[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"refractive-error-correction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:refractive-error-correction":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100630651","phase-2-metric-optimized-spectacle-prescriptions-for-children-with-down-syndrome-100630651",false,"NCT07490444","Metric-Optimized Spectacle Prescriptions for Children With Down Syndrome","Metric-derived Corrections Versus Clinically-derived Corrections for Children With Down Syndrome","Inclusion Criteria:\n\n* Down syndrome\n* Age 5 to 12 years\n* Ability to sit for study measures\n* Able to be dilated\n\nExclusion Criteria:\n\n* Nystagmus\n* History of Ocular or Refractive Surgery\n* Corneal or lenticular opacities\n* Ocular disease\n* Anisometropic or strabismic amblyopia\n* Contact allergy to aluminum","ALL","5 Years","12 Years",{"count":20,"type":21},24,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","This study seeks to determine whether glasses prescriptions determined from computer analysis of detailed images of the eyes provide better vision outcomes for children with Down syndrome than prescriptions determined using routine clinical methods.",[27,28],"Refractive Error Correction","Visual Acuity",[30,31,32,33,34],"Down syndrome","Children","Glasses","Spectacles","Vision","RECRUITING","2026-06-16",{"date":38,"type":39},"2026-06-18","ACTUAL",{"date":41,"type":39},"2026-05-26",{"date":43,"type":21},"2028-05-01",{"name":45,"class":46},"Ohio State University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":47},"100627360","clinical-outcomes-of-the-use-of-a-femtosecond-laser-treatment-in-a-patient-with-implanted-monofocal-iols-100627360","NCT07447622","Clinical Outcomes of the Use of a Femtosecond Laser Treatment in a Patient With Implanted Monofocal IOLs","Assessment of Clinical and Refractive Outcomes of the Use of a Femtosecond Laser to Create Near Vision or Correct Refractive Error in a Patient With Implanted Monofocal IOLs","Inclusion Criteria:\n\n1. Ability to understand study requirements, follow study instructions and to return for required study follow-up visits as confirmed by provision of written informed consent.\n2. Participant has undergone cataract surgery with an implantation of mono focal IOL.\n3. Participant has no significant residual visual issues which the Investigator believes would make the patient ill-suited for the treatment.\n4. Vision must be clinically stable in the Investigator's judgment.\n5. Each eye has Corrected Distance Visual Acuity (CDVA) of at least 0.2 logMAR (20\u002F32).\n\nSpecific inclusion criteria for Cohort 1: Creating near vision (participants must fulfill all criteria to be enrolled in Cohort 1).\n\n1. Participant has a mono focal intraocular lens implanted in both eyes.\n2. Both eyes have uncorrected distance visual acuity (UDVA) of 20\u002F40 (0.3 logMAR) or better at 4 meters.\n3. Each eye has near vision assessed as Distance Corrected Near Visual Acuity (DCNVA) worse than Jeager 8 and\u002For ETDRS 0.5 logMAR.\n\nSpecific inclusion criteria for Cohort 2: Refractive correction (participants must fulfill all criteria to be enrolled in Cohort 2).\n\n1. Participant has a mono focal intraocular lens implanted in one or both eyes.\n2. The eye to be treated requires an adjustment of at least 1.0 D in sphere or cylinder.\n3. Difference between UDVA and CDVA pre-treatment is at least 2 lines i.e. 0.2 logMAR.\n\nExclusion Criteria:\n\n1. Participants not able to complete the informed consent form.\n2. Clinically significant corneal abnormalities including corneal dystrophy (e.g., epithelial, stromal, or endothelial dystrophy), inflammation, keratitis, keratoconjunctivitis, keratouveitis, keratopathy, keratectasia or edema per the Investigator's expert medical opinion.\n3. Previous corneal surgery.\n4. Previous refractive surgery or proposed refractive surgery procedures throughout the entire duration of the participants' participation in the clinical study (including, but not limited to LASIK, astigmatic keratotomy and limbal relaxing incisions).\n5. History of or current retinal conditions or predisposition to retinal conditions including retinal detachment, diabetic retinopathy, age related macular degeneration which are assessed to by Investigator to confound outcomes.\n6. Amblyopia.\n7. History of or current anterior or posterior segment inflammation of any etiology, or any disease producing an inflammatory reaction in the eye (e.g., iritis or uveitis).\n8. Optic nerve atrophy.\n9. Iris neovascularization.\n10. Participants with diagnosed degenerative eye disorders (e.g., macular degeneration or other retinal disorders).\n11. Uncontrolled glaucoma.\n12. Any participant currently participating in any other investigational drug or device studies.\n13. Participants unable to reliably perform visual acuity testing or defocus curve assessments, including intolerance to trial frame correction or inconsistent test responses, in the opinion of the Investigator.\n14. Clinically significant posterior capsule opacification (PCO) in the study eye that, in the Investigator's judgment, could affect visual acuity, contrast sensitivity, or confound study outcomes.\n15. Any participant disqualified by the Principal Investigator or Medical Monitor for any ocular issue.",true,{"count":57,"type":21},12,[59],"NA","This study aims to assess the safety and efficacy of evaluating near vision or refractive error in eyes implanted with a mono focal intraocular lens (IOL) using a low-energy femtosecond laser.",[62,27],"Near Vision","NOT_YET_RECRUITING","2026-02-26",{"date":66,"type":39},"2026-03-03",{"date":68,"type":21},"2026-03",{"date":70,"type":21},"2026-09",{"name":72,"class":73},"Perfect Lens, LLC","INDUSTRY",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":55,"sex":16,"minAge":80,"maxAge":18,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":90,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":47},"100596484","algorithm-assisted-subjective-refraction-program-dedicated-to-children-100596484","NCT07046065","Algorithm-assisted Subjective Refraction Program Dedicated to Children","Inclusion Criteria:\n\n1. Age between 6 and 12 years\n2. Subject able to recognize and name the letters of the Latin alphabet\n3. Pupillary distance (PD) not less than 49mm\n4. Distance refractive error for spherical equivalence (SE) within the range of \\[-6.00 to +6.00 D\\] maximum of the two absolute values RE and LE; Cyl ≤ 3.00 D\n5. Monocular Visual acuity ≥ +0.30 LogMAR (0.5 Decimal VA) in each eye at distance\n6. Visual acuity difference \\\u003C 0.20 logMAR between right and left eyes at distance\n\nExclusion Criteria:\n\n1. Vulnerability of the subject\n2. Amblyopia\n3. Strabismus\n4. Any current or evolving pathology manifested in the eye or the appendages which might have an influence on vision, or interfere with refractive state\n5. Any previous ocular surgery, which might have an influence on vision or interfere with study assessments (e.g. iridectomy, refractive surgery…)\n6. Any ocular or systemic condition known to affect refractive status (e.g., keratoconus, diabetes, Down's syndrome, etc.)\n7. Any neurological or speech disorders that might interfere with the ability to understand and answer questions or communicate with the ECP\n8. Any untreated and\u002For uncontrolled systemic condition which might have an influence on vision or interfere with study assessments\n9. Current use of ocular or systemic medications, which, in the Investigator's opinion, may significantly affect pupil size, accommodation or refractive state\n10. History of myopia control intervention that may affect refractive assessment (e.g., atropine, orthokeratology, rigid gas permeable lenses (RGP) etc.) except myopia control spectacles\n11. Contraindications of cycloplegia (e.g. high Intra-ocular pressure - more than 22mmHg in either eye, narrow anterior angle, history of allergy to cycloplegic agents or seizures, etc)\n12. Aphakic or pseudoaphakic (intraocular lens),\n13. Prismatic prescription in either Right or Left eye (horizontal or vertical). -","6 Years",{"count":82,"type":21},166,[59],"Current refraction assessment in children is dependent on the Eye Care Specialist and lacks standardization. Essilor has developed new algorithm assisted subjective refraction software dedicated to children of 6-12 years old and suitable for use with Vision-S™ and Vision-R™ phoropters, in addition to existing software.\n\nTwo different versions of the software have been developed: the first incorporating only the steps needed to perform an entire subjective refraction process (vA), and the second, identical to the first but incorporating additional steps useful for managing the child's attention and cooperation (vB).\n\nThe software performance in terms of subjective refraction results will be compared to a conventional subjective refraction method performed with the Vision-R™700 phoropter in manual mode.",[86,87,88,89,27,31],"Refractive Assessment","Refractive Disorders","Hyperopia and Myopia","Astigmatism",[91,92,93],"cycloplegic refraction","non-cycloplegic refraction","subjective refraction","2025-06-23",{"date":96,"type":39},"2025-07-01",{"date":98,"type":39},"2025-05-23",{"date":100,"type":21},"2025-12-31",{"name":102,"class":73},"Essilor International"]