[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"reading\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:reading":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,56],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":34,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100634946","enhancing-letter-speech-sound-learning-and-reading-network-activation-with-transcranial-electrical-stimulation-100634946",false,"NCT07546292","Enhancing Letter-Speech Sound Learning and Reading Network Activation With Transcranial Electrical Stimulation","Transcranial Electrical Stimulation and the Reading Brain: Toward Novel Interventions for Reading Impairments","LexiStim","Inclusion Criteria:\n\n* Age 18-35\n* All genders\n* Written informed consent by the participant\n* German speaking (native)\n* Right-handed\n\nExclusion Criteria:\n\n* Diagnoses of neurological disorders, intellectual disabilities, or psychiatric disorders (We do not exclude participants with common comorbidities of dyslexia, specifically dyscalculia, Attention Deficit\u002FHyperactivity Disorder, or Autism Spectrum Disorders)\n* History of any acquired brain damage or evidence of fetal alcohol syndrome\n* Hearing problems and vision problems that cannot be corrected\n* Inability to follow procedures or understand the instructions given in (Swiss-)German\n* Current use of psychoactive medications or substances, or a history of substance abuse that may affect brain function, performance or MRI signal quality\n* A nonverbal IQ \\\u003C 80\n* Having previously participated in a transcranial electrical stimulation study\n* Knowledge to read or write in a language using foreign letters (i.e., different from the Latin alphabet)\n* Contraindications to brain stimulation or MRI, such as: History of epilepsy or severe migraine; Skull breach such as craniotomy; Wearing neurostimulators or cardiac pacemakers; Wearing hearing aid devices or cochlear implants, which are not MR safe; Having metal pieces in their body (e.g., piercings that cannot be removed and contain metal, screws or plates from surgical operations, wounds from metal splinters or similar); Claustrophobia or problems lying in the scanner (e.g., pain, anxiety); Previous surgery on the head or heart; Being pregnant (a pregnancy test will be conducted at the MR center before the measurement if a female participant suspects she might be pregnant or is uncertain about her pregnancy status according to the Swiss Ethics Leitlinie:\n\nhttps:\u002F\u002Fswissethics.ch\u002Fassets\u002Fpos\\_papiere\\_leitfaden\u002F20110906\\_kek\\_mri.pdf); Having problems lying still (strong cold, tremor, etc.); Wearing non-removable dental braces",true,"ALL","18 Years","35 Years",{"count":22,"type":23},60,"ESTIMATED","INTERVENTIONAL",[26],"NA","This study investigates the effects of transcranial electrical stimulation (tES) on the brain and its potential to enhance reading-related learning. Adult participants with a range of reading abilities will receive transcranial random noise stimulation (tRNS) while they perform an artificial orthography learning task. This task simulates letter-speech sound learning, an important first step during reading acquisition known to be impaired in individuals with developmental dyslexia. The effects of the intervention will be assessed using both behavioral measures and functional magnetic resonance imaging (fMRI).",[29,30,31,32,33],"Dyslexia, Developmental","Reading","Dyslexia","Learning","Learning Disabilities",[31,35,36,37,38,39,40,41,42],"tRNS","transcranial electrical stimulation","non-invasive brain stimulation","neuromodulation","reading","functional magnetic resonance imaging","fMRI","audiovisual-learning","RECRUITING","2026-05-19",{"date":46,"type":47},"2026-05-22","ACTUAL",{"date":49,"type":47},"2026-04-23",{"date":51,"type":23},"2027-06",{"name":53,"class":54},"Silvia Brem","OTHER",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":24,"phases":67,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":55},"100562862","timing-and-facilitation-effects-of-theta-burst-stimulation-in-the-reading-and-language-networks-100562862","NCT06608680","Timing and Facilitation Effects of Theta-Burst Stimulation in the Reading and Language Networks","Timing and Facilitation Effects of Theta-Burst Stimulation in the Reading and Language Systems","TAFE","Inclusion Criteria:\n\n* Subjects must have a minimum of low average intellectual functioning (\\>=80) on at least one subscale on the Wechsler Abbreviated Scale of Intelligence-2 (WASI-2; Wechsler, 2011) to be included.\n* Within a normal range of reading skills as \\>85 on the Test of Word Reading Efficiency - Second Edition (TOWRE-2; Torgesen et al., 2012) and the Woodcock-Johnson IV Tests of Achievement (WJ-IV; Schrank et al., 2014)\n* Individuals with a documented history of learning disability will not be included. This will be determined via demographics questionnaire.\n* Subjects must be between the ages of 18 and 30 to be included. This will be determined via demographics questionnaire.\n* Because reading is critically linked to language, only individuals who are native speakers of English will be included in the study. This will be determined via demographics questionnaire.\n* The reading network is typically localized to the left side of the brain. However, left-handed individuals may have different brain lateralization, introducing an important confound to the study. Therefore, only right-handed individuals will be included in the study. This will be determined via demographics questionnaire.\n* Individuals who have hearing deficits (\\>25dB at 500+ Hz), visual deficits (\\>20\u002F40), serious emotional problems, certain neurological conditions (e.g., uncontrolled seizure disorders) will not be included. This will be determined via CABI Screening Forms and Demographics Questionnaire.\n* Individuals with certain metals in their bodies or with certain health conditions will not be included. If an individual has braces on their teeth, a cardiac pacemaker; hearing aid; other metal in their body or eyes (which may include certain metallic-embedded tattoos), including but not limited to pins, screws, shrapnel, plates, dentures or other metal objects they will not be included. This will be determined via CABI Screening forms.\n* Individuals with MRI Screening and Contraindication Forms which do not pass MRI Tech review will not be included.\n* Individuals with TMS Screening Forms which do not pass TMS Tech review will not be included.","30 Years",{"count":66,"type":23},50,[26],"The purpose of this study is to understand how transcranial magnetic stimulation affects how quickly, easily, and accurately a person read. Transcranial magnetic stimulation is a technique that uses magnetic fields to briefly affect how well certain brain regions function. The investigators would like to better understand how long the effects of transcranial magnetic stimulation occur in the reading system and at what point the effect is strongest in this system. The main questions it aims to answer are:\n\n1. At what point after stimulation are the greatest effects on behavior seen\n2. How excitatory and inhibitory stimulation affect behavior\n\nResearchers will compare stimulation types against a sham condition to see effects on reading and language behavior.\n\nParticipants will be asked to\n\n* undergo reading, language, and cognitive testing\n* receive an MRI\n* receive TMS stimulation\n* perform language, reading, and motor tasks",[30,70,71],"Language","Control Subjects",[73,74,75,30,70],"transcranial magnetic stimulation","TMS","MRI","2024-09-19",{"date":78,"type":47},"2024-09-23",{"date":80,"type":47},"2023-05-01",{"date":82,"type":23},"2028-12-31",{"name":84,"class":54},"Georgia State University"]