumbar Radiculopathy","Randomized, Parallel-Group, Superiority Trial of Mirror Image Spine Correction Exercises Versus Conservative Physiotherapy for Lumbar Nerve Root Microstructural Integrity Assessed by Diffusion Tensor Imaging in Adults With Lumbar Radiculopathy","MIRROR-LR","Inclusion Criteria:\n\n* Adults aged 18 years or older. Clinical diagnosis of unilateral lumbar radiculopathy. Presence of at least two of the following: dermatomal radiating leg pain, neurological deficit, positive neural tension test.\n\nMRI-confirmed lumbar nerve root compression or irritation consistent with symptoms.\n\nPain intensity of 3\u002F10 or greater. Able to undergo MRI and Diffusion Tensor Imaging (DTI). Able to understand study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Previous lumbar spine surgery. Bilateral radiculopathy or unclear diagnosis. Tumor, infection, fracture, inflammatory spinal disease, or cauda equina syndrome.\n\nSevere progressive neurological deficit requiring urgent treatment. Contraindications to MRI (pacemaker, incompatible implants, severe claustrophobia).\n\nRecent lumbar injections or surgery. Other neurological or musculoskeletal disorders affecting outcomes. Pregnancy if MRI contraindicated by local policy. Cognitive impairment or inability to follow instructions.",{"count":52,"type":22},64,[25],"Lumbar radiculopathy is a common condition caused by irritation or compression of a lumbar nerve root, often resulting in radiating leg pain, numbness, weakness, and functional limitation. Conservative physiotherapy is commonly used as first-line treatment, but outcomes vary among patients.\n\nThis randomized controlled trial will compare Mirror Image Spine Correction Exercises with standardized conservative physiotherapy in adults with lumbar radiculopathy. Participants will be randomly assigned to one of two treatment groups for 12 weeks.\n\nThe primary outcome is lumbar nerve root microstructural integrity measured using Diffusion Tensor Imaging (DTI), including Fractional Anisotropy and other diffusion parameters. Secondary outcomes include pain intensity, disability, spinal alignment, and adverse events.\n\nThe purpose of this study is to determine whether a targeted posture-correction exercise approach provides greater improvement than conventional physiotherapy.",[56,28,57,58],"Radiculopathy","Sciatica","Disc Disease Lumbar",[60,61,62,63,64,65,66,67,68,69],"Mirror Image Exercise","Physiotherapy","Diffusion Tensor Imaging","DTI","Conservative Physiotherapy","Low Back Pain","Nerve Root Compression","Postural Correction","Randomized Controlled Trial","Rehabilitation","NOT_YET_RECRUITING","2026-04-23",{"date":73,"type":34},"2026-04-30",{"date":75,"type":22},"2026-09-01",{"date":77,"type":22},"2027-09-30",{"name":79,"class":80},"University of Sharjah","OTHER",1,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":94,"conditions":95,"keywords":100,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":81},"100633807","the-selective-intraperineural-nerve-root-block-study-100633807","NCT07531485","The Selective Intraperineural Nerve Root Block Study","Feasibility, Safety and Diagnostic Accuracy of Selective Intraperineural Nerve Root Block for Identifying Compressed Nerve Root in Lumbosacral Radicular Pain. A Prospective Cohort Study","SINRBS","Inclusion Criteria\n\n* Unilateral sciatica \\>1 month with activity\u002Fdaily life impairment.\n* Suspected L5\u002FS1 root compression at L4-5\u002FL5-S1 with unconfirmed pain correlation, including disc herniation (MSU 1-B\u002F1-A\u002F2-A), lateral recess\u002Fforaminal stenosis (Lee grade 2\u002F3), atypical sciatica, or imaging-exam inconsistency.\n* Candidates for single-segment, single-root lumbar decompression, electing surgery after informed consent.\n\nExclusion Criteria\n\n* No significant pre-SINRB\u002Fsurgery pain, or weakness\u002Fnumbness as primary symptom.\n* Unidentifiable responsible compressed nerve root (RCNR) per surgery.\n* Suspected compression of the same nerve root at more than one segment.\n* Pregnancy, active malignancy, or surgical contraindications.\n* Inability to cooperate with assessment due to comorbidities or dysfunction.","90 Years",{"count":92,"type":22},80,[25],"Before lumbosacral decompression surgery for radicular pain, selective nerve root block(SNRB) is a common procedure to identify the responsible compressed nerve root(RCNR) and predict surgical outcomes. However, the diagnostic accuracy of conventional SNRB is unsatisfactory, especially in terms of specificity. The main limitation is the uncontrolled distribution of anesthetics during injection: when anesthetics spread to surrounding soft tissues instead of acting directly on the RCNR, false-negative results may occur with persistent radicular pain; when anesthetics diffuse to two or more nerve roots including the RCNR, false-positive results may occur even if a normal nerve root is punctured, leading to misdiagnosis.\n\nThis study aims to evaluate the diagnostic accuracy of a novel three-dimensional computed tomography multiplanar volume reconstruction (3D-CT MPVR) guided selective intraperineural nerve root block(SINRB) for identifying the RCNR in patients with lumbosacral radicular pain. The investigators hypothesize that this technique will achieve higher diagnostic specificity and overall accuracy than conventional SNRB, by ensuring anesthetics are delivered directly to the target nerve root. This improvement will help clinicians make more accurate surgical plans, achieve better targeted decompression, and ultimately improve postoperative pain relief and functional recovery for patients.\n\nThe main research questions to be addressed in this study are:\n\n* What is the procedural success rate of SINRB?\n* Whether SINRB may cause clinically detectable nerve injury?\n* Whether sciatica is relieved after SINRB when only the responsible compressed nerve root is blocked?\n* Whether sciatica is relieved after SINRB when only a normal unaffected nerve root is blocked?\n\nParticipants will:\n\n* Undergo one or two SINRB procedures and a single-level lumbar decompression surgery\n* Get assessment of pain, mobility disorder and neurological function",[28,96,97,98,99],"Radiculopathy Sacral","Radiculopathy Multiple Sites","Herniated Disc","Foraminal Stenosis",[101,102,103,104],"intraperineural","3D-CT MPVR","diagnostic selective nerve root block","lumbosacral radiculopathy","2026-04-11",{"date":107,"type":34},"2026-04-15",{"date":109,"type":22},"2026-04-13",{"date":111,"type":22},"2027-01-01",{"name":113,"class":80},"Xi'an Honghui Hospital",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":121,"targetDuration":4,"studyType":123,"phases":4,"briefSummary":124,"conditions":125,"keywords":128,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":81},"100631040","patient-satisfaction-during-lomber-transforaminal-epidural-steroid-injection-the-role-of-sedation-anxiety-and-pain-100631040","NCT07495501","Patient Satisfaction During Lomber Transforaminal Epidural Steroid Injection: The Role of Sedation, Anxiety, and Pain","Patient Satisfaction During Lomber Transforaminal Epidural Steroid Injection: The Role of Sedation, Anxiety, and Pain: A Prospective Observational Study","Inclusion Criteria:\n\n* Adults aged 18 to 80 years\n* No prior history of any interventional pain procedure\n* Ability to read and write in Turkish and to complete the study questionnaires\n* Written informed consent provided.\n* Planned lumbar transforaminal epidural steroid injection for radicular pain\n\nExclusion Criteria:\n\n* Refusal to provide written informed consent.\n* Inability to complete the satisfaction questionnaires reliably due to lack of Turkish literacy, significant cognitive impairment or severe visual or hearing impairment\n* Presence of major comorbidities such as decompensated cardiac or respiratory failure, uncontrolled arrhythmia or angina, myocardial infarction or stroke within the past 3 months, advanced liver or kidney failure, uncontrolled obstructive sleep apnea associated with morbid obesity, or severe pulmonary hypertension.",{"count":122,"type":22},120,"OBSERVATIONAL","Transforaminal epidural steroid injection (TFESI) is a minimally invasive procedure commonly used for the management of lumbar radicular pain. It is intended to reduce inflammation around the affected nerve root, limit edema, and modulate nociceptive transmission, with the aim of relieving pain, improving physical function, and potentially reducing the need for surgery. Although TFESI may improve function and quality of life, treatment benefit is not uniform, and the degree of pain relief and patient satisfaction may differ across individuals.\n\nThis prospective observational study aims to evaluate postprocedural pain intensity and patient satisfaction in individuals undergoing lumbar TFESI and to identify clinical and demographic factors associated with satisfaction. Demographic and clinical characteristics, medical and surgical history, procedural pain scores, anxiety level, postprocedural pain scores, sedation status, fluoroscopy-related metrics, and intraprocedural events will be recorded. Patient satisfaction will be assessed 1 hour after the procedure using a Likert-based questionnaire, and operator satisfaction will also be documented.\n\nBy examining patient-reported outcomes together with procedural and clinical variables, this study seeks to provide a more standardized assessment of real-world TFESI outcomes and to support better patient selection and follow-up strategies.",[126,28,127],"Lumbar Disc Disease","Radicular Pain",[129,130,131,132,133],"Patient satisfaction","Sedation","Anxiety","Epidural steroid injection","Pain intensity","2026-03-21",{"date":136,"type":34},"2026-03-27",{"date":138,"type":22},"2026-04-01",{"date":140,"type":22},"2026-09-15",{"name":142,"class":80},"Mersin University",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":147,"acronym":148,"eligibilityCriteria":149,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":150,"enrollmentInfo":151,"targetDuration":4,"studyType":23,"phases":153,"briefSummary":154,"conditions":155,"keywords":159,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":81},"100602554","a-multicomponent-intervention-for-patients-with-lumbosacral-radiculopathy-move-more-100602554","NCT07125027","A Multicomponent Intervention for Patients With Lumbosacral Radiculopathy: Move-MORE","Move-MORE","Inclusion Criteria:\n\n* ● Adults age 18-65 years at the time of enrollment\n\n  * Ability to stand for 10 minutes\n  * Presence of lumbosacral radicular pain within the past week that extends below the knee (i.e., pain radiating from the low back into the leg in a nerve root distribution) with or without accompanying low back pain, of at least 12 weeks' duration, AND\n  * Tampa Scale of Kinesiophobia score ≥ 23\n  * At least one positive physical examination finding consistent with lumbosacral radiculopathy, including at least one of the following:\n\n    * Positive straight leg raise test (eliciting radicular pain below the knee at ≤70 degrees of elevation);\n    * Positive Valsalva maneuver (eliciting radiculcar pain below the knee);\n    * Positive slump test;\n    * Neurological deficit in a lumbar nerve root distribution, including at least one of the following:\n\n      * Dermatomal sensory loss,\n      * Myotomal weakness, or\n      * Reduced or absent deep tendon reflexes (e.g., patellar or Achilles reflex) corresponding to the affected nerve root.\n  * Daily access to the internet via cell phone, tablet, or computer\n  * Willing to engage with Move-MORE 4-5 times per week on your own\n  * Willing to attend a two-hour-long virtual Zoom meeting once per week for eight weeks\n  * Willing to attend two in-person study visits and a follow-up visit\n  * Willing to complete 18 questionnaires pertaining to your pain symptoms, quality of life, psychosocial experiences, and your experiences in the trial\n  * Willing to wear an actigraphy device all day, every day, and while sleeping, for the duration of study participation and willing to keep it charged\n  * Willing to respond to a daily online survey for the duration of study participation\n  * Able to speak, read, and understand the English language\n  * Able to provide written informed consent\n  * Moderately motivated to participate as reported on a numeric rating scale (≥ 4\u002F10)\n\nExclusion Criteria:\n\n* ● Participants will be excluded if they have clinical signs or symptoms of lumbosacral radiculopathy with progressive neurologic deficits (loss of motor or sensory function) or intolerable pain.\n\n  * Participants with lumbosacral radiculopathy with progressive neurologic deficits will be referred for immediate medical attention, and are not eligible for participation in this study.\n\n    ● Participants will be excluded if they have clinical signs or symptoms suggestive of cauda equina syndrome, including any of the following:\n  * New-onset urinary retention or overflow incontinence not attributable to other known causes;\n  * Fecal incontinence;\n  * New onset of saddle anesthesia (loss of sensation in the buttocks, perineum, and inner thighs);\n  * Severe or progressive bilateral lower extremity weakness;\n\n    * Participants with suspected cauda equina syndrome will be referred for immediate medical attention, and are not eligible for participation in this study.\n\n      * Presence of moderate to severe foot drop, defined as noticeable weakness in ankle dorsiflexion that interferes with walking or requires the use of an assistive device (e.g., ankle-foot orthosis). Participants with suspected or worsening foot drop will be referred for further evaluation and are not eligible for study participation.\n      * Current use of a spinal cord stimulator\n      * Have received epidural steroid injection in the prior 3 months\n      * Have received a surgical intervention for low back pain or lumbosacral radiculopathy in the previous 6 months\n      * Current active mindfulness meditation practice 1 time\u002Fweek or more, and\u002For history of formal training in mindfulness\u002Fmeditation practice\n      * Concurrent diagnosis of cancer\n      * Current unmanaged or uncontrolled mental illness known to cause psychosis: schizophrenia, schizotypal disorders, bipolar I disorder with psychosis, major depressive disorder with psychosis\n      * Diagnosis of Borderline Personality Disorder or score \\>6 on the McLean Screening Instrument for Borderline Personality Disorder\n      * Initiation of or changes to an exercise regimen within 2 weeks prior to screening and\u002For enrollment\n      * Major medical or surgical event requiring hospitalization (for any reason other than a minor scheduled medical procedure) within 3 months prior to screening; or, scheduled or will be scheduled to occur within the 20 weeks (i.e., five months) after enrollment\n      * Currently participating in another interventional research study or participated in another interventional study within 2 weeks prior to screening\n      * Any reason the Clinical Investigator or Principal Investigator believes confers increased risk to the potential participant, if they were to enroll in the study","66 Years",{"count":152,"type":22},32,[25],"The Move-MORE study is designed to evaluate a multicomponent mindfulness and movement program for patients with lumbosacral radiculopathy. The program brings together mindfulness training to help participants develop awareness of their body and manage pain-related stress, gentle movement practice to improve comfort with physical activity and support function, and motivational interviewing to strengthen motivation, confidence, and the ability to make healthy changes.\n\nThe main objectives are to determine whether it is feasible for participants to use each component of the program when delivered online, to assess how acceptable and engaging each component is, and to evaluate the impact on pain, physical function, and daily activity levels. The study intervention will be conducted entirely remotely. Participants will complete online surveys, brief daily check-ins on their phone, and wear a small activity monitor on the hip to measure movement. They will also undergo quantitative sensory testing to evaluate pain sensitivity. At the end of the program, participants will share feedback about their experiences via qualitative interviews.\n\nThe findings will help identify which parts of the program provide the greatest benefit, with the ultimate goal of developing a more targeted and effective digital program for people with this condition.",[156,57,157,28,158],"Lumbosacral Radiculopathy","Chronic Low Back Pain With a Neuropathic Component","Chronic Pain (Back \u002F Neck)",[160,161,162,163,164,165,166,167,56,156,168,169,170,171],"Mindfulness","Physical Activity","Motivational Interviewing","Meditation","Tai Chi\u002FQi Gong","Movement","Mindfulness-Oriented Recovery Enhancement","Mindfulness-Based Interventions","Lumbar Radiculopathy","Chronic low back pain","Low back pain","Back Pain","2025-11-10",{"date":174,"type":34},"2025-11-12",{"date":176,"type":34},"2025-08-15",{"date":178,"type":22},"2026-11",{"name":180,"class":80},"National University of Natural Medicine",{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":4,"eligibilityCriteria":187,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":188,"enrollmentInfo":189,"targetDuration":4,"studyType":123,"phases":4,"briefSummary":191,"conditions":192,"keywords":195,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":81},"100585560","radiofrequency-for-chronic-radicular-lumbar-pain-geriatric-vs-young-patients-100585560","NCT06903949","Radiofrequency for Chronic Radicular Lumbar Pain: Geriatric vs. Young Patients","Comparison of the Analgesic Efficacy of Radiofrequency Application to Lumbar Root Ganglia in Geriatric and Young Patients With Chronic Radicular Lumbar Pain","Inclusion Criteria:\n\n* 18 years of age or older patients\n* Patients that diagnosed with chronic radicular lumbar pain\n* Have not received adequate response despite conservative treatments\n* Have complete medical data available in the hospital data system\n\nExclusion Criteria:\n\n* Missing data in the patient's follow-up records\n* The patient has previously undergone interventional pain management\n* The patient has previously had lumbar surgery","100 Years",{"count":190,"type":22},130,"This study aims to evaluate the treatment response and lumbar magnetic resonance imaging (MRI) findings of patients who have undergone pulsed radiofrequency therapy for chronic radicular lumbar pain at the dorsal root ganglia. By comparing young (18-64 years) and geriatric (≥65 years) patient groups, the study seeks to assess the impact of age on treatment response and opioid consumption. Additionally, it aims to analyze the potential relationship between paraspinal muscle fat infiltration and treatment outcomes.",[28,193,194],"Radiculopathy, Lumbosacral Region","Chronic Pain",[28,193,194],"2025-03-29",{"date":198,"type":34},"2025-04-01",{"date":200,"type":22},"2025-05-15",{"date":202,"type":22},"2025-12-15",{"name":204,"class":205},"Ankara Etlik City Hospital","OTHER_GOV",{"id":207,"slug":208,"hasResults":11,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":213,"enrollmentInfo":214,"targetDuration":4,"studyType":23,"phases":216,"briefSummary":217,"conditions":218,"keywords":220,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":81},"100563066","efficacy-and-safety-of-electroacupuncture-on-lumbar-disc-herniation-with-radiculopathy-100563066","NCT06611332","Efficacy and Safety of Electroacupuncture on Lumbar Disc Herniation with Radiculopathy","Efficacy and Safety of Electroacupuncture on Lumbar Disc Herniation with Radiculopathy: a Randomized Controlled Trial","Inclusion Criteria:\n\n1. Aged from 18 to 70 years old.\n2. With intervertebral disc protrusion confirmed by a MRI or CT, accompanied by radicular pain in the lower extremities.\n3. With a NRS score ≥ 4 points for both low back pain and leg pain, and the pain lasts for at least 3 months;\n4. Voluntarily participating the trial and signing the informed consent form.\n\nExclusion Criteria:\n\n1. Previous surgical treatment of the spine.\n2. Received any physical therapy for lumbar disc herniation within the recent 3 months.\n3. Complicated with diseases that can cause low back and leg pain.\n4. Symptomatic foraminal stenosis caused by severe degenerative diseases, accompanied by severe nerve injuries.\n5. Previous severe mental illness, organ failure, or malignant tumor.\n6. Planned spinal surgery or other major surgeries within the next 3 months.\n7. Pregnancy or lactation.","70 Years",{"count":215,"type":22},170,[25],"Lumbar disc herniation with radiculopathy (LDHR) is the local displacement of the intervertebral disc and its contents beyond the edge of the normal intervertebral disc space, resulting in pain, weakness or numbness in the muscle or dermatomal distribution area. Electroacupuncture is based on obtaining the needling sensation manually and applying electrical stimulation of different frequencies and intensities, aiming to enhance the intensity of acupoint stimulation to improve the effect. As a kind of acupoint stimulation therapy, electroacupuncture has shown analgesic effects in animal experiments. However, at present, the clinical evidence of electroacupuncture applied in the treatment of LDHR is still insufficient. Therefore, this randomized, single-blind, sham electroacupuncture controlled trial aims to evaluate the efficacy and safety of electroacupuncture as a treatment for LDHR.",[219,28],"Lumbar Disc Herniation",[221,222,223,224,225],"electroacupuncture","radiculopathy","sham control","randomized controlled trial","lumbar disc herniation","2024-09-23",{"date":228,"type":34},"2024-09-24",{"date":230,"type":22},"2024-10-15",{"date":232,"type":22},"2025-10-25",{"name":234,"class":80},"Jiangxi University of Traditional Chinese Medicine",{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":240,"acronym":4,"eligibilityCriteria":241,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":242,"targetDuration":4,"studyType":23,"phases":244,"briefSummary":245,"conditions":246,"keywords":247,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":260,"locationsCount":262},"100548481","impact-of-direct-current-electrical-stimulation-on-treatment-of-lumbosacral-radiculopathy-100548481","NCT06421558","Impact of Direct Current Electrical Stimulation on Treatment of Lumbosacral Radiculopathy","Impact of Direct Current Neuromuscular Electrical Stimulation on Physical Therapy Treatment of Lumbosacral Radiculopathy","Inclusion Criteria:\n\n* Must show evidence of lumbo-sacral radiculopathy as determined by EMG and straight leg raise test.\n* Must be able to attend weekly sessions for the 6-week period of the study (no extended travel)\n* Must be at least 18 years old.\n\nExclusion Criteria:\n\n* Currently pregnant\n* Cardiac pacemaker\n* Active or recent cancer\n* Active or recent blood clots\n* History of epilepsy\n* Open wounds\n* Spinal fusion surgery",{"count":243,"type":22},150,[25],"This study will compare two methods of electrical stimulation (alternating current and direct current) as an adjunctive therapy to treating lumbosacral radiculopathy. Both types of electrical stimulation have been used in clinical practice for physical therapy, however direct current stimulation is much less common and there is less known about its impact on physical therapy outcomes. The aim of this project is to show the efficacy of a novel device, the Neubie direct current device, compared to traditional TENS unit in clinical physical therapy treatment of radiculopathy. Outcomes measured will include: pain intensity, functional status, neurological status, electrophysiological changes and patient satisfaction.",[28,96,97],[248,249,250,251,252],"electrical stimulation","direct current","e-stim","neubie","emg","2024-07-25",{"date":255,"type":34},"2024-07-29",{"date":257,"type":34},"2024-04-01",{"date":259,"type":22},"2025-08-01",{"name":261,"class":41},"NeuFit - Neurological Fitness and Education",16,{"id":264,"slug":265,"hasResults":11,"nctId":266,"briefTitle":267,"officialTitle":268,"acronym":4,"eligibilityCriteria":269,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":270,"enrollmentInfo":271,"targetDuration":4,"studyType":23,"phases":273,"briefSummary":274,"conditions":275,"keywords":276,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":287,"locationsCount":81},"100495272","ultrasound-guided-microendoscopic-versus-fluoroscopic-guided-lumbar-transforaminal-epidural-steroid-injections-100495272","NCT05729022","Ultrasound-Guided Microendoscopic Versus Fluoroscopic-Guided Lumbar Transforaminal Epidural Steroid Injections","Ultrasound-Guided Microendoscopic Versus Fluoroscopic-Guided Lumbar Transforaminal Epidural Steroid Injections: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 18 and 64 years old of either sex\n* Disease status of American Society of Anesthesiologists grades I to II\n* Patients presenting with single-level disc disease and radiculopathy (L2-L3; L3-L4; L4-L5) for steroid injection\n* Confirmation of herniated disk by CT or MRI\n* Able to give informed consent\n\nExclusion Criteria:\n\n* Age under 18 or over 64 years old\n* Pregnant women\n* Disease status of American Society of Anesthesiologists grades III to IV\n* Unable to provide an informed consent\n* Radiculopathies at multiple spinal levels\n* Non-lumbar herniated discs\n* Clinically obvious or known spinal deformity or stenosis\n* Previous spine surgery\n* Local or systemic infection\n* Allergy to steroids, anesthetics, or contrast material\n* Uncorrectable coagulopathy and patients on anticoagulation therapy\n* Patients who refuse the procedure\n* Spine tuberculosis or tumors\n* Prior injections within 3 months","64 Years",{"count":272,"type":22},124,[25],"The purpose of this study is to compare the Microendoscopic combined with ultrasound technique to the standard routinely used X-ray guided transforaminal steroid injection technique.",[28,58],[277,278,279,280],"Epidural Injections","Lumbar Manipulation","Fluoroscopy","Ultrasound","2024-06-19",{"date":283,"type":34},"2024-06-21",{"date":285,"type":22},"2024-12-01",{"date":36,"type":22},{"name":288,"class":80},"American University of Beirut Medical Center",{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":293,"acronym":294,"eligibilityCriteria":295,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":296,"targetDuration":4,"studyType":23,"phases":298,"briefSummary":299,"conditions":300,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":309,"locationsCount":81},"100527134","precision-treatment-of-lumbar-spine-surgery-through-advanced-nerve-root-blockade-100527134","NCT06143813","Precision Treatment of Lumbar Spine Surgery Through Advanced Nerve Root Blockade","PLAN","Inclusion Criteria:\n\n* Age \\>18 years old\n* Suspected lumbar radiculopathy persistent ≥ 8 weeks\n* Radiological evidence of lumbar nerve root compression (herniated disc, recess stenosis, foraminal stenosis)\n\nExclusion Criteria:\n\n* Prior lumbar spine surgery\n* Mental illness\n* Language barrier in Danish\n* Severe physical co-morbidity\n* Known allergies to medicine used in the study\n* Pregnant\n* Plans to move abroad during the next 12-months",{"count":297,"type":22},180,[25],"The overall purpose of the study is to investigate whether selective spinal nerve root blocks can improve diagnostics of radiculopathy due to lumbar disc herniation (LDH), foraminal stenosis (FS), and recess stenosis (RS), and hence identify the patients that will benefit from surgical intervention.",[28,96,98,99,301],"Stenosis, Spinal","2024-04-29",{"date":304,"type":34},"2024-05-02",{"date":306,"type":34},"2023-11-09",{"date":308,"type":22},"2027-11-01",{"name":310,"class":80},"University of Aarhus",{"id":312,"slug":313,"hasResults":11,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":317,"eligibilityCriteria":318,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":319,"targetDuration":4,"studyType":23,"phases":321,"briefSummary":322,"conditions":323,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":330,"completionDateStruct":332,"leadSponsor":334,"locationsCount":81},"100510230","cardiovascular-risk-in-digital-osteoarthritis-100510230","NCT05923736","Cardiovascular Risk in Digital Osteoarthritis","Assessment of Cardiovascular Risk in Digital Osteoarthritis: A Case-control Study.","RICARDI","Inclusion Criteria:\n\nFor all subjects:\n\n* Adult male or female subject\n* Able to give informed consent to participate in research\n* Affiliated with a Social Security plan\n\nFor the digital osteoarthritis group:\n\n* Consultant in Rheumatology at Clermont-Ferrand University Hospital\n* Affected by digital osteoarthritis meeting ACR diagnostic criteria with radiographic signs of osteoarthritis validated by a radiologist.\n\nFor the control group :\n\n* Rheumatology consultant at the Clermont-Ferrand University Hospital or hospitalized in this department for a non-arthritic, non-rheumatic pathology.\n* Patients with spinal disc pathology (lumbago, radiculalgia due to disco-radicular conflict) or non-severe osteoporosis, i.e. with a densitometric T score between -2.5 and -3 DS.\n\nExclusion Criteria:\n\nFor all topics :\n\n* Refusal to participate\n* Pregnant women, nursing mothers\n* Subjects under guardianship or curatorship, deprived of liberty, or under court protection\n\nFor the digital osteoarthritis group:\n\n\\- Existence of diagnostic arguments for another inflammatory rheumatism (rheumatoid arthritis, spondylarthritis, psoriatic arthritis, lupus, gout, chondrocalcinosis...) or another arthrosic localization (gonarthrosis, coxarthrosis, discarthrosis) symptomatic at the time of inclusion or affecting daily activities.\n\nFor the control group :\n\n* Existence of chronic inflammatory rheumatism (rheumatoid arthritis, spondylitis, psoriatic arthritis, lupus, gout, chondrocalcinosis...)\n* Existence of digital osteoarthritis\n* Existence of another painful arthritic site (knee, hip, rachi) Existence of finger pain, whatever the etiology.",{"count":320,"type":22},100,[25],"The goal of this cross-sectional case control study is to investigate the cardiovascular risk in digital osteoarthritis. This study aims to compare the cardiovascular risk between group of patients with digital osteoarthritis and control group of patients with non-osteoarthritis disease paired by measurement of carotid intima-media thickness. All participants will undergo an ultrasound scan to measure carotid intima media thickness, a clinical assessment with the rheumatologist and a cardiovascular risk assessment.",[324,325,326,28],"Osteoarthritis Hand","Lumbago","Osteoporosis","2024-04-02",{"date":329,"type":34},"2024-04-03",{"date":331,"type":34},"2023-10-04",{"date":333,"type":22},"2026-10-04",{"name":335,"class":80},"University Hospital, Clermont-Ferrand"]