[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"recovery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:recovery":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,21,0,[8,60,98,135,156,187,216,246,279,306,331,366,411,440,469,496,523,548,572,597,623],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":40,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":59},"100644951","the-impact-of-enhanced-music--natural-visuals-on-emotional-health-100644951",false,"NCT07676110","The Impact of Enhanced Music & Natural Visuals on Emotional Health","Impacts of Music, Audio Enhancements, Audio Guidance, and Visuals on Physical and Emotional Well-being. (Emotional Health - Longitudinal 1 Randomized, Controlled Multi-center Study)","Inclusion Criteria:\n\n* You are 13 years of age or older\n* You can read, write, and speak English at a 5th-grade level or higher\n* You are legally capable of providing informed consent (adult participants) or capable of providing assent (child participants)\n* To the best of your knowledge, you are willing and able to commit to the session(s) and activities of this study\n* You are willing and able to use the sound-delivery and data-collection apparatus of this study\n* You are willing to use your own personal equipment. Depending on the study, you may need to have your own ear buds\u002Fheadphones and\u002For a \"smart\" device with internet and\u002For Bluetooth access (e.g., smartphone, iPad).\n* You have normal hearing in both ears.\n* You never experience ringing noises or buzzing sensations in your ears (tinnitus)\n* You do not use a heart\u002Fcardiac pacemaker and do not have any history of cardiac rhythm disturbances, such as cardiac conduction delays or blocks\n* You have no known history of fainting, fainting, spells or seizures, spinning sensations, or trouble with balance (medical terms include epilepsy, seizures, syncope, vertigo, nystagmus)\n* You do not use of any of the following medications: Beta blockers, steroids, ephedrine, acute anti-anxiety medication (e.g., benzodiazepines such as diazepam\u002FValium, lorazepam\u002FAtivan or clonazepam\u002FKlonopin), or acute or chronic pain medications (including narcotics and codeine)\n* For any study session, you will not be under the influence of any substances that could prevent safe participation and will not have consumed e.g., alcohol, THC, Psilocybin, or other mood-altering drugs in the 12 hours preceding the session.\n\nExclusion Criteria:\n\n\\-",true,"ALL","13 Years",{"count":20,"type":21},200,"ESTIMATED","INTERVENTIONAL",[24],"NA","The investigators are conducting research on factors related to the self-regulation of mood and arousal states across a range of everyday activities as well as different levels of stress. Behavioral interventions-such as meditation, listening to music, or visualizing art or nature-offer important alternatives and\u002For adjunctive strategies to pharmaceutical tools or other mechanisms supporting physical and emotional well-being. This research will expand on the knowledge base regarding the impact of biophysical stimulation and\u002For frame of mind on an individual's self-directed management of physical and emotional health. Motivation, confidence, and composure are critical aspects of self-efficacy, framing a person's mindset to make healthy choices across daily activities.\n\nThe research in this protocol is carried out across multiple sites and studies by means of digital tools and a consistent participant experience workflow. Together, these resources are intended to support individuals across multiple self-directed experiences utilized in the maintenance of their basic health. Before, during, and after session experiences, the participant provides objective (physiological) responses and\u002For subjective (self-report) responses and reflections; some studies also include interviews or focus groups. The combined set of responses can be summarized, connected to other measures, and input to machine learning models to improve personalization of stimuli. By studying the effects of soundBrilliance experiences across a variety of contexts and participant samples, the investigators can better refine each element of the stimulus to improve satisfaction, tolerance, and targeted outcomes.",[27,28,29,30,31,32,33,34,35,36,37,38,39],"Emotion Management Skills","Lifestyle, Healthy","Lifestyle Intervention","Recovery","Exercise and Recovery","Exercise Training","Anxiety and Mood Disorders","Sleep","Motivation","Comfort","Pain Management","Rehabilitation","Creativity and Mindfulness",[41,42,43,44,45,46],"Music","Visuals","Visual Imagery","Biophysical Stimuli","Emotional Health","Emotional Management","RECRUITING","2026-06-23",{"date":50,"type":51},"2026-06-30","ACTUAL",{"date":53,"type":51},"2026-05-25",{"date":55,"type":21},"2027-06",{"name":57,"class":58},"soundBrilliance LLC","INDUSTRY",3,{"id":61,"slug":62,"hasResults":11,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":16,"sex":17,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":4,"studyType":22,"phases":72,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":94,"locationsCount":97},"100643145","ucla-magnesium-formulation-athlete-study-100643145","NCT07640685","UCLA Magnesium Formulation Athlete Study","Effects of Magnesium Glycinate and Magnesium L-Threonate on Sleep, Recovery, and Performance in Collegiate Athletes","Mg-Form","Inclusion Criteria:\n\n* Age 18 to 35 years.\n* Current UCLA varsity athlete.\n* Actively training or competing during the study period.\n* Willing to wear WHOOP or a study-approved wearable device continuously during baseline and treatment periods if wearable data are used.\n* Willing to take assigned study capsules nightly for 28 days.\n* Willing to complete brief daily REDCap surveys and weekly adherence\u002Fsafety check-ins.\n* Able to provide informed consent and comply with study procedures.\n\nExclusion Criteria:\n\n* Current magnesium supplementation without completion of an appropriate washout before baseline.\n* Current investigational drug or investigational supplement use.\n* Current use of prescription or over-the-counter sleep medications unless reviewed and permitted by the study clinician.\n* Diagnosed sleep disorder that, in the investigator's judgment, would confound outcomes or increase risk.\n* Significant kidney disease or another medical condition that may increase risk with magnesium supplementation.\n* Known intolerance or allergy to magnesium glycinate, magnesium L-threonate, placebo, or inactive study ingredients.\n* Use of medications with clinically relevant magnesium interactions unless reviewed and permitted by the study clinician.\n* Any other condition that, in the investigator's judgment, would make participation unsafe, compromise voluntary consent, or prevent valid outcome assessment.","18 Years","35 Years",{"count":71,"type":21},150,[24],"This randomized, double-blind, placebo-controlled trial will compare magnesium glycinate, magnesium L-threonate, and placebo in UCLA varsity athletes. Participants will complete a baseline monitoring period followed by 4 weeks of blinded nightly supplementation. WHOOP or study-approved wearable data will be used to evaluate sleep efficiency, total sleep time, sleep consistency, heart rate variability, resting heart rate, and recovery metrics. Baseline and final testing will assess selected reaction and physical performance outcomes. The primary outcome is change in WHOOP-derived sleep efficiency from baseline week to final treatment week.",[75,30,34],"Athletic Performance",[77,78,79,80,81,82,83,84,85,86],"magnesium glycinate","magnesium L-threonate","collegiate athletes","sleep duration","athlete recovery","WHOOP","heart rate variability","reaction time","placebo-controlled trial","dietary supplement","NOT_YET_RECRUITING","2026-06-05",{"date":90,"type":51},"2026-06-11",{"date":92,"type":21},"2026-07",{"date":55,"type":21},{"name":95,"class":96},"University of California, Los Angeles","OTHER",1,{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":16,"sex":105,"minAge":68,"maxAge":106,"enrollmentInfo":107,"targetDuration":4,"studyType":22,"phases":109,"briefSummary":110,"conditions":111,"keywords":116,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":97},"100638836","whey-protein-and-adaptogenic-supplementation-in-physically-active-females-100638836","NCT07594444","Whey Protein and Adaptogenic Supplementation in Physically Active Females","Whey Protein and Adaptogenic Herb Supplementation in Physically Active Females: A Randomised Controlled Trial","Inclusion Criteria:\n\n* Female, aged 18-45 years\n* Currently participating in regular structured athletic or physical training (≥3 sessions per week)\n* Free from musculoskeletal injury that would prevent testing\n* Willing to maintain usual diet and training habits during the study\n* Not currently using protein supplements or adaptogenic supplements\n\nExclusion Criteria:\n\n* Pregnant, breastfeeding, or planning pregnancy during the study period\n* Known allergy or sensitivity to dairy, pea protein, pumpkin seed, chia seed, ashwagandha, shatavari, or nightshades\n* Current use of prescribed medication that may interact with the supplements\n* Thyroid disorders, autoimmune conditions, hormone-sensitive conditions, or other medical conditions that may be affected by supplementation\n* Diagnosed eating disorder or condition affecting protein metabolism\n* Current musculoskeletal injury preventing participation in testing\n* Current use of other protein supplements or adaptogens","FEMALE","45 Years",{"count":108,"type":21},60,[24],"The goal of this clinical trial is to learn whether whey protein or plant protein supplements, with or without an adaptogenic herb blend, can improve strength, recovery, stress, and wellbeing in active females. The adaptogenic blend contains ashwagandha root extract and shatavari root extract.\n\nThe main questions the study aims to answer are:\n\n* Do whey protein and plant protein supplements improve muscle strength and recovery in physically active females?\n* Does adding ashwagandha and shatavari improve stress, recovery, sleep, and wellbeing compared with protein alone?\n* Are there differences between whey protein and plant protein when combined with the adaptogenic blend?\n\nResearchers will compare four supplement groups:\n\n* Whey protein\n* Whey protein with ashwagandha and shatavari\n* Plant protein\n* Plant protein with ashwagandha and shatavari\n\nParticipants will:\n\n* Take their assigned supplement daily for 6 weeks\n* Attend testing sessions before and after the intervention\n* Complete questionnaires about recovery, sleep, stress, soreness, and digestive health\n* Provide saliva samples to measure stress, hormone, immune, and inflammation markers\n* Complete muscle strength tests, including handgrip strength and push-up testing\n* Complete a 24-hour dietary recall. The study includes physically active females aged 18 to 45 years who regularly participate in structured training.",[112,30,113,114,115],"Sports Nutritional Sciences","Muscle Strength Recovery","Muscle Strength","Supplements",[117,118,119,120,121,122,123,124,125],"Whey Protein","Plant protein","Ashwagandha","Shatavari","Adaptogens","Sports","Exercise","Active females","physically active females","2026-06-03",{"date":88,"type":51},{"date":129,"type":21},"2026-07-01",{"date":131,"type":21},"2026-09-20",{"name":133,"class":134},"Sports Performance and Applied Research in Trials and Analysis","NETWORK",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":17,"minAge":68,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":143,"phases":4,"briefSummary":144,"conditions":145,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":97},"100425752","the-role-of-wearable-devices-in-predicting-and-detecting-complications-and-adverse-events-100425752","NCT04824066","The Role of Wearable Devices in Predicting and Detecting Complications and Adverse Events","Inclusion Criteria:\n\n1. Age 18 years or older\n2. Individuals scheduled to undergo one of the following surgical or non-surgical treatments: cardiothoracic surgery, orthopedic surgery, vascular surgery, colorectal surgery, pancreatic surgery, other major abdominal surgeries, treatment for chronic disease, or systemic therapy (i.e., chemotherapy, immunotherapy, or targeted therapy), radiotherapy, or ablation.\n3. Amenable to using one of the wearable devices of interest (Fitbit, iWatch, Biostrap).\n4. Individuals willing to provide informed consent and who have capacity for all study procedures\n\nExclusion Criteria:\n\n1. Individuals with mental incapacity and\u002For cognitive impairment that would preclude adequate understanding of, or cooperation with the study protocol.\n2. Any pregnant participant.",{"count":142,"type":21},2400,"OBSERVATIONAL","The overarching goal of this research is to use machine learning analysis of high-resolution data-collected by wearable technology-to predict complications and poor recovery in patients undergoing treatment for benign or malignant conditions.",[30,146],"Treatment Complication","2026-05-24",{"date":149,"type":51},"2026-05-28",{"date":151,"type":51},"2021-07-10",{"date":153,"type":21},"2029-06-30",{"name":155,"class":96},"Massachusetts General Hospital",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":162,"eligibilityCriteria":163,"healthyVolunteers":16,"sex":105,"minAge":68,"maxAge":4,"enrollmentInfo":164,"targetDuration":4,"studyType":22,"phases":166,"briefSummary":167,"conditions":168,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":186},"100626071","the-recover-study---postpartum-recovery-of-pelvic-floor-structures-and-the-impact-of-early-rehabilitation-100626071","NCT07430865","The RECOVER Study - Postpartum Recovery of Pelvic Floor Structures and the Impact of Early Rehabilitation","The RECOVER Study - Recovery of Pelvic Floor Structure and Function After Vaginal Childbirth- a Longitudinal Cohort Study With an Embedded Pilot Trial","RECOVER","Inclusion Criteria:\n\n* Individuals (over 18 years) who delivered a single child vaginally between 37 and 41 weeks of gestation, with a birthweight of at least 2500 grams.\n\nExclusion Criteria:\n\n* Delivered via c-section\n* Multiparous with previous third- or fourth-degree tears\n* History of major urogynecological surgery\n* Known neurological disorder (e.g., stroke, multiple sclerosis) that could affect the assessment outcomes\n* Severe connective tissue disorders that could affect the assessment outcomes\n* New pregnancy of more than 6 weeks during the study period\n* Pain with vaginal penetration, tampon use, or gynecological examinations that would prevent participation in assessments\n* Visible signs for wound complications assessed via REEDA tool (redness, oedema, ecchymosis, discharge, approximation) will exclude the participants from the first ultrasound assessment and vaginal palpation.",{"count":165,"type":21},380,[24],"The goal of this observational study with an embedded pilot clinical trial is to learn how the pelvic floor recovers after vaginal childbirth and whether early individualized pelvic floor muscle training can improve recovery in people who experience pelvic floor symptoms after vaginal delivery. The main questions it aims to answer are:\n\n* How do pelvic floor muscles and surrounding tissues change and recover during the first year after vaginal childbirth?\n* How are these structural changes and their recovery related to urinary, bowel, and vaginal symptoms?\n* In participants with pelvic floor symptoms after vaginal childbirth, does early individualized pelvic floor muscle training improve symptoms and support structural recovery compared with usual care?\n\nResearchers will compare participants who receive the early pelvic floor muscle training to those receiving standard postpartum care to see if the training helps improve pelvic floor function and reduce symptoms.\n\nParticipants will:\n\nAttend clinic visits at six weeks, and six months after childbirth\n\nComplete questionnaires about urinary, bowel, and vaginal symptoms, as well as physical activity and quality of life at six weeks, and four, six months, and twelve months after childbirth\n\nUndergo clinical pelvic floor assessments, including vaginal palpation of muscle strength, tone, and perineal body stability\n\nHave ultrasound examinations of the pelvic floor to assess muscle structure, tissue integrity, and perineal body morphology\n\nFor those in the pilot trial, participate in an early, individualized pelvic floor muscle training program\n\nThis study will provide important information about how the pelvic floor heals after childbirth, how structural changes are linked to symptoms, and whether early personalized training can help prevent long-term problems.",[169,170,171,172,173,174,175,30],"Urinary Incontinence","Pelvic Organ Prolapse (POP)","Bowel Symptoms","Postpartum","Physiotherapy and Rehabilitation","Pelvic Floor Muscle Training","Pelvic Floor","2026-05-21",{"date":178,"type":51},"2026-05-27",{"date":180,"type":51},"2026-04-07",{"date":182,"type":21},"2029-12-31",{"name":184,"class":185},"Vastra Gotaland Region","OTHER_GOV",2,{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":193,"eligibilityCriteria":194,"healthyVolunteers":11,"sex":17,"minAge":68,"maxAge":4,"enrollmentInfo":195,"targetDuration":4,"studyType":22,"phases":197,"briefSummary":199,"conditions":200,"keywords":202,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":212,"leadSponsor":214,"locationsCount":97},"100636452","phase-3-methadone-for-enhanced-postoperative-analgesia-in-intermediate-risk-noncardiac-surgery-melody-100636452","NCT07565870","Methadone for Enhanced Postoperative Analgesia in Intermediate-Risk Noncardiac Surgery (MELODY)","Methadone for Enhanced Postoperative Analgesia in Intermediate-Risk Noncardiac Surgery: A Multicentre Randomized Controlled Trial (MELODY Trial)","MELODY","Inclusion Criteria\n\n* Age ≥18 years\n* Elective intermediate-risk noncardiac surgery under general anesthesia\n* ASA physical status I-III\n* Expected hospital stay ≥24 hours\n* Ability to provide informed consent\n\nExclusion Criteria\n\n* Severe hepatic dysfunction (Child-Pugh C)\n* Severe renal impairment (eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m²)\n* Known allergy to methadone or opioids\n* Pregnancy or breastfeeding\n* Chronic opioid use or opioid use disorder\n* Planned use of epidural or regional analgesia\n* Inability to complete study assessments",{"count":196,"type":21},400,[198],"PHASE3","Postoperative pain control remains suboptimal for a large proportion of surgical patients and is frequently associated with slower recovery and higher reliance on opioids after surgery. Current intraoperative analgesic approaches predominantly use short-acting opioids, whose rapid pharmacokinetics can lead to variable drug exposure and inconsistent control of nociceptive stimuli.\n\nMethadone has a different pharmacologic profile, combining prolonged μ-opioid receptor activity with N-methyl-D-aspartate receptor antagonism, allowing sustained analgesia following a single intraoperative administration and potentially enhancing postoperative recovery.\n\nThe MELODY trial is a multicentre, randomized, patient-blinded clinical study designed to compare a single intravenous dose of methadone given at induction with conventional short-acting opioid-based anesthesia in adults undergoing intermediate-risk noncardiac surgery. The primary aim is to evaluate whether this strategy leads to improved quality of recovery on the first postoperative day.",[201,30],"Postoperative Pain",[203,204,205,206,207],"Methadone","QoR-15","Quality of Recovery","Multimodal Analgesia","General Anesthesia","2026-04-29",{"date":210,"type":51},"2026-05-04",{"date":129,"type":21},{"date":213,"type":21},"2027-03-30",{"name":215,"class":96},"Alexandre P. Joosten",{"id":217,"slug":218,"hasResults":11,"nctId":219,"briefTitle":220,"officialTitle":221,"acronym":222,"eligibilityCriteria":223,"healthyVolunteers":11,"sex":17,"minAge":68,"maxAge":4,"enrollmentInfo":224,"targetDuration":4,"studyType":22,"phases":226,"briefSummary":227,"conditions":228,"keywords":230,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":239,"completionDateStruct":241,"leadSponsor":243,"locationsCount":245},"100605482","bracing-after-ankle-fracture-100605482","NCT07163091","Bracing After Ankle Fracture","Bracing After Ankle Fracture (BAF): a Randomised Multicenter Non-inferiority Trial Comparing Ankle Stirrups to Walkers on Pain, Function and Social Interaction for Adults After Ankle Fracture - Study Protocol","BAF","Inclusion Criteria:\n\n* 18 years or older\n* Surgically or non-surgically treated ankle fracture\n\nExclusion Criteria:\n\n* Pathological fractures\n* Inadequacy to read or speak danish\n* Open fractures\n* Prolonged need for immobilisation (e.g. non-union or insufficient wound healing)\n* Inability to adhere to trial procedures (e.g. neuropathy or severe psychiatric disorder)\n* Restricted weightbearing\n* Uninterest in participating",{"count":225,"type":21},1400,[24],"Ankle fractures are common, debilitating and usually treated with immobilisation using a foot-ankle brace (walker). Emerging evidence suggests that a less restrictive brace may reduce recovery time without increasing the risk of complications, and patients tend to prefer ankle stirrups. However, evidence supporting their non-inferiority remains limited and inconclusive. Thus, the aim is assess if an ankle stirrup is non-inferior to a standard walker in reducing pain and function measured by the Manchester-Oxford Foot Questionnaire (MOXFQ) three months after ankle fracture. The hypothesis is that ankel stirrups align better with patients preferenes for less immobilising braces and offer sufficient stability while the fracture heals. Secondarily it may lead to faster recovery of function, return to work and reduced cost. The sample size of a maximum of 1400 patients allow us to assess non-inferiority in age and sex specific subgroups and treatment (surgical or non-sugical). Non-inferiority will be assessed in a pragmatic, multicenter, randomised controlled trial involving Scandinavian orthopedic departments.",[229,38,30],"Ankle Fracture",[231,232,233,234,235,236],"ankle fracture","Brace","walker","ankle stirrup","intervention","RCT","2026-04-28",{"date":208,"type":51},{"date":240,"type":51},"2026-04-23",{"date":242,"type":21},"2029-09-30",{"name":244,"class":96},"Odense University Hospital",16,{"id":247,"slug":248,"hasResults":11,"nctId":249,"briefTitle":250,"officialTitle":250,"acronym":251,"eligibilityCriteria":252,"healthyVolunteers":11,"sex":253,"minAge":254,"maxAge":255,"enrollmentInfo":256,"targetDuration":4,"studyType":22,"phases":258,"briefSummary":259,"conditions":260,"keywords":266,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":271,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":97},"100635950","effects-of-hot-baths-prior-or-after-a-damaging-protocol-on-muscle-function-and-hsp70-expression-100635950","NCT07559344","Effects of Hot Baths Prior or After a Damaging Protocol on Muscle Function and HSP70 Expression","Prehotemp","Inclusion Criteria:\n\n* Sex: Healthy, athletic men practicing track and field (10 to 12 hours\u002Fweek)\n* Age: 19 to 25 years old\n* Social security coverage\n* Signed informed consent\n\nExclusion Criteria:\n\n* Age over 26 years\n* Low level of physical activity (less than 8 hours per week)\n* Recent sprain (type 1, 2, or 3) or ligament rupture in the lower limb (within the last 8 months)\n* Exposure to an altitude of 2500m within 15 days prior to the protocol\n* Presence of arterial hypotension:\n* Systolic blood pressure below 90 mmHg\n* Diastolic blood pressure below 60 mmHg\n* A drop in systolic blood pressure greater than 20 mmHg upon moving from a lying to a standing position.\n* A drop in diastolic blood pressure greater than 10 mmHg upon moving from a lying to a standing position.\n* Presence of dizziness, lightheadedness, or blurred vision upon moving from a lying to a standing position.\n* Participant under guardianship\u002Fconservatorship or deprived of liberty.","MALE","19 Years","25 Years",{"count":257,"type":21},96,[24],"Muscle lengthening contractions lead to physiological responses such as strength loss, soreness, immune cell infiltration, and CK production, along with elevated heat shock proteins (HSPs), which protect and regenerate cells. Passive heating before or after exercise can aid in recovery by restoring strength and reducing soreness, requiring a core temperature of over 38.5°C for 20 minutes to be effective. Studies show that combined mechanical and thermal stress induces a cumulative HSP response, enhancing cellular protection. Thermal stress alone peaks at 16- 24 hours, whereas mechanical stress shows a biphasic response, with peaks at 3-6 hours and around 39 hours. Thus, combining heat with exercise could optimize HSP production, improving recovery by increasing and accelerating the HSP response. However, more research is needed to determine the best timing for thermal stress in human applications, especially in sports and therapy contexts.\n\nThis study aimed to compare the effects of hot-water immersion administered before versus after muscle-lengthening exercise on muscle function and HSP70 expression in healthy young athletes.",[30,261,262,263,264,265],"Mechanical Stress","Heat Stress","HSP70","Cumulative Response","Hot-water Immersion",[30,267,268,263,269,270],"mechanical stress","heat stress","cumulative response","hot-water immersion",{"date":272,"type":51},"2026-04-30",{"date":274,"type":51},"2026-02-16",{"date":276,"type":21},"2027-02",{"name":278,"class":96},"Centre Hospitalier Universitaire, Amiens",{"id":280,"slug":281,"hasResults":11,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":4,"eligibilityCriteria":285,"healthyVolunteers":11,"sex":17,"minAge":68,"maxAge":69,"enrollmentInfo":286,"targetDuration":288,"studyType":143,"phases":4,"briefSummary":289,"conditions":290,"keywords":293,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":304,"locationsCount":97},"100634497","the-effect-of-different-acoustic-conditions-on-6-minute-walk-test-performance-and-recovery-100634497","NCT07540455","The Effect of Different Acoustic Conditions on 6-Minute Walk Test Performance and Recovery","An Investigation of the Effect of Different Auditory Conditions on 6-Minute Walk Performance and Recovery in Healthy Young Adults: A Randomised Cross-Over Study","Inclusion Criteria:\n\n* Aged between 18 and 35,\n* Able to walk unaided (without the use of a walking aid),\n* Participants who agree to take part in the study on a voluntary basis and sign the informed consent form\n\nExclusion Criteria:\n\n* A history of myocardial infarction or unstable angina within the last month,\n* Acute illness or pain during the test that would prevent walking,\n* A lower limb injury or surgery within the last 3 months,\n* Resting systolic blood pressure \\>180 mmHg or diastolic blood pressure \\>100 mmHg,\n* Resting heart rate exceeding 120 beats per minute,\n* Those with cardiovascular or pulmonary conditions that may limit exercise,\n* Those with neurological conditions (balance disorders, stroke, epilepsy, etc.),\n* Those with musculoskeletal problems (lower limb fracture, severe arthritis, acute injury, etc.),\n* Those with an acute infection, fever or severe fatigue that could prevent walking during the test,\n* Those with a body mass index of 35 or above (obesity),\n* Those with a history of active vertigo, Meniere's disease or vestibular system disorders,\n* Participants with a diagnosed hearing problem",{"count":287,"type":21},40,"1 Day","Study Design: Randomized Cross-Over Study\n\nObjective:\n\nThis study aims to compare the acute effects of three different auditory conditions (metronome, binaural beats, and silent control) on 6-Minute Walk Test (6MWT) performance, post-exercise recovery physiology, and perceived exertion in healthy young adults.\n\nBackground:\n\nAuditory-motor coupling mechanisms suggest that rhythmic auditory stimuli can lower the excitation threshold of motor neurons, thereby enhancing walking efficiency. Rhythmic stimuli such as metronomes are known to improve walking speed and coordination. Binaural beats are an auditory stimulus type generated by presenting two tones of slightly different frequencies to each ear, triggering cortical neural entrainment. It has been reported that listening to binaural beats at theta frequency following exercise increases parasympathetic activation and accelerates recovery. This study aims to examine these two auditory stimuli in comparison with a control condition in healthy young adults.\n\nParticipants:\n\nHealthy young adults aged 18-35 who can walk independently and have no cardiovascular, pulmonary, neurological, or musculoskeletal conditions. Minimum sample size will be calculated using G\\*Power following a pilot study, with a 20% dropout margin added.\n\nRandomization:\n\nAll participants will be exposed to all three conditions on separate days. The order of application will be determined by computer-based simple randomization (randomizer.org). Six possible sequence combinations will be used to balance order effects. A washout period of at least 24 hours will be applied between sessions.\n\nInterventions:\n\nMetronome Condition: Each participant's natural walking cadence will be measured, and the metronome tempo will be set at 110% of this baseline value.\n\nBinaural Beats Condition: A carrier frequency of 120 Hz will be delivered to the right ear and 100 Hz to the left ear, generating a 20 Hz binaural beat in the Beta frequency band. Participants will listen for 6 minutes at rest immediately before the walking test.\n\nControl Condition: No auditory stimulus will be applied.\n\nThe 6MWT will be conducted in all conditions along a 30-meter flat corridor in accordance with ATS\u002FERS standards.\n\nMeasurement Time Points: Pre-test, immediately post-test, and at the 1st, 3rd, and 5th minutes of the recovery period.\n\nOutcome Measures:\n\nPrimary: Total distance covered during 6MWT (meters), walking cadence (steps\u002Fmin) Secondary: Heart rate, blood pressure, peripheral oxygen saturation (SpO₂), perceived dyspnea, general fatigue, and quadriceps femoris muscle fatigue assessed via the Modified Borg Scale\n\nStatistical Analysis:\n\nOne-Way Repeated Measures ANOVA for walking distance and cadence; Two-Way Repeated Measures ANOVA (condition × time) for physiological parameters; Friedman test for Borg scale data; Bonferroni-corrected post-hoc tests where significant differences are found. Significance level set at p\\\u003C0.05.\n\nStudy Duration: April - June 2026 (3 months)",[30,291,292],"Fatigue Recovery","Healhty",[294,295,296,297],"6 minutes walk test","metronome","binaural","recovery","2026-04-14",{"date":300,"type":51},"2026-04-20",{"date":302,"type":21},"2026-04-15",{"date":129,"type":21},{"name":305,"class":96},"Hasan Kalyoncu University",{"id":307,"slug":308,"hasResults":11,"nctId":309,"briefTitle":310,"officialTitle":311,"acronym":312,"eligibilityCriteria":313,"healthyVolunteers":11,"sex":17,"minAge":68,"maxAge":4,"enrollmentInfo":314,"targetDuration":4,"studyType":22,"phases":316,"briefSummary":317,"conditions":318,"keywords":320,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":325,"startDateStruct":327,"completionDateStruct":329,"leadSponsor":330,"locationsCount":97},"100633054","physical-recovery-during-bracing-after-ankle-fracture-re-baf-100633054","NCT07521696","Physical Recovery During Bracing After Ankle Fracture (Re-BAF)","Physical Recovery During Bracing After Ankle Fracture (Re-BAF): A Multi-Center Superiority Analysis Nested Within a Non-inferiority Randomised Controlled Trial (BAF; NCT07163091)","Re-BAF","Inclusion Criteria:\n\n* 18 years or older\n* Surgically or non-surgically treated ankle fracture\n\nExclusion Criteria:\n\n* Pathological fractures\n* Open fractures (skin perforation)\n* Prolonged need for immobilisation (e.g. non-union or insufficient wound healing)\n* Non-weight bearing treatment\n* Inability to adhere to trial procedures (e.g. neuropathy or severe psychiatric disorder)\n* Allergy to SENS Motion adhesive patches\n* Inability to read or speak Danish\n* Uninterest in participating",{"count":315,"type":21},280,[24],"Ankle fractures are among the most common fractures and represent the second most frequent fracture type requiring surgery. Many patients experience long-term pain, stiffness, and reduced ankle function, which substantially limits their physical activity. Even five years after injury, more than a third of patients have not regained their pre-injury activity levels.\n\nStandard treatment typically involves immobilisation using a rigid foot-ankle brace (walker). Although effective in protecting fracture healing, these braces may be overly restrictive, contributing to ankle stiffness, swelling, delayed physical recovery and return to daily activities, and reduced quality of life. Patients increasingly express a preference for lighter, movement-permitting ankle supports, such as minimal ankle stirrups. Recent evidence suggests that braces and elastic bands that allow more ankle movement than walkers may enhance faster recovery without increasing complications.\n\nHowever, high quality evidence is necessary for more robust conclusions. The Scandinavian Bracing after Ankle Fracture (BAF) multicentre randomised controlled trial (NCT07163091) therefore investigates whether an ankle stirrup is non-inferior to a standard walker with respect to patient-reported ankle pain and function, measured by the Manchester-Oxford Foot Questionnaire (MOXFQ) three months after ankle fracture. The primary hypothesis is that ankle stirrups better align with patients' preferences for less restrictive bracing while providing sufficient stability during fracture healing. Secondarily, ankle stirrups may promote faster recovery and physical activity.\n\nThe Re-BAF trial is nested within a larger multicentre non-inferiority trial (Bracing after Ankle Fracture \\[BAF\\], ClinicalTrials.gov ID: NCT07163091), aiming to investigate whether an ankle stirrup is non-inferior to a standard foot-ankle brace in improving patient-reported foot and ankle function, as measured by the Manchester-Oxford Foot Questionnaire (\\[MOXFQ\\], primary BAF outcome) after ankle fracture.\n\nThe aim of the Re-BAF trial is to investigate whether ankle stirrups are superior to standard foot-ankle braces in improving physical activity, assessed using objectively measured thigh-worn accelerometry from baseline (i.e. randomisation) to 12-week follow-up. We hypothesize that early and continuous movement during rehabilitation, enabled by an ankle stirrup, is superior in improving physical activity compared with a foot-ankle brace, without compromising fracture healing.",[229,30,319,38],"Physical Activity",[321,30,38,322,323,324],"Ankle Fractures","Braces","Physical activity","Randomized Controlled Trial",{"date":326,"type":51},"2026-04-13",{"date":328,"type":21},"2026-04-01",{"date":242,"type":21},{"name":244,"class":96},{"id":332,"slug":333,"hasResults":11,"nctId":334,"briefTitle":335,"officialTitle":336,"acronym":337,"eligibilityCriteria":338,"healthyVolunteers":11,"sex":17,"minAge":339,"maxAge":340,"enrollmentInfo":341,"targetDuration":4,"studyType":22,"phases":343,"briefSummary":344,"conditions":345,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":357,"lastUpdatePostDateStruct":358,"startDateStruct":360,"completionDateStruct":362,"leadSponsor":364,"locationsCount":97},"100632971","evaluation-of-the-addpro-vocational-reintegration-program-add-pro-eval-100632971","NCT07520617","Evaluation of the ADD'Pro Vocational Reintegration Program (ADD-PRO-EVAL)","Evaluation of the ADD'Pro Program: A Partnership-Based Approach to Support Vocational Reintegration of Patients Receiving Addiction Care (ADD-PRO-EVAL)","ADD-PRO-EVAL","Inclusion Criteria:\n\n* Adult of working age (18 years or older)\n* Diagnosed substance use disorder receiving medical care\n* Unemployed or on sick leave with a vocational reorientation project\n* Motivated to work in the competitive labour market\n* Living in or wishing to work in the Puy-de-Dôme department (63), France\n* Legally authorised to work\n* Capable of providing written informed consent\n* Affiliated with a French social security scheme\n\nExclusion Criteria:\n\n* Medical care provided under a court-ordered treatment obligation\n* Previously included in the ADD'Pro program\n* Residing outside the Puy-de-Dôme with no plan to work in the department\n* Under legal guardianship (tutelle, curatelle, or sauvegarde de justice)\n* Deprived of liberty","16 Years","70 Years",{"count":342,"type":21},100,[24],"The goal of this clinical trial is to evaluate whether an integrated medico-psychosocial vocational support program (ADD'Pro) can improve employment outcomes in adults with substance use disorders receiving care at a specialized addiction day hospital.\n\nThe main question it aims to answer is:\n\n\\- Does participation in the ADD'Pro program increase the rate of competitive employment (at least one day worked in the open labour market) at 6 months compared to standard employment services?\n\nResearchers will compare participants enrolled in the ADD'Pro program to participants referred to conventional employment services (France Travail or Cap Emploi) to see if structured, dual medico-psychosocial support leads to higher rates of vocational reintegration, better employment preparation, improved quality of life, and reduced physiological stress reactivity.\n\nParticipants will:\n\n* Be randomly assigned to either the ADD'Pro program or standard employment services\n* If assigned to ADD'Pro: receive immediate individualised support from a vocational counsellor (CIP) at the CeCler Association, running in parallel with their hospital addiction care, with no fixed end date\n* If assigned to standard care: be referred to conventional employment services with monthly follow-up interviews at the hospital, and the option to join ADD'Pro after 6 months\n* Complete structured interviews and validated questionnaires at inclusion, 3, 6, and 12 months\n* A sub-sample of up to 50 participants will additionally take part in a simulated job interview stress test (adapted TSST) with salivary biomarker collection and heart rate monitoring at inclusion and 6 months",[346,347,348,349,30,350,351,352,353,354,355,356],"Addiction","Addiction Disorders","Substance Use Recovery","Return to Work","Recovery Outcomes","Substance Use Disorder (SUD)","Employment, Supported","Employment","Substance Related Disorders","Vocational Rehabilitation","Substance Use (Drugs, Alcohol)","2026-04-02",{"date":359,"type":51},"2026-04-09",{"date":361,"type":21},"2026-04",{"date":363,"type":21},"2029-04",{"name":365,"class":96},"University Hospital, Clermont-Ferrand",{"id":367,"slug":368,"hasResults":11,"nctId":369,"briefTitle":370,"officialTitle":371,"acronym":372,"eligibilityCriteria":373,"healthyVolunteers":11,"sex":17,"minAge":68,"maxAge":340,"enrollmentInfo":374,"targetDuration":4,"studyType":143,"phases":4,"briefSummary":376,"conditions":377,"keywords":388,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":403,"lastUpdatePostDateStruct":404,"startDateStruct":406,"completionDateStruct":407,"leadSponsor":409,"locationsCount":97},"100627766","using-integrated-care-and-wearable-technology-to-evaluate-outcomes-of-the-shields--stripes-program-for-veterans-and-first-responders-100627766","NCT07452900","Using Integrated Care and Wearable Technology to Evaluate Outcomes of the Shields & Stripes Program for Veterans and First Responders","Evaluating Integrated Care and Wearable Technology Outcomes in the Shields & Stripes Program for Veterans and First Responders: A Retrospective Mixed-Methods Study","S&S Wellness","Inclusion Criteria:\n\n* Adults aged 18-70 years\n* Current or former members of the U.S. Armed Forces or first responder professions (e.g., law enforcement, firefighting, EMS)\n* Participants who completed the Shields \\& Stripes holistic wellness program\n* Providers who worked within the Shields and Stripes program.\n\nExclusion Criteria:\n\n-None",{"count":375,"type":21},80,"This study aims to evaluate outcomes from the Shields \\& Stripes (S\\&S) program - a 12-week, multidisciplinary wellness intervention designed for veterans and first responders. The S\\&S program integrates occupational therapy (OT), mental health (MH), physical therapy (PT), and registered dietitian (RD) services to promote recovery, resilience, and performance in individuals who have experienced cumulative stress, trauma exposure, or occupational burnout.\n\nThis research will use a retrospective mixed-methods observational design to analyze data collected from previous S\\&S participants who consent to research use of their de-identified information. No intervention or treatment changes will occur as part of this study.\n\nQuantitative data will include biometric information (e.g., sleep, activity, and heart rate variability via Oura Ring), standardized self-report measures (GAD-7, PHQ-9, PCL-5, RAND-36, PSQI, ISI), satisfaction surveys, and laboratory nutrition panels. Qualitative data will include semi-structured interviews with consenting participants and S\\&S providers following program completion.\n\nThe purpose of the study is to identify patterns of improvement in physical, psychological, and occupational functioning and to explore how integrated, team-based care supports holistic recovery. Findings may inform the development of future evidence-based wellness programs for military and first-responder populations.\n\nParticipation involves minimal risk, and all data will be de-identified before analysis.",[378,379,34,380,381,382,383,30,384,385,386,387],"Holistic Care","Mental Health","PTSD","Depression - Major Depressive Disorder","Anxiety","Resilience","Occupation","Biometrics Measurement","Veteran","Quality of Life",[389,390,391,392,379,393,394,395,396,397,34,398,380,382,399,387,400,401,402],"Shields & Stripes","Veterans","First Responders","Occupational Therapy","Physical Therapy","Registered Dietitian","Integrated Wellness","Biometric Data","Oura Ring","Heart Rate Variability","Depression","Holistic Health","Multidisciplinary Rehabilitation","Functional Outcomes","2026-03-06",{"date":405,"type":51},"2026-03-10",{"date":328,"type":21},{"date":408,"type":21},"2027-04-30",{"name":410,"class":96},"Baylor University",{"id":412,"slug":413,"hasResults":11,"nctId":414,"briefTitle":415,"officialTitle":416,"acronym":417,"eligibilityCriteria":418,"healthyVolunteers":11,"sex":17,"minAge":68,"maxAge":340,"enrollmentInfo":419,"targetDuration":4,"studyType":22,"phases":421,"briefSummary":422,"conditions":423,"keywords":428,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":431,"lastUpdatePostDateStruct":432,"startDateStruct":434,"completionDateStruct":436,"leadSponsor":438,"locationsCount":97},"100612557","the-effectiveness-and-efficacy-of-an-online-cognitive-behavioral-psychotherapeutic-program-100612557","NCT07255131","The Effectiveness and Efficacy of an Online Cognitive Behavioral Psychotherapeutic Program","The Effectiveness and Efficacy of an Online Group Cognitive Behavioral Psychotherapy in Patients With Cystic Fibrosis and Caregivers in Comparison to Control Groups by the Hellenic Cystic Fibrosis Association A Randomized Controlled Trial","RAKITZIHCFA","Inclusion Criteria:\n\n* Age 18-70\n* Members of the Hellenic Cystic Fibrosis Association\n* Willingness to participate on 13 sessions via Zoom\n\nExclusion Criteria:\n\n* Age over 70\n* Not members of the Hellenic Cystic Fibrosis Association\n* Not able to participate on 13 sessions via Zoom",{"count":420,"type":21},52,[24],"An online group cognitive behavioral psychotherapeutic program will be offered to patients with cystic fibrosis and to caregivers by the Hellenic Cystic Fibrosis Association. These 2 above therapy groups will be compared with control groups in a randomized controlled trial",[381,424,382,425,30,426,427],"Anxiety Chronic","Functional Outcome","Obsessive Compulsive Disorders","Assertiveness",[429,430],"Cystic Fibrosis","Group cognitive behavioral psychotherapy","2026-01-23",{"date":433,"type":51},"2026-01-27",{"date":435,"type":51},"2025-09-26",{"date":437,"type":21},"2028-12-20",{"name":439,"class":96},"Rakitzi, Stavroula",{"id":441,"slug":442,"hasResults":11,"nctId":443,"briefTitle":444,"officialTitle":444,"acronym":4,"eligibilityCriteria":445,"healthyVolunteers":16,"sex":17,"minAge":68,"maxAge":69,"enrollmentInfo":446,"targetDuration":4,"studyType":22,"phases":448,"briefSummary":449,"conditions":450,"keywords":455,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":460,"lastUpdatePostDateStruct":461,"startDateStruct":463,"completionDateStruct":465,"leadSponsor":467,"locationsCount":97},"100619446","impact-of-haskap-berries-on-recovery-from-high-intensity-resistance-training-100619446","NCT07344727","Impact of Haskap Berries on Recovery From High Intensity Resistance Training","Inclusion Criteria:\n\n* 2+ years of barbell squat experience\n* Currently squatting at least once a week\n\nExclusion Criteria:\n\n* BMI \\\u003C18 or \\> 40 kg\u002Fm\\^2\n* potential allergy to Haskap or placebo ingredients\n* anti-inflammatory, weight loss, anabolic steroids, testosterone, or other drugs that may interfere with the measures of the study or any other medications that may interfere with study measures\n* pregnant or lactating woman\n* diagnosis with type 1 or type 2 diabetes, hypo-\u002Fhyperthyroidism or any other condition that may interfere with study measures\n* smoke cigarettes\n* lower extremity injury within the last year\n* currently following a special diet including vegan, vegetarian, low carbohydrate, or ketogenic.\n* currently consuming any of the following products: tart cherry juice, pomegranate juice, or 1 or more cups of acai or other berries per day.",{"count":447,"type":21},30,[24],"The purpose of this clinical trial is to determine how certain food items affect oxidative stress, inflammation, and performance recovery from exercise induced muscle damage in a resistance trained population. The main questions The investigators aim to answer are the following:\n\n* Do Haskaps speed the recovery of oxidative stress and inflammation markers after an intense lower body workout in resistance trained adults?\n* Do Haskaps speed the recovery of performance measures after an intense lower body workout in resistance trained adults?\n* The data collected in this investigation may also be used to ask additional questions not yet identified. For example, the investigators may use the stored samples to evaluate how the blood metabolites of participants differ before and after intense exercise. These additional questions are called secondary analyses. Please note that no genetic analysis will be conducted and racial and ethnic differences among participants will not be used in any secondary analyses.\n\nResearches will compare Haskap juice to a color, flavor and carbohydrate matched placebo to see if Haskaps speed recovery in inflammation, oxidative stress and performance.\n\n* Participants will be asked to drink either Haskap juice or placebo and follow a low polyphenolic diet\n* Participants will perform an intense resistance workout\n* Participants will have their blood drawn before and after the workout\n* Performance will be analyzed at 24, 48 and 72 hours after the workout",[451,452,453,30,454],"Inflammation","Oxidative Stress","Resistance Exercise","Exercise Performance Recovery",[456,457,297,458,459],"exercise performance","resistance exercise","oxidative stress","inflammation","2026-01-19",{"date":462,"type":51},"2026-01-21",{"date":464,"type":51},"2025-10-21",{"date":466,"type":21},"2026-05",{"name":468,"class":96},"Montana State University",{"id":470,"slug":471,"hasResults":11,"nctId":472,"briefTitle":473,"officialTitle":474,"acronym":4,"eligibilityCriteria":475,"healthyVolunteers":16,"sex":17,"minAge":68,"maxAge":69,"enrollmentInfo":476,"targetDuration":4,"studyType":22,"phases":477,"briefSummary":478,"conditions":479,"keywords":481,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":487,"lastUpdatePostDateStruct":488,"startDateStruct":490,"completionDateStruct":492,"leadSponsor":494,"locationsCount":97},"100619285","effect-of-blood-flow-restriction-on-recovery-after-maximal-resistance-exercise-100619285","NCT07342634","Effect of Blood Flow Restriction on Recovery After Maximal Resistance Exercise","Effect of Blood Flow Restriction on Recovery After Maximal Resistance Exercise: a Controlled Clinical Trial","Inclusion Criteria:\n\n* Individuals exhibiting one or more of the following characteristics will not be included:\n* (1) diabetes and hypertension;\n* (2) inflammatory rheumatological, psychiatric, cardiovascular and\u002For respiratory disease;\n* (3) pre-existing injury restricting their ability to perform vigorous physical activities;\n* (4) having one or more predisposing risk factors for thromboembolism.\n\nExclusion Criteria:\n\n* Participants will be excluded from the study if they:\n* (1) have a health problem that does not allow them to continue;\n* (2) wish to leave the study;\n* (3) use medications, electrotherapy, or other therapeutic methods during the study period that could interfere with any results;\n* (4) not sign the consent form.",{"count":375,"type":21},[24],"Resistance training has been widely performed due to its health benefits. However, performing this training at high intensity causes significant muscle stress, leading to fatigue and compromising performance. It is essential to implement effective recovery strategies to optimize physiological adaptations. Among the accessible techniques, blood flow restriction (BFR) has shown promise for its potential to accelerate muscle recovery.",[30,480],"Recovery Time",[482,483,484,485,486],"Resistance training","physiological stress","post-exercise recovery","blood flow restriction therapy","functional physical performance","2026-01-05",{"date":489,"type":51},"2026-01-15",{"date":491,"type":21},"2026-02-01",{"date":493,"type":21},"2026-12",{"name":495,"class":96},"Paulista University",{"id":497,"slug":498,"hasResults":11,"nctId":499,"briefTitle":500,"officialTitle":501,"acronym":502,"eligibilityCriteria":503,"healthyVolunteers":11,"sex":17,"minAge":68,"maxAge":4,"enrollmentInfo":504,"targetDuration":506,"studyType":143,"phases":4,"briefSummary":507,"conditions":508,"keywords":513,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":515,"lastUpdatePostDateStruct":516,"startDateStruct":518,"completionDateStruct":520,"leadSponsor":521,"locationsCount":97},"100612796","romanian-validation-and-cross-cultural-adaptation-of-the-qor-15ro-100612796","NCT07258238","Romanian Validation and Cross-cultural Adaptation of the QoR-15Ro","Romanian Validation and Cross-cultural Adaptation of the QoR-15 Post-anesthetic Recovery Quality Questionnaire: The QoR-15Ro","QoR-15Ro","Inclusion Criteria:\n\n* Patients over 18 years old.\n* Comprehensive and sign informed consent.\n* Knows and understands the Romanian language.\n* Undergo a scheduled surgical intervention under any type of anesthetic procedure from the specialties of general surgery, urology, neurosurgery, plastic and reconstructive surgery.\n* Score \\> 26 points in the Mini Mental State Examination (MMSE) test.\n\nExclusion Criteria:\n\n* Patients under 18 years old.\n* Not having signed the informed consent.\n* Not knowing or understanding the Romanian language.\n* Surgical intervention from other specialties than general surgery, urology, neurosurgery, plastic and reconstructive surgery.\n* Score \\\u003C 27 points in the Mini Mental State Examination (MMSE) test.",{"count":505,"type":21},250,"15 Days","Optimal postoperative recovery after any surgical procedure requiring anesthesia is essential to achieving high-quality care. The Quality of Recovery questionnaire (QoR-15) was validated by its authors in 2013 in the study \"Development and psychometric evaluation of a postoperative quality of recovery score: the QoR-15.\" This instrument enables a comprehensive evaluation by integrating traditional physiological measures with the patient's subjective perception of their health status. With the consent of the original author, the present study aims to validate the Romanian version of the questionnaire and adapt it to our clinical environment.",[509,510,30,511,512],"Humans","Anesthesia","Postoperative Care","Postoperative Period",[205,514,204],"Postoperative Recovery","2025-12-01",{"date":517,"type":51},"2025-12-08",{"date":519,"type":21},"2026-01-01",{"date":50,"type":21},{"name":522,"class":96},"SUUMC Central Military Hospital Dr Carol Davila",{"id":524,"slug":525,"hasResults":11,"nctId":526,"briefTitle":527,"officialTitle":528,"acronym":4,"eligibilityCriteria":529,"healthyVolunteers":16,"sex":105,"minAge":68,"maxAge":69,"enrollmentInfo":530,"targetDuration":4,"studyType":22,"phases":531,"briefSummary":532,"conditions":533,"keywords":535,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":539,"lastUpdatePostDateStruct":540,"startDateStruct":542,"completionDateStruct":544,"leadSponsor":546,"locationsCount":4},"100603385","ashwagandha-withania-somnifera-and-its-effects-on-recovery-perceived-and-muscle-strength-in-male-handball-players-100603385","NCT07135830","Ashwagandha (Withania Somnifera) and Its Effects on Recovery Perceived and Muscle Strength in Male Handball Players","Ashwagandha (Withania Somnifera) and Its Effects on Recovery Perceived and Muscle Strength in Male Handball Players: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Handball players competing nationally\n\nExclusion Criteria:\n\n* Injured athletes\n* Female athletes",{"count":447,"type":21},[24],"This study aims to assess the potential recovery and strength effects of male handball players.",[534,30],"Strength Training Adaptations",[536,537,297,538],"ashwagandha","strength","handball","2025-08-15",{"date":541,"type":51},"2025-08-22",{"date":543,"type":21},"2025-08-25",{"date":545,"type":21},"2025-09-30",{"name":547,"class":96},"University of Maia",{"id":549,"slug":550,"hasResults":11,"nctId":551,"briefTitle":552,"officialTitle":553,"acronym":4,"eligibilityCriteria":554,"healthyVolunteers":16,"sex":17,"minAge":555,"maxAge":4,"enrollmentInfo":556,"targetDuration":4,"studyType":143,"phases":4,"briefSummary":557,"conditions":558,"keywords":560,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":563,"lastUpdatePostDateStruct":564,"startDateStruct":566,"completionDateStruct":568,"leadSponsor":570,"locationsCount":4},"100598293","cheers-health-restore-study-100598293","NCT07069608","Cheers Health Restore Study","Cheers Health Restore Observational Study","Inclusion Criteria:\n\n* Adults aged 21 years or older\n* Regular alcohol consumers (defined as ≥1 drinking night per week)\n* Ownership of and willingness to use a wearable device compatible with the Alethios platform (e.g., Fitbit, Apple Watch, Oura)\n* Ability and willingness to log alcohol consumption, Cheers Restore usage, and complete daily and weekly surveys via smartphone or web\n* Willingness to use Cheers Restore during the study period when consuming alcohol\n* English-speaking, capable of understanding informed consent\n\nExclusion Criteria:\n\n* AUDIT-C score above gender-specific thresholds for hazardous drinking (≥4 for men, ≥3 for women)\n* History of alcohol use disorder or prior treatment for substance misuse\n* Routine binge drinking (≥5 drinks\u002Foccasion for men, ≥4 for women)\n* Use of confounding substances:\n* THC (any form)\n* Recreational drugs\n* Prescription stimulants, sedatives, or sleep aids\n* Diagnosed sleep or psychiatric conditions known to impair sleep quality (e.g., insomnia, obstructive sleep apnea, restless legs syndrome, narcolepsy, major depressive disorder, post-traumatic stress disorder, bipolar disorder, schizophrenia, attention deficit\u002Fhyperactivity disorder)\n* Pregnancy or breastfeeding\n* Anticipated travel or scheduling conflicts disrupting normal sleep\u002Falcohol routines\n* Inability to comply with platform-based data collection requirements","21 Years",{"count":342,"type":21},"This observational cohort study, sponsored by Cheers Health and conducted by Principal Investigator Dr. Nirav Shah, aims to evaluate the potential role of Cheers Restore in supporting sleep quality, physiological recovery, and next-day well-being following alcohol consumption in healthy adults. Over a 6 week period, the study will utilize wearable devices and self-reported outcomes captured via the Alethios platform to assess real-world responses to use of Cheers Restore. Outcomes will be compared across three behavioral conditions: (1) alcohol consumption followed by Cheers Restore use, (2) alcohol-only nights without use of Cheers Restore, and (3) non-drinking nights.",[34,559,30],"Alcohol Aftereffects",[561,562],"alcohol use","wellness","2025-07-06",{"date":565,"type":51},"2025-07-16",{"date":567,"type":21},"2025-07-15",{"date":569,"type":21},"2025-10-31",{"name":571,"class":58},"Cheers Health",{"id":573,"slug":574,"hasResults":11,"nctId":575,"briefTitle":576,"officialTitle":577,"acronym":4,"eligibilityCriteria":578,"healthyVolunteers":11,"sex":17,"minAge":579,"maxAge":4,"enrollmentInfo":580,"targetDuration":4,"studyType":22,"phases":582,"briefSummary":583,"conditions":584,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":589,"lastUpdatePostDateStruct":590,"startDateStruct":592,"completionDateStruct":594,"leadSponsor":596,"locationsCount":97},"100369604","optimized-recovery-after-trauma-in-geriatric-patient-100369604","NCT04092504","Optimized Recovery After Trauma in Geriatric Patient","Optimized Recovery After Trauma in Geriatric Patient (Gero - ERAT)","Inclusion Criteria:\n\n* ≥ 65 years old\n* In hospital due to physical trauma\n* Able to speak and understand Swedish\n\nExclusion Criteria:\n\n* Documented palliative care\n* Cognitive impairment","65 Years",{"count":581,"type":21},540,[24],"Currently, there is evidence that structured care within the healthcare system increases the conditions for good care and better recovery. We want to investigate whether a new care concept (gero-ERAT) that combines two variants of structured care can improve the recovery of elderly patients affected by a physical trauma.\n\nOur hope is that the project will reduce the complications, short care times, fewer re-admissions and that more patients can return to regular living, which reduces the suffering for the patient and his relatives. In addition to patient benefit, a successful outcome will also result in reduced costs for healthcare and society as a whole. The concept of care is based on an increased patient participation, which is in line with the values of the Västra Götaland region and the Sahlgrenska university hospital\n\nThrough the PhD project, four studies will be published. A qualitative interview study to investigate patients' experiences of care and recovery after trauma.\n\nAfter that, a prospective cohort survey of two groups is carried out; conventional care and gero-ERAT. Data will begin to be collected in the control group and when the control group is full geroRATAT will be implemented in the care department and we then collect data in the intervention group.\n\nBased on collected data, we will publish two additional studies one with a focus on health economics as well as one focusing on care time and recovery based on age and harvest estimation.",[585,387,586,587,588,38,30],"Geriatric Assessment","Trauma","Fragility","Injury","2024-11-21",{"date":591,"type":51},"2024-11-25",{"date":593,"type":51},"2019-05-09",{"date":595,"type":21},"2028-01-01",{"name":184,"class":185},{"id":598,"slug":599,"hasResults":11,"nctId":600,"briefTitle":601,"officialTitle":602,"acronym":4,"eligibilityCriteria":603,"healthyVolunteers":11,"sex":17,"minAge":68,"maxAge":579,"enrollmentInfo":604,"targetDuration":4,"studyType":143,"phases":4,"briefSummary":606,"conditions":607,"keywords":610,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":614,"lastUpdatePostDateStruct":615,"startDateStruct":617,"completionDateStruct":619,"leadSponsor":621,"locationsCount":97},"100535320","evaluation-of-a-new-recovery-oriented-model-of-psychiatric-inpatient-care-100535320","NCT06250296","Evaluation of a New Recovery-oriented Model of Psychiatric Inpatient Care","Evaluation of a New Recovery-oriented Model of Care on Psychiatric Inpatient Wards.","Inclusion Criteria:\n\n* Patients hospitalized in one of the three participating wards\n\nExclusion Criteria:\n\n* Incapacity to give informed consent\n* Insufficient knowledge of French",{"count":605,"type":21},700,"This project will study the effects of a major reorganization of psychiatric inpatient wards. This reorganization will affect many aspects of day-to-day work, with the aim of improving the individualization of care, the integration of relatives and the participation of the patients in treatment planning. This new organization will initially involve a first pilot ward, before being extended to other wards.\n\nThe aim of this project is to understand whether this new organization has positive effects on the use of coercive measures, the average length of stay, the improvement in patients' clinical condition, as well as on patient satisfaction, their perception of coercion, the wards' atmosphere on the unit and patients' personal recovery.\n\nAll patients admitted to three wards of the Division of adult psychiatry of the Geneva University Hospital aged 18 and over, with a good knowledge of French and being treated for any type of diagnosis except dementia, are invited to take part in the study. They will be assessed at discharge regarding the selected outcomes. The study will last 18 months: during the first 9 months, the new model will be applied on the pilot ward, and the wo other wards will serve as comparison wards. After 9 months, the model will also be applied to these other two wards.",[608,609,30],"Psychiatric Hospitalization","Coercion",[611,612,297,613],"psychiatric inpatient care","coercion","patient satisfaction","2024-07-01",{"date":616,"type":51},"2024-07-03",{"date":618,"type":51},"2024-02-15",{"date":620,"type":21},"2025-10",{"name":622,"class":96},"University Hospital, Geneva",{"id":624,"slug":625,"hasResults":11,"nctId":626,"briefTitle":627,"officialTitle":627,"acronym":628,"eligibilityCriteria":629,"healthyVolunteers":11,"sex":17,"minAge":68,"maxAge":4,"enrollmentInfo":630,"targetDuration":4,"studyType":143,"phases":4,"briefSummary":632,"conditions":633,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":645,"lastUpdatePostDateStruct":646,"startDateStruct":648,"completionDateStruct":650,"leadSponsor":652,"locationsCount":97},"100444999","dundrum-forensic-redevelopment-evaluation-study-d-forest-study-100444999","NCT05074732","Dundrum Forensic Redevelopment Evaluation Study: D-FOREST Study.","D-FOREST","Inclusion Criteria:\n\n* Admitted to the National Forensic Mental Health Service (NFMHS) Ireland after 1st December 2019 until 7 years after the transfer of the National Service to the newly developed complete National Forensic Service at Portrane, North Dublin, Ireland.\n\nExclusion Criteria:\n\n* This study comprises a complete cohort of admissions to the NFMHS. All adult patients admitted during the time period will be included in the study, regardless of their length of stay.",{"count":631,"type":21},350,"The DUNDRUM Forensic Redevelopment Evaluation study (D-FOREST study) is a multi-site comprehensive evaluation of a complete National Forensic Mental Health Service. The study will have a prospective, observational, longitudinal design which will permit the evaluation of benefit over time for individual patients, groups of patients and the evaluation of the benefit in terms of service based outcomes of the redevelopment of a complete National Forensic Mental Health Service e.g. effects on waiting list times, length of stay. The study will systematically evaluate multiple domains of recovery in a complete National Forensic Service, including patients' physical health, mental health, offending behaviours and social and occupational functioning.",[634,635,636,637,638,30,639,640,641,642,643,644],"Schizophrenia","Forensic Psychiatry","Outcome Measure","Violence","Personality Disorders","Obesity","Type II Diabetes","Cardiovascular Diseases","Frailty","Psychosis","Treatment-resistant Schizophrenia","2021-10-02",{"date":647,"type":51},"2021-10-12",{"date":649,"type":51},"2019-12-01",{"date":651,"type":21},"2027-12-31",{"name":653,"class":96},"Health Service Executive, Ireland"]