[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"refractive-errors\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:refractive-errors":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,41,76,99,121,151,173,194,215,240,260,294,323,351],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100288134","corneal-elastography-and-patient-specific-modeling-100288134",false,"NCT03030755","Corneal Elastography and Patient Specific Modeling","Inclusion Criteria:\n\n* Any patient with keratoconus diagnosed by standard criteria, including topographic steepness, irregular astigmatism with a pattern consistent with keratoconus.\n* Any patient deemed a candidate for LASIK (laser vision correction) and scheduled for surgery.\n\nExclusion Criteria:\n\n* Inability to provide informed consent, including non-English speaking (if interpreter not available) and cognitively\u002Fmentally impaired (if legal guardian not available).",true,"ALL","16 Years","80 Years",{"count":20,"type":21},60,"ESTIMATED","OBSERVATIONAL","The goal of this research is to develop measurement tools and simulation technology for characterizing and predicting individual responses to corneal treatments and for advancing understanding of corneal ectasia risk factors. Patients who either 1) have keratoconus and are being evaluated for corneal crosslinking or 2) have refractive error and are being evaluated for refractive surgery procedures such as LASIK will have their eyes imaged to assess their mechanical properties and will have computational simulations performed to predict the response to treatment. One aim of the study is to test the hypothesis that computational models can predict the cornea's shape changes within clinically acceptable limits of error.",[25,26,27],"Cornea; Ectasia","Refractive Errors","Keratoconus","RECRUITING","2026-06-01",{"date":31,"type":32},"2026-06-03","ACTUAL",{"date":34,"type":4},"2016-05",{"date":36,"type":21},"2027-05",{"name":38,"class":39},"The Cleveland Clinic","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":40},"100618563","strengthening-community--to--hospital-eye-care-pathways-from-boko-eye-care-center-in-rural-assam-100618563","NCT07333248","Strengthening Community- to- Hospital Eye Care Pathways From Boko Eye Care Center in Rural Assam","Strengthening Community -to- Hospital Eye Care Pathways From Boko Eye Care Center in Rural Assam - From Referral to Treatment","Inclusion Criteria:\n\nAdults diagnosed with eye conditions requiring referral or surgical treatment.\n\nExclusion Criteria:\n\nPatients requiring emergency treatment, patients medically unfit for surgery, or patients unwilling to participate.\n\nEligibility: Enrolment criteria: Participants will be enrolled consecutively at the time of screening in community outreach camps and at the Boko Eye Care Center if they meet the following operational criteria:\n\ni. Adult (≥18 years) with a diagnosed eye condition requiring referral to Sri Sankaradeva Nethralaya for tertiary evaluation or surgical treatment, as determined by the examining optometrist\u002Fophthalmologist.\n\nii. Resident of the Boko Eye Care Center catchment area (villages linked to the Eye Care Center under Sri Sankaradeva Nethralaya outreach).\n\niii. Patients willing to provide informed consent to participate in the study and to allow follow-up for referral completion and surgical acceptance outcomes.","18 Years",{"count":50,"type":21},2000,"INTERVENTIONAL",[53],"NA","This operational research project aims to strengthen continuity of eye care delivery between community screening and hospital-based treatment in rural Assam by redesigning referral pathways from the Boko Eye Care Center (ECC) to Sri Sankaradeva Nethralaya (SSDN) base hospital. Despite active outreach in the Boko region from the Boko ECC through conducting regular outreach screenings, less than 30 percent of patients referred to the base hospital actually arrive for evaluation and less than 25 percent of those advised for surgery proceed to treatment. The proposed study addresses these gaps by examining behavioural, structural and logistical barriers to referral completion and surgical uptake, and by implementing a coordinated patient-centered referral and engagement strategy.\n\nThe proposed intervention comprises of five sequential components: (1) root cause analysis to identify bottlenecks and facilitators in the current referral pathway, (2) community engagement activities to improve awareness and proactive health-seeking behaviour, (3) implementation of an integrated referral and engagement model supported by trained community team and structured referral tracking, (4) strengthening referral completion through patient navigation, scheduled transport and follow-up reminders, and (5) enhancement of surgical acceptance through standardized counseling, affordability support and social reinforcement. The outcomes will be measured prospectively, focusing on increase in hospital footfall from the Boko catchment area, proportion of referred patients who complete hospital visits, and proportion of patients who were advised for surgery and had undergone the procedure. The proposed project aims to achieve a minimum of 70 percent referral completion and 45 percent surgical conversion by the end of the 36-month study period.",[56,26],"Cataract",[58,59,60,61,62,63,64,65],"Referral completion","Cataract surgery uptake","Patient navigation","Community engagement","Rural eye care","Surgical acceptance","Assam","LMIC","NOT_YET_RECRUITING","2026-05-11",{"date":69,"type":32},"2026-05-14",{"date":71,"type":21},"2026-06-15",{"date":73,"type":21},"2028-01-31",{"name":75,"class":39},"Seva Canada Society",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":51,"phases":86,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":4},"100632794","factors-influencing-subjective-visual-quality-in-human-eyes-100632794","NCT07518316","Factors Influencing Subjective Visual Quality in Human Eyes","Factors Influencing Subjective Visual Quality in Normal Human Eyes and Before and After Refractive Surgery","Inclusion Criteria:\n\n* Myopic or myopic astigmatism patients aged 18 to 45 years.\n* Transparent ocular media, absence of ocular diseases such as corneal leucoma, cataract, etc.\n* Round pupils with normal light reflex, absence of dyscoria, corectopia, significant persistent pupillary membrane, or absence of the pupil.\n* Absence of severe psychological or psychiatric disorders, ability to cooperate with examinations and questionnaire completion.\n* Subject agrees to participate in this clinical study and cooperate with examinations and related procedures.\n\nExclusion Criteria:\n\n* Opacities of the ocular media, such as corneal leucoma, cataract, etc.\n* Pupil deformation, displacement, significant persistent pupillary membrane, or absence of the pupil.\n* Severe psychological or psychiatric disorders.\n* Concurrent diagnosis of other ocular diseases (e.g., glaucoma, corneal opacity, uveitis, etc.).\n* History of ocular surgery or trauma.\n* Nystagmus or inability to cooperate.","45 Years",{"count":85,"type":21},300,[53],"To assess subjective visual symptoms using the QoV questionnaire, measure pupil size using the Atongmu Pupillometer, measure wavefront aberrations using the OPD-Scan III Aberrometer, and measure\u002Fcalculate the effective optical zone using the Pentacam system. The relationships between pupil size, higher-order aberrations (HOAs), effective optical zone after refractive surgery, and subjective visual symptoms will be explored.",[89,26],"Corneal Wavefront Aberration","2026-04-04",{"date":92,"type":32},"2026-04-08",{"date":94,"type":21},"2026-03-18",{"date":96,"type":21},"2026-09-01",{"name":98,"class":39},"Tianjin Eye Hospital",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":16,"minAge":106,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":40},"100505087","to-study-the-effects-of-refractive-surgery-on-oct-measurements-in-the-eye-100505087","NCT05856786","To Study the Effects of Refractive Surgery on OCT Measurements in the Eye","To Study the Effects of Refractive Surgery on Optical Coherence Tomography (OCT) Measurements in the Eye: A Pilot Study","Inclusion Criteria:\n\n1. Patients undergoing refractive surgery\n2. For patients undergoing bilateral eye surgery, the one with higher degree of ametropia will be included.\n\nExclusion Criteria:\n\n1. Astigmatism more than 3 Diopters\n2. Visual acuity worse than 20\u002F25\n3. Patients with unstable visual fixation\n4. Severe Dry Eye","19 Years",{"count":108,"type":21},33,"Corrective eye surgeries, such as Lasik, are widely used to correct focusing problems such as myopia, or nearsightedness. Often these patients develop other conditions like myopic maculopathy or glaucoma which require monitoring with optical coherence tomography (OCT). Since OCT is a light-based test and changes the refractive status of the eye (in the cornea or the lens), it can potentially affect the results of the OCT measurements but has not been sufficiently studied. This pilot study aims at studying the potential change in OCT parameters in the eye after undergoing such surgery.",[111,26,112],"Optical Coherence Tomography","Myopia","2026-03-17",{"date":94,"type":32},{"date":116,"type":32},"2024-06-01",{"date":118,"type":21},"2026-12",{"name":120,"class":39},"University of Nebraska",{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":127,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":16,"minAge":129,"maxAge":4,"enrollmentInfo":130,"targetDuration":4,"studyType":51,"phases":132,"briefSummary":133,"conditions":134,"keywords":135,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":40},"100474470","cognitive-level-enhancement-through-vision-exams-and-refraction-100474470","NCT05458323","Cognitive Level Enhancement Through Vision Exams and Refraction","Cognitive Level Enhancement Through Vision Exams and Refraction: a Randomized Controlled Trial to Assess Impact of Near and Distance Spectacles on Reducing Rates of Cognitive Decline With Aging in Community Dwelling Older People in India","CLEVER","Inclusion Criteria\n\n1. Community dwelling\n2. Residency\n\n   a. Participants must plan to reside in the local area for the study duration\n3. Presenting vision in the better eye due to uncorrected refractive error\n\n   1. Impaired distance vision less than 6\u002F18\n   2. Near vision less than N6 at 40 cm\n4. Willingness\n\n   1. to participate\n   2. to be randomized\n   3. to adhere to the protocol\n\nExclusion criteria\n\n1. Impaired baseline cognition\n\n   a. HMSE score less than or equal to 18\n2. Non-refractive causes of vision impairment\n3. Severely impaired mobility\n\n   1. immobile\n   2. bedridden\n   3. wheelchair\n   4. using walker\n4. Severe medical illness likely to limit the life span\n\n   1. Cancer\n   2. Heart disease\n   3. Stroke\n   4. HIV or AIDS\n   5. Chronic lung disease\n   6. Kidney disease\n5. Hearing loss assessment\n\n   1. self-reported hearing impairment\n   2. inability to hear\n   3. fail in whisper test hearing screening(unable to repeat three out of six words)","60 Years",{"count":131,"type":21},820,[53],"The investigators aim to conduct a mixed-method study in which a randomised controlled trial (RCT) and a descriptive qualitative study will be conducted. The RCT aims to determine whether free near and distance glasses provided to residents in Hyderabad, India, aged ≥ 60 years, with under- or un- corrected refractive error and normal baseline hearing and cognition (HMSE \\> 18), can improve quality of life, reduce falls, reduce depression, improve social interaction and physical activity cost-effectively over 36 months. The primary qualitative research aim is to a) contextualize the RCT with information on the milieu and culture in which the trial will be conducted; b) provide data on the lived experiences of older adults with reduced vision in the study area, and c) conduct a process evaluation of the trial.\n\nThe primary outcome measure is the three-year change in cognition measured by LASI- DAD (Longitudinal Aging Study in India(LASI)- Diagnostic Assessment of Dementia(DAD) global cognitive score.\n\nSecondary Outcome Measures: Three year change in Quality of Life score measured by WHO QOL-BREF; Visual functioning from the RASCH-scaled version of INDVFQ(Indian Visual Functioning(INDVFQ);self-reported physical activity score measured using IPAQ questionnaire; PHQ9 score; domain specific cognitive score (orientation, executive function, language\u002Ffluency, memory) measured by HMSE; Total cost of care including direct and indirect costs; Quality adjusted life years; Incremental Cost Effectiveness Ratio; Number of falls measured by Quick Screen score over the three years; Social network density at 3 years (SNI 1-3 represents a \"limited\" social network, 4-5 is a \"medium\" social network, and SNI ≥6 is a \"diverse\" social network) measured by the SNI score; An additional secondary outcome will be LASI-DAD global cognitive score analysed by excluding any tests determined pre-hoc to depend on visual acuity.",[26],[136,137,138,139,140,141],"Cognitive Decline","Elderly","Refractive Error","Spectacles","cost effectiveness analysis","dementia","2026-03-04",{"date":144,"type":32},"2026-03-06",{"date":146,"type":32},"2024-01-18",{"date":148,"type":21},"2028-12-31",{"name":150,"class":39},"Queen's University, Belfast",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":15,"sex":16,"minAge":158,"maxAge":159,"enrollmentInfo":160,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":162,"conditions":163,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":40},"100628355","morphological-characteristics-of-the-maxillomandibular-region-in-a-3d-representation-and-the-refractive-status-of-the-eye-100628355","NCT07460557","Morphological Characteristics of the Maxillomandibular Region in a 3D Representation and the Refractive Status of the Eye","Analysis of the Relationship Between the Morphological Characteristics of the Maxillomandibular Region in a 3D Representation and the Refractive Status of the Eye After the Completion of Growth and Development","Inclusion Criteria:\n\nHealthy young adults aged 21 to 25 years.\n\nSame ethnic background (to reduce population-related morphological variability).\n\nBest-corrected visual acuity ≥ 1.0.\n\nNormal findings of the anterior and posterior ocular segments.\n\nRefractive status determined by objective autorefractometry and confirmed by subjective refraction.\n\nBody mass index (BMI) between 18.5 and 24.9 kg\u002Fm².\n\nWillingness to participate and provision of written informed consent.\n\nExclusion Criteria:\n\nPrevious ocular surgery.\n\nPrevious facial surgery.\n\nCraniofacial anomalies.\n\nActive or previous orthodontic therapy that may affect maxillomandibular relationships.\n\nStrabismus.\n\nAmblyopia.\n\nOcular trauma.\n\nFacial trauma.\n\nSystemic diseases that may affect facial morphology or ocular biometric parameters.","21 Years","25 Years",{"count":161,"type":21},120,"The goal of this observational study is to learn more about the relationship between the size and shape of the eye and the shape of the face in healthy young adults. In particular, the study focuses on whether specific eye measurements are linked to certain facial characteristics after growth and development have been completed.\n\nThe main question it aims to answer is:\n\nDoes the size and internal structure of the eye relate to the three-dimensional shape of the face in young adults aged 21 to 25, and are these relationships different in people who are nearsighted (myopic), farsighted (hyperopic), or have normal vision (emmetropic)?\n\nRefractive errors such as nearsightedness and farsightedness are very common and are largely influenced by the length of the eye (axial length) and other internal eye measurements. During childhood and adolescence, it develops at the same time as the eye socket (orbit) and the bones of the face. However, most previous studies have examined either the eye or the bony orbit separately. Very few have combined detailed eye measurements with modern three-dimensional (3D) facial measurements in the same individuals.\n\nThis study will include 120 healthy young adults between 21 and 25 years of age, after facial growth is complete. Participants will be divided into three groups based on their refractive status: myopic (nearsighted), emmetropic (normal vision), and hyperopic (farsighted), with similar numbers of men and women in each group.\n\nAll participants will undergo a standard ophthalmologic examination. This will include measurement of visual acuity, refraction (to determine glasses prescription), and detailed eye biometry using a non-contact optical device (IOLMaster 700). The measurements will include axial length (eye length), corneal curvature, anterior chamber depth, lens thickness, and corneal diameter (white-to-white). These are routine, non-invasive measurements commonly used in clinical eye care.\n\nIn addition, participants will undergo non-invasive 3D facial imaging. A short video of the face will be recorded while a camera moves around the participant. Using photogrammetry software, this video will be converted into a precise 3D model of the face. From this model, specific facial landmarks will be identified, and distances and proportions of different facial regions (upper, middle, and lower thirds of the face; cheek width; jaw width; chin projection) will be measured. This method does not involve radiation and does not cause discomfort.\n\nThe researchers will then analyze whether there are statistical relationships between eye measurements and facial dimensions. They will also compare the three refractive groups to determine whether certain facial patterns are more common in myopic, emmetropic, or hyperopic individuals.\n\nParticipation is voluntary. All participants will sign informed consent before enrollment. The study has been approved by relevant ethics committees and will be conducted according to international ethical standards. All data will be anonymized and stored securely. No additional risks are expected beyond those associated with a routine eye examination.\n\nThe results of this study may improve understanding of how eye growth and facial development are related. In the long term, this could contribute to better knowledge of the anatomical background of refractive errors and support future interdisciplinary research in ophthalmology, orthodontics, and craniofacial medicine.",[26],"2026-03-03",{"date":166,"type":32},"2026-03-10",{"date":168,"type":21},"2026-03-01",{"date":170,"type":21},"2026-07-01",{"name":172,"class":39},"University of Zagreb",{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":4,"eligibilityCriteria":179,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":180,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":182,"conditions":183,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":193},"100592663","clinical-data-collection-of-myopic-patients-after-ptk-prk-with-czm-mel-90-excimer-laser-100592663","NCT06996353","Clinical Data Collection of Myopic Patients After PTK-PRK With CZM MEL 90 Excimer Laser","Clinical Data Collection of Myopic Patients After PTK-PRK With CZM MEL 90 Excimer Laser for Verification of Predicted Refractive Outcome Using EpiMaster Software Considering Epithelial Remodelling","Inclusion Criteria:\n\n* Inclusion criteria are according to the user manual of CZM MEL 90 Excimer Laser for treatment of refractive errors\n* Patient present with myopic or myopic and astigmatic error\n* Patient will be able to understand the patient information and willing to sign an informed consent\n* Patient will be willing to comply with all follow-up visits and the respective examinations\n\nExclusion Criteria:\n\n* Exclusion criteria are according to the user manual of CZM MEL 90 Excimer Laser for treatment of refractive errors",{"count":181,"type":21},150,"The objective of the clinical investigation presented to is to verify predictions of post-operative PTK-PRK refractive outcome made by the EpiMaster application software by comparing these to post-operative clinical data after routine PTK-PRK treatments.",[26],"2026-01-07",{"date":186,"type":32},"2026-01-09",{"date":188,"type":32},"2025-05-26",{"date":190,"type":21},"2027-06",{"name":192,"class":39},"London Vision Clinic",2,{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":198,"acronym":4,"eligibilityCriteria":199,"healthyVolunteers":15,"sex":16,"minAge":200,"maxAge":201,"enrollmentInfo":202,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":204,"conditions":205,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":4},"100612742","xinxing-eye-cohort-study-100612742","NCT07257536","Xinxing Eye Cohort Study","Inclusion Criteria:\n\n* Primary and secondary school students in Xinxing County and people covered by the national basic public health service, including children aged 0-6, seniors over 65 years old and diabetic patients, etc.\n* Voluntarily participate in this study and provide signed informed consent\n\nExclusion Criteria:\n\n* Unable to cooperate with research-related examinations, such as those with disabilities, communication barriers, or other reasons that prevent examinations\n* With serious systemic disease that may affect the examination, or participating in the research examination may endanger one's health\n* Other people who the researchers consider unsuitable to participate in this study","0 Years","100 Years",{"count":203,"type":21},3000,"To establish the baseline levels and monitor the progress of two newly introduced global eye health indicators in Xinxing County, including effective refractive error coverage (eREC) and effective cataract surgery coverage (eCSC). And to assess the prevalence and treatment status of common eye disease in Xinxing County.",[26,56],"2025-11-30",{"date":208,"type":32},"2025-12-02",{"date":210,"type":21},"2025-12-15",{"date":212,"type":21},"2028-11-30",{"name":214,"class":39},"Zhongshan Ophthalmic Center, Sun Yat-sen University",{"id":216,"slug":217,"hasResults":11,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":4,"eligibilityCriteria":221,"healthyVolunteers":15,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":222,"targetDuration":224,"studyType":22,"phases":4,"briefSummary":225,"conditions":226,"keywords":230,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":4},"100611430","assessing-the-turkish-ddivat-for-visual-acuity-measurement-100611430","NCT07240480","Assessing the Turkish DDIVAT for Visual Acuity Measurement","Validation of the Turkish Version of the DDIVAT Visual Acuity Measuring Device in a Turkish-speaking Population","Inclusion Criteria:\n\n* Adults aged 18 years or older\n\nTurkish-speaking individuals able to understand the study purpose\n\nWillingness to participate and provide written informed consent\n\nParticipants with or without refractive errors (e.g., myopia, hyperopia, astigmatism)\n\nExclusion Criteria:\n\n* Age below 18 years\n\nIndividuals unable to complete visual acuity testing\n\nPresence of severe ocular pathology (e.g., corneal opacity, retinal detachment) that prevents accurate measurement\n\nCognitive or communication difficulties preventing informed consent",{"count":223,"type":21},200,"1 Day","The goal of this observational methodological study is to validate the Turkish version of the DDIVAT visual acuity measuring device in a Turkish-speaking adult population.\n\nThe main questions it aims to answer are:\n\nDoes the Turkish version of the DDIVAT provide reliable and valid visual acuity measurements in Turkish speakers?\n\nAre the results of the DDIVAT comparable to those obtained with the standard Snellen chart used in clinical practice?\n\nResearchers will compare DDIVAT visual acuity test results with Snellen chart results to see if both methods produce consistent measurements.\n\nParticipants will:\n\nBe adults aged 18 years or older, including both patients and healthy volunteers.\n\nUndergo visual acuity testing using the DDIVAT system displayed on a smart TV connected to the university server.\n\nHave their visual acuity re-measured using the standard Snellen optotype under the same conditions.\n\nNo medication or invasive procedure will be used. The study carries no risk to participants.",[227,26,112,228,229],"Visual Acuity","Hyperopia","Astigmatism",[227,26],"2025-11-26",{"date":233,"type":32},"2025-12-04",{"date":235,"type":21},"2025-12-01",{"date":237,"type":21},"2026-05-31",{"name":239,"class":39},"Trakya University",{"id":241,"slug":242,"hasResults":11,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":15,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":247,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":249,"conditions":250,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":4},"100611532","measurment-of-optic-disc-parameters-rnfl-thickness-and-ganglion-cell-complex-in-myopic-hypermetropic-and-emmetropic-patients-using-oct-and-axial-length-measurments-100611532","NCT07241806","Measurment of Optic Disc Parameters, RNFL Thickness and Ganglion Cell Complex in Myopic, Hypermetropic and Emmetropic Patients Using OCT and Axial Length Measurments","Correlation Between Axial Length and Degree of Refractive Error With Optic Disc Parameters , Ganglion Cell Complex and Peripapillary RNFL Thickness","Inclusion Criteria:\n\n* Adults age starting from 18 years old Diagnosed with myopia (≤ -0.50 D) or hyperopia (≥ +0.50 D) Clear ocular media for high-quality OCT imaging No prior ocular surgeries Willing to provide informed consent IOP below 21\n\nExclusion Criteria:\n\n* Presence of glaucoma or optic nerve pathologies Retinal diseases or degenerative changes Systemic diseases affecting the eye (e.g., diabetes, hypertension) History of trauma or intraocular surgery High astigmatism (\\> ±2.00 D) Poor OCT image quality",{"count":248,"type":21},266,"To evaluate the optic disc parameters, thickness of ganglion cell complex (GCC), and thickness of peripapillary retinal nerve fiber layer (RNFL) in myopic and hyperopic and emmetrop patients using optical coherence tomography (OCT), and to correlate these changes with axial length and degree of refractive error.",[26],"2025-11-17",{"date":253,"type":32},"2025-11-21",{"date":255,"type":21},"2026-01",{"date":257,"type":21},"2027-12",{"name":259,"class":39},"Assiut University",{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":15,"sex":16,"minAge":267,"maxAge":268,"enrollmentInfo":269,"targetDuration":271,"studyType":22,"phases":4,"briefSummary":272,"conditions":273,"keywords":276,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":40},"100581406","real-world-study-of-myopia-prevention-and-control-in-children-100581406","NCT06849895","Real-World Study of Myopia Prevention and Control in Children","Real-World Study of Myopia Prevention and Control in Children: a Prospective Cohort Study","Inclusion Criteria:\n\n1. All students from the enrolled schools;\n2. Participants must be able to cooperate with and complete all required ophthalmic examinations;\n3. Written informed consent must be obtained from their parents or legal guardians.\n\nExclusion Criteria:\n\n1. Ocular abnormalities (e.g., strabismus, amblyopia, or other significant eye diseases);\n2. Systemic diseases that may affect ocular health;\n3. Current participation in other myopia intervention programs.","6 Years","12 Years",{"count":270,"type":21},15000,"3 Years","This prospective, school-based cohort study aims to enroll approximately 15,000 primary school students from multiple districts in Shanghai, China and to observe the outcomes on myopia prevention and control in children with varying refractive status (including sufficient hyperopia reserve, relative insufficiency in hyperopia reserve, pre-myopia and myopia) who are exposed to a school-based categorized and integrated interventions strategy in real-world settings.\n\nThe primary objective of this study is to observe the change in the incidence and prevalence of myopia as well as the the progression of myopia among primary school students population under a school-based interventions, including increasing outdoor activities and wearing special designed optical lenses. The second objective is to identify factors influencing the outcomes and assess the compliance of different intervention methods. Additionally, a cost-effectiveness analysis will be conducted to assess the implementation process, providing technical solutions and operational models for wider application.",[112,26,274,275],"Children","Cohort",[277,278,279,280,281,282,283,284],"myopia","premyopia","outdoor activities","myopia prevention","myopia control","children","compliance","defocus optical lenses","2025-02-23",{"date":287,"type":32},"2025-02-27",{"date":289,"type":21},"2025-02-28",{"date":291,"type":21},"2028-02-28",{"name":293,"class":39},"Shanghai Eye Disease Prevention and Treatment Center",{"id":295,"slug":296,"hasResults":11,"nctId":297,"briefTitle":298,"officialTitle":299,"acronym":300,"eligibilityCriteria":301,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":48,"enrollmentInfo":302,"targetDuration":4,"studyType":51,"phases":304,"briefSummary":305,"conditions":306,"keywords":307,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":317,"completionDateStruct":319,"leadSponsor":321,"locationsCount":322},"100368420","correcting-myopia-among-secondary-school-children-to-increase-academic-high-school-attendance-rates-in-rural-communities-100368420","NCT04077086","Correcting Myopia Among Secondary School Children to Increase Academic High School Attendance Rates in Rural Communities","SWISH (See Well to Stay In ScHool): Randomised Trial of Spectacle Distribution to Secondary School Children With Myopia to Increase Academic High School Attendance Rates in Rural Communities)","SWISH","Inclusion Criteria:\n\n* Year 1 classes (likely age 12-13 years) at the recruited schools\n* Have uncorrected (without glasses) visual acuity of ≤6\u002F12 in both eyes;\n* Refractive error meets cut-offs shown to be associated with significantly greater improvement in visual acuity when corrected (myopia ≤-0.75 diopters (D, or astigmatism (non-spherical refractive error) ≥1.00 D);\n* Visual acuity can be improved to \\>= 6\u002F7.5 in at least one eye with glasses.\n\nExclusion Criteria:\n\n* Presence of visually-significant ocular condition besides refractive error",{"count":303,"type":21},10000,[53],"Chinese children are some of the most short-sighted in the world, but only one in five children in poor areas who needs glasses has them. Our team has already shown in other trials that giving children free glasses leads to better grades and that free glasses have a bigger impact on grades than factors like parents' education level and the amount of money a family has. The effect on grades from glasses is greater than from other health services in school, like giving vitamins. Only about one in three children in rural China goes on to a regular, non-vocational high school. The investigators would like to show the Chinese government strong evidence of what glasses can do to help children continue their education, in order to help convince the government to carry out national programs to provide free glasses for children who need them.\n\nStudy Plan: The investigators will choose 111 middle schools at random in Liaoning, northern China, and all children in Year 1 at each school will go at random into one of two groups: either a group getting free glasses, with support from teachers to push them to wear the glasses (\"Intervention\") or a group getting just glasses prescriptions (\"Control.\") The main study outcome will be the proportion of children going on to academic (as opposed to vocational) high school, and the study is powered to detect a 10% difference in this figure between groups.The study will also assess whether children wear their glasses at school and how often they use blackboards (which disadvantage short-sighted children) vs textbooks to learn from. These other outcomes will help us to better understand the causal pathway between vision and high school attendance. We will also study the total cost of providing glasses and the teacher support to wear them per additional student attending academic high school, as well as student mental health outcomes. We will also collect data on the progression of nearsightedness. The hypothesis of this study is that providing glasses will increase academic high school attendance.",[26],[308,112,309,310,311,312,313],"Refractive error","Academic high school attendance","Education attainment","Spectacle wear compliance","Mental health well-being","Progression of shortsightedness","2024-12-20",{"date":316,"type":32},"2024-12-27",{"date":318,"type":32},"2024-11-28",{"date":320,"type":21},"2027-07",{"name":150,"class":39},3,{"id":324,"slug":325,"hasResults":11,"nctId":326,"briefTitle":327,"officialTitle":328,"acronym":4,"eligibilityCriteria":329,"healthyVolunteers":15,"sex":16,"minAge":330,"maxAge":4,"enrollmentInfo":331,"targetDuration":4,"studyType":51,"phases":333,"briefSummary":334,"conditions":335,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":341,"lastUpdatePostDateStruct":342,"startDateStruct":344,"completionDateStruct":346,"leadSponsor":348,"locationsCount":40},"100559512","clinical-investigation-for-a-multifunction-ophthalmic-measurement-device-100559512","NCT06565091","Clinical Investigation for a Multifunction Ophthalmic Measurement Device","Development Clinical Investigation for a Multifunction Ophthalmic Measurement Device","Inclusion Criteria:\n\nAdults ≥ 18 years old and Healthy children\\* ≥ 4 years and \\\u003C18 of age.\n\nParticipants initially coming to the center for a routine consultation\n\nParticipants who are affiliated to a social security scheme or beneficiaries of such a scheme (L. 1121-8-1 of the Public Health Code of \"Code de Santé Publique\"),\n\nParticipants able to sit upright in front of the investigational device.\n\nInclusion Criteria\\* (for Healthy children):\n\nHealthy children ≥ 4 years and \\\u003C18 of age. The parents must have consented to their child's participation.\n\nChildren who are affiliated to parent's social security scheme or beneficiaries of such a scheme (L. 1121-8-1 of the Public Health Code of \"Code de Santé Publique\")\n\nChildren initially coming to the center for a routine consultation\n\nChildren able to sit upright in front of the instrument.\n\nExclusion Criteria:\n\nParticipants with implanted electronic medical device such as pacemaker, insulin pump, cochlear implant, electrostimulator or hearing aid,\n\nParticipants not able to sit upright in front of the instrument or subjects with forehead or chin injuries which prevent the head from being supported on the forehead \u002F chin rest.\n\nParticipants who are deprived of their liberty by judicial or administrative decision and persons hospitalized without their consent (Article L. 1121-6 of \"Code de Santé Publique\"),\n\nParticipants who are subject to a legal protection measure (curatorship, guardianship, safeguard of justice ...) or unable to express their consent (Article L1121-8 of \"Code de Santé Publique\"),\n\nParticipants who are not affiliated to a social security scheme or beneficiaries of such a scheme (L. 1121-8-1 of the Public Health Code of \"Code de Santé Publique\"),\n\nParticipants under exclusion period from another investigation,\n\nWomen who are pregnant or breastfeeding women; (Article L1121-5 of \"Code de Santé Publique\"). No additional risk had been identified for pregnant woman in participating in the investigation. Nevertheless, pregnancy induces ocular changes: in case of AE, the causality with the device or with pregnancy may be difficult to establish, justifying the non-inclusion of this population.\n\nParticipants with neurologic disorder, particularly epileptic or sensory motor troubles,\n\nParticipants with history of recent ocular surgeries (including refractive surgery less than 2 weeks),\n\nParticipants who are ESSILOR International\u002FESSILOR Luxottica employees,\n\nParticipants with monophthalmia,\n\nParticipants with obvious fixation disorder, strabismus, or nystagmus,\n\nFor tonometry measurements: subjects who have: Edematous\u002Fulcerated cornea, following keratoplasty or ocular surgery, following penetrating trauma, severe Keratoconus with risk of hydrops and in case of retinal detachment. Anterior and posterior chamber sulcus IOL, intrastromal rings or lens (type Kamra).\n\nParticipants with pupil \\\u003C 2 mm,\n\nParticipants who are with spherical equivalent refraction out of the range -20.00 to + 20.00 D (frontofocometer measurement),\n\nParticipants with an astigmatism greater than 8.00 D (\\\u003C8.00 D) (frontofocometer measurement),\n\nParticipants with corneal power out of the range \\[35-55D\\],\n\nParticipants with axial length out of the range \\[18-34 mm\\],\n\nParticipants with Intraocular pressure out of \\[7-50 mm Hg\\] range,\n\nParticipants to a previous phase of this clinical investigation.\n\nExclusion Criteria (for Healthy children):\n\nChildren with neurologic disorders, particularly epileptic or sensory motor troubles,\n\nChildren with history of recent ocular surgeries (including refractive surgery less than two weeks)\n\nChildren with monophthalmia,\n\nChildren with obvious fixation disorder, strabismus, or nystagmus,\n\nChildren with pupil \\\u003C 2 mm\n\nChildren with a spherical equivalent refraction out of the range \\[-20.00 to + 20.00 D\\] (frontofocometer measurement),\n\nChildren with an astigmatism higher than 8.00 D (\\>8.00 D)\n\nChildren with axial length out of the range \\[18-34 mm\\]","4 Years",{"count":332,"type":21},378,[53],"The purpose of this clinical investigation is to evaluate the clinical utility of a multifunctional measuring device for Ophtalmology.\n\nThe results of this clinical investigation will be used to refine and validate the device design.\n\n378 participants total will be included in the trial, each having only one visit at the investigation center.",[336,27,337,26,338,339,340],"Accommodation Disorder","Dry Eye","Accommodative Fatigue","Accommodative Inertia","Aberration, Corneal Wavefront","2024-08-19",{"date":343,"type":32},"2024-08-21",{"date":345,"type":32},"2024-06-10",{"date":347,"type":21},"2025-08",{"name":349,"class":350},"Essilor International","INDUSTRY",{"id":352,"slug":353,"hasResults":11,"nctId":354,"briefTitle":355,"officialTitle":355,"acronym":4,"eligibilityCriteria":356,"healthyVolunteers":15,"sex":16,"minAge":330,"maxAge":48,"enrollmentInfo":357,"targetDuration":4,"studyType":51,"phases":359,"briefSummary":360,"conditions":361,"keywords":362,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":371,"leadSponsor":373,"locationsCount":40},"100495590","effect-of-colour-temperature-of-reading-lamp-on-refractive-error-development-100495590","NCT05733182","Effect of Colour Temperature of Reading Lamp on Refractive Error Development","Inclusion Criteria:\n\n* aged between 4 and 18 years\n\nExclusion Criteria:\n\n* have received myopia control intervention",{"count":358,"type":21},798,[53],"This is a 12-month longitudinal randomized controlled trial aiming to evaluate the effect of colour temperature of reading lamp on refractive error development.",[26],[112,363,364,365],"Environment","Colour temperature","Lighting","2024-02-28",{"date":368,"type":32},"2024-03-01",{"date":370,"type":32},"2022-07-01",{"date":372,"type":21},"2027-06-30",{"name":374,"class":39},"The Hong Kong Polytechnic University"]