[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"recovery-time\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:recovery-time":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,53,89,121,146,170],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":35,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100643122","the-effects-of-anesthesia-on-postoperative-cognitive-functions-in-patients-undergoing-sleeve-gastrectomy-100643122",false,"NCT07637357","The Effects of Anesthesia on Postoperative Cognitive Functions in Patients Undergoing Sleeve Gastrectomy","The Effects of Total Intravenous Anesthesia and Inhalational Anesthesia on Postoperative Cognitive Functions in Patients Undergoing Sleeve Gastrectomy","Inclusion Criteria:\n\nPatients of both sexes, Patients Aged between 18 and 65 years, Patients classified as ASA(American Society of Anesthesiologists) physical status I- III, Patients with a BMI (Body Mass Index) between 35 and 50 kg\u002Fm² scheduled to undergo sleeve gastrectomy as a type of bariatric surgery for the first time.\n\nExclusion Criteria:\n\nPatients classified as ASA physical status 4 or high, Patients with known allergy to any of the drugs used in the study, Patients with bleeding disorders, Patients with serum creatinine levels \\>2 mg\u002FdL, Patients with severe arrhythmias and EF\\\u003C30%, Patients with a known history of drug abuse are excluded.","ALL","18 Years","65 Years",{"count":20,"type":21},60,"ESTIMATED","3 Months","OBSERVATIONAL","In this study, the investigators want to examine the effects of intravenous anesthetic drugs and gases on cognitive functions in the postoperative period in individuals who will undergo surgery for obesity. The investigators believe that the anesthesia method we apply with inhalation gases is also as reliable method as total intravenous anesthesia for postoperative cognitive functions in these patients who undergoe sleeve gastrectomy.\n\nThe anesthesia method applied intravenously and with inahalational gases have been applied safely for many years. Comparisons between these two anesthesia technics in obese individuals and for postoperative cognitive dysfunctions are limited.\n\nStudies on the examination of cognitive functions in postoperative patients have gained momentum with the use of neuropsychiatric tests performed on patients who have undergone cardiac surgery and these tests have also been performed on individuals who have undergone non-cardiac surgery. And yet, similar declines in cognitive functions have been observed. For these reasons, the effects of surgery itself and anesthesia methods on cognitive functions have been studied up to date.\n\nIn this study, the investigators plan to evaluate patients who will undergo obesity surgery in both anesthesia methods by the recovery times from anesthesia and the residual effects of anesthesia, and after awakening they plan to evaluate their cognitive functions with neuropsychiatric tests that will be performed at certain intervals.",[26,27,28,29,30,31,32,33,34],"POCD - Postoperative Cognitive Dysfunction","Recovery Time","Postoperative Neurocognitive Disorder","Postoperative Delirium","Bariatric Sleeve Gastrectomy","Delayed Neurocognitive Recovery","Total Intravenous Anesthesia","Inhalational Anesthesia","Cognitive Functions",[36,37,38,39],"total intravenous anesthesia","inhalational anesthesia","sleeve gastrectomy","postoperative cognitive dysfunctions","RECRUITING","2026-06-04",{"date":43,"type":44},"2026-06-09","ACTUAL",{"date":46,"type":44},"2025-09-30",{"date":48,"type":21},"2026-07-30",{"name":50,"class":51},"Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":16,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":74,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":52},"100621323","phase-4-propofol-only-versus-dexmedetomidine-propofol-in-children-undergoing-magnetic-resonance-imaging-100621323","NCT07369128","Propofol-Only Versus Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging","A Randomized, Dose-Ranging Trial of Propofol-Only and Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging","Inclusion Criteria:\n\n* Patients presenting as outpatients, scheduled to receive an anesthetic for MRI of brain, body (spine, chest, abdomen, and\u002For pelvis) and\u002For extremity (arm and\u002For leg).\n* Patients must be a candidate for the sedation technique described in this study with a natural airway. This decision will be made by a staff member of the Department of Anesthesiology.\n* Between 1 and 12 years of age.\n* ASA status I, II, or III\n\nExclusion Criteria:\n\n* Inpatient at BCH\n* Diagnosis of a difficult airway, severe obstructive sleep apnea that is not compatible with spontaneous ventilation in a supine position, or requires an oral airway.\n* Congenital heart disease or history of dysrhythmia.\n* Taking digoxin or beta-blocker\n* Anxiolytic medication is ordered before the MRI (e.g., midazolam or ketamine).\n* History or a family (parent or sibling) history of malignant hyperthermia.\n* Allergy to or has a contraindication to propofol, lidocaine, or dexmedetomidine.\n* Tracheostomy or other mechanical airway device present\n* Received within the past 12 hours an oral or intravenous alpha-adrenergic, beta-adrenergic agonist, or antagonist drugs (e.g., clonidine, propranolol, albuterol).\n* Patient is not scheduled to receive anesthesia-sedation care or is noted to \"try-without anesthesia\" for the MRI\n* Patient has significant developmental or psychological delays\n* Patient scheduled for scan of duration \\\u003C30 minutes or \\>90 minutes","1 Year","12 Years",{"count":63,"type":21},105,"INTERVENTIONAL",[66],"PHASE4","The most common imaging procedure requiring sedation\u002Fanesthesia for the pediatric population is magnetic resonance imaging (MRI). However, the optimal anesthetic\u002Fsedation plan has not been determined for these procedures. Historically, common medications have included the use of pentobarbital and propofol, but in 2015, publication in the New England Journal of Medicine highlighted the accumulating evidence for the possible neurotoxic effects of these types of anesthetics in animal models and a collection of epidemiologic studies in humans. Although these initial possibilities have since been proven as less of a concern, in the interim, data has shown that alternative sedative agents, such as dexmedetomidine, may not have the same neurotoxic effect and could possibly even provide neuroprotection. Dexmedetomidine also possesses other beneficial traits such as reducing risks of pulmonary atelectasis or upper airway collapse, typically found with the administration of propofol.\n\nA concern raised by previous studies has been the possibility that the addition of dexmedetomidine could increase recovery times, leading to disruptions in workflow. Although it has been shown that large doses of dexmedetomidine exposure may lead to longer PACU stays, it is uncertain whether a small dose of dexmedetomidine would have such a significant impact. Based on the investigators' pilot trial6, the investigators found that a bolus of 1 mcg\u002Fkg dose of dexmedetomidine with a bolus of titrated propofol of 2-3 mg\u002Fkg and an infusion of propofol of 100 mcg\u002Fkg\u002Fmin provided adequate sedation for successful scans, reduced propofol (infusion) exposure by 60%, and did not significantly increase recovery times.\n\nFinally, there is a paucity in literature for studies examining a range of doses subsequently; often, a control group is compared to a single, self-selected dose of choice. Here, the investigators hope to provide a range of doses to minimize selection bias in our study design and determine the dose that would provide the optimal sedation for these scans and minimize excess anesthetic exposure.",[69,70,71,72,27,73],"MRI Sedation","Pediatric Sedation","Propofol Dosage","Emergence Delirium, Anesthesia","Dexmedetomidine",[75,76,77,78,79],"pediatrics","sedation","dexmedetomidine","propofol","MRI","2026-05-27",{"date":82,"type":44},"2026-05-29",{"date":84,"type":21},"2026-06",{"date":86,"type":21},"2028-03",{"name":88,"class":51},"Boston Children's Hospital",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":96,"sex":97,"minAge":17,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":64,"phases":101,"briefSummary":103,"conditions":104,"keywords":106,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":52},"100589098","effects-of-blood-flow-restriction-on-post-exercise-recovery-in-amateur-runners-100589098","NCT06949995","Effects of Blood Flow Restriction on Post-Exercise Recovery in Amateur Runners","Effects of Blood Flow Restriction on Post-Exercise Recovery in Amateur Runners: A Stratified Randomized Controlled Trial","Inclusion Criteria:\n\n* Individuals who present one or more of the following characteristics will not be included:\n* 1 presence of any health condition that contraindicates or prevents exercise;\n* 2 diabetes and diagnosed high blood pressure;\n* 3 inflammatory, psychiatric, cardiovascular and\u002For respiratory rheumatological disease; - -4 being dependent on alcohol, consuming drugs and\u002For being a smoker;\n* 5 history of knee surgery (e.g., meniscal repair and ligament reconstruction) or recent lower limb musculoskeletal injury that may impair performance during tests or interventions (e.g., muscle injury, tendinopathy, patellofemoral pain and\u002For back pain column in the last six months);\n* 6 use of ergogenic supplements to improve physical performance and\u002For muscle mass and\u002For vasoactive medications;\n* 7 having one or more risk factors predisposing to thromboembolism\n\nExclusion Criteria:\n\n* Participants will be excluded from the study if they:\n* 1 have a health problem that does not allow them to continue;\n* 2 wish to leave the study;\n* 3 not sign the consent form",true,"MALE","40 Years",{"count":100,"type":21},34,[102],"NA","Street running has become an increasingly popular sport. As a result, effective recovery strategies after exercise are essential. In this context, two techniques stand out: one already validated, active recovery (AR), and another with potential, blood flow restriction (BFR). This study aims to investigate whether using both techniques simultaneously can benefit practitioners and improve outcomes compared to complete rest.",[105,27],"Recovery Methods",[107,108,109,110,111],"Running","physiological stress","functional physical performance","post-exercise recovery techniques","blood flow restriction therapy","2026-05-13",{"date":114,"type":44},"2026-05-14",{"date":116,"type":44},"2025-10-27",{"date":118,"type":21},"2026-12",{"name":120,"class":51},"Paulista University",{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":64,"phases":130,"briefSummary":131,"conditions":132,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":142,"leadSponsor":144,"locationsCount":52},"100634198","sublingual-caffeine-on-reducing-recovery-time-and-postoperative-agitation-in-elderly-patients-undergoing-general-anesthesia-100634198","NCT07536568","Sublingual Caffeine on Reducing Recovery Time and Postoperative Agitation in Elderly Patients Undergoing General Anesthesia","Efficacy of Sublingual Caffeine on Reducing Recovery Time and Postoperative Agitation in Elderly Patients Undergoing General Anesthesia: A Double-Blind Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 65 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status II.\n* Scheduled for elective ophthalmology surgery under general anesthesia.\n\nExclusion Criteria:\n\n* History of severe cardiac arrhythmias or uncontrolled hypertension.\n* ASA III patients were excluded to reduce the risk of adverse events in elderly patients with severe systemic diseases.\n* Known allergy or hypersensitivity to caffeine.\n* Pre-existing cognitive impairment or dementia (All patients will undergo preoperative cognitive screening using the online Mini-Cog test or Montreal Cognitive Assessment \\[MoCA\\]).\n* History of seizures or epilepsy.\n* History of alcohol or drug abuse.\n* Chronic use of CNS stimulants or sedatives.\n* Emergency surgeries.\n* Prolonged procedures for more than 3 hours.",{"count":129,"type":21},50,[102],"This study aims to evaluate the efficacy of sublingual caffeine in reducing recovery time and incidence of postoperative agitation in elderly patients undergoing general anesthesia.",[133,134,27,135,136,137],"Sublingual","Caffeine","Postoperative Agitation","Elderly Patients","General Anesthesia","2026-04-18",{"date":140,"type":44},"2026-04-21",{"date":138,"type":44},{"date":143,"type":21},"2026-08-30",{"name":145,"class":51},"Cairo University",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":96,"sex":16,"minAge":17,"maxAge":153,"enrollmentInfo":154,"targetDuration":4,"studyType":64,"phases":156,"briefSummary":157,"conditions":158,"keywords":160,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":169,"locationsCount":52},"100619285","effect-of-blood-flow-restriction-on-recovery-after-maximal-resistance-exercise-100619285","NCT07342634","Effect of Blood Flow Restriction on Recovery After Maximal Resistance Exercise","Effect of Blood Flow Restriction on Recovery After Maximal Resistance Exercise: a Controlled Clinical Trial","Inclusion Criteria:\n\n* Individuals exhibiting one or more of the following characteristics will not be included:\n* (1) diabetes and hypertension;\n* (2) inflammatory rheumatological, psychiatric, cardiovascular and\u002For respiratory disease;\n* (3) pre-existing injury restricting their ability to perform vigorous physical activities;\n* (4) having one or more predisposing risk factors for thromboembolism.\n\nExclusion Criteria:\n\n* Participants will be excluded from the study if they:\n* (1) have a health problem that does not allow them to continue;\n* (2) wish to leave the study;\n* (3) use medications, electrotherapy, or other therapeutic methods during the study period that could interfere with any results;\n* (4) not sign the consent form.","35 Years",{"count":155,"type":21},80,[102],"Resistance training has been widely performed due to its health benefits. However, performing this training at high intensity causes significant muscle stress, leading to fatigue and compromising performance. It is essential to implement effective recovery strategies to optimize physiological adaptations. Among the accessible techniques, blood flow restriction (BFR) has shown promise for its potential to accelerate muscle recovery.",[159,27],"Recovery",[161,108,162,111,109],"Resistance training","post-exercise recovery","2026-01-05",{"date":165,"type":44},"2026-01-15",{"date":167,"type":21},"2026-02-01",{"date":118,"type":21},{"name":120,"class":51},{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":4,"eligibilityCriteria":176,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":177,"enrollmentInfo":178,"targetDuration":4,"studyType":64,"phases":179,"briefSummary":182,"conditions":183,"keywords":186,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":52},"100577142","phase-1-recovery-times-of-half-dose-sugammadex-and-neostigmine-for-rocuronium-induced-neuromuscular-blockade-100577142","NCT06794450","Recovery Times of Half Dose Sugammadex and Neostigmine for Rocuronium-induced Neuromuscular Blockade","Comparison of Recovery Times Between 1 mg\u002Fkg Sugammadex and 60 mcg\u002Fkg Neostigmine for Moderate Neuromuscular Blockade Induced by Rocuronium in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients who underwent laparoscopic cholecystectomy under general anesthesia\n* Using muscle relaxant rocuronium\n* Aged 18-59 years\n* American Society of Anesthesiologists (ASA) physical status classification of 1 or 2.\n\nExclusion Criteria:\n\n* History of drug allergies to the agents used\n* Renal dysfunction\n* Musculoskeletal disorders\n* Central nervous system disorders\n* Difficult airways requiring intubation without the use of muscle relaxants.","59 Years",{"count":20,"type":21},[180,181],"PHASE1","PHASE2","In operating procedure with general anesthesia muscle relaxant is usually used to increase success rate of the operation and to give better outcome. The use of reversal drugs aims to reduce the risk of post-operative complications due to muscle relaxants. Neostigmine is commonly used as a reversal drug, but its indirect mechanism of action results in a long and unpredictable recovery time. Sugammadex directly bind and inactivate rocuronium, in which resulting in a faster and predictable recovery time. However, the high price limits the use of sugammadex.\n\nThis study aims to compare the effect of half dose sugammadex and neostigmine against the moderate neuromuscular blockade of rocuronium.\n\nThe main questions it aims to answer are:\n\nDoes half dose sugammadex gives faster recovery time? Researchers will compare sugammadex to neostigmine to see if sugammadex gives faster recovery time.\n\nParticipants will:\n\nBe given sugammadex or neostigmine as a reversal drug after the operation done",[184,185,27],"Neuromuscular Blocking Agents","Reversal of Neuromuscular Blockade",[187,188,189],"Sugammadex","Neostigmine","recovery time from neuromuscular blockade","2025-01-25",{"date":192,"type":44},"2025-01-28",{"date":194,"type":44},"2024-11-05",{"date":196,"type":21},"2025-02",{"name":198,"class":51},"Universitas Padjadjaran"]