[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"recurrent-urinary-tract-infections\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:recurrent-urinary-tract-infections":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,40,83,112],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100607629","emotional-urinary-tract-infection-100607629",false,"NCT07191041","Emotional Urinary Tract Infection","Emotional Distress in Recurrent Urinary Tract Infection","UTI","Inclusion Criteria:\n\n* Female patients ≥ 18 years of age\n* Diagnosis of recurrent uncomplicated urinary tract infection (≥2 infections in 6 months or ≥3 infections in one year)\n* Ability to complete questionnaires\n\nExclusion Criteria:\n\n* Patients who had a urologic procedure in the last 3 months\n* History of bladder malignancy\n* History of exposure to pelvic radiation therapy\n* Unwilling or unable to comply with study data collection","FEMALE","18 Years",{"count":20,"type":21},170,"ESTIMATED","OBSERVATIONAL","This project proposes a rigorous investigation into the psychological impact of positive urine culture results and recurrent urinary tract infections (UTIs) in women, with a particular focus on Interstitial Cystitis and Bladder Pain Syndrome patients. Interstitial cystitis (IC) or bladder pain syndrome (BPS) is a poorly understood chronic disorder that has an immense impact on quality of life. Stress has been demonstrated to exacerbate bladder symptoms in IC\u002FBPS patients. Because it is often difficult to differentiate IC\u002FBPS symptoms from UTIs, laboratory tests such as urine cultures are often obtained to rule out infectious etiology. Positive lab results can disrupt emotion regulation and impact a variety of health-related coping and outcomes. Chen et al demonstrated in a cohort of 57 IC\u002FBPS patients that the pain index was associated with anxiety mood status and a tendency to develop a sense of hopelessness and helplessness. The impact of positive laboratory results has not been investigated in recurrent UTI patients. Identifying triggers for worsening urinary symptoms is important in the overall management of bladder symptoms therefore it is important to evaluate the impact positive lab results on psychosocial stress level in this population in order provide better patient counseling. By employing validated questionnaires and comprehensive assessments, the study aims to provide evidence-based recommendations for patient counseling and management strategies tailored to address emotional distress and symptom severity. The findings will contribute to improving the overall well-being and quality of life for women affected by recurrent UTIs and associated conditions.",[25,26],"Urinary Tract Infection(UTI)","Recurrent Urinary Tract Infections","NOT_YET_RECRUITING","2025-09-22",{"date":30,"type":31},"2025-09-24","ACTUAL",{"date":33,"type":21},"2026-08-28",{"date":35,"type":21},"2027-12-30",{"name":37,"class":38},"Northwell Health","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":64,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":39},"100588378","a-trial-of-d-mannose-for-the-prophylaxis-of-recurrent-urinary-tract-infections-100588378","NCT06940622","A Trial of D-mannose for the Prophylaxis of Recurrent Urinary Tract Infections","A Randomized Controlled Trial of D-mannose for the Prophylaxis of Recurrent Urinary Tract Infections in Post-menopausal Women","DmannoseRCT","Inclusion Criteria:\n\n* Female, post-menopausal, age ≥ 55 years old\n* Diagnosis of recurrent UTI, defined as ≥ 3 symptomatic culture-proven UTI episodes in 12 months or ≥ 2 in 6 months.\n* Currently free from a UTI determined based on absence of symptoms as determined by the UTI symptom assessment questionnaire79 and negative urine culture (\\\u003C103 colony forming units per ml of urine).\n* Able to attend all follow-up appointments for the study.\n* A negative upper and lower urinary tract evaluation, including pelvic examination for pelvic organ prolapse (less than stage 2), measurement of post-void residual (less than 50 ml), and imaging (renal ultrasound and standing voiding cystourethrogram) to exclude kidney stone, hydronephrosis, reflux, or urethral diverticulum.\n\nExclusion Criteria:\n\n* Current use of D-mannose. Patients willing to stop taking D-mannose will be offered to join the trial after a 4-week wash-out period.\n* Complicated UTIs, including need for catheter drainage or intermittent catheterization, neurogenic bladder, bladder augmentation, or urinary diversion.\n* Ongoing supplement use (Box 1). Patients willing to stop taking the listed supplements will be offered to join the trial after a 4-week wash-out period.\n* Evidence of upper tract infection (pyelonephritis), including temperature higher than 38°C, flank\u002Flumbar pain or tenderness\n* Diagnosis of interstitial cystitis or overactive bladder syndrome\n* Prophylactic antibiotics started in the last 3 months and unwilling to discontinue, or intention to start in the next 12 months\n* Use of Uromune or other vaccine approaches to reduce rUTI\n* Participation in a research study involving an investigational product in the past 12 weeks\n* Receipt of phage treatment\n* History of chronic diarrhea requiring regular therapy\n* Inability to swallow or known history of gastrointestinal malabsorption\n* History of recurrent vaginal yeast infections\n* Systemic disease precluding enrollment in this study (uncontrolled diabetes with HgA1C above 7, ongoing chemotherapy or immunotherapy, renal insufficiency \\[creatinine \\> 1.5 g\u002Fdl\\]), mental or cognitive impairment, weight loss diet requiring excessively large amounts of fluid intake, or other health-related specific diet).\n* Nursing home resident\n* BMI \\>40\n\nBox 1 Supplements to avoid\n\n* Multi-Vitamins and Multi-Mineral capsules\n* Specific Vitamins or Minerals (e.g., Calcium, Citrical, Calcium Gummies, Vitamin A, D, Niacin, Pyridoxine, Selenium, Vitamin E, B6, Iron, Omega 3, D3, Magnesium, B-Complex, Women's Ultra MultiVitamin, GNC B-Complex, B-12, PreserVision Areds2, Vitamins D, B Pollen)\n* Probiotics\n* Cranberry Mannose or Cranberry Extract Weight loss products to avoid\n* Medifast\n* Vitafusion\n* OptiVin Products\n* Appetite Suppressants\n* Keto-Fuel","55 Years","85 Years",{"count":51,"type":21},90,"INTERVENTIONAL",[54],"NA","A randomized, double-blind, placebo-controlled, 12-month study to determine the effectiveness of D-mannose (2g daily) supplementation in rUTI (recurrent urinary tract infection) prevention in post-menopausal women.",[57,26,58,59,60,61,15,62,63],"Recurrent UTIs","Recurrent Urinary Tract Infections in Women","Recurrent Urinary Tract Infection","Cystitis Recurrent","Cystitis Chronic","UTI - Urinary Tract Infection","UTI - Lower Urinary Tract Infection",[65,66,67,68,69,70,71,72,73],"D-mannose","dmannose","uti","ruti","recurrent urinary tract infection","urinary tract infection","cystitis","chronic uti","chronic cystitis","RECRUITING","2025-09-18",{"date":28,"type":31},{"date":78,"type":31},"2025-08-01",{"date":80,"type":21},"2030-09-30",{"name":82,"class":38},"University of Texas Southwestern Medical Center",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":90,"sex":91,"minAge":18,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":52,"phases":95,"briefSummary":96,"conditions":97,"keywords":98,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":111},"100427499","bacterial-interference-for-preventing-recurrent-urinary-tract-infection---new-ways-of-treatment-100427499","NCT04846803","Bacterial Interference for Preventing Recurrent Urinary Tract Infection - New Ways of Treatment","BIrUTI","Inclusion Criteria:\n\n* Diagnosed with recurrent cystitis including 2 times of rUTI within the last 6 months or 3 times in the last 12 months, where at least 2 cultures show the same bacteria.\n* Normal investigation for lower urinary tract diseases (LUTD) including voiding diary, symptom scores, flexible cystoscopy, voiding diagram and test for residual urine.\n* Failed previously treatments.\n* Patients with native bladder with both spontaneous voiding, the need for clean intermittent catheter (CIC) or indwelling catheter.\n* Patients with neurogenic and non-neurogenic bladder dysfunction.\n* Patients with urostomy, kidney transplantation or another complicated genesis.\n* Written consent.\n\nExclusion Criteria:\n\n* Malignancy in the urinary tract, kidney-, ureteral- or bladder stones, age \\\u003C 18 years, pregnancy, breastfeeding. Patients in ongoing orally antibiotic treatment. Not able to speak or understand Danish.",true,"ALL","90 Years",{"count":94,"type":21},80,[54],"Urinary tract infection (UTI) is one of the most common bacterial infections worldwide. It affects 150 million people annually. Treatment of patients with UTI entails a high consumption of antibiotics and large social and health costs. With this protocol, we want to elucidate alternative treatment methods for especially recurrent urinary tract infection. Bacteria have internal competitiveness (bacterial interference) and it is known that the non-pathogenic E.coli can outcompete the pathogenic E.coli in laboratory studies.\n\nWe intend to strengthen the clinical evidence that it can be used as patient treatment through a clinical, placebo-controlled, double-blind trial at Odense University Hospital.",[26],[99,100,101,102],"rUTI","E.coli","prophylactic","bladder lavage","2025-09-14",{"date":75,"type":31},{"date":106,"type":31},"2024-01-09",{"date":108,"type":21},"2027-12-01",{"name":110,"class":38},"Odense University Hospital",2,{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":91,"minAge":18,"maxAge":120,"enrollmentInfo":121,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":123,"conditions":124,"keywords":132,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":111},"100571359","evaluating-the-efficacy-and-patient-experience-of-catheter-free-intravesical-instillation-100571359","NCT06719232","Evaluating the Efficacy and Patient Experience of Catheter-Free Intravesical Instillation","Evaluating the Efficacy and Patient Experience of Catheter-Free Intravesical Instillation: a Prospective Observational Study","NOCATIN","Inclusion Criteria:\n\n* Male and female patients aged between 18 and 80 years.\n* Patients for whom the treating physician has determined that intravesical instillation is necessary due to one of the following conditions:\n* Interstitial cystitis\u002Fbladder pain syndrome (IC\u002FBPS).\n* Recurrent urinary tract infections (UTIs).\n* Non-muscle invasive bladder cancer.\n* Post-radiation cystitis.\n* Post-chemotherapy cystitis.\n* Negative urine culture within the last two weeks.\n* Patients who provide verbal and written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Urinary tract infection within the past month or currently active infection.\n* Diagnosed bleeding disorders or recurrent macroscopic hematuria.\n* Post-void residual urine volume greater than 100 ml.\n* Mental condition that prevents reliable cooperation.","80 Years",{"count":122,"type":21},300,"This study aims to evaluate a catheter-free method for delivering medications directly into the bladder, known as intravesical instillation, which is commonly used to treat conditions such as interstitial cystitis\u002Fbladder pain syndrome (IC\u002FBPS), recurrent urinary tract infections, bladder cancer, and post-chemotherapy or post-radiation cystitis.\n\nThe study investigates whether this method, which eliminates the need for catheterization, reduces discomfort and complications while maintaining treatment effectiveness. By collecting data on patient experiences and outcomes, the study seeks to determine if this approach provides a safer and more comfortable alternative to traditional catheter-based treatments.",[125,126,127,128,129,130,131,26],"Interstitial Cystitis","Recurrent Cystitis","Haemorrhagic Cystitis","Bladder Cancer","Bladder Disease","Intravesical Instillation","Bladder Pain Syndrome",[133,134,69,135,136,137,138,139,140],"intravesical therapy","catheterization","IC\u002FBPS","Interstitial Cystitis\u002FBladder Pain syndrome","Post-chemotherapy Cystitis","Post-Irradiation Cystitis","Intravesical instillation","UroDapter","2024-12-07",{"date":143,"type":31},"2024-12-12",{"date":145,"type":31},"2024-10-01",{"date":147,"type":21},"2025-12",{"name":149,"class":150},"Jahn Ferenc South Pest Teaching Hospital","OTHER_GOV"]