[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"recompensation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:recompensation":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100599634","a-study-to-predict-recompensation-in-patients-with-decompensated-cirrhosis-using-spleen-stiffness-and-simple-blood-tests-100599634",false,"NCT07087041","A Study to Predict Recompensation in Patients With Decompensated Cirrhosis Using Spleen Stiffness and Simple Blood Tests","Prediction of Recompensation and Stable Recompensation in Patients With Decompensated Cirrhosis Using Spleen Stiffness Combined With Non-Invasive Markers: A Prospective, Observational, Multicenter Study","LEAD-2","Inclusion Criteria:\n\n* Male or female, aged 18 to 75 years (inclusive)\n* Clinically diagnosed decompensated cirrhosis\n* First decompensated event occurred within 12 months of screening, or no decompensated events in the past 12 months despite a history of decompensation\n* Received effective etiological treatment per guidelines:\n\n  * For HBV: Sustained antiviral suppression\n  * For alcohol-related liver disease: Sustained abstinence for ≥2 months\n  * For MAFLD-related cirrhosis: Improved liver function after lifestyle\u002F metabolic intervention\n\nExclusion Criteria:\n\n* Missing data on first decompensated event\n* Prior orthotopic liver transplantation or TIPS\n* Prior splenectomy, splenic embolization, or other shunt surgery\n* History or current diagnosis of hepatocellular carcinoma\n* Acute variceal bleeding within the last 4 weeks or unstable condition\n* Uncontrolled moderate-to-severe ascites\n* Cholestatic cirrhosis; untreated chronic liver diseases; non-cirrhotic portal hypertension; vascular liver diseases (e.g., Budd-Chiari syndrome)\n* Acute or chronic portal vein thrombosis\n* Severe comorbidities of heart, lung, kidney, brain, hematologic, or psychiatric systems\n* Other systemic malignancies (except cured cases)\n* Pregnant or breastfeeding women","ALL","18 Years","75 Years",{"count":21,"type":22},735,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn if spleen stiffness and other non-invasive markers can help predict recompensation in people with decompensated cirrhosis who are receiving effective treatment for the cause of their liver disease. The main questions it aims to answer are:\n\n* Can spleen stiffness and blood test results predict who will get better and stay better after cirrhosis becomes worse?\n* What are the features of people who recover after decompensation?\n\nParticipants will:\n\n* Be people with decompensated cirrhosis who are already getting effective treatment (such as antiviral therapy or alcohol abstinence)\n* Be followed over time to check if they remain stable or have more liver problems\n* Have non-invasive tests done, including spleen stiffness measurement and blood tests\n\nResearchers will track how many participants recover and stay recovered over time, and use that information to build a tool to help predict outcomes in others with cirrhosis.",[26,27,28,29,30,31],"Decompensated Cirrhosis","Hepatitis B Virus (HBV) Infection","Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)","Alcohol-Related Liver Disease","Portal Hypertension","Recompensation",[31,26,33],"Spleen Stiffness","NOT_YET_RECRUITING","2025-07-23",{"date":37,"type":38},"2025-07-25","ACTUAL",{"date":40,"type":22},"2025-07-15",{"date":42,"type":22},"2028-12-30",{"name":44,"class":45},"Beijing Friendship Hospital","OTHER",28]