[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"recurrent-pregnancy-lossrpl\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:recurrent-pregnancy-lossrpl":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,82],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100610876","high-intensity-low-frequency-periodic-rtms-over-the-right-dorsolateral-prefrontal-cortex-on-cardiac-autonomic-regulation-in-women-with-recurrent-pregnancy-loss-and-anxiety-100610876",false,"NCT07233278","High-Intensity, Low-Frequency Periodic rTMS Over the Right Dorsolateral Prefrontal Cortex on Cardiac Autonomic Regulation in Women With Recurrent Pregnancy Loss and Anxiety","High-intensity, Low-frequency Periodic rTMS Over the Right Dorsolateral Prefrontal Cortex for Acute Cardiac Autonomic Regulation in Women With Recurrent Pregnancy Loss and Generalized Anxiety Disorder: a Randomized, Sham-controlled Mechanistic Trial (NEURO-CARD-rTMS-2)","Inclusion Criteria:\n\n* (i) Female, aged 18-45 years, and right-handed;\n* (ii) Diagnosed with recurrent pregnancy loss (RPL), defined as two or more consecutive spontaneous miscarriages occurring before 28 weeks of gestation;\n* (iii) Not currently pregnant or in a state of missed miscarriage;\n* (iv) Meeting the DSM-5 diagnostic criteria for GAD, with a HAMA score of at least 16, a CGI-S score of at least 4, and a HAMD-17 score of no more than 17.\n\nExclusion Criteria:\n\n* (i) Contraindications to transcranial magnetic stimulation (TMS), such as metallic implants or a history of epilepsy;\n* (ii) Unstable blood pressure (systolic \\>180 mmHg or \\\u003C90 mmHg);\n* (iii) Coexisting major organic disorders, including hyperthyroidism, atrial fibrillation, valvular heart disease, sinus bradycardia, neurological diseases, cerebrovascular disease, or pulmonary disorders;\n* (iv) Significant suicide risk;\n* (v) Other current major psychiatric disorders, including substance use disorder, schizophrenia, delusional disorder, unspecified psychotic disorder, bipolar disorder, or delirium. To preserve diagnostic homogeneity of the study sample, participants whose current primary diagnosis is another anxiety-related disorder will also be excluded, including panic disorder, social anxiety disorder, separation anxiety disorder, specific phobia, obsessive-compulsive and related disorders, and trauma- and stressor-related disorders; Current use of psychotropic medication at screening, or continuous use within the 4 weeks before screening of antidepressants, anxiolytics, antipsychotics, mood stabilizers, or sedative-hypnotics, in order to minimize hemodynamic confounding.","FEMALE","18 Years","45 Years",{"count":20,"type":21},46,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to determine whether high-intensity, low-frequency periodic repetitive transcranial magnetic stimulation (rTMS) applied to the right dorsolateral prefrontal cortex (DLPFC) can modulate cardiac autonomic regulation in women with recurrent pregnancy loss (RPL) and comorbid anxiety. The main questions it aims to answer are:\n\nDoes 120% resting motor threshold (RMT) rhythmic low-frequency rTMS reduce heart rate during stimulation time windows compared with sham stimulation?\n\nDoes 120% RMT rTMS alter heart-rate-variability (HRV) spectral power at the target frequency (0.0167 Hz) compared with sham stimulation?\n\nResearchers will compare active rTMS with sham rTMS to determine whether the active intervention produces measurable changes in cardiac autonomic activity.\n\nParticipants will:\n\nUndergo a single session of rTMS or sham stimulation consisting of 20 consecutive stimulation time windows (each 60 seconds: 40 seconds of 1-Hz stimulation plus 20 seconds of rest) targeting the right DLPFC;\n\nHave continuous electrocardiography (ECG) recordings collected during the entire stimulation session;\n\nComplete clinical and psychiatric assessments before participation.",[27,28],"Recurrent Pregnancy Loss(RPL)","Anxiety",[30,28,31,32,33],"Recurrent pregnancy loss","Dorsolateral Prefrontal Cortex","Cardiac Autonomic Regulation","repetitive transcranial magnetic stimulation","RECRUITING","2026-06-02",{"date":37,"type":38},"2026-06-03","ACTUAL",{"date":40,"type":38},"2025-11-17",{"date":42,"type":21},"2026-12-30",{"name":44,"class":45},"Shenyang Medical College","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":65,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100628395","noninvasive-implantation-potential-vs-morphology-based-selection-in-ivf-single-blastocyst-transfer-100628395","NCT07461077","Noninvasive Implantation Potential vs Morphology-Based Selection in IVF Single Blastocyst Transfer","Clinical Outcomes of Non-invasive Embryo Implantation Potential Assessment Versus Conventional Morphological Selection for Single Blastocyst Transfer Following Conventional IVF: A Multicenter Randomized Controlled Trial","NICSAI-SBT-RCT","Inclusion Criteria:\n\n1. Conventional IVF insemination;\n2. Meeting either of the following:\n\n   1. Advanced maternal age: female age 35-43 years;\n   2. Recurrent miscarriage: ≥2 spontaneous pregnancy losses (\\\u003C28 gestational weeks), including biochemical pregnancy (hCG \\>25 IU\u002FL) ;\n3. Willingness to culture all Day 3 embryos to the blastocyst stage in the fresh cycle, or to culture ≥6 embryos (with at least one embryo ≥7 cells), and to cryopreserve all blastocysts as single-blastocyst vitrification;\n4. Willingness to undergo frozen-thawed single-blastocyst transfer;\n5. At least two blastocysts formed on Day 5\u002FDay 6 from 2PN fertilization, with morphological grading ≥4BC\u002F4CB;\n6. Provision of written informed consent.\n\nExclusion Criteria:\n\n1. Any use of intracytoplasmic sperm injection-based fertilization, including but not limited to ICSI, TESA, and PGT-related cycles;\n2. Known monogenic disorders or chromosomal abnormalities at enrollment;\n3. Patients who use donated eggs to achieve pregnancy;\n4. Definite conditions affecting uterine cavity anatomy or endometrial receptivity, such as untreated uterine malformations (e.g., septate uterus, unicornuate uterus, didelphys uterus) or untreated hydrosalpinx;\n5. Contraindications to pregnancy or to assisted reproductive technology;\n6. Any other condition deemed by the investigators to make the participant unsuitable for this study.","20 Years","43 Years",{"count":57,"type":21},520,[24],"Background: Morphology-based embryo selection cannot detect aneuploidy, which is common in advanced maternal age and recurrent pregnancy loss. NICS-AI combines non-invasive chromosome screening (NICS) of cell-free DNA from spent blastocyst culture medium with AI integration of developmental day and morphology to improve embryo ranking.\n\nMethods: This multicenter, single-blind, parallel randomized controlled trial will include 520 participants. Participants undergoing conventional IVF will be eligible if they meet either (i) female age 35-43 years or (ii) recurrent miscarriage (≥2 losses \\\u003C28 gestational weeks, including biochemical pregnancy with serum hCG \\>25 IU\u002FL). They must consent to blastocyst culture\u002Fvitrification and frozen-thawed single blastocyst transfer (SBT), and have ≥2 Day-5\u002FDay-6, 2PN-derived blastocysts with morphology grade ≥4BC\u002F4CB at randomization. Key exclusions include any ICSI-based fertilization or PGT-related procedures, known genetic disease meeting PGT indications, donor oocytes, untreated uterine anomalies\u002Fhydrosalpinx, or contraindications to pregnancy\u002FART.\n\nRandomization\u002Finterventions: Participants will be randomized 1:1 to NICS-AI-guided selection or morphology-based selection. In the NICS-AI arm, culture-medium DNA is tested and an AI-derived composite implantation score ranks embryos; controls use morphology alone (tie-break by cryopreservation order).\n\nOutcomes\u002Fanalysis: The primary endpoint is live birth after the first SBT (delivery with ≥1 live-born infant per transfer cycle, per randomized participant). Secondary endpoints include first clinical pregnancy, early miscarriage (\\\u003C12 weeks, excluding biochemical pregnancy), ongoing pregnancy to 12 weeks, and cumulative pregnancy\u002Flive birth outcomes within 1 year (≤3 SBTs from one retrieval). Safety includes fetal malformations and neonatal outcomes through 1 year postpartum.",[61,27,62,63,64],"Advanced Age","Infertility (IVF Patients)","Sequence Analysis","Embryo Quality",[66,67,68,69,70],"NICS","AI","single embryo transfer","live birth rate","Embryo quality","NOT_YET_RECRUITING","2026-03-04",{"date":74,"type":38},"2026-03-10",{"date":76,"type":21},"2026-04-30",{"date":78,"type":21},"2032-03-31",{"name":80,"class":45},"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University",1,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":92,"conditions":93,"keywords":94,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":81},"100562528","genomics-and-microbiome-investigation-in-cases-of-recurrent-pregnancy-losses-100562528","NCT06604338","Genomics and Microbiome Investigation in Cases of Recurrent Pregnancy Losses","Evaluation of Predisposing Factors for Idiopathic Recurrent Pregnancy Losses: a Study Using a Genomic and Microbiota Approach","Inclusion Criteria:\n\n* RPL group: history of at least two spontaneous pregnancy losses, regardless of whether they have living children, and whose etiology for the pregnancy losses was not determined by the care team\\'s protocols;\n* Control group: at least two full-term pregnancies and no history of difficulty getting pregnant, pregnancy loss or other infertility factors.\n\nExclusion Criteria:\n\n* RPL group: less than two spontaneous pregnancy losses and those with a known cause for repeated pregnancy losses;\n* Control group: N\u002FA",{"count":90,"type":21},20,"OBSERVATIONAL","Recurrent pregnancy losses (RPL) are characterized by the occurrence of more than one spontaneous pregnancy loss. It is caused by different known factors, but about half of the cases remain without an explanation. Efforts are being done in the scientific community to solve this cases. In this study, the investigators aim to investigate genetic factors that might predispose to RPL, as well as the influence of the uterine microbiota (microorganisms that normally live in the uterus of women).",[27],[95,96,97,98,99,100],"Miscarriage","Recurrent miscarriage","Abortion","Recurrent abortion","Genetic susceptibility","Microbiome","2024-09-17",{"date":103,"type":38},"2024-09-19",{"date":105,"type":38},"2023-04-14",{"date":107,"type":21},"2025-12",{"name":109,"class":45},"Hospital de Clinicas de Porto Alegre"]