[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"reconstruction-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:reconstruction-surgery":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100587955","feasibility-of-tracheobronchial-defect-reconstruction-using-allogenic-aortic-patch-100587955",false,"NCT06935110","Feasibility of Tracheobronchial Defect Reconstruction Using Allogenic Aortic Patch","Inclusion Criteria:\n\n1. Congenital tracheal deformities: Includes congenital tracheomalacia, congenital tracheobronchial malformations, complete tracheal rings, etc., with severe clinical symptoms and cases where treatment is recommended after evaluation.\n2. Acquired tracheal stenosis: Includes tracheal narrowing caused by diseases, endotracheal intubation, or postoperative scar tissue, with severe clinical symptoms and cases where treatment is recommended after evaluation.\n3. Tracheal injury or tissue defect caused by trauma or burns: Cases requiring surgical repair.\n4. Tracheal tumors: Reconstruction of tracheal tissue following the removal of benign or malignant tumors.\n\nExclusion Criteria:\n\n1. Patients who are unable to provide informed consent.\n2. Pulmonary tumors that can be treated with standard lobectomy.\n3. Locally invasive tumors that are unresectable.\n4. Presence of contralateral lymph node metastasis.\n5. Presence of distant metastasis, except for solitary, resectable brain metastasis.\n6. Tracheal lesions amenable to standard resection with direct anastomosis.\n7. Preoperative evaluation indicates inability to undergo standard lobectomy.\n8. Patients infected with human immunodeficiency virus (HIV) or with other immunodeficiency disorders.\n9. Any condition or circumstance deemed by the principal investigator to potentially interfere with the conduct of the trial (e.g., severely impaired cardiopulmonary function, significant liver or kidney dysfunction, poorly controlled diabetes, high-risk groups, or pregnancy).\n10. Individuals with concerns about the potential risks of the trial.","ALL","18 Years",{"count":18,"type":19},10,"ESTIMATED","INTERVENTIONAL",[22],"NA","The investigators investigate the feasibility and safety of using cryopreserved aortic patches for tracheal or bronchial defect repair.",[25,26,27],"Trachea Diseases","Airway Remodeling","Reconstruction Surgery",[29,30,31,32],"cryopreserved aortic patch","airway repair","tracheal reconstruction","bronchial reconstruction","RECRUITING","2026-06-11",{"date":36,"type":37},"2026-06-12","ACTUAL",{"date":39,"type":37},"2025-09-15",{"date":41,"type":19},"2029-10",{"name":43,"class":44},"National Taiwan University Hospital","OTHER",2,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":20,"phases":56,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100577486","phase-3-flap-sparing-in-postoperative-radiotherapy-of-oral-cavity-cancers-100577486","NCT06798922","Flap Sparing in Postoperative Radiotherapy of Oral Cavity Cancers","Flap Sparing in Postoperative Radiotherapy of Oral Cavity Cancers: a De-escalation Randomized Phase III Trial","OPTIFLAP","Inclusion Criteria:\n\n* Patient aged 18 years or older\n* Performance Status 0-2\n* Patient with oral cavity cancer (soft tissue or soft tissue-bone flap), treated by reconstructive surgery with a flap. Oropharynx cancer whose flap extends significantly into the oral cavity may be included in the study\n* Quality of resection with margins \\> 1 mm\n* Patient candidate to post-operative radiotherapy (Intensity-Modulated Radiation Therapy (IMRT) or proton therapy)\n* Concomitant chemotherapy is allowed (stratification parameter)\n* Patient must have signed a written informed consent form prior to any trial specific procedures\n* Patient affiliated to the social security system\n\nExclusion Criteria:\n\n* Local flap (small size limiting IMRT modulation potential)\n* History of radiotherapy of head and neck area\n* Metastatic disease\n* History of other malignancy within the previous 3 years (except for appropriately treated in-situ cervix carcinoma and non-melanoma skin carcinoma)\n* Simultaneous participation in another clinical study may compromise the conduct of this study.\n* Pregnant or lactating women\n* Patient assessed by the investigator to be unable or unwilling to comply with the requirements of the protocol\n* Patient deprived of freedom or under guardianship",{"count":55,"type":19},348,[57],"PHASE3","Patients with oral cavity cancer treated by reconstructive surgery with a flap.\n\nPatients will be treated in the study for :\n\n* Experimental arm: Post-operative radiotherapy with flap sparing\n* Control arm: Standard post-operative radiotherapy without flap sparing (current practice) Radiotherapy by IMRT using photons or proton therapy (IMPT)",[60,61,62,27],"Oral Cavity Carcinoma","Flap","Radiotherapy, Adjuvant",[64,65,66,67,68],"protontherapy","flap","oral cavity carnicoma","radiotherapy","IMRT","2026-03-02",{"date":71,"type":37},"2026-03-03",{"date":73,"type":37},"2025-03-01",{"date":75,"type":19},"2034-03-01",{"name":77,"class":44},"Centre Francois Baclesse",25,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":20,"phases":90,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":4},"100591257","artificial-intelligence-combined-with-3d-preformed-chest-wall-defection-reconstruction-system-in-chest-wall-tumor-surgery-100591257","NCT06978075","Artificial Intelligence Combined With 3D-Preformed Chest Wall Defection Reconstruction System in Chest Wall Tumor Surgery","Research on the Application of Artificial Intelligence (AI) Assisted Chest Wall Tumor Resection Combined With Personalized 3D Preformed Chest Wall Defection Reconstruction System in Chest Wall Tumor Surgery","AICW3DPCWDRS","Inclusion Criteria:\n\n1. 18-70 years old, male or female not limited\n2. Anesthesia ASA score I-II\n3. Malignant tumor of soft tissue in the chest\n4. Malignant tumors of ribs, rib cartilage, and sternum\n5. Tumors with uncertain or unknown properties of ribs, rib cartilage, and sternum\n6. Giant benign tumors of ribs, rib cartilage, and sternum\n7. The preoperative examination results indicate that the tumor has not undergone distant metastasis\n8. Willing to participate in the research and sign the informed consent form\n\nExclusion Criteria:\n\n1. Patients with distant metastasis detected during preoperative examination\n2. Inoperable tumor\n3. During the examination, it was discovered that the patient had another type of malignant tumor present\n4. ECOG 4\n5. Suffering from active or chronic fungal\u002Fbacterial\u002Fviral infections\n6. History of allergy to anesthesia related drugs\n7. Heart and lung dysfunction, liver and kidney dysfunction, inability to tolerate surgery\n8. Patients with mental disorders who are unable to cooperate with treatment","80 Years",{"count":89,"type":19},50,[22],"Chest wall tumors should be completely resection as much as possible while malignant chest wall tumors should be extensively resection. If not completely resection, it will recur in the short time and affect the patient's survival. At present, the surgical resection range mainly relies on preoperative imaging examination and the experience of the surgeon. It lacks precise guidance. This can easily lead to incomplete resection. In addition, the reconstruction materials required for reconstruct the excised chest wall defection are often generated in a standardized manner, lacking intraoperative adjustability. To address this clinical issue, we plan to carry out the research on the application of artificial Intelligence (AI) assisted chest wall tumor resection combined with personalized 3D preformed chest wall defection reconstruction system in chest wall tumor surgery.",[93,27],"Chest Wall Tumor",[95],"chest wall tumor resection and reconstrucion","NOT_YET_RECRUITING","2025-05-11",{"date":99,"type":37},"2025-05-18",{"date":101,"type":19},"2025-07-01",{"date":103,"type":19},"2028-12-31",{"name":105,"class":44},"Wu Weiming"]