[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"recovery-of-function\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:recovery-of-function":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,49,76,110,137,170,198],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100643936","cognitive-reserve-and-post-fatigue-recovery-in-older-adults-100643936",false,"NCT07667985","Cognitive Reserve and Post-Fatigue Recovery in Older Adults","Determining the Post-Physical and Mental Fatigue Recovery Perspectives of Older Adults Based on Their Cognitive Reserves","Inclusion Criteria:\n\n* being 65 years of age or older,\n* not having any neurological, psychiatric, or systemic disease that would affect one's mental state, and not using any medication for these conditions.\n\nExclusion Criteria:\n\n* Being younger than 65 years old,\n* having an illness or taking medication that affects mental health, or being\n* unable to complete the questionnaires.",true,"ALL","65 Years","90 Years",{"count":21,"type":22},400,"ESTIMATED","OBSERVATIONAL","As people grow older, it is common to experience a drop in physical stamina and memory functions. This can make recovering from daily physical and mental fatigue more difficult, which directly impacts an individual's independent daily life and overall quality of life.\n\n\"Cognitive reserve\" is a term that describes the brain's built-in resilience. Built over a lifetime through education, work, and social activities, a higher cognitive reserve acts like a buffer, helping the brain adapt to stress and aging. While research shows that a high cognitive reserve protects against conditions like dementia, we still do not fully understand how it helps older adults bounce back from normal, everyday physical and mental exhaustion.\n\nThe goal of this study is to investigate how cognitive reserve levels influence how individuals aged 65 and older perceive their recovery after experiencing physical and mental fatigue.\n\nWhat the Study Involves\n\nThe researchers will evaluate participants aged 65 and older to measure their baseline cognitive reserve levels. The study will look closely at how these levels affect the participants':\n\nAbility to cope with daily physical and mental fatigue. Need for rest and rest patterns. Time and ability to return to normal daily activities. Overall perception of their mental and physical recovery. Expected Outcome By understanding this relationship, the study aims to fill a gap in medical literature and help healthcare providers design better, more personalized rehabilitation and lifestyle support programs to improve the quality of life for older adults.",[26,27,28,29,30],"Cognitive Reserve","Aging","Mental Fatigue","Fatigue","Recovery of Function",[32,33,34,35],"aging","cognitive reserve","fatigue","Post-Fatigue Recovery","RECRUITING","2026-06-19",{"date":39,"type":40},"2026-06-25","ACTUAL",{"date":42,"type":40},"2026-06-20",{"date":44,"type":22},"2026-09-22",{"name":46,"class":47},"Uşak University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":18,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100636679","effectiveness-of-vr-rehabilitation-for-people-with-asymmetrical-gait-patterns-100636679","NCT07568821","Effectiveness of VR Rehabilitation for People With Asymmetrical Gait Patterns","Evaluation of the Effectiveness of Rehabilitation in Patients With Gait Pattern Asymmetry Using a Virtual Reality","Inclusion Criteria:\n\n* Diagnosed and clinically confirmed gait pattern asymmetry in the course of neurological diseases\n* Informed consent to participate in the study and willingness to comply with rehabilitation recommendations\n\nExclusion Criteria:\n\n* Active rheumatic diseases, cancer, advanced diabetes, cardiovascular diseases, and other conditions that may affect the safety and effectiveness of rehabilitation\n* Contraindications to VR therapy (epilepsy, motion sickness, dizziness, nausea)\n* Lower limb injuries or surgeries within the last 6 months\n* Severe mental disorders preventing understanding of instructions\n* Lack of informed consent to participate in the study","20 Years",{"count":58,"type":22},40,"INTERVENTIONAL",[61],"NA","A randomized comparative study will be conducted to evaluate the rehabilitation process using a VR-based application versus conventional therapy in 40 patients (sample size determined using a sample size calculator). After meeting the eligibility criteria, participants will be randomly assigned to two groups: the experimental group (20 patients with gait pattern asymmetry), performing a gait training program using a VR rehabilitation application, and the control group (20 patients with gait pattern asymmetry), performing only a conventional gait training program.\n\nParticipants in both groups will take part in a 2-week rehabilitation program (Monday to Friday), with daily training sessions lasting up to 2 hours. Patient assessment will be conducted twice: an initial evaluation before the start of the intervention (Assessment I) and a follow-up evaluation after completion of the 2-week program (Assessment II), at the same time of day, under the same conditions, and using the same measurement tools.",[64,30,65],"Disability Evaluation","Rehabilitation","NOT_YET_RECRUITING","2026-05-05",{"date":69,"type":40},"2026-05-11",{"date":71,"type":22},"2027-03-01",{"date":73,"type":22},"2027-08-01",{"name":75,"class":47},"University of Rzeszow",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":59,"phases":87,"briefSummary":88,"conditions":89,"keywords":99,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":4},"100631668","cabg-ai-supported-discharge-education-100631668","NCT07503678","CABG-AI-Supported Discharge Education","The Effect of Artificial Intelligence-Supported Individualized Discharge Education on Postoperative Pain, Anxiety, Stress Response, Recovery, and Discharge Education Satisfaction in Patients Undergoing Coronary Artery Bypass Graft Surgery: A Randomized Controlled Trial","AI-D-E-CABG","Inclusion Criteria:\n\n* Patients who have undergone coronary artery bypass graft (CABG) surgery.\n* Age 18 years or older.\n* Hemodynamically stable at the time of enrollment.\n* Able to understand and communicate in Turkish.\n* Able to use or have access to a mobile phone capable of viewing the educational video.\n* Able to provide informed consent.\n* Scheduled for routine postoperative follow-up at the study hospital.\n\nExclusion Criteria:\n\n* Patients undergoing emergency CABG surgery.\n* Presence of severe cognitive impairment that prevents understanding or following instructions.\n* Diagnosed psychiatric disorders (e.g., schizophrenia, severe depression) that interfere with study participation.\n* Severe vision or hearing impairment that prevents receiving the education.\n* Presence of postoperative complications requiring intensive care readmission.\n* Patients with endocrine disorders affecting stress biomarkers (e.g., Cushing's syndrome, Addison's disease).\n* Chronic use of corticosteroids or medications that significantly alter cortisol levels.\n* Patients who decline to participate or withdraw consent.\n* Patients who are unable to complete follow-up assessments.","18 Years",{"count":86,"type":22},128,[61],"This randomized controlled trial will evaluate the effectiveness of artificial intelligence-supported individualized discharge education for patients undergoing coronary artery bypass graft (CABG) surgery. Participants will be assigned to either the intervention group, which will receive personalized AI-generated discharge education delivered through a nurse-avatar video in addition to standard verbal education, or the control group, which will receive standard discharge education only. The study will compare postoperative pain, anxiety, physiological stress response, recovery, and satisfaction with discharge education between the two groups. Outcomes will be measured during hospitalization and at the routine postoperative follow-up visit. The findings may help improve patient education methods and postoperative recovery in cardiac surgery patients.",[90,91,92,30,93,94,95,96,97,98],"Coronary Artery Disease","Postoperative Care","Patient Discharge","Anxiety","Pain","Stress, Physiological","Surgical Nursing","Nursing","Discharge Education",[90,91,92,100,96],"discharge education","2026-03-25",{"date":103,"type":40},"2026-03-31",{"date":105,"type":22},"2026-06-01",{"date":107,"type":22},"2027-02-01",{"name":109,"class":47},"Hasan Kalyoncu University",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":59,"phases":119,"briefSummary":120,"conditions":121,"keywords":124,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":136},"100571776","tapering-heart-failure-medication-in-patients-with-heart-failure-with-recovered-ejection-fraction-open-label-prospective-random-trial-100571776","NCT06724653","Tapering Heart Failure Medication in Patients With Heart Failure With Recovered Ejection Fraction; Open Label Prospective Random Trial","HFrecEF","Inclusion Criteria:\n\n* initial echocardiogram ejection fraction less than 40%\n* follow up echocardiogram ejection fraction over 50% and LVEDD index normal range\n* NTprobnp criteria\n\n  1. eGFR ≥60 ; less 440\n  2. eGFR 45-59: less 980\n  3. eGFR 30-44; less 1220\n  4. eGFR \\\u003C 30 : less 5300\n  5. in HD; no criteria for NTproBNP\n* on more than 3 heart failure medication ( RAS blocker, beta blocker, mineral corticoid receptor antagonist, SGLT 2 inhibitor)\n\nExclusion Criteria:\n\n1. under age 18 year\n2. uncontrolled BP ( over 150\u002F90)\n3. coronary revascularization within 6 months\n4. significant valve disease\n5. arrhythmia requiring rate control\n6. CKD with albuminuria ( over 30mg\u002Fg)\n7. Pregnancy",{"count":118,"type":22},150,[61],"Study start date is on Nov 27th 2024.\n\nA patient with an initial ejection fraction (EF) of less than 40%, whose follow-up shows an improvement to an EF of 50% or higher, along with the left ventricular end-diastolic diameter returning to the normal range and taking 3 more heart failure medication randomed to drug tapering group ( RAS blocker or beta blocker) or continuing medication group.",[122,123,30],"Heart Failure","Ejection Fraction",[125,126],"heart failure with recovered ejection fraction","Tapering","2026-03-23",{"date":129,"type":40},"2026-03-27",{"date":131,"type":40},"2025-03-06",{"date":133,"type":22},"2027-11-26",{"name":135,"class":47},"Chungnam National University Hospital",2,{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":18,"enrollmentInfo":144,"targetDuration":4,"studyType":59,"phases":146,"briefSummary":148,"conditions":149,"keywords":156,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":48},"100452609","phase-4-rehabilitation-for-survivors-of-out-of-hospital-cardiac-arrest-100452609","NCT05173740","Rehabilitation for Survivors of Out-of-hospital Cardiac Arrest","The ROCK Trial. A Multidisciplinary Rehabilitation Intervention Targeted Return-to-work in Sudden Out-of-hospital Cardiac Arrest Survivors A Pragmatic Randomised Controlled Trial","Inclusion criteria:\n\n* All adult survivors with first time out-of-hospital cardiac arrest\n* Discharged from the Hospitals will be assessed eligible for inclusion\n\nExclusion criteria:\n\n* Survivors who prior to the cardiac arrest were not part of the labour force with at least two years until they are qualified to receive retirement state pensions\n* Patients that cannot understand and fulfil the study surveys (in Danish)\n* Patients with short witnessed cardiac arrests with return of spontaneous circulation estimated less than 4 minutes and immediate awakening without ICU treatment",{"count":145,"type":22},214,[147],"PHASE4","This study is a parallel group multicentre investigator-initiated clinical randomised controlled superiority trial that will include a total of 214 survivors of OHCA.\n\nParticipants will to be randomized with a 1:1 allocation ratio to either a intervention consisting of a comprehensive initiated tailored rehabilitation intervention focusing on supporting RTW plus usual care compared to usual care alone.",[150,151,152,153,154,65,30,155],"Cardiac Arrest","Heart Arrest","Cardiopulmonary Resuscitation","Return to Work","Return-to-work","Cardiac Rehabilitation",[157,158,151,152,159,154,160,65,30,155],"Labour marked","Cardiac arrest","Return to work","Back to Work","2025-12-01",{"date":163,"type":40},"2025-12-08",{"date":165,"type":40},"2022-02-01",{"date":167,"type":22},"2028-07-31",{"name":169,"class":47},"Rigshospitalet, Denmark",{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":4,"eligibilityCriteria":176,"healthyVolunteers":16,"sex":177,"minAge":178,"maxAge":179,"enrollmentInfo":180,"targetDuration":4,"studyType":59,"phases":182,"briefSummary":183,"conditions":184,"keywords":186,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":194,"leadSponsor":196,"locationsCount":4},"100586870","can-lower-body-occlusion-influence-sports-recovery-100586870","NCT06921005","Can Lower-body Occlusion Influence Sports Recovery?","Can Lower-body Occlusion During Low-intersity Cycling Influence Recovery of Youth Elite Soccer Players?","Inclusion Criteria:\n\n* soccer players\n* elite athletes\n* present in the pitch training sessions\n\nExclusion Criteria:\n\n* injured athletes\n* female athletes","MALE","17 Years","23 Years",{"count":181,"type":22},15,[61],"This study ai ms to compare the recovery kinetics of different interventions: i) active recovery; ii) continuous vascular occlusion during active recovery; iii) intermittent vascular occlusion during active recovery; iv) control group.",[30,185],"Sports",[187,188,189],"sports","recovery","blood flow restriction","2025-04-02",{"date":192,"type":40},"2025-04-10",{"date":192,"type":22},{"date":195,"type":22},"2025-06-20",{"name":197,"class":47},"University of Maia",{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":202,"acronym":4,"eligibilityCriteria":203,"healthyVolunteers":16,"sex":17,"minAge":84,"maxAge":4,"enrollmentInfo":204,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":205,"conditions":206,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":48},"100358617","effects-of-exercise-therapy-and-soft-brace-on-knee-osteoarthritis-100358617","NCT03949400","Effects of Exercise Therapy and Soft Brace on Knee Osteoarthritis","Inclusion Criteria:\n\nAssigned for exercise and education due to knee osteoarthrosis Age 18 years or older at the time of recruitment Able to read and understand Danish\n\nExclusion Criteria:\n\nNot mentally able to reply to the questionnaire",{"count":58,"type":22},"The primary aim of the study is to investigate the effects of supervised exercise therapy and education on the immediate response to using a soft knee brace in patients with knee osteoarthritis (OA).",[65,207,94,208,209,30,210,211,212],"Treatment Outcome","Knee Brace","Outcome Assessment (Health Care)","Patient Reported Outcome Measures","Adults","Osteoarthritis, Knee","2019-05-10",{"date":215,"type":40},"2019-05-14",{"date":217,"type":40},"2018-04-24",{"date":219,"type":22},"2029-05-20",{"name":221,"class":47},"University College of Northern Denmark"]