[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"recurrent-cystitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:recurrent-cystitis":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100644981","colipral-probiotic-strain-escherichia-coli-5c-ecp24-for-prevention-of-recurrent-cystitis-in-menopausal-women-100644981",false,"NCT07676604","Colipral® (Probiotic Strain Escherichia Coli 5C (ECP24®)) for Prevention of Recurrent Cystitis in Menopausal Women","Study to Evaluate the Efficacy and Safety of Colipral® (Probiotic Strain Escherichia Coli 5C (ECP24®)) in the Prevention of Recurrent Cystitis in Menopausal Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial","Inclusion Criteria:\n\n* Menopausal female patients.\n* Age between 55 and 70 years.\n* Diagnosis of recurrent cystitis: ≥2 episodes in 6 months or ≥3 episodes in 12 months, with at least 1 documented episode from urine culture in the last 12 months (if available).\n\nExclusion Criteria:\n\n* Complicated urinary tract infections (UTIs) or major complicating factors, including relevant anatomical abnormalities, catheterization, active calculosis, or significant immunosuppression.\n* Hormone replacement therapy (HRT) that has been ongoing or discontinued for less than 6 months.\n* Pyelonephritis within the past 6 months.\n* Ongoing continuous antibiotic prophylactic therapy (or inability to suspend it).\n* Chronic inflammatory bowel diseases (ulcerative colitis or Crohn's disease).\n* Allergy to the probiotic or its excipients.","FEMALE","55 Years","70 Years",{"count":20,"type":21},134,"ESTIMATED","INTERVENTIONAL",[24],"NA","Recurrent cystitis is a common condition in menopausal women and is associated with impaired quality of life and increased antibiotic use. This randomized, double-blind, placebo-controlled clinical trial aims to evaluate the efficacy and safety of Colipral® in preventing recurrent cystitis in menopausal women. Participants will be randomized to receive either Colipral® (probiotic strain Escherichia coli 5C (ECP24®)))or placebo for 12 weeks and will be followed for a total of 24 weeks. The study will assess the occurrence of symptomatic cystitis recurrences confirmed by urine culture, as well as symptoms, quality of life, urinary pain, and antibiotic consumption.",[27],"Recurrent Cystitis","NOT_YET_RECRUITING","2026-07-01",{"date":31,"type":32},"2026-07-02","ACTUAL",{"date":34,"type":21},"2027-07-06",{"date":36,"type":21},"2027-07-31",{"name":38,"class":39},"Liaquat University of Medical & Health Sciences","OTHER",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":48,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":63,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":5},"100571359","evaluating-the-efficacy-and-patient-experience-of-catheter-free-intravesical-instillation-100571359","NCT06719232","Evaluating the Efficacy and Patient Experience of Catheter-Free Intravesical Instillation","Evaluating the Efficacy and Patient Experience of Catheter-Free Intravesical Instillation: a Prospective Observational Study","NOCATIN","Inclusion Criteria:\n\n* Male and female patients aged between 18 and 80 years.\n* Patients for whom the treating physician has determined that intravesical instillation is necessary due to one of the following conditions:\n* Interstitial cystitis\u002Fbladder pain syndrome (IC\u002FBPS).\n* Recurrent urinary tract infections (UTIs).\n* Non-muscle invasive bladder cancer.\n* Post-radiation cystitis.\n* Post-chemotherapy cystitis.\n* Negative urine culture within the last two weeks.\n* Patients who provide verbal and written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Urinary tract infection within the past month or currently active infection.\n* Diagnosed bleeding disorders or recurrent macroscopic hematuria.\n* Post-void residual urine volume greater than 100 ml.\n* Mental condition that prevents reliable cooperation.","ALL","18 Years","80 Years",{"count":52,"type":21},300,"OBSERVATIONAL","This study aims to evaluate a catheter-free method for delivering medications directly into the bladder, known as intravesical instillation, which is commonly used to treat conditions such as interstitial cystitis\u002Fbladder pain syndrome (IC\u002FBPS), recurrent urinary tract infections, bladder cancer, and post-chemotherapy or post-radiation cystitis.\n\nThe study investigates whether this method, which eliminates the need for catheterization, reduces discomfort and complications while maintaining treatment effectiveness. By collecting data on patient experiences and outcomes, the study seeks to determine if this approach provides a safer and more comfortable alternative to traditional catheter-based treatments.",[56,27,57,58,59,60,61,62],"Interstitial Cystitis","Haemorrhagic Cystitis","Bladder Cancer","Bladder Disease","Intravesical Instillation","Bladder Pain Syndrome","Recurrent Urinary Tract Infections",[64,65,66,67,68,69,70,71,72],"intravesical therapy","catheterization","recurrent urinary tract infection","IC\u002FBPS","Interstitial Cystitis\u002FBladder Pain syndrome","Post-chemotherapy Cystitis","Post-Irradiation Cystitis","Intravesical instillation","UroDapter","RECRUITING","2024-12-07",{"date":76,"type":32},"2024-12-12",{"date":78,"type":32},"2024-10-01",{"date":80,"type":21},"2025-12",{"name":82,"class":83},"Jahn Ferenc South Pest Teaching Hospital","OTHER_GOV"]