[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"rate-of-positive-culture-from-morphine-aspirate\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:rate-of-positive-culture-from-morphine-aspirate":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":5},"100643339","investigation-of-chemical-stability-and-sterility-of-morphine-in-intrathecal-pumps-for-long-term-pain-management-100643339",false,"NCT07641608","Investigation of Chemical Stability and Sterility of Morphine in Intrathecal Pumps for Long-Term Pain Management","Morphine in Intrathecal Pumps for Long-Term Pain Management","Inclusion Criteria: • Adult patients (age ≥ 18 years), Diagnosed with chronic pain and currently treated with an implantable intrathecal pump.\n\n* Receiving intrathecal Morphine (Rafa Laboratories, 20 mg\u002Fml; registration no. 106-25-28981-00).\n* Scheduled for a routine pump refill procedure at an interval of 3 to 6 months.\n\nExclusion Criteria:• Patients receiving polyanalgesic mixtures (admixtures of morphine with other drugs) in the intrathecal pump.\n\n* Evidence of active systemic infection or localized infection at the pump implantation site.\n* History of recent pump malfunction or refills occurring outside the standard 3 to 6-month window.\n* Inability to provide informed consent.\n* Pregnant patients.","ALL","18 Years","99 Years",{"count":20,"type":21},5,"ESTIMATED","OBSERVATIONAL","Intrathecal drug delivery systems (IDDS) are effective for managing chronic pain by delivering medications directly into the cerebrospinal fluid. Morphine, a primary opioid used in these systems, must remain chemically stable and sterile over prolonged periods to ensure patient safety and therapeutic efficacy . Previous studies have evaluated morphine stability in vitro under simulated conditions , indicating minimal degradation in saline over time . However, there is limited real-world data regarding the residual morphine in pump reservoirs after extended use . This study seeks to bridge this gap by analyzing morphine aspirated from intrathecal pumps during routine refills in a clinical setting, while comparing it to in vitro samples taken in the clinic .. Objectives Primary Objective: To determine the chemical stability of morphine in intrathecal pump reservoirs over a 3 to 6-month period of clinical use.\n\nSecondary Objective: To assess the sterility of residual morphine and evaluate any microbial contamination.",[25],"Rate of Positive Culture From Morphine Aspirate","NOT_YET_RECRUITING","2026-06-07",{"date":29,"type":30},"2026-06-11","ACTUAL",{"date":32,"type":21},"2027-01-01",{"date":34,"type":21},"2028-01-01",{"name":36,"class":37},"Meir Medical Center","OTHER"]