[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"recovery-following-primary-total-knee-arthroplasty\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:recovery-following-primary-total-knee-arthroplasty":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100588078","phase-4-perioperative-colchicine-for-tka-100588078",false,"NCT06936709","Perioperative Colchicine for TKA","Effect of Colchicine in the Perioperative Period on Reducing Post-Operative Pain in Total Knee Arthroplasty","Inclusion Criteria:\n\n* Patients 18 years or older undergoing elective total knee arthroplasty for osteoarthritis.\n\nExclusion Criteria:\n\n* Subject has impaired hepatic function (Child-Pugh Class \\>B)\n* Subject has impaired renal function (GFR \\\u003C 60 ml\u002Fmin\u002F1.73 m2)\n* Subject has known adverse reaction to colchicine\n* Subject has chronic opioid use (Filled opioid medication twice within 6 months of surgical date)\n* Subject is pregnant or expecting to become pregnant during the time of the study associated with colchicine exposure (postoperative days 0-3)\n* Subject is unable to provide informed consent\n* Subject is actively prescribed medication that interact with colchicine in a manner that would increase the risk of colchicine toxicity, i.e.:\n* Antifungals: Ketoconazole, itraconazole, fluconazole, etc…\n* Macrolides : Clarithromycin, erythromycin\n* HIV protease : Ritonavir, Atazanavir, saquinavir, etc...\n* Ca2+: Verapamil and Diltiazem\n* Cyclosporine\n* Danazol\n* Amiodorone\n* Quinidine\n* Anti-hepaciviral combinations\n* Grapefruit juice\n* Statins: atorvastatin, lovastatin, simvastatin, etc…\n* Gemfibrozil and other fibrates\n* Digoxin","ALL","18 Years",{"count":19,"type":20},75,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","This study is a prospective, randomized, double-blinded, placebo-controlled study of the drug colchicine in the acute postoperative period for patients who are undergoing a total knee arthroplasty (TKA). Patients aged 18 years or older who are undergoing TKA will be invited to participate in the study. The primary endpoint of this study is to determine if colchicine, an anti-inflammatory medication commonly used for gout attacks, will decrease the postoperative pain of patients undergoing elective TKA.",[26,27,28],"Osteoarthritis of Knee","Recovery Following Primary Total Knee Arthroplasty","Perioperative Pain Control",[30,31,32],"Total Knee Arthroplasty","Colchicine","Postoperative Pain","NOT_YET_RECRUITING","2025-08-15",{"date":36,"type":37},"2025-08-17","ACTUAL",{"date":39,"type":20},"2025-12-01",{"date":41,"type":20},"2026-03-01",{"name":43,"class":44},"Geisinger Clinic","OTHER"]