[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"reflex-syncope\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:reflex-syncope":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100631585","fainting-detection-and-early-warning-in-syncope-evaluation-study-arise-100631585",false,"NCT07502599","Fainting Detection And Early Warning In Syncope Evaluation Study (ARISE)","Fainting Detection And Early Warning In Syncope Evaluation Study","ARISE","Inclusion Criteria:\n\n* Willing and capable to provide informed consent\n* Age 18 or above\n* Previously underwent a clinically indicated ARS assessment without complications (including deep breathing, Valsalva maneuver, and tilt table testing).\n* Previously diagnosed with OH, Vasovagal syncope, OR control subjects assessed as normal, based on the ARS assessment. Participant enrollment shall be based on the type of diagnosis.\n* Willing to complete all required study activities.\n\nExclusion Criteria:\n\n* Currently enrolled in another clinical trial that might interfere with data collection.\n* Subject is pregnant or planning to become pregnant during the study\n* Active Implantable Medical Device, e.g. cardiac implantable electronic devices, bladder stimulators, diaphragm stimulators, implantable neuro stimulator, implantable active monitoring devices, implantable active drug administration devices, etc.\n* Have a prosthetic cardiac valve or previously underwent cardiac valve surgery.\n* Known allergy to materials used in the study (adhesive, ECG electrodes)\n* Diagnosed with syncope due to cardiologic causes.\n* Have had a myocardial infarction in the previous 90 days\n* Have been diagnosed with tachycardia that requires current medical treatment\n* Have any contraindications for exercise testing, tilt table test, Valsalva maneuver test or deep breathing test (judged by the study Principal Investigator)","ALL","18 Years",{"count":20,"type":21},40,"ESTIMATED","OBSERVATIONAL","To characterize the impact of orthostatic hypotension (OH) and Vasovagal syncope on signals measured using a wearable Holter monitor in the clinic and ambulatory setting.\n\nTo evaluate the relationship of signals measured from the Holter monitor with reported symptom severity of orthostatic intolerance per standard data collection, analysis, and questionnaires.",[25,26],"Orthostatic Hypotension","Reflex Syncope",[28,29],"tilt table test","valsalva","RECRUITING","2026-06-16",{"date":33,"type":34},"2026-06-17","ACTUAL",{"date":36,"type":21},"2026-06",{"date":38,"type":21},"2028-08",{"name":40,"class":41},"Boston Scientific Corporation","INDUSTRY",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":18,"enrollmentInfo":51,"targetDuration":53,"studyType":22,"phases":4,"briefSummary":54,"conditions":55,"keywords":56,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":42},"100605455","implantable-loop-recorder-and-cardioneuroblation-100605455","NCT07162740","Implantable Loop Recorder and Cardioneuroblation","Comparative Study of Right Atrial Versus Bi-atrial Cardioneuroablation of Asystolic Reflex Syncope Verified by Implantable Loop Recorder","ILR-CNA","Inclusion Criteria:\n\n* Age 18 to 60 years\n* Clinical diagnosis of reflex syncope as per class I criteria of the ESC guidelines\n* History of recurrent severe syncopes (≥2 in the last year or ≥3 in the last 2 years), significantly affecting the quality of life, nonresponding to lifestyle measures.\n* Documentation by means of prolonged ECG monitoring of an asystolic pause \\>6 sec or of an asystolic syncope \\>3 sec and\u002For an asystolic syncope induced during tilt testing (Vasis 2B form).\n\nExclusion Criteria:\n\n* Intrinsic sinus dysfunction or atrioventricular node disease.\n* Constitutional hypotension and orthostatic intolerance syndromes\n* Overt structural heart disease\n* Alternative diagnoses of syncope\n* Pregnancy or breastfeeding",{"count":52,"type":21},50,"12 Months","The study aims to determine which method of vagal ganglia ablation is most effective in preventing recurrences of reflex asystole syncope. Currently, some centers perform ablation only in the right atrium, others in both atria (biatrial). There are no comparative studies between the two procedures",[26],[57,58,59,60,61,62],"Syncope","reflex syncope","implantable loop recorder","Vagal ganglia ablation","Cardioneuroablation","Asystole","NOT_YET_RECRUITING","2025-09-08",{"date":66,"type":34},"2025-09-09",{"date":68,"type":21},"2025-10-01",{"date":70,"type":21},"2027-10-01",{"name":72,"class":73},"Istituto Auxologico Italiano","OTHER",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":82,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":102},"100504997","cardioinhibitory-reflex-syncope-permanent-pacemaker-therapy-or-cardioneuroablation-100504997","NCT05855603","Cardioinhibitory Reflex Syncope. Permanent Pacemaker Therapy or Cardioneuroablation?","Recurrent Cardioinhibitory Reflex Syncope. PermANent PAcemaker Therapy or CardionEuroablation? A Multicenter RAndomized Clinical Trial","PANACEA","Inclusion Criteria:\n\n* Aged more than 40 years.\n* Having a 12-month history that includes at least two documented episodes of spontaneous reflex syncope or one episode that led to injury in addition to at least two presyncopal events, refractory to all recommended types of standard treatment.\n* Bradycardia-syncope correlation (at least 3 seconds of asystole due to sinus arrest or atrio-ventricular block) confirmed by ECG during spontaneous syncope.\n* If lacking ECG evidence during spontaneous syncope, a cardioinhibitory response (VASIS type 2A or 2B) on tilt test.\n* Displaying indicators for pacing such as those suggested in the ESC guidelines for a class I recommendation for patients with reflex syncope.\n* Significantly decreased quality of life due to syncope.\n* Sinus rhythm on ECGs.\n* Obtained written informed consent.\n\nExclusion Criteria:\n\n* Intrinsic sinus or atrioventricular nodal disease with a proven indication for permanent pacemaker implantation.\n* Evidence of structural heart disease.\n* Contraindications to ablation in the right or left atrium.\n* Life expectancy \\\u003C12 months.\n* Lacking willingness to comply with the randomization procedure.","40 Years",{"count":84,"type":21},90,"INTERVENTIONAL",[87],"NA","Reflex syncope is the most common form of syncope. It can lead to injuries and affect quality of life. Nonpharmacological and medical therapies have limited effectiveness. In certain patients, cardiac pacing seem to be beneficial. More recently cardioneuroablation (CNA) has emerged as a novel therapy for reflex syncope. The investigators aim to determine whether CNA is more effective than cardiac pacing at reducing the rate of cardioinhibitory-type reflex syncope.",[26],[61,91,92],"Permanent cardiac pacing","Vasovagal syncope","2024-01-22",{"date":95,"type":34},"2024-01-25",{"date":97,"type":34},"2023-11-22",{"date":99,"type":21},"2027-02-22",{"name":101,"class":73},"Institut d'Investigació Biomèdica de Bellvitge",10]