[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"rebound-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:rebound-pain":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,59,91,105,132],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":58},"100053446","phase-4-intravenous-dexamethasone-with-single-shot-versus-continuous-brachial-plexus-block-for-rebound-pain-after-shoulder-surgery-100053446",false,"NCT07699744","Intravenous Dexamethasone With Single-Shot Versus Continuous Brachial Plexus Block for Rebound Pain After Shoulder Surgery","Pain Management Protocol Optimization for Rebound Pain Prevention and Enhanced Recovery After Shoulder Surgery: A Randomized Noninferiority Trial of Intravenous Dexamethasone Combined With Single-Shot Versus Continuous Brachial Plexus Block","Inclusion Criteria:\n\n* Adult patients aged 19 to 79 years scheduled for elective shoulder surgery under brachial plexus block and monitored anesthesia care (MAC)\n\nExclusion Criteria:\n\n* Pre-existing neurological deficit of the brachial plexus\n* Emergency surgery\n* American Society of Anesthesiologists (ASA) physical status classification IV or higher\n* Contraindication or history of hypersensitivity to local anesthetics or dexamethasone\n* Severe pulmonary disease (e.g., chronic obstructive pulmonary disease)\n* Body mass index (BMI) ≥ 35 kg\u002Fm²\n* Long-term use of steroids\n* Long-term use of analgesics\n* Inability to cooperate or communicate\n* Pregnancy","ALL","19 Years","79 Years",{"count":20,"type":21},92,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Shoulder surgery often causes severe pain after the operation. To control this pain, doctors commonly perform a nerve block (interscalene brachial plexus block), which numbs the shoulder area. However, when the effect of a single-injection nerve block wears off, many patients experience sudden, intense pain known as \"rebound pain\".\n\nOne way to prevent rebound pain is to place a thin catheter near the nerves so that local anesthetic can be given continuously for a longer period (continuous nerve block). However, this method is technically demanding and can cause problems such as catheter dislodgement, infection, and inconvenience for patients. Another simpler option is to give a single-injection nerve block together with an intravenous (IV) injection of dexamethasone, a steroid medication known to prolong the effect of nerve blocks and reduce rebound pain.\n\nThe purpose of this study is to determine whether a single-injection nerve block combined with IV dexamethasone (5 mg) is not inferior to a continuous nerve block in preventing rebound pain after shoulder surgery. A total of 92 adult patients scheduled for elective shoulder surgery will be randomly assigned to one of the two groups. The main outcome is the rebound pain score, defined as the difference between the last pain score recorded in the recovery room (while the nerve block is still working) and the highest pain score reported within the first 24 hours after the nerve block. The investigators expect that the simpler single-injection method with IV dexamethasone will provide comparable pain control while avoiding the complications and inconvenience of catheter-based continuous nerve blocks.",[27,28,29,30],"Pain, Postoperative","Rebound Pain","Shoulder Injuries","Rotator Cuff Injuries",[32,33,34,35,36,37,38,39,40,41,42,43,44,45],"Rebound pain","Interscalene brachial plexus block","Single-shot nerve block","Continuous peripheral nerve block","Perineural catheter","Dexamethasone","Intravenous dexamethasone","Shoulder surgery","Rotator cuff repair","Regional anesthesia","Postoperative analgesia","Multimodal analgesia","Non-inferiority trial","Enhanced recovery after surgery","NOT_YET_RECRUITING","2026-07-09",{"date":49,"type":50},"2026-07-13","ACTUAL",{"date":52,"type":21},"2026-07-15",{"date":54,"type":21},"2027-07-15",{"name":56,"class":57},"Seoul National University Hospital","OTHER",1,{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":11,"sex":16,"minAge":67,"maxAge":4,"enrollmentInfo":68,"targetDuration":4,"studyType":22,"phases":70,"briefSummary":72,"conditions":73,"keywords":76,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":58},"100644256","prevention-of-rebound-pain-after-orthopaedic-surgery-with-peripheral-nerve-block-reboundpart-a-100644256","NCT07666971","Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block (REBOUND)_part A","Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block: a Single-blinded Randomised Controlled Trial","REBOUND","Inclusion Criteria:\n\n* Patients scheduled for elective orthopaedic surgery on the upper limb\n* Patients scheduled for elective orthopaedic surgery on the lower limb.\n* Score ASA I-III; Patients aged over 18 years; Signed informed consent.\n* Surgery under general anaesthesia or under sedation\n\nExclusion Criteria:\n\n* Refusal or inability to understand the informed consent\n* Allergy to any of the following medications: ropivacaine, paracetamol, ibuprofen, ketorolac, morphine,sufentanil, ondansetron, or dexamethasone\n* Patients with long term opioid treatment\n* Bleeding diathesis\n* Neurological disorders of the operated limb\n* Known renal insufficiency (eGFR \\\u003C30 mL\u002Fmin)\n* Known hepatic insufficiency (Child-Pugh class B or C);\n* Pregnant or breastfeeding women;\n* Alcohol dependence syndrome;\n* Patients under spinal anaesthesia;\n* Patients undergoing amputation procedures","18 Years",{"count":69,"type":21},100,[71],"NA","Rebound pain after peripheral nerve blocks reduces the benefits of regional anesthesia and increases opioid consumption. This rebound pain most likely results from suboptimal pain management, as patients receiving a peripheral nerve block are typically not given scheduled opioid doses. Oral Patient Controlled Analgesia (PCA) consists of an oral morphine prescription that allows patients to self-administer doses based on their pain score.\n\nThis study will compare patients undergoing elective orthopaedic surgery under general anaesthesia or sedation with a peripheral nerve block, receiving oral morphine PCA either with or without additional scheduled oral morphine doses.",[74,28,75],"Post Operative Analgesia","Post Operative Pain, Acute",[77,78,79,80,81],"rebound pain","postoperative pain","pain management","orthopaedic surgery","peripheral nerve block","2026-06-19",{"date":84,"type":50},"2026-06-24",{"date":86,"type":21},"2026-06",{"date":88,"type":21},"2027-09",{"name":90,"class":57},"Centre Hospitalier Universitaire Vaudois",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":11,"sex":16,"minAge":67,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":22,"phases":97,"briefSummary":72,"conditions":98,"keywords":99,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":102,"completionDateStruct":103,"leadSponsor":104,"locationsCount":58},"100644261","prevention-of-rebound-pain-after-orthopaedic-surgery-with-peripheral-nerve-block-reboundpart-b-100644261","NCT07666009","Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block (REBOUND)_part B",{"count":69,"type":21},[71],[74,28,75],[77,78,79,80,81],"2026-06-18",{"date":84,"type":50},{"date":86,"type":21},{"date":88,"type":21},{"name":90,"class":57},{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":67,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":22,"phases":115,"briefSummary":116,"conditions":117,"keywords":121,"overallStatus":123,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":128,"leadSponsor":130,"locationsCount":58},"100642380","the-effect-of-intravenous-dexketoprofen-on-the-severity-and-incidence-of-rebound-pain-100642380","NCT07642674","The Effect of Intravenous Dexketoprofen on the Severity and Incidence of Rebound Pain","Evaluation of the Effect of Intravenous Dexketoprofen on the Severity and Incidence of Rebound Pain in Patients Undergoing Interscalene Brachial Plexus Block","Inclusion Criteria:\n\nAge 18-70 years ASA score of I-III Arthroscopic shoulder surgery\n\nExclusion Criteria:\n\nPatients who do not wish to participate in the study Creatinine clearance \\\u003C50 mL\u002F min Patients for whom NSAID use is contraindicated due to heart failure, Patients with psychiatric or cognitive dysfunction that would impair their ability to assess visual analog scale (VAS) pain scores Patients for whom peripheral nerve block is contraindicated","70 Years",{"count":114,"type":21},66,[71],"Orthopedic shoulder surgeries are associated with severe postoperative pain, particularly within the first 24-48 hours after surgery. In postoperative pain management, single or continue interscalene brachial plexus blocks, acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids administered as needed are commonly used as components of multimodal analgesia.\n\nRebound pain is defined as severe postoperative pain (VAS ≥ 7) occurring within the first 24 hours after resolution of the block. It is considered an adverse effect of regional anesthesia and typically develops 8-12 hours after a single-shot nerve block. Risk factors for rebound pain include pre-existing pain, female sex, younger age, bone surgery, lack of intraoperative dexamethasone administration, and inadequate analgesia.\n\nThe primary objective of this study is to evaluate the effect of intravenous dexketoprofen administered during the postoperative period on the incidence and severity of rebound pain in patients undergoing shoulder surgery with interscalene brachial plexus block",[118,119,28,120],"Postoperative Pain","Pain Management","Interscalene Block",[122],"Rebaund pain, Interscalene block, postoperative pain","RECRUITING","2026-06-11",{"date":126,"type":50},"2026-06-12",{"date":124,"type":50},{"date":129,"type":21},"2027-01-01",{"name":131,"class":57},"Eskisehir Osmangazi University",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":16,"minAge":67,"maxAge":4,"enrollmentInfo":139,"targetDuration":4,"studyType":22,"phases":141,"briefSummary":142,"conditions":143,"keywords":145,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":58},"100604220","phase-4-effect-of-local-anesthetic-concentration-on-rebound-pain-a-randomized-control-study-100604220","NCT07146685","Effect of Local Anesthetic Concentration on Rebound Pain: A Randomized Control Study","RPRCT","Inclusion Criteria:\n\n* Total shoulder replacement patients (anatomic and reverse)\n* Adult patients (greater than or equal to 18 years)\n* Any gender\n* Any race\n\nExclusion Criteria:\n\n* \\- Chronic Pain diagnoses including:\n* substance\u002Fopioid use disorder\n* complex regional pain syndromes\n* fibromyalgia\n* Daily persistent opioid use spanning 3 months prior to surgery date\n* Allergy to local anesthetics or NSAIDS\n* Respiratory pathologies including:\n* CPAP- non-compliant \u002F untreated obstructive sleep apnea\n* COPD\n* Restrictive lung disease (pulmonary fibrosis, interstitial pneumonia, etc)\n* Contralateral diaphragm dysfunction\n* BMI \\> 40\n* Ipsilateral extremity pre-existing nerve injury\n* GFR \\\u003C 60\n* NSAID contraindications\n* Inability to follow up\n* Revision surgery\n* Patients requesting block as primary (avoidance of general anesthesia)\n* Need or request for brachial plexus catheter or liposomal bupivacaine\n* Vulnerable populations (pregnancy, incarceration, etc)\n* non-English speaking",{"count":140,"type":21},168,[24],"Randomized control study that compares different concentrations of local anesthetic to investigate whether a lower concentration of local anesthetic would contribute to lower rebound pain scores at 24 hours post op in patients undergoing anatomic or reverse total shoulder arthroplasty.",[28,144,120],"Shoulder Arthroplasty",[146,77,147,148],"local anesthetics","brachial plexus","shoulder arthroscopy","2025-08-20",{"date":151,"type":50},"2025-08-28",{"date":153,"type":21},"2026-01-01",{"date":155,"type":21},"2029-01-01",{"name":157,"class":57},"University of Virginia"]