[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"randomised-controlled-trial\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:randomised-controlled-trial":34},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,48,76,107,132,165],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100643524","phase-4-comparing-intraoperative-indocyanine-green-fluorescence-imaging-with-standard-clinical-assessment-for-flap-perfusion-in-head-and-neck-reconstruction-vision-trial-100643524",false,"NCT07635420","Comparing Intraoperative Indocyanine Green Fluorescence Imaging With Standard Clinical Assessment for Flap Perfusion in Head and Neck Reconstruction (VISION Trial)","Comparing Intraoperative Indocyanine Green Fluorescence Imaging With Standard Clinical Assessment for Flap Perfusion in Head and Neck Reconstruction: A Randomised Controlled Trial (VISION Trial)","VISION","Inclusion Criteria:\n\n* Age ≥18 years at the time of inclusion\n* Scheduled to undergo microvascular free flap reconstruction as part of oncologic, trauma, or benign surgery in the head and neck area\n* Ability to understand study information and provide written informed consent\n\nExclusion Criteria:\n\n* Known allergy to indocyanine green or iodine\n* Severe hepatic or renal impairment\n* Confirmed or suspected pregnancy\n* Breastfeeding","ALL","18 Years",{"count":20,"type":21},244,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","This is a prospective multicentre randomised controlled trial evaluating whether intraoperative indocyanine green (ICG) fluorescence angiography improves outcomes in head and neck free flap reconstruction compared with standard clinical assessment of flap perfusion. Adult patients undergoing microvascular free flap reconstruction for oncologic, trauma, or benign head and neck defects will be randomised to either intraoperative ICG angiography or conventional clinical perfusion assessment. The primary outcome is partial flap loss requiring intervention within 30 days after surgery. Secondary outcomes include total flap loss, flap-related re-exploration, flap salvage, and postoperative complications.",[27,28,29,30,31,32,33,34],"Head and Neck Cancer (H&N)","Free Tissue Flaps","Free Flap","Free Flap Evaluation","Indocyanine Green","Indocyanine Green (ICG)","Microsurgery","Randomised Controlled Trial","NOT_YET_RECRUITING","2026-06-08",{"date":38,"type":39},"2026-06-09","ACTUAL",{"date":41,"type":21},"2026-10-01",{"date":43,"type":21},"2029-08-01",{"name":45,"class":46},"Region Skane","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":59,"conditions":60,"keywords":65,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100632870","effectiveness-of-a-needle-free-connector-with-anti-reflux-technology-in-reducing-complications-from-long-peripheral-venous-catheters-in-hospitalised-adult-patients-randomised-clinical-trial-100632870","NCT07519304","Effectiveness of a Needle-free Connector With Anti-reflux Technology in Reducing Complications From Long Peripheral Venous Catheters in Hospitalised Adult Patients: Randomised Clinical Trial","FLUSH-ETI","Inclusion Criteria:\n\n* Patients requiring placement of a long peripheral venous catheter.\n* Patients who have provided written informed consent.\n* Patients with an expected hospital stay of ≥7 days.\n\nExclusion Criteria:\n\n\\- Inability to place a long peripheral venous catheter in the upper limbs.",{"count":56,"type":21},62,[58],"NA","A study to evaluate a needle-free connector (a stopper) featuring anti-reflux technology (to prevent blood from flowing back) for catheters (polyurethane tubes inserted into a vein), with the aim of reducing complications associated with these devices: blockages, infections, pain, etc.",[61,62,63,64,34],"Vascular Access Devices","Catheters","Occlusion","Thrombosis",[66],"Needleless connector","2026-04-15",{"date":69,"type":39},"2026-04-16",{"date":71,"type":21},"2026-04-20",{"date":73,"type":21},"2026-12-31",{"name":75,"class":46},"Hospital Arnau de Vilanova",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":106},"100623290","comprehensive-maintenance-program-a-health-haven-for-copd-in-lleidathe-napoleon-project-100623290","NCT07394712","Comprehensive Maintenance Program: a Health Haven for COPD in Lleida.The NAPOLEON Project.","NAPOLEON","Inclusion Criteria:\n\n* Adults aged 40 to 75 years.\n* Confirmed medical diagnosis of chronic obstructive pulmonary disease (COPD) of moderate to severe severity, based on clinical evaluation and pulmonary function testing.\n* Clinically stable for at least 4 weeks following the last severe exacerbation, as confirmed by the treating pulmonologist.\n* Referred to an outpatient pulmonary rehabilitation program due to persistent symptoms and a history of exacerbations, with moderate to severe dyspnea (Medical Research Council \\[MRC\\] dyspnea scale score \\> 2), according to physician assessment.\n* Completed at least 6 out of 8 sessions of a standard 8-week initial pulmonary rehabilitation program.\n\nExclusion Criteria:\n\n* Presence of medical contraindications to physical exercise, including unstable cardiovascular conditions (e.g., recent myocardial infarction, uncontrolled arrhythmias), severe musculoskeletal or neurological disorders, recent surgery, or acute medical conditions (e.g., recent stroke) that impair participation.\n* Severe cognitive impairment that limits the ability to understand instructions or participate actively in the program.\n* Unstable psychiatric disorders that may compromise adherence to or continuity with the exercise regimen.\n* Lack of availability or refusal to attend the scheduled sessions of the community-based exercise program.\n* Participation in another pulmonary rehabilitation program within the 6 months prior to study enrollment.","40 Years","75 Years",{"count":86,"type":21},86,[58],"Introduction:\n\nPulmonary rehabilitation programs (PRPs) are known to reduce symptoms such as dyspnea and fatigue, while improving functional capacity and quality of life in individuals with chronic obstructive pulmonary disease (COPD). However, the benefits of an initial pulmonary rehabilitation program (PRP) tend to diminish rapidly over time, prompting the development of strategies to maintain these effects. Such strategies include supervised exercise programs, telephone follow-ups, and home-based exercise regimens. Nevertheless, the optimal maintenance strategy remains uncertain.\n\nObjectives:\n\nThe primary objective is to evaluate the impact of a supervised, multidimensional maintenance PRP on symptoms and quality of life in individuals with COPD. Additionally, the study aims to compare exercise capacity, healthcare resource utilization, economic benefits, and participant perceptions between the intervention and control groups.\n\nMethodology:\n\nA 12-month randomized controlled trial (RCT) with two parallel groups will be conducted in adults with COPD who have completed an initial 8-week PRP. Participants will be randomly assigned in a 1:1 ratio to either the intervention or control group. The intervention group will undergo a maintenance PRP consisting of two weekly supervised exercise sessions and monthly educational sessions on COPD in a comprehensive health center over a 3-month period. The control group will receive standard clinical care recommendations regarding physical activity. Clinical evaluations will be conducted at four time points throughout the study: baseline (T0), 3 months (T1), 6 months (T2), and 12 months (T3). Full pulmonary function tests and anthropometric assessments will be performed at T0 and T3. Other variables, including symptom burden, quality of life, functional capacity, mental health, physical activity, sleep-wake pattern, and healthcare utilization, will be systematically collected at all four time points.",[90,91,34],"COPD - Chronic Obstructive Pulmonary Disease","Pulmonary Rehabilitation",[93,94,95],"Pulmonary rehabilitation","chronic obstructive pulmonary disease (COPD)","Randomised controlled trial","RECRUITING","2026-02-05",{"date":99,"type":39},"2026-02-06",{"date":101,"type":39},"2025-10-01",{"date":103,"type":21},"2026-10",{"name":105,"class":46},"Institut de Recerca Biomèdica de Lleida",2,{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":22,"phases":116,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":128,"leadSponsor":130,"locationsCount":106},"100595544","acceptance-and-commitment-therapy-based-intervention-for-parents-of-a-child-with-medical-complexity-100595544","NCT07033832","Acceptance and Commitment Therapy-based Intervention for Parents of a Child With Medical Complexity","Acceptance and Commitment Therapy-based Intervention to Decrease Psychological Symptoms and Increase Psychological Flexibility for Parents of a Child With Medical Complexity: a Pilot Randomization-controlled Trial.","Inclusion Criteria:\n\n* parent of a child with medical complexity aged 1-18\n* able to communicate in Chinese and read Chinese\n* willing to participate in face-to-face activities\n\nExclusion Criteria:\n\n* a reported mental health disorder\n* engaging in other psychosocial educational programs related to stress reduction\n* inability to communicate in Cantonese",{"count":115,"type":21},30,[58],"A pilot randomized controlled trial of an Acceptance and Commitment Therapy-based intervention will be conducted to decrease psychological symptoms, while increase psychological flexibility for parents of a child with medical complexity during their difficulties.",[119,120,121,34,122,123],"Acceptance and Commitment Therapy","Child With Medical Complexity","Psychological Flexibility","Depression, Anxiety","Parental Stress","2025-07-02",{"date":126,"type":39},"2025-07-08",{"date":124,"type":39},{"date":129,"type":21},"2026-06-30",{"name":131,"class":46},"The Hong Kong Polytechnic University",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":139,"sex":17,"minAge":140,"maxAge":141,"enrollmentInfo":142,"targetDuration":4,"studyType":22,"phases":144,"briefSummary":145,"conditions":146,"keywords":150,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":47},"100560628","the-effect-of-health-belief-model-based-cancer-education-on-cancer-information-load-knowledge-and-attitudes-towards-cancer-screenings-100560628","NCT06579625","The Effect of Health Belief Model-Based Cancer Education on Cancer Information Load, Knowledge and Attitudes Towards Cancer Screenings","The Effect of Health Belief Model-Based Cancer Education Given to Caregivers of Cancer Patients on Cancer Information Load, Knowledge and Attitudes Towards Cancer Screenings","Inclusion Criteria:\n\n* Individuals who agree to participate in the study, are aged 30-70,\n* Are literate,\n* Do not have any auditory, visual, cognitive, or orthopedic disabilities that would prevent participation,\n* Are not receiving palliative care services, will be included. This includes caregivers of cancer patients.\n\nExclusion Criteria:\n\n* Individuals under the age of 30 or over the age of 70,\n* Those who are illiterate,\n* Those with disabilities that would prevent participation in the study,\n* Those who provide care for cancer patients receiving palliative care services will not be included in the study.",true,"30 Years","70 Years",{"count":143,"type":21},79,[58],"Participants will be randomly assigned to the experimental and control groups. The study will involve a total of 78 participants, with 39 in the experimental group and 39 in the control group. The 39 participants assigned to the experimental group will first complete the cancer knowledge burden, and attitudes and information about cancer screenings scales. They will then receive cancer education consisting of four modules, which will be completed over four weeks. At the end of these four weeks, they will complete the scales again. One month after the education, the experimental group will complete the scales once more for follow-up monitoring. The control group will first complete the cancer knowledge burden, and attitudes and information about cancer screenings scales after agreeing to participate in the study. They will complete the scales again one month later. The evaluation of the education in the experimental group will involve comparing the scales completed before and after the education.",[147,148,149,34],"Cancer","Education","Caregiver",[147,151,149,152,153,154,155],"Cancer Screening","Health Belief Model","Information","Attitude","Health Education","2024-08-29",{"date":158,"type":39},"2024-09-03",{"date":160,"type":21},"2024-09-10",{"date":162,"type":21},"2024-10-28",{"name":164,"class":46},"Ankara University",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":171,"enrollmentInfo":172,"targetDuration":4,"studyType":22,"phases":174,"briefSummary":175,"conditions":176,"keywords":179,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":4},"100527877","effectiveness-of-a-virtual-reality-based-sensory-stimulation-intervention-in-preventing-delirium-in-intensive-care-units-100527877","NCT06153472","Effectiveness of a Virtual Reality-Based Sensory Stimulation Intervention in Preventing Delirium in Intensive Care Units","Inclusion Criteria:\n\n* All ICU patients admitted to the study setting will be recruited if they are have: (1) ≥ 18 years, (2) the first time admitted to ICU and (3) a Richmond Agitation-Sedation Scale (RASS) score ≥-3\n\nExclusion Criteria:\n\n* Patients will be excluded if they have: (1) been diagnosed with dementia, delirium or acute psychiatric illness at admission, (2) been diagnosed with end-stage cancer, (3) severe hearing impairment and cannot be corrected by hearing aids and (4) been admitted to ICU with radioactive material.","90 Years",{"count":173,"type":21},324,[58],"The goal of this clinical trial is to evaluate the effectiveness of a VR-based sensory stimulation system in preventing ICU delirium in patients. The main questions it aims to answer are:\n\nIs the VR-based sensory stimulation system more effective in preventing ICU delirium compared to usual care? Does VR sensory stimulation improve patient psychological well-being and clinical outcomes in the ICU?\n\nParticipants will:\n\nExperimental Group:\n\nEngage in VR-based sensory stimulation sessions involving visual or\u002Fand auditory stimulation.\n\nControl Group:\n\nReceive usual care without additional VR-based interventions.\n\nComparison:\n\nResearchers will compare the outcomes between the experimental group (receiving VR-based sensory stimulation) and the control group (receiving usual care) to determine the effects of VR sensory stimulation on ICU delirium prevention, as well as its impact on patient psychological well-being and clinical outcomes.",[177,178,34],"Delirium","Intensive Care Unit",[180,181,182,183,184],"delirium","intensive care unit","randomised controlled trial","sensory stimulation","virtual reality","2023-11-22",{"date":187,"type":39},"2023-12-01",{"date":189,"type":21},"2024-01",{"date":191,"type":21},"2026-12",{"name":193,"class":46},"Chinese University of Hong Kong"]