[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"radiculopathy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:radiculopathy":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,40,65,101,136,163,189,219,243,274,300],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100641257","effect-of-high-power-laser-therapy-on-disc-morphology-and-functional-outcome-in-patients-with-cervical-radiculopathy-100641257",false,"NCT07661290","Effect of High-Power Laser Therapy on Disc Morphology and Functional Outcome in Patients With Cervical Radiculopathy","Inclusion Criteria:\n\n\\- Adults aged between 40 to 60 years.\n\n• A Body Mass Index (BMI) range of 18.5-35 (normal to overweight) will be required.\n\n• Diagnosed with cervical radiculopathy, confirmed by clinical examination and diagnostic imaging (e.g., MRI).\n\n• Pain intensity level of at least 4 on the Visual Analog Scale (VAS).\n\n• No previous history of surgery on the cervical spine.\n\n• Able to provide informed consent and participate in the study protocol.\n\nExclusion Criteria:\n\n* Pregnant women or those planning to become pregnant. • Individuals with severe comorbidities that could interfere with the study, such as uncontrolled diabetes, cancer, or systemic inflammatory diseases.\n\nIndividuals with severe cervical stenosis or spinal cord compression.\n\n• Individuals any form of malignancy, active infection, or dermatological issues on the neck.\n\n• Patients using opioid analgesics or other strong pain medications that could alter the results.\n\n• Previous treatment with high-power laser therapy within the last six months.","ALL","40 Years","60 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","The study aims to evaluate the effectiveness of high-power laser therapy (HPLT) in patients with cervical radiculopathy, focusing on its impact on disc morphology, and overall functional activity",[26],"Radiculopathy","RECRUITING","2026-07-01",{"date":30,"type":31},"2026-07-02","ACTUAL",{"date":33,"type":31},"2026-06-30",{"date":35,"type":20},"2026-11-20",{"name":37,"class":38},"Cairo University","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":15,"minAge":47,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":21,"phases":50,"briefSummary":51,"conditions":52,"keywords":53,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":58,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":39},"100461541","interest-of-the-virtual-reality-as-an-analgesic-support-and-in-the-management-the-pre-procedural-anxiety-in-rheumatology-100461541","NCT05289999","Interest of the Virtual Reality as an Analgesic Support and in the Management the Pre-procedural Anxiety in Rheumatology","REAVIR","Inclusion Criteria:\n\n* Adult patient (age ≥ 18 years)\n* Hospitalized in a day-hospitalization department at the General Hospital of Le Mans\n* For whom a diagnosis of radiculalgia with a duration of less than 6 months is made, for which the imaging is compatible with the symptoms according to the clinician's interpretation\n* For whom the indication of at least 2 epidural injections by the way of the sacrococcygeal hiatus is retained\n* Having never experienced an epidural injection through the sacrococcygeal hiatus\n* Patient able and willing to answer the auto-administered surveys\n* Person affiliated or beneficiary of a social security\n* Free, informed and written consent signed by the participant and the investigator (at the latest on the day of inclusion and before any examination required by the research) after oral and written information\n\nExclusion Criteria:\n\n* Patient with comorbidity of epilepsy\n* Patient with a contraindication to performing epidural injections through the sacrococcygeal hiatus\n* Patient suffering from blindness and \u002F or deafness\n* Person with a known significant intolerance towards the use of screens and \u002F or virtual reality devices\n* Patient receiving benzodiazepines and \u002F or other sedative treatment\n* Patient with a known depressive disease followed by a psychiatrist\n* Pregnant, breastfeeding or parturient woman\n* Person deprived of liberty by judicial or administrative decision\n* Person under forced psychiatric care\n* Person subject to legal protection\n* Person unable to express consent\n* Patient who had participated in an interventional study during the last 30 days\n* Severely impaired physical and \u002F or mental health which, according to the investigator, may affect the compliance of the study participant","18 Years",{"count":49,"type":20},70,[23],"As a part of the current rheumatological practice skills, epidural injections through the sacrococcygeal hiatus take part in the strategy for managing radicular diseases. This technical act is easily performed in an outpatient context since it is a brief procedure, performed under clinical and ultrasound control, with good tolerance. Nevertheless, epidural injections by the way of the sacrococcygeal hiatus can be responsible of anxiety for the patient and meet the definition of pain induced by treatment. Among the non-pharmacological methods that can be offered to the patient in this context, hypnosis and distraction allow psycho-corporal support acting on certain factors influencing the painful experience of the gesture: duration of the gesture, calm and pleasant environment, etc... That is the context in which the use of virtual reality is of interest. Its use in supporting procedures generating induced pain has already been evaluated in several studies, in particular in the fields of surgery and anaesthesiology. The use of a virtual reality device also seems suitable in the context of epidural injections, but this theoretical and plausible interest remains to be demonstrated. To our knowledge, the literature on the use of a virtual reality headset to support invasive procedures in rheumatology remains poorly developed. The objective of this study is therefore to assess the interest of using a virtual reality headset in the support of pain relief and the management of peri-procedural anxiety when performing epidural injections through the sacrococcygeal hiatus.",[26],[54,55,56,57],"epidural injection","virtual reality","pain management","performance anxiety",{"date":28,"type":31},{"date":60,"type":31},"2022-06-10",{"date":62,"type":20},"2026-12-31",{"name":64,"class":38},"Centre Hospitalier le Mans",{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":15,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":76,"studyType":77,"phases":4,"briefSummary":78,"conditions":79,"keywords":83,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":100},"100634746","safety-and-effectiveness-of-ultrasound-guided-pharmacopuncture-for-spinal-diseases-100634746","NCT07543692","Safety and Effectiveness of Ultrasound-guided Pharmacopuncture for Spinal Diseases","Safety and Effectiveness of Ultrasound-guided Pharmacopuncture for Spinal Diseases: A Multi-center, Registry Study","Inclusion Criteria:\n\n1. Patients diagnosed with spinal diseases (KCD codes M and S).\n2. Patients whose Numeric Rating Scale (NRS) score for the most predominant pain (neck pain with upper limb radiating pain OR low back pain with lower limb radiating pain) caused by spinal diseases is 5 or higher.\n3. Outpatients or inpatients scheduled to utilize an ultrasound scan during pharmacopuncture (the decision to perform ultrasound-guided pharmacopuncture is made according to the clinician's routine medical judgment, not for research purposes).\n4. Patients who voluntarily agree to participate in the clinical study and sign the informed consent form.\n\nExclusion Criteria:\n\n1. Patients who have difficulty completing the written informed consent form.\n2. Women who are pregnant, planning to become pregnant, or breastfeeding.\n3. Patients deemed inappropriate for study participation by the investigator due to severe underlying diseases (e.g., cancer or other malignant neoplasms) that may interfere with treatment effects or result interpretation.\n4. Individuals who are deemed unsuitable for participation in the clinical study by the researcher.","19 Years","69 Years",{"count":75,"type":20},600,"8 Weeks","OBSERVATIONAL","This multi-center registry study aims to evaluate the safety and effectiveness of ultrasound-guided pharmacopuncture for patients diagnosed with spinal diseases. A total of 600 patients, aged 19 to under 70 years, will be enrolled across six Korean medicine hospitals. Eligible participants must have a pain Numeric Rating Scale (NRS) of 5 or higher for their most dominant spinal pain, which includes neck pain with upper extremity radiating pain, or low back pain with lower extremity radiating pain. As a non-interventional observational study, it will include patients who are already planned to receive ultrasound-guided pharmacopuncture as part of their routine clinical care. The primary outcome is the change in the most dominant spinal pain intensity measured by the NRS from baseline to 4 weeks. Secondary outcomes include functional disability evaluated using the Neck Disability Index (NDI) or Oswestry Disability Index (ODI), quality of life using the EQ-5D-5L, and patient satisfaction. Safety will be closely monitored by assessing all adverse events at every visit, evaluating their incidence, severity, and causality related to the procedure. Participants will be selected based on strict inclusion and exclusion criteria to ensure safety and consistency. Ethical standards including informed consent, data privacy, and ongoing safety monitoring will be rigorously upheld throughout the study.",[80,81,82,26],"Spinal Disease","Neck Pain","Low Back Pain",[84,85,86,87,88,89],"Pharmacopuncture","Ultrasound-guided","Registry","Observational Study","Korean Medicine","Spinal Pain","NOT_YET_RECRUITING","2026-04-27",{"date":93,"type":31},"2026-05-01",{"date":95,"type":20},"2026-04-28",{"date":97,"type":20},"2027-12-31",{"name":99,"class":38},"Jaseng Medical Foundation",6,{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":15,"minAge":47,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":21,"phases":111,"briefSummary":112,"conditions":113,"keywords":117,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":39},"100635923","mirror-image-spine-correction-exercises-versus-conservative-physiotherapy-for-lumbar-radiculopathy-100635923","NCT07558993","Mirror Image Spine Correction Exercises Versus Conservative Physiotherapy for Lumbar Radiculopathy","Randomized, Parallel-Group, Superiority Trial of Mirror Image Spine Correction Exercises Versus Conservative Physiotherapy for Lumbar Nerve Root Microstructural Integrity Assessed by Diffusion Tensor Imaging in Adults With Lumbar Radiculopathy","MIRROR-LR","Inclusion Criteria:\n\n* Adults aged 18 years or older. Clinical diagnosis of unilateral lumbar radiculopathy. Presence of at least two of the following: dermatomal radiating leg pain, neurological deficit, positive neural tension test.\n\nMRI-confirmed lumbar nerve root compression or irritation consistent with symptoms.\n\nPain intensity of 3\u002F10 or greater. Able to undergo MRI and Diffusion Tensor Imaging (DTI). Able to understand study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Previous lumbar spine surgery. Bilateral radiculopathy or unclear diagnosis. Tumor, infection, fracture, inflammatory spinal disease, or cauda equina syndrome.\n\nSevere progressive neurological deficit requiring urgent treatment. Contraindications to MRI (pacemaker, incompatible implants, severe claustrophobia).\n\nRecent lumbar injections or surgery. Other neurological or musculoskeletal disorders affecting outcomes. Pregnancy if MRI contraindicated by local policy. Cognitive impairment or inability to follow instructions.",{"count":110,"type":20},64,[23],"Lumbar radiculopathy is a common condition caused by irritation or compression of a lumbar nerve root, often resulting in radiating leg pain, numbness, weakness, and functional limitation. Conservative physiotherapy is commonly used as first-line treatment, but outcomes vary among patients.\n\nThis randomized controlled trial will compare Mirror Image Spine Correction Exercises with standardized conservative physiotherapy in adults with lumbar radiculopathy. Participants will be randomly assigned to one of two treatment groups for 12 weeks.\n\nThe primary outcome is lumbar nerve root microstructural integrity measured using Diffusion Tensor Imaging (DTI), including Fractional Anisotropy and other diffusion parameters. Secondary outcomes include pain intensity, disability, spinal alignment, and adverse events.\n\nThe purpose of this study is to determine whether a targeted posture-correction exercise approach provides greater improvement than conventional physiotherapy.",[26,114,115,116],"Radiculopathy Lumbar","Sciatica","Disc Disease Lumbar",[118,119,120,121,122,82,123,124,125,126],"Mirror Image Exercise","Physiotherapy","Diffusion Tensor Imaging","DTI","Conservative Physiotherapy","Nerve Root Compression","Postural Correction","Randomized Controlled Trial","Rehabilitation","2026-04-23",{"date":129,"type":31},"2026-04-30",{"date":131,"type":20},"2026-09-01",{"date":133,"type":20},"2027-09-30",{"name":135,"class":38},"University of Sharjah",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":15,"minAge":47,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":21,"phases":146,"briefSummary":147,"conditions":148,"keywords":150,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":162},"100512416","evaluation-of-the-impact-of-tractions-vs-placebo-tractions-in-patients-with-cervical-radiculopathy-100512416","NCT05952167","Evaluation of the Impact of Tractions vs. Placebo Tractions in Patients With Cervical Radiculopathy","Evaluation of the Impact of Tractions vs. Placebo Tractions in Patients With Cervical Radiculopathy, Randomised Controlled Trial in a Single-blind Study","TracCerv2","Inclusion Criteria:\n\n* Patient over 18\n* Neck Disability Index ≥ 15\u002F50\n* Presence of at least three of the four signs clinically validating the presence of cervical radiculopathy (Wainner et al. 2003)\n\n  * a) upper limb nerve tension test A (ULNT1a): positive,\n  * b) amplitude of cervical rotation on the side concerned: \\\u003C 60°,\n  * c) positive cervical distraction test: relief\n  * d) positive Spurling test: reproduction of symptoms.\n* Cervical radiculopathy diagnosed 3 to 24 months previously\n* Absence of cervical traction in the 5 years prior to inclusion\n* MRI or CT scan performed prior to hospitalisation in relation to current pathology\n* Patient able to understand the protocol and having given oral informed consent to take part in the research.\n* Patient affiliated to the social security system or entitled beneficiary.\n\nExclusion Criteria:\n\n* Patients with vertebral artery pathology at the time of inclusion\n* Patients with myelopathy, cervical cancer, cervical fracture, cervical dislocation, cervical spondylolisthesis, spinal infection, symptomatic cervical pain without radiculopathy and\u002For cervical surgery in the 2 years prior to inclusion.\n* Patient participating in another clinical research protocol with an impact on the objectives of the research.\n* Patient who is pregnant, breastfeeding or able to procreate without effective contraception\\*.\n* Patient under guardianship, curatorship or deprived of liberty\n* Patient under activated future protection mandate\n* Patient under family habilitation\n* Patient under court protection.",{"count":145,"type":20},206,[23],"Cervical radiculopathy is a common disease related to compression of the nerve roots of the spine (prevalence: 3.5\u002F1000). Dysfunction and pain are the main repercussions and can lead to time off work and high costs in terms of treatment.\n\nSecond-line surgical treatments appear to be less effective and present risks of side effects. In the first instance, treatments are conservative and include medication but above all physiotherapy with manual therapy, muscle exercises and cervical traction. These cervical tractions performed by a physiotherapist require little equipment and are inexpensive compared with the surgical alternative. They involve stretching the cervical spine and soft tissues to open the intervertebral foramen and mobilise the facet joints.\n\nSeveral authors have written summaries of their interest. Thoomes reports two studies and describes an absence of effect. In a meta-analysis, Romeo et al. added three more recent studies to the previous review and concluded that traction is effective, highlighting an \"effect-dose\" relationship. These recent results therefore seem to reverse the recommendations made barely two years later. Nevertheless, almost all the studies compared \"manual therapy + exercises\" with \"manual therapy + exercises + cervical traction\". Only Young et al. tested \"manual therapy + exercises + cervical traction at an effective weight\" compared to \"manual therapy + exercises + cervical traction placebo at an ineffective weight\". The study did not reveal any difference between the groups. However, several limitations appear in this study when comparing the protocol to studies that have shown efficacy. The main limitation is the low intensity (i.e. protocol with fewer sessions and longer duration). These clinical limitations may explain the lack of evidence of a positive outcome. Following on from a preliminary study evaluating an intensive cervical traction protocol over five days, and in order to discern the effect specific to the treatment (specific effect) and the effect independent of the nature of the treatment (contextual effect), the investigators wish to evaluate the impact of this intensive protocol by comparing it with placebo traction.\n\nIn current practice, treatment varies between establishments. The paucity of studies on cervical traction in radiculopathy has resulted in routine use being guided by habit rather than evidence. It remains a clinical question which raises a major issue requiring a robust experimental design. Ultimately, this study follows on from a preliminary study and is part of a comprehensive research project aimed at proposing new recommendations for the use of traction in patients suffering from cervical radiculopathy. The investigators are investigating the impact of an intensive traction vs. placebo traction protocol in patients with cervical radiculopathy.",[26,149],"Cervical",[151,152],"Cervical traction","Cervical radiculopathy","2026-04-10",{"date":155,"type":31},"2026-04-15",{"date":157,"type":31},"2024-03-25",{"date":159,"type":20},"2031-09-25",{"name":161,"class":38},"Centre Hospitalier Departemental Vendee",8,{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":167,"acronym":4,"eligibilityCriteria":168,"healthyVolunteers":11,"sex":15,"minAge":47,"maxAge":169,"enrollmentInfo":170,"targetDuration":4,"studyType":21,"phases":172,"briefSummary":173,"conditions":174,"keywords":177,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":39},"100432286","intermittent-dosing-of-dorsal-root-ganglion-stimulation-as-an-alternate-paradigm-to-continuous-low-frequency-therapy-100432286","NCT04909138","Intermittent Dosing of Dorsal Root Ganglion Stimulation as an Alternate Paradigm to Continuous Low-Frequency Therapy","Inclusion Criteria:\n\n* Age between 18 and 99\n* 1-year or more use of continuous DRG therapy as delivered a permanently implanted Abbott PROCLAIM XR Dorsal Root Ganglion Neurostimulator System for chronic back and\u002For leg pain\n* Endorse at least 50% pain relief in the targeted area over the last year\n* Must have been seen for routine follow-up within last 4 months\n* Must have been reprogrammed in standard fashion at least once prior to randomization\n* Willing and able to complete protocol requirements, including:\n\n  * Complete health questionnaires and pain scales as specified in the protocol\n  * Sign the study-specific informed consent form\n  * Complete follow-ups at the designated time periods\n\nExclusion Criteria:\n\n* Significant lead migration, as determined by clinician\n* Other concurrent neuromodulation system in place\n* Corticosteroid injection in previous 30 days prior to enrollment\n* Intermittent dosing and\u002For failure within last 6m\n* Changing or unstable pain medications within 30 days","90 Years",{"count":171,"type":20},30,[23],"This study seeks to evaluate the use of intermittent dosing as an alternative paradigm for patients with DRG stimulation in place for at least 1 year and minimum 50% pain relief in the targeted area.\n\nPatients will be prospectively randomized to one of two stimulation paradigms both of which involve intermittent dosing at 30 seconds ON and 90 seconds OFF. Group 1 will have their frequency set at 20 Hz with amplitude levels adjusted in order to remain in the therapeutic window (subthreshold stimulation). Group 2 will have their frequency set at 5 Hz with amplitude levels adjusted in order to remain in the therapeutic window (subthreshold stimulation) This study will be performed in a crossover fashion, meaning patients will be changed to the alternate dosing regimen at the 13-week time period.\n\nPatients will be seen and evaluated prior to randomization and reprogramming, and thereafter evaluated at 4, 8, and 12-weeks. At the 12-week time period, patients will begin a 1-week washout period of continuous stimulation. At the 13-week time period, patients will be evaluated, crossed over to the other study arm and thereafter evaluated at 17, 21, and 25-weeks.",[175,26,176],"CRPS (Complex Regional Pain Syndromes)","Peripheral Neuropathy",[178,179],"Chronic Pain","Dorsal Root Ganglion Stimulation","2026-01-18",{"date":182,"type":31},"2026-01-21",{"date":184,"type":31},"2022-10-15",{"date":186,"type":20},"2027-06",{"name":188,"class":38},"Rush University Medical Center",{"id":190,"slug":191,"hasResults":11,"nctId":192,"briefTitle":193,"officialTitle":194,"acronym":195,"eligibilityCriteria":196,"healthyVolunteers":11,"sex":15,"minAge":47,"maxAge":197,"enrollmentInfo":198,"targetDuration":4,"studyType":21,"phases":200,"briefSummary":201,"conditions":202,"keywords":204,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":218},"100589611","exercise-therapy-after-caudal-epidural-steroid-injection-100589611","NCT06956664","Exercise Therapy After Caudal Epidural Steroid Injection","Comparative Efficacy of Physiotherapeutic Exercise Regimens Implemented After Caudal Epidural Steroid Injection","CAPER","Inclusion Criteria:\n\n* Age 18 to 70 years.\n* MRI-confirmed lumbar intervertebral disc herniation.\n* Has received a caudal epidural steroid injection (CESI) within the past 2 weeks at Çankırı State Hospital.\n* Low-back or leg pain intensity ≥ 3 cm on a 10-cm Visual Analogue Scale after the injection.\n* Medically cleared for moderate aerobic and core-stabilisation exercise (no cardiac or orthopaedic contraindications).\n* Able to attend supervised physiotherapy three times per week for six weeks.\n* Willing and able to give written informed consent and to comply with study procedures.\n* Sufficient Turkish literacy (minimum primary-school education) to complete questionnaires.\n\nExclusion Criteria:\n\n* Uncontrolled systemic disease (e.g., poorly controlled diabetes mellitus, congestive heart failure, active hepatitis C or other significant liver disease).\n* Neurological red flags such as myelopathy or cauda equina syndrome.\n* Previous lumbar spine surgery at the affected disc level.\n* Current pregnancy or planning pregnancy during the study period.\n* Severe musculoskeletal, cardiovascular, or respiratory condition that precludes safe exercise participation.\n* Use of systemic corticosteroids or opioid analgesics that cannot be stabilised for the duration of the trial.\n* Ongoing litigation or workers' compensation claim related to low-back pain.\n* Inability to communicate effectively with study staff or to follow instructions.","70 Years",{"count":199,"type":20},42,[23],"\\*\\*Brief Summary\\*\\*\n\nLumbar radicular pain arising from intervertebral disc herniation is commonly managed with a caudal epidural steroid injection (CESI), a minimally invasive procedure that delivers anti-inflammatory medication to the sacral hiatus. Although CESI affords short-term analgesia, a sizable proportion of patients continue to experience pain-related disability and diminished quality of life, underscoring the need for optimised post-injection rehabilitation.\n\nThis single-centre, three-arm, parallel-group randomised controlled trial will evaluate the comparative efficacy of two evidence-informed exercise paradigms-moderate-intensity aerobic training and progressive lumbopelvic stabilisation-when each is superimposed upon a standard physiotherapy package of heat, therapeutic ultrasound and transcutaneous electrical nerve stimulation (TENS). Forty-two adults (18-70 years) with MRI-confirmed lumbar disc herniation who have undergone CESI at Çankırı State Hospital will be randomly allocated (1:1:1) to one of the following six-week interventions, initiated two weeks post-injection and delivered thrice weekly under physiotherapist supervision:\n\n1. Conventional physiotherapy alone (heat + ultrasound + TENS).\n2. Conventional physiotherapy plus aerobic exercise (treadmill walking at 55-80 % of age-predicted maximal heart rate with structured warm-up\u002Fcool-down).\n3. Conventional physiotherapy plus core-stabilisation exercise (phased activation of deep trunk musculature progressing to dynamic tasks on unstable surfaces).\n\nPrimary end-points are pain intensity (10 cm Visual Analogue Scale) and back-specific disability (Oswestry Disability Index). Secondary end-points include generic health-related quality of life (SF-12) and lumbar proprioceptive body awareness (Fremantle Back Awareness Questionnaire). Outcomes will be captured at baseline, post-intervention (6 weeks) and at 3- and 6-month follow-up to ascertain both immediate and sustained effects.\n\nStudy Question Does adjunctive aerobic or core-stabilisation exercise confer superior reductions in pain and disability, and greater gains in quality of life and body awareness, compared with conventional physiotherapy alone in adults following CESI for lumbar disc herniation?\n\nIt is hypothesised that both exercise approaches will yield clinically and statistically superior outcomes relative to standard care, with stabilisation training providing the most durable functional benefits. Findings are expected to refine post-CESI rehabilitation algorithms and inform evidence-based clinical guidance for physiotherapists managing lumbar disc pathology.",[203,82,26],"Intervertebral Disc Displacement",[205,82,206,207,208],"Caudal Epidural Injection","Exercise Therapy","Aerobic Exercise","Core Stabilization","2025-08-05",{"date":211,"type":31},"2025-08-08",{"date":213,"type":31},"2025-04-28",{"date":215,"type":20},"2026-02-15",{"name":217,"class":38},"Çankırı Karatekin University",3,{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":4,"eligibilityCriteria":225,"healthyVolunteers":11,"sex":15,"minAge":47,"maxAge":4,"enrollmentInfo":226,"targetDuration":4,"studyType":77,"phases":4,"briefSummary":228,"conditions":229,"keywords":232,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":39},"100599116","artificial-intelligence-ai-based-prediction-of-treatment-response-in-sciatica-patients-receiving-transforaminal-epidural-steroid-injection-100599116","NCT07080307","Artificial Intelligence (AI)-Based Prediction of Treatment Response in Sciatica Patients Receiving Transforaminal Epidural Steroid Injection","Artificial Intelligence-Based Predictive Models for Estimating Treatment Response in Sciatica Patients Treated With Transforaminal Epidural Steroid Injection (TFESI)","Inclusion Criteria:\n\n* Age 18 years or older\n* Presence of clinical and radiological radiculopathy findings consistent with L4, L5, or S1 nerve root involvement\n* Symptoms present for at least 3 months\n* Resistant to conservative treatment\n* Scheduled for transforaminal epidural steroid injection (TFESI) by a pain medicine specialist\n* Being willing to participate in the study and having signed a consent form\n\nExclusion Criteria:\n\n* Malignancy\n* Coagulation disorders\n* Pregnancy\n* History of allergic reaction to the injected substances\n* History of major psychiatric disorders\n* Presence of known coagulopathy\n* Receiving systemic steroid treatment for any reason\n* Having received an epidural steroid injection within the last 3 months",{"count":227,"type":20},1500,"This prospective observational study aims to develop artificial intelligence (AI)-based predictive models to estimate treatment response in patients with sciatica undergoing transforaminal epidural steroid injection (TFESI). Approximately 1500 adult patients diagnosed with sciatica and scheduled for TFESI at Marmara University Training and Research Hospital Algology Clinic will be enrolled. Clinical, radiological, laboratory, and psychological data will be systematically collected before the procedure and at multiple follow-up points (1 hour, 3 weeks, 3 months, and 6 months post-treatment). Pain relief, measured by a 50% or greater reduction in the Numeric Rating Scale (NRS), will be the primary outcome. The study will use these comprehensive data sets to train and validate AI algorithms, aiming to create a decision-support system that can predict individual patient responses to TFESI and improve personalized treatment planning.",[115,82,230,26,231],"Lumbar Spinal Stenosis","Lumbar Disc Herniation",[233],"sciatica, radiculopathy, lumbar disc herniation, spinal stenosis, low back pain","2025-07-15",{"date":236,"type":31},"2025-07-23",{"date":238,"type":20},"2025-07",{"date":240,"type":20},"2026-10",{"name":242,"class":38},"Marmara University",{"id":244,"slug":245,"hasResults":11,"nctId":246,"briefTitle":247,"officialTitle":248,"acronym":4,"eligibilityCriteria":249,"healthyVolunteers":11,"sex":15,"minAge":47,"maxAge":4,"enrollmentInfo":250,"targetDuration":4,"studyType":21,"phases":252,"briefSummary":253,"conditions":254,"keywords":258,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":271,"locationsCount":273},"100502091","strategic-use-of-big-data-in-spine-surgery---testing-digital-prediction-of-outcome-in-clinical-praxis-100502091","NCT05817747","Strategic Use of Big Data in Spine Surgery - Testing Digital Prediction of Outcome in Clinical Praxis","Strategic Use of Big Data in Spine Surgery - Testing a Digital Prediction of Outcome Tool in Clinical Praxis","Inclusion Criteria:\n\n* Refered to a participating clinic regarding surgery for lumbar spinal stenosis or cervical radiculopathy\n* 18 years of age or older\n* Magnetic Resonance Imaging (MRT) examination within the last 12 months confirming the diagnosis, concurrent with symptoms described by the referring physician\n* Giving informed consent\n\nExclusion Criteria:\n\n* Another condition found to be the reason for the symptoms.\n* Not giving informed consent\n* Need for further investigation that prevents inclusion within one month of the doctor visit.",{"count":251,"type":20},900,[23],"The goal of this prospective, multicenter clinical trial is to determine if the use of the postoperative outcome prediction model the Dialogue Support tool can alter postoperative patient-reported outcome and satisfaction compared to current practice.\n\nThe main questions it aims to answer are:\n\n* Does its use alter patient-reported outcome measured by general assessment regarding leg pain and Satisfaction in lumbar spinal stenosis?\n* Does its use alter patient-reported outcome as measured by general assessment regarding arm pain and Satisfaction in cervical rhizopathy?\n* How does the Quality of Life in patients - who after assessment by spinal surgeon do not proceed to surgery - compare with patients with the same baseline profile who did undergo surgery?\n\nEligible participants will be presented with their predicted postoperative outcome generated by the Dialogue Support tool, as an adjunct to the ordinary assessment by a spine surgeon.\n\nResearchers will compare participants with a matched control group from the Swedish Spine Register (\"Swespine\") to see if the Dialogue Support tool can alter postoperative patient-reported outcome and satisfaction.",[255,256,257,26],"Constriction, Pathologic","Spine Degeneration","Surgery",[259,152,260,257,261,262,263],"Spine","Lumbar spinal stenosis","Neck","Prognostic model","External validation","2025-05-12",{"date":266,"type":31},"2025-05-13",{"date":268,"type":31},"2022-03-01",{"date":270,"type":20},"2029-03-01",{"name":272,"class":38},"Sahlgrenska University Hospital",10,{"id":275,"slug":276,"hasResults":11,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":11,"sex":15,"minAge":47,"maxAge":4,"enrollmentInfo":281,"targetDuration":4,"studyType":77,"phases":4,"briefSummary":283,"conditions":284,"keywords":286,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":294,"completionDateStruct":296,"leadSponsor":298,"locationsCount":39},"100383528","impact-of-muscle-degeneration-in-chronic-low-back-pain-100383528","NCT04273828","Impact of Muscle Degeneration in Chronic Low Back Pain","Impact of Muscle Degeneration in Chronic Ow Back Pain in Patients Undergoing Neural Decompression","Inclusion Criteria:\n\n1. adults 18 years of age and older;\n2. with symptoms of lumbosacral neural compression (radiculopathy or neurogenic lameness);\n3. failed conservative treatment for at least 6 weeks;\n4. undergoing surgery for neural decompression (discectomy and \u002F or foraminotomy and \u002F or hemilaminectomy);\n5. with complete pre and postoperative medical records in all evaluations.\n\nExclusion Criteria:\n\n1. need for lumbar arthrodesis;\n2. deep infection requiring surgical cleaning;\n3. patients submitted to joint facet rhizotomy;\n4. active rheumatologic disease, including seronegative arthropathies.",{"count":282,"type":20},168,"Surgical interventions for the removal of intervertebral disc fragments or to enlarge a narrow spine canal are commonly performed worldwide and are considered efficient. Concomitant low back pain is not uncommon among patients with lumbar nerve compression and neurological symptoms. When present, controversy persists in the literature regarding its ideal management. Although neurological symptoms improve after decompressive surgery, the presence of residual chronic low back pain may worsen satisfaction scores and cause functional disability.\n\nThe hypothesis of the present study is that the presence of atrophy of the paraspinal and trunk muscles predicts chronic low back pain after lumbar neural decompression. If confirmed, this finding will aid in better planning of physical rehabilitation strategies for this group of patients, as well as a clearer prediction regarding surgical treatment outcomes for patients and health professionals.",[230,231,26,285],"Back Pain",[287,288,289,290],"back pain","lumbar disc herniation","lumbar spinal stenosis","Decompression, surgical","2025-03-10",{"date":293,"type":31},"2025-03-13",{"date":295,"type":31},"2020-04-06",{"date":297,"type":20},"2025-06-27",{"name":299,"class":38},"Hospital Israelita Albert Einstein",{"id":301,"slug":302,"hasResults":11,"nctId":303,"briefTitle":304,"officialTitle":305,"acronym":306,"eligibilityCriteria":307,"healthyVolunteers":308,"sex":15,"minAge":47,"maxAge":4,"enrollmentInfo":309,"targetDuration":4,"studyType":21,"phases":311,"briefSummary":312,"conditions":313,"keywords":317,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":320,"lastUpdatePostDateStruct":321,"startDateStruct":323,"completionDateStruct":325,"leadSponsor":327,"locationsCount":330},"100442000","post-market-clinical-follow-up-study-with-the-cervical-disc-prothesis-move-c-100442000","NCT05035693","Post Market Clinical Follow up Study With the Cervical Disc Prothesis MOVE®-C","\"PMCF MOVE®-C\" International, Prospective, Multicentre, Non-randomised Post-market Clinical Follow-up Study Clinical and Radiological Outcome After Mono- and Bisegmental Cervical Intervertebral Disc Prosthetics","PMCF_MOVE®-C","Inclusion Criteria:\n\n1. Diagnosis of discopathy or disc hernia with radiculopathy or stenosis of the foramen and spinal canal,\n2. documented individual history of neck and\u002For upper extremity pain and\u002For functional\u002Fneurological deficit associated with the cervical level to be treated,\n3. no surgical treatment regarding the planned index surgery within the last six weeks prior implantation,\n4. unsuccessful conservative medical care regarding the indication within the last six weeks,\n5. age ≥18 years,\n6. patient must agree to fully participate in the clinical trial and give informed consent in writing,\n7. patient is capable to realise the nature, aims and possible consequences of the clinical trial (MPG §20.2.1),\n8. patient information has been provided and all written consents of the patient are available.\n\nExclusion Criteria:\n\n* Known contraindication against the use of cervical intervertebral disc prostheses in accordance with the manufacturer's instructions for use:\n\n  1. Bone mineral density with T-score ≤ -1.5 as determined by spine DXA if male ≥ 60 years of age or female ≥ 50 years of age,\n  2. active systemic infection or infection at the operative site,\n  3. sustained osteoporotic fracture of the spine, hip or wrist,\n  4. spinal metastases,\n  5. known allergy to titanium or polycarbonate-urethane,\n  6. confirmed pregnancy,\n  7. severe cervical myelopathy,\n  8. patients requiring a treatment that destabilises the spine (e.g. posterior element decompression),\n  9. advanced cervical anatomical deformity at the operative site (e.g. ankylosing spondylitis, scoliosis),\n  10. advanced degenerative changes (e.g. spondylosis) at the index vertebral level,\n  11. patient is kept in an institution under judicial or official orders (MPG §20.3).",true,{"count":310,"type":20},170,[23],"Study design: International, prospective, multicentre, non-randomised, observational study according to § 23b MPG.\n\nObjectives: Observational study to confirm the safety and performance of the cervical disc prosthesis MOVE®-C.",[314,315,316,26],"Discopathy","Herniated Cervical Disc","Stenoses, Spinal",[318,319,314,26],"Herniated Disc","Cervical Spine","2024-11-13",{"date":322,"type":31},"2024-11-15",{"date":324,"type":31},"2021-03-11",{"date":326,"type":20},"2027-03-11",{"name":328,"class":329},"NGMedical GmbH","INDUSTRY",7]