[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"rectal-neoplasm\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:rectal-neoplasm":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,96,122],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100596135","knowledge-enhanced-digital-intervention-to-prevent-low-anterior-resection-syndrome-100596135",false,"NCT07041515","Knowledge-enhanced Digital Intervention to Prevent Low Anterior Resection Syndrome","A Randomized, Multicenter Clinical Trial to Evaluate the Feasibility and Utility of a Postoperative Management App for Patients Undergoing Rectal Resection","Inclusion Criteria:\n\n1. Adults aged 20-70 years\n2. Patients scheduled for anal-sparing rectal resection or stomy repair diagnosed with rectal cancer (within 15 cm from Anal Verge)\n3. Patients with an expected survival period of 1 year or more\n4. Patients or their primary caregivers use smartphones (apps)\n5. Patients who are aware of their own status and can provide consent for this study\n\nExclusion Criteria:\n\n1. If you are receiving chemotherapy or radiotherapy at the time of consent\n2. If you are scheduled for major colectomy such as total colectomy or partial colectomy in addition to rectal resection\n3. If you cannot be contacted by phone\n4. If you cannot read and understand Korean\n5. If you cannot provide consent based on clear and sufficient information","ALL","20 Years","70 Years",{"count":20,"type":21},320,"ESTIMATED","INTERVENTIONAL",[24],"NA","Low anterior resection syndrome refers to changes in bowel habits such as frequent defecation, urgent defecation, and fecal incontinence, which result in decreased bowel function. It occurs very commonly after surgery for colorectal cancer, especially rectal cancer, and symptoms appear severely immediately after surgery, followed by a recovery process. It is known that symptoms improve significantly after one year of surgery, but in some patients, symptoms persist, which significantly affects the quality of life and causes social problems.\n\nThere is no established treatment method for low anterior resection syndrome, and accurate evaluation and customized treatment are required according to the patient's surgical or radiotherapy treatment content and symptoms. It is also important to monitor the change in symptoms during the treatment process, and a customized step-by-step treatment strategy for such patients is required. However, such a customized step-by-step treatment strategy for such patients is very complex, and there are no clear guidelines to date, and the research design for some clinical trials has been recently reported.\n\nThe purpose of this study was to develop an app-based Patient-Reported Outcome (PRO) standardized questionnaire for patients after rectal cancer surgery to systematically collect and monitor symptom information, establish a multidisciplinary management plan tailored to patients, and provide education and treatment to improve the quality of life of rectal cancer survivors. A management program utilizing a research device (app) can reduce the incidence of Major LARS after rectal cancer surgery compared to standard treatment.",[27],"Rectal Neoplasm",[29,30,31],"rectal neoplasm","low anterior resection syndrome","Patient Reported Outcome","NOT_YET_RECRUITING","2025-06-18",{"date":35,"type":36},"2025-06-27","ACTUAL",{"date":38,"type":21},"2025-07-01",{"date":40,"type":21},"2032-01-30",{"name":42,"class":43},"National Cancer Center, Korea","OTHER_GOV",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":95},"100564575","evaluating-the-impact-of-financial-navigation-on-financial-catastrophe-and-distress-for-cancer-care-100564575","NCT06630962","Evaluating the Impact of Financial Navigation on Financial Catastrophe and Distress for Cancer Care","Evaluating the Impact of Financial Navigation on Financial Catastrophe and Distress for Cancer Care: A Randomized Control Trial- COST-FIN","COST-FIN","Inclusion Criteria:\n\n* Age 18 years and older\n* Recently diagnosed with breast, colorectal or prostate cancer within 6 weeks of presentation at the study site\n* Have not received definitive chemotherapy, radiotherapy, or undergone major surgery (diagnostic or temporary interventions, such as excisional biopsy or temporary colostomy may still enroll)\n* Candidate for definitive cancer treatment\n\nExclusion Criteria:\n\n* Unable to provide consent\n* Has initiated definitive cancer treatment at the study site or elsewhere in the past\n* Only receiving best supportive care","18 Years",{"count":54,"type":21},200,[24],"The goal of this study is to investigate the effectiveness of a structured financial navigation program in reducing financial catastrophe and financial distress for cancer patients in Nigeria.\n\nThe main study questions being investigated are:\n\n1. If a financial navigation program can effectively and significantly reduce financial catastrophe and distress for cancer patients in Nigeria?\n2. If a financial navigation program is financially sustainable and cost-effective for cancer centers in Nigeria?\n\nParticipants will be required to:\n\n1. Complete surveys about their demographics, clinical history, and socioeconomic status\n2. Complete questionnaires about their quality of life and psychological wellbeing\n3. Report all costs related to their cancer care\n\nInvestigators will compare participants in the financial navigation program and those not in the financial navigation program to identify potential differences in catastrophic health expenditure and financial distress.",[58,59,60,27],"Breast Neoplasm","Prostate Neoplasm","Colon Neoplasm",[62,63,64,58,59,60,27,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83],"Financial Navigation","Financing Cancer Care","Nigeria","Health Insurance","Randomized Control Trial","Healthcare Cost","Health Expenditure","Financial Risk Sharing","Universal Health Insurance","National Health Insurance Scheme","Catastrophic Health Spending","Financial Distress","Sub-Saharan Africa","Health Plan Implementation","Global Health","Healthcare Economics and Organizations","Clinical Oncology","Cancer Care Facilities","Surgical Oncology","Global Burden of Disease","Social Determinants of Health","Health Impact Assessment","RECRUITING","2024-10-04",{"date":87,"type":36},"2024-10-08",{"date":89,"type":36},"2024-07-15",{"date":91,"type":21},"2026-09",{"name":93,"class":94},"Northwestern University","OTHER",2,{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":105,"phases":4,"briefSummary":106,"conditions":107,"keywords":108,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":121},"100514905","radiotherapy--total-neoadjuvant-therapy-for-recurrent-rectal-cancer-in-previously-irradiated-patients-an-italian-association-for-radiotherapy-and-clinical-oncology-airo-gi-platform-a-multi-centre-prospective-observational-study-100514905","NCT05984576","Radiotherapy & Total Neoadjuvant Therapy for Recurrent Rectal Cancer in Previously Irradiated Patients, an Italian Association for Radiotherapy and Clinical Oncology (AIRO)-GI Platform: a Multi-centre Prospective Observational Study","RETRY","Inclusion Criteria:\n\n* Age ≥ 18 years old;\n* Eastern Cooperative Oncology Group (ECOG) 0-1;\n* Adequate hematological function, i.e.:\n* Granulocyte count \\> 1500\u002FµL;\n* Hemoglobin level \\>10 g\u002FdL;\n* Platelet count \\> 100000\u002FµL;\n* Alanine aminotransferase (ALT)\u002Faspartate aminotransferase (AST): 7-45 international units (UI)\u002FL.\n* Potentially curable Oligo-metastatic disease;\n* Life expectancy of more than 24 months;\n* Histologically (if feasible) or radiologically MRI (magnetic resonance imaging), if no contraindications, and CT (computed tomography) and\u002For Positron Emission Tomography scan (PET) proven pelvic local recurrent rectal cancer (LRRC);\n* Previous pelvic irradiation \\> 6 months;\n* Availability of the previous treatment plan in DICOM format only (Digital Imaging and COmmunications in Medicine).\n\nExclusion Criteria:\n\n* Age \\\u003C18 y.o.;\n* Pregnancy or lactating female patients;\n* Psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule (those conditions should be discussed with the patient before registration in the trial);\n* Important comorbidities (such as: severe cardiac or coagulative disease, moderate or severe restrictive\u002Fobstructive lung deficit, severe cognitive impairment, moderate and severe renal and hepatic impairment.\n* Refusal to sign written informed consent.",{"count":104,"type":21},88,"OBSERVATIONAL","The introduction of neoadjuvant chemoradiation therapy (CRT) and the use of advanced surgical techniques have led to a reduction in mortality and recurrence rates for rectal cancer, the rate of which currently stands at 4-8%. Complete cytoreduction (achieving R0) of local recurrence is the main factor correlating with survival, but surgery can often be very complex because of the change in anatomical planes caused by previous surgery. Reirradiation of the recurrence may increase the rate of optimal resection (R0) and may palliate symptoms in unresectable disease. It is a very complex procedure, because one has to take into account the dose previously received by the organs at risk (OARs) and at the same time be able to deliver an effective dose to the recurrence. However with modern irradiation techniques (VMAT) it is possible to increasingly spare the OARs and deliver adequate doses in this setting as well.\n\nBesides radiotherapy with conventional fractionation, other promising options are stereotactic body radiotherapy (SBRT) with and proton (PT) and carbon ion RT (CIRT). Another topic of interest is chemotherapy intensification (CHT): recent studies of concomitant and neoadjuvant chemotherapy (Total Neoadjuvant Therapy) have shown high rates of antitumour response, however even this option should be evaluated with caution, because it must take into account previous cancer treatments received by the patient.\n\nBased on the evidence reported in the literature, it is reasonable to assume that treatment of local recurrence of rectal cancer should be multimodal, integrating surgical treatment with CHT and RT, using the different technologies available. To this end, proper stratification of patients is necessary in order to target the appropriate therapy according to the type of recurrence and their clinical condition.",[27],[109,110,111],"Radiotherapy","Reirradiation","Recurrent Rectal Cancer","2023-08-02",{"date":114,"type":36},"2023-08-09",{"date":116,"type":36},"2023-06-21",{"date":118,"type":21},"2031-06-05",{"name":120,"class":94},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",1,{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":130,"targetDuration":4,"studyType":22,"phases":132,"briefSummary":133,"conditions":134,"keywords":135,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":146},"100260479","loop-ileostomy-closurestapled-or-hand-sewn-anastomoses-suture-or-mesh-closure-of-the-stoma-site-100260479","NCT02669992","Loop Ileostomy Closure:Stapled or Hand-sewn Anastomoses? Suture or Mesh Closure of the Stoma Site?","Loop Ileostomy Closure.Stapled or Hand-sewn Anastomoses? Suture or Mesh Closure of the Stoma Site in the Abdominal Wall. A Prospective Randomised Multicenter Trial.","LISTO","Inclusion Criteria:\n\n* loop ileostomy after rectal cancer surgery\n* loop ileostomy closure is permitted and possible according to clinical practice\n\nExclusion Criteria:\n\n* patient unable to understand written or oral information",{"count":131,"type":21},400,[24],"There are severel problems associated with the closing of a temporary loop-ileostomy after surgery for rectal cancer. The purpose of this study is to answer two questions:\n\n1. The choice of anastomotic method - does it influence the postoperative course?\n2. The use of a prophylactic mesh when closing the stoma site - will there be less hernias?",[27],[136],"Ileostomy","2023-01-25",{"date":139,"type":36},"2023-01-26",{"date":141,"type":36},"2015-06",{"date":143,"type":21},"2027-12",{"name":145,"class":94},"Karolinska University Hospital",11]