[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"recession-gingival\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:recession-gingival":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,43,74,103,132,157],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100619779","early-effects-of-orthognathic-surgery-on-periodontal-phenotype-a-6-month-prospective-clinical-and-radiographic-evaluation-100619779",false,"NCT07349056","Early Effects of Orthognathic Surgery on Periodontal Phenotype: A 6-Month Prospective Clinical and Radiographic Evaluation","Evaluation of Periodontal Phenotype Following Orthognathic Surgery: A Two-Center, 6-Month Prospective Clinical and CBCT Study","Inclusion Criteria:\n\n* Adults aged ≥18 years.\n* Presence of a Class III molar relationship of any severity at baseline.\n* Presence of a Class II molar relationship of any severity at baseline.\n* Presence of transverse arch discrepancies.\n* Presence of vertical maxillary excess.\n* Presence of maxillary and\u002For mandibular asymmetry.\n* Presence of anterior open bite.\n* Full permanent dentition up to the first molars, with no supernumerary teeth and no agenesis (congenital absence) of teeth up to the first molars.\n* No previous orthodontic treatment.\n* No history of tooth extraction other than second or third molars.\n* Availability of complete baseline and end-of-follow-up periodontal parameters and phenotype records suitable for evaluation.\n* Healthy periodontium with no signs of gingival hypertrophy.\n* No systemic disease history or medication use that could affect gingival\u002Fperiodontal conditions.\n\nExclusion Criteria:\n\n* Patients planned for orthodontic camouflage treatment with fixed appliances for Class II\u002FClass III correction instead of orthognathic surgery.\n* History of interproximal enamel reduction (interproximal stripping).\n* Presence of dental implants.\n* Age \\\u003C 18 years.\n* Pregnant or breastfeeding individuals.\n* Any systemic condition contraindicates orthognathic surgery.\n* Psychiatric disorders.\n* Syndromic conditions.\n* History of previous orthognathic surgery.\n* Refusal to sign the informed consent form.\n* Individuals belonging to a vulnerable population.","ALL","18 Years","65 Years",{"count":20,"type":21},100,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn how the health and thickness of the gums and supporting bone around the teeth change over 6 months in adults having jaw surgery to correct the bite. The main questions it aims to answer are:\n\n* Do gum and tooth-support measurements change from before surgery to 1, 3, and 6 months after surgery?\n* Do CT scan-based measurements of the tooth-supporting bone change over the same time period?\n\nParticipants will:\n\n* Have a gum check-up (periodontal examination) before surgery and at 1, 3, and 6 months after surgery.\n* Have CT scan-based measurements (CBCT) taken at the same time points for study assessment.",[25,26,27,28,29],"Gingival Biotype","Gingival Phenotype","Buccal Bone Thickness","Recession, Gingival","Dental Surgery","RECRUITING","2026-06-05",{"date":33,"type":34},"2026-06-08","ACTUAL",{"date":36,"type":34},"2026-02-23",{"date":38,"type":21},"2027-02-23",{"name":40,"class":41},"Trakya University","OTHER",2,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100518947","comparison-of-two-methods-of-covering-a-single-lower-front-tooth-with-receded-gums-100518947","NCT06037161","Comparison of Two Methods of Covering a Single Lower Front Tooth With Receded Gums","Comparison of Surgical Techniques to Treat Isolated Gingival Recession in Mandibular Incisors: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Males and females of \\> 18 years of age\n* Single Cairo's RT1 (Recession Type 1) and RT2 ( Recession Type 2) recession defects (≥3 mm in depth) in mandibular anterior teeth (Incisors).\n* Presence of identifiable cemento-enamel junction (CEJ)\n* Presence of a step ≤1 mm at the CEJ level and\u002For the presence of a root abrasion, but with an identifiable CEJ, will be accepted\n* Periodontally and systemically healthy patients\n* No contraindications for periodontal surgery and not taking medications known to interfere with periodontal tissue health or healing; and no prior periodontal surgery on the involved sites\n\nExclusion Criteria:\n\n* Vaping, chewing tobacco or smoking \\> 10 cigarettes per day\n* Uncontrolled Diabetes Mellitus (HbA1c \\> 7)\n* Pregnancy and Lactation\n* Diseases affecting connective tissue metabolism\n* Long-term steroid use\n* Recession defects associated with caries\n* Teeth associated with pulpal pathology",true,{"count":52,"type":21},36,"INTERVENTIONAL",[55],"NA","The primary objective of this randomized clinical trial is to compare the mean root coverage achieved with Coronally Advanced Flap (CAF) + Connective Tissue Graft (CTG) (control) to Gingival Pedicle Split Thickness flap (GPST) + CTG (test) for the treatment of isolated gingival recession defects in mandibular incisors. The secondary objectives are to compare the percentage of complete root coverage and keratinized tissue gain between the two techniques.",[28],[59,60,61,62,63],"Connective tissue graft(s)","cosmetic periodontal plastic surgery","gingival recession","mucogingival surgery","treatment planning","2026-05-19",{"date":66,"type":34},"2026-05-20",{"date":68,"type":34},"2023-05-19",{"date":70,"type":21},"2027-07-30",{"name":72,"class":41},"Case Western Reserve University",1,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":50,"sex":16,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":53,"phases":85,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":73},"100600843","l-prf-vs-connective-tissue-with-customized-healing-abutment-in-immediate-implant-placement-100600843","NCT07102758","L-PRF vs Connective Tissue With Customized Healing Abutment in Immediate Implant Placement","Evaluation of Soft and Hard Tissue Augmentation by Connective Tissue Graft or Leukocyte-Platelet Rich Fibrin in Immediate Implant Placement With Customized Healing Abutment: A Randomized Controlled Clinical Trial.","Inclusion Criteria:\n\n* Intact labial\u002Fbuccal bone plate\n* The presence of non-restorable single-rooted maxillary centrals, canines or premolars.\n* Sufficient bone volume.\n* Good oral hygiene.\n* Nonsmokers.\n* Sufficient bone width (≥ 1 mm) in the buccal plate of the remaining bone to place an implant confirmed by cone beam computer tomography (CBCT).\n\nExclusion Criteria:\n\n* Insufficient bone volume.\n* Active infection.\n* Patients on chemotherapy or radiotherapy.\n* Patients who have systemic disorders {uncontrolled diabetes mellitus, autoimmune disease, …etc},\n* Pregnant patients,\n* Patients with bone diseases\n* Presence of periapical pathology.","21 Years","45 Years",{"count":84,"type":21},16,[55],"comparison between L-prf and connective tissue with dental implant",[28,88],"Bone Loss in Jaw",[90,91,92,93],"L-prf","connective tissue","customized healing abutment","implant","2025-08-10",{"date":96,"type":34},"2025-08-14",{"date":98,"type":21},"2025-08-05",{"date":100,"type":21},"2027-08-20",{"name":102,"class":41},"Kafrelsheikh University",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":53,"phases":114,"briefSummary":115,"conditions":116,"keywords":119,"overallStatus":123,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":128,"leadSponsor":130,"locationsCount":4},"100588069","how-can-prefabricated-membranes-load-ascorbic-acid-can-curtail-gingival-recession-100588069","NCT06936592","How Can Prefabricated Membranes Load Ascorbic Acid Can Curtail Gingival Recession?","How Can Prefabricated Membrane-loaded Ascorbic Acid Curtail the Gingival Recession?","recession","Inclusion Criteria:\n\n1. Patients of both genders with ages more than 18 years.\n2. At least two adjacent teeth in maxillary or mandibular anterior sextant with Cairo classification (RT1 or RT 2) labial GR defect.\n3. Good general health with no contraindications for periodontal surgery (American Society of Anesthesiologists I).\n4. Non-smoker patients.\n\nExclusion Criteria:\n\n1. Pregnant and lactating women.\n2. Teeth exhibiting pathologic mobility.\n3. Mal alignment teeth.\n4. Patients under active orthodontic therapy.\n5. Periodontal therapy during the last 6 months.\n6. Patients received antibiotics or non-steroidal anti-inflammatory drugs six months before the beginning of the study.","55 Years",{"count":113,"type":21},30,[55],"Periodontal diseases are a prevalent issue, often leading to gingival recession, where the gingival margin recedes, exposing the tooth root and causing various problems. Gingival recession can be managed through both non-surgical and surgical interventions The non-surgical approach often involves plaque control and addressing any underlying inflammatory conditions. However, in cases of advanced recession, surgical treatment may be necessary Several treatment techniques have been proposed, which can be divided into pedicle and free grafts. The latter can also be classified as free gingival grafts (FGG) or as connective tissue grafts (CTG). Other treatment options include soft tissue substitutes or regenerative therapies Harvesting graft from the palate has several problems, such as pain, inflammation, bleeding, flap necrosis, and infection at the donor site. For this reason, we need a substitute for soft tissue graft harvesting Carbopol polymers, also known as carbomers, are widely utilized in pharmaceutical formulations for their excellent mucoadhesive properties. This high molecular weight, cross-linked acrylic acid polymers are particularly effective in enhancing the adhesion of formulations to mucosal surfaces, thereby improving drug delivery and bioavailability",[117,118,28],"Gingival Recession, Localized","Gingival Diseases",[109,120,121,122],"membrane","ascorbic acide","graft","NOT_YET_RECRUITING","2025-04-17",{"date":126,"type":34},"2025-04-20",{"date":124,"type":21},{"date":129,"type":21},"2025-10-18",{"name":131,"class":41},"Minia University",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":53,"phases":141,"briefSummary":142,"conditions":143,"keywords":144,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":73},"100576187","the-effect-of-periodontal-dressings-and-various-materials-on-the-donor-sites-quality-of-life-after-free-gingival-graft-surgery-100576187","NCT06782035","The Effect of Periodontal Dressings and Various Materials on the Donor Site's Quality of Life After Free Gingival Graft Surgery","The Influence of Periodontal Dressings (Ora-Aid) and Various Materials on the Donor Site's Quality of Life After Free Gingival Graft Surgery","Inclusion Criteria:\n\nSystemically healthy Non-smoker Insufficient attached gingiva Not using any medication regularly Age 18-85 years No previous graft taken from the same area Not in pregnancy or lactation period Agreement to participate in the study and sign the \"Informed Consent Form\"\n\nExclusion Criteria:\n\nSystemic disease Regular systemic medication use Under 18 years old Pregnant or breastfeeding women Smoker Previous graft taken from the same area","85 Years",{"count":52,"type":21},[55],"The inadequate width of attached gingiva, resulting from the loss of the attached gingiva band, is one of the primary mucogingival issues. Free gingival graft (FGG) is a mucogingival surgical technique used to increase the amount of attached gingiva, cover exposed root surfaces in localized gingival recessions, deepen the vestibule, and eliminate frenulum and muscle attachments. The harvested tissue is keratinized attached gingiva. Due to ease of access, the palate is most commonly preferred as the donor site.\n\nComplications that may arise following FGG surgery are generally donor site-related. Reported complications include postoperative bleeding, recurrent herpetic lesions, delayed healing, paresthesia, mucocele, arteriovenous shunt, and postoperative pain. To aid healing and reduce discomfort and pain associated with the wound site in the palate after surgery, various materials have been applied to the donor site to facilitate recovery.\n\nFollowing FGG surgery, patients will be divided into three groups based on the application of different materials to the wound site in the palate: leukocyte- and platelet-rich fibrin (L-PRF), Ora-Aid oral wound dressing, and a palatal surgical stent. In the Ora-Aid group, after harvesting the graft and placing it in the recipient site, the wound area will be irrigated with saline solution, and Ora-Aid will be trimmed to the appropriate size and shape. It will be gently pressed onto the wound for 5-10 seconds until it adheres. Ora-Aid and L-PRF will be secured to the wound site with a 4\u002F0 silk cross suture. The Ora-Aid application will serve as the test group, the L-PRF application as the positive control group, and the palatal surgical stent as the negative control group. Randomization will be performed using a computer program.\n\nPostoperatively, patients' pain levels will be assessed on the 3rd, 7th, and 14th days using the Visual Analog Scale (VAS) test and the OHIP-14 questionnaire. Wound site epithelialization will be evaluated during follow-up sessions on the 7th and 14th days and at 1 month. After evaluating all questionnaire results, statistical analyses will be conducted.",[28],[145,146,147],"Free gingival graft","Mucogingival surgery","Periodontal dressing","2025-01-13",{"date":150,"type":34},"2025-01-17",{"date":152,"type":34},"2025-01-02",{"date":154,"type":21},"2025-05-25",{"name":156,"class":41},"Izmir Katip Celebi University",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":50,"sex":16,"minAge":17,"maxAge":164,"enrollmentInfo":165,"targetDuration":4,"studyType":53,"phases":167,"briefSummary":168,"conditions":169,"keywords":173,"overallStatus":123,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":73},"100570019","clinical-evaluation-of-gingival-biotype-changes-using-a-coronally-advanced-flap-caf-in-combination-with-leucocyte-and-platelet--rich-fibrin-l-prf-membranes-of-different-thickness-for-the-treatment-of-rt1-gingival-recession-a-randomized-controlled-clinical-trial-100570019","NCT06701799","Clinical Evaluation of Gingival Biotype Changes Using a Coronally Advanced Flap (CAF) in Combination with Leucocyte and Platelet- Rich Fibrin (L-PRF) Membranes of Different Thickness for the Treatment of RT1 Gingival Recession: a Randomized Controlled Clinical Trial.","CAF in Association with Different Thickness of L-PRF Membranes of for the Treatment of RT1 Gingival Recession: a Randomized Controlled Clinical Trial.","Inclusion Criteria:\n\n* Systemic factors (no systemic diseases; no coagulation disorders; no medications affecting periodontal status in the previous 6 months; no pregnancy or lactation)\n* Never smokers\u002Fformer smokers \\>=10years\n* Full-mouth plaque score (FMPS)and a full-mouth bleeding score (FMBS) lower than 15%\n* No periodontal surgery on the experimental sites\n* \\>= 20 teeth without mobility\n* No presence of cervical carious lesions or periapical lesions at experimental sites\n* At least one RT1 buccal gingival recession\n\nExclusion Criteria:\n\n* Systemic diseases\n* Coagulation disorders\n* Medications affecting periodontal status in the previous 6 months\n* Pregnancy or lactation\n* Smokers","80 Years",{"count":166,"type":21},40,[55],"Gingival thickness plays a key role not only in the etiology but also in the treatment of gingival recessions. More recently, authors reported that as the gingival thickness decreases, the gingival recession severity increases . When gingival inflammation occurs, if the tissue is thin the consequent destruction can quickly produce a gingival recession (GR) .\n\nWhen treating a gingival recession, the clinician should aim not only to completely cover the exposed root surface but also to prevent a future recession recurrence. The treatment gold standard is the CAF associated with connective tissue graft. This technique has demonstrated high rates in gingival recession reduction and positive predictability in obtaining complete root coverage. However, some disadvantages about this surgical approach can be easily highlighted: patients experience more discomfort, longer chair-time it's necessary and a second wound area is created. In this scenario, The Platelet rich in fibrin and leucocyte (L-PRF) could be a valuable alternative treatment of gingival defects. It's a platelet concentrate, obtained by a fast and simple procedure that does not require anticoagulant and bovine thrombin. It can also be categorized as a live tissue thanks to platelets, leukocytes, growth factors and stem cells trapped in a polymerized fibrin mesh. L- PRF is used in various fields of regenerative medicine; It promotes stabilization and revascularization of the flaps, contributes to soft tissue wound healing and reduces post-operative discomfort. The purpose of this study will be to evaluate if the different thickness of platelet- rich fibrin (L-PRF) membranes in association with a Coronally Advanced Flap (CAF), for the treatment of RT1 gingival recessions, may influence the Complete Root Coverage (CRC).",[170,28,171,172],"Mucogingival Defects","Gingival Recession, Mucogingival Surgery","L-PRF",[174,172,175,176,25],"Coronally Advanced Flap","Platelet concentrate","Gingival Recession","2024-11-19",{"date":179,"type":34},"2024-11-22",{"date":181,"type":21},"2024-11-30",{"date":183,"type":21},"2025-11-30",{"name":185,"class":41},"G. d'Annunzio University"]