[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"regional-anesthesia-morbidity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:regional-anesthesia-morbidity":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,48,77,103,135,165,196,223,249],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100053656","ketamine-versus-dexmedetomidine-as-an-adjuvant-in-scalp-block-in-supratentorial-brain-tumor-excision-surgeries-100053656",false,"NCT07698665","Ketamine Versus Dexmedetomidine as an Adjuvant in Scalp Block in Supratentorial Brain Tumor Excision Surgeries","Efficacy of Ketamine Versus Dexmedetomidine as an Adjuvant to Bupivacaine in Scalp Block in Adults Undergoing Supratentorial Brain Tumor Excision Surgeries for Hemodynamics and Pain Control, Double-blinded Randomized Study","Inclusion Criteria:\n\n* Age from 20 to 60 years, both sexes, American Society of Anesthesiologists (ASA) physical status II-III, Supratentorial tumor excision, Supine Position.\n\nand operation time: less than 6 hours.\n\nExclusion Criteria:\n\n* Patient refusal, disturbed consciousness level (Glasgow Coma Scale \\[GCS\\] \\\u003C 15). Patients who required reintubation during the study period, those not extubated. immediately after surgery, or those who awoke with neurological deficits impairing. pain assessments were excluded from the final analysis, history of psychotic disorders or previous surgeries, Poor cognitive function.\n\nPostictal state or uncontrolled\u002Frecurrent seizures, known allergy to dexmedetomidine or ketamine, difficult intubation (Mallampati score \\> III) or multiple intubation attempts, operation duration \\> 6 hours, renal dysfunction (creatinine \\> 1.2 mg\u002FdL, BUN \\> 20 mg\u002FdL), heart block and patients with chronic headache disorders or those receiving chronic analgesic therapy (for \\>3 months) were excluded.",true,"ALL","20 Years","60 Years",{"count":21,"type":22},90,"ESTIMATED","INTERVENTIONAL",[25],"NA","Supratentorial brain tumor surgeries are associated with significant nociceptive stimulation and postoperative pain, which may adversely affect patient outcomes. Scalp block has emerged as an effective regional anesthetic technique to improve analgesia and reduce opioid consumption.\n\nObjective: To compare efficacy of ketamine versus dexmedetomidine as adjuvants to bupivacaine in scalp blocks for supratentorial brain tumor surgeries, focusing on analgesia, opioid consumption, and hemodynamic stability.\n\nMethods:\n\nThis randomized double-blinded controlled trial included 80 patients undergoing supratentorial tumor excision, allocated equally into two groups: Group K received bupivacaine with ketamine (2 mg\u002Fkg), and Group D received bupivacaine with dexmedetomidine (1 µg\u002Fkg). Intraoperative hemodynamics, fentanyl consumption, postoperative pain scores (NRS), analgesic requirements, and complications were assessed.",[28,29,30],"Regional Anesthesia Morbidity","Supratentorial Brain Tumor","Acute Pain",[32,33,34],"Scalp block","Dexemetomedine","Supratentorial","RECRUITING","2026-07-07",{"date":38,"type":39},"2026-07-13","ACTUAL",{"date":41,"type":39},"2026-01-01",{"date":43,"type":22},"2026-07-30",{"name":45,"class":46},"Cairo University","OTHER",2,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100644907","impact-of-communication-delays-on-anesthesia-response-to-medical-emergencies-and-ultrasound-guided-regional-anesthesia-100644907","NCT07675863","Impact of Communication Delays on Anesthesia Response to Medical Emergencies and Ultrasound-Guided Regional Anesthesia","The Impact of Communication Delays on Anesthesia Response to Medical Emergencies and Ultrasound-Guided Regional Anesthesia: A Randomized Simulation Study","ICARUS","Inclusion Criteria:\n\n* Medical students from Dalhousie University and Canadian Armed Forces (CAF) medical technicians or nurses at a minimum of Rank Qualification Medical Technician Private\n\nExclusion Criteria:\n\n* prior experience and training in regional anesthesia techniques\n* visual\u002Fauditory impairments that make unmodified video chats difficult",{"count":57,"type":22},42,[25],"Hypotheses The investigators hypothesize that a communication delay of 80 seconds compared to no delay will be associated with longer procedural times and decreased quality during brachial plexus block scanning. Secondly, the communication delay will be associated with more errors in treatment and a delay of essential treatments in a medical emergency.\n\nBackground The near future will see crewed missions in deep space. As the number of people travelling to space increases, so will the chances of traumatic injury and other medical emergencies. Given many changes to body systems in microgravity and the scarcity of equipment and personnel in space, treating medical emergencies is already very difficult. Because most pain medications interfere with cognition, and general anesthesia would be very risky in these conditions, regional anesthesia ('nerve blocks') has been suggested as a less risky alternative. However, nerve blocks are highly specialized skills and responding to medical emergencies in general requires extensive medical training, it is likely that astronauts will require guidance from earth-based physicians.\n\nAs crews venture deeper into space, the ability of teams to communicate in real time with earth-based medical teams decreases. For missions to the moon, communication delays of 3 to 160 seconds in each direction are expected. In the event of a medical emergency, space crews may require consultation with ground teams. The investigators predict that this communication delay will impact task duration, create opportunities for miscommunication and potentially result in higher rates of complications.\n\nObjectives\n\n* Quantify the difference (communication delay versus no delay) in time to identify critical structures while scanning brachial plexus block sonoanatomy and time to essential treatment during a medical emergency.\n* Quantify the difference (communication delay versus no delay) in quality and ease of imaging while scanning brachial plexus block sonoanatomy.\n* Quantify the difference in completeness of emergency treatment using a composite measure (communication delay versus no delay).\n* Describe the challenges and solutions for team functioning and remote mentorship when a communication delay exists.\n\nMethods This is a within-subjects, mixed-methods, simulation-based randomized study. Regional anesthesia novices (medical students) and Canadian Armed Forces (CAF) medical technicians or CAF nurses will be recruited and given a 4-hour training session on the basics of brachial plexus blocks and their complications. Participants will be placed in teams of 3, participating in two simulation scenarios. Once the team enters the simulation space, they will be able to ask for assistance from a \"remote\" team of experts. Teams will be guided through identifying the sonoanatomy for brachial plexus blocks and responding to a complication from placing a peripheral nerve block. Every team will complete both the no communication delay and 80-second communication delay. Teams will be randomly assigned the order in which they perform each condition.\n\nTime to \"block\" (when the participant identifies where they would place the local anesthetic) and time to essential treatments during an emergency will be recorded. Participants will rate the ease of ultrasound image acquisition and ease of communication, while the expert team will rate the quality of the ultrasound images and the ease of communication. Quantitative outcomes will be analyzed using univariate statistics. After the scenario, teams will debrief the scenario with a focus on communication, safe identification of target nerves and their ability to respond to a complication. Transcriptions of the debriefing sessions will be analyzed for themes using qualitative analysis.",[61,28,62,63],"Regional Anesthesia","Regional Anesthesia Success","Remote Consultation, Teleconsultation",[65,66],"Communication delay","Space Medicine","2026-06-23",{"date":69,"type":39},"2026-06-30",{"date":71,"type":22},"2026-07-11",{"date":73,"type":22},"2027-04-15",{"name":75,"class":46},"Nova Scotia Health Authority",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":16,"sex":17,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":76},"100636109","erector-spinae-block-versus-paravertebral-block-on-chronic-pain-after-mastectomy-100636109","NCT07561411","Erector Spinae Block Versus Paravertebral Block on Chronic Pain After Mastectomy","The Effect of Erector Spinae Block Versus Paravertebral Block on the Incidence of Chronic Pain After Mastectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients between 18 and 80 years old.\n* Scheduled to total mastectomy with or without axillary dissection\n* Willing to receive regional anesthesia in addition to GA\n* ASA classification 1-3\n\nExclusion Criteria:\n\n* Previous thoracic surgery with an incision of \\>2 cm\n* Patient's refusal\n* Allergy to local anesthetics\n* Pregnant women\n* Any contraindications to thoracic PVB, including intrathoracic infection, infection at the puncture site, cancer invasion of the puncture site, severe spinal deformity, history of spinal surgery, and severe coagulopathy; anticoagulants intake.\n* American Society of Anesthesiologists (ASA) classification of 4 or higher,\n* History of chronic pain or untreated clinical severe depression","18 Years","80 Years",{"count":87,"type":22},132,[25],"The goal of this clinical trial is to learn if the erector spinae block can reduce the incidence of chronic pain compared to the paravertebral block in adult patients undergoing total mastectomy. The study includes patients aged 18 to 80 years scheduled for mastectomy, with or without axillary dissection. The main questions it aims to answer are:\n\n* Does erector spinae block reduce the incidence of chronic pain at 3 months after mastectomy compared to paravertebral block?\n* Does erector spinae block affect postoperative outcomes such as opioid consumption at 48 hours, pain scores (in PACU, 24 and 48 hours), block performance time, and the incidence of complications, anxiety or depression, and pain intensity at 3 months?\n\nResearchers will compare patients receiving erector spinae block to those receiving paravertebral block to determine if erector spinae block provides equivalent or improved outcomes in terms of chronic pain and perioperative measures.\n\nParticipants will:\n\n* Be randomly assigned to receive either erector spinae block or paravertebral block prior to surgery\n* Undergo total mastectomy (with or without axillary dissection)\n* Have their pain assessed in the PACU and at 24 and 48 hours postoperatively\n* Have opioid consumption measured during the first 48 hours after surgery\n* Be followed up at 3 months to assess chronic pain, pain intensity, and psychological outcomes (anxiety or depression)",[91,92,28,93],"Mastectomy; Lymphedema","Chronic Pain","Opioid Use","2026-06-01",{"date":96,"type":39},"2026-06-02",{"date":98,"type":39},"2026-05-19",{"date":100,"type":22},"2028-05-01",{"name":102,"class":46},"American University of Beirut Medical Center",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":23,"phases":113,"briefSummary":114,"conditions":115,"keywords":122,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":76},"100614824","pericapsular-nerve-group-peng-block-combined-with-lateral-femoral-cutaneous-nerve-lfcn-block-or-wound-infiltration-for-postoperative-analgesia-in-anterior-approach-total-hip-arthroplasty-a-randomized-controlled-trial-100614824","NCT07284615","Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block or Wound Infiltration for Postoperative Analgesia in Anterior Approach Total Hip Arthroplasty: A Randomized Controlled Trial","Lateral Femoral Cutaneous Nerve (LFCN) Block or Wound Infiltration (WI) Combined With Pericapsular Nerve Group (PENG) Block for Analgesia in Elective Anterior Approach Total Hip Arthroplasty: A Randomized Controlled Trial","Peng_lfcn\u002FWI","Inclusion Criteria:\n\n* Age \\> 18 years\n* Elective total hip arthroplasty\n* Spinal (subarachnoid) anesthesia\n* Written informed consent provided by the patient or by the legal guardian, if appointed\n\nExclusion Criteria:\n\n* INR \\> 1.5\n* aPTT \\> 1.5\n* Platelet count \\\u003C 75,000\u002Fmm³\n* Signs suggestive of infection at the puncture site\n* Absence of informed consent to the procedure\n* Documented or suspected allergy to local anesthetics",{"count":112,"type":22},102,[25],"This prospective, randomized controlled trial aims to compare two multimodal regional anesthesia strategies for postoperative analgesia in elective total hip arthroplasty (THA) performed via anterior approach. Patients will be randomized to receive either a Pericapsular Nerve Group (PENG) block combined with a Lateral Femoral Cutaneous Nerve (LFCN) block, or a PENG block combined with wound infiltration (WI).\n\nThe primary outcome is postoperative pain intensity at rest, measured by Numerical Rating Scale (NRS) at 6 hours after surgery. Secondary outcomes include dynamic pain scores at 6, 24, and 48 hours, total opioid consumption, time to first rescue analgesia, quadriceps strength, hip flexion angle, length of stay, and adverse events.\n\nAll procedures are routinely used in clinical practice and carry minimal additional risk. Safety will be continuously monitored by the Principal Investigator and the study team according to an internal Safety Monitoring Plan.",[116,117,118,119,28,120,121],"Arthropathy of Hip","Hip Arthropathy","Locoregional Anesthesia","Complication of Anesthesia","Hospital Stay, Length of Stay in Hospital From Time of Surgery Till Discharge","Opioid Consumption",[123,124,125],"Postoperative muscle weakness","ERAS","Regional Block","2026-03-21",{"date":128,"type":39},"2026-03-25",{"date":130,"type":39},"2026-01-26",{"date":132,"type":22},"2026-11",{"name":134,"class":46},"Ospedale Edoardo Bassini",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":143,"enrollmentInfo":144,"targetDuration":4,"studyType":23,"phases":146,"briefSummary":147,"conditions":148,"keywords":150,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":4},"100603834","randomized-trial-of-erector-spinae-plane-block-using-liposomal-bupivacaine-versus-bupivacaine-hydrochloride-on-quality-of-recovery-for-video-assisted-thoracic-surgery-100603834","NCT07141667","Randomized Trial of Erector Spinae Plane Block Using Liposomal Bupivacaine Versus Bupivacaine Hydrochloride on Quality of Recovery for Video-assisted Thoracic Surgery","Erector Spinae Plane Block Using Liposomal Bupivacaine Versus Bupivacaine Hydrochloride for Video-assisted Thoracic Surgery:Comparing Local Anesthetics on Quality of Recovery and Pain Score:A Randomised,Single-blind,Clinical Trial","LB-ESPB","Inclusion Criteria:\n\n* 18-75 yr of age\n* ASA physical status 1 to 3\n* Undergoing unilateral lung VATS under general anesthesia\n* Obtaining informed consent from patients or legal representative\n\nExclusion Criteria:\n\n* Unexpected convention of VATS to open thoracotomy,or unexpected post-operative admission to ICU for continued ventilation\n* Unable to understand the Quality of Recovery-15 (QoR-15) and Numerical Rating Scale(NRS)\n* Allergy to or contraindications for amide local anesthetics,opioids,or NSAIDs\n* Long-term treatment with opioids or corticosteroids (\\>2 weeks)\n* Drug use or substance abuse within the past 2 years\n* Consuming more than 3 standard drinks per day (10g of alcohol,equivalent to 50g of Chinese high-alcohol liquor)\n* Pre existing dementia that may interfere with perioperative assessment\n* Contraindications for nerve block,including infection or tumor at the puncture site,definitively diagnosed diabetic peripheral neuropathy\n* Suffering from severe hepatic insufficiency (Child-Pugh C),or severe renal insufficiency with dialysis,or severe heart failure (METS\\\u003C4)\n* Pregnant or lactating women\n* Previous thoracic surgeries (such an thoracic surgery or breast surgery),or preoperatively pathological pain conditions (e.g.,metastatic tumors,herpes zoster,etc)","75 Years",{"count":145,"type":22},80,[25],"Video-assisted thoracoscopic surgery (VATS) has emerged as the standard surgical modality for pulmonary tumor. Compared with open thoracotomy, VATS is associated with reduced surgical trauma, attenuated postoperative pain, and a lower incidence of postoperative pulmonary complications. Nevertheless, 27-63% of VATS patients still develop moderate to severe postoperative pain, with the incidence of chronic postsurgical pain (CPSP) remaining at 25-44%.\n\nRegional analgesic techniques constitute a pivotal component of enhanced recovery after surgery (ERAS) protocols in thoracic surgery. Thoracic epidural analgesia (TEA) and paravertebral block (PVB) have been regarded as the gold-standard regional analgesic modalities for open thoracotomy. Accumulating evidence indicates that erector spinae plane block (ESPB) achieves postoperative analgesic efficacy comparable to that of PVB. In contrast to TEA, both PVB and ESPB are associated with a lower risk of complications such as hypotension, urinary retention, and epidural hematoma.\n\nA recent randomized controlled trial comparing continuous ESPB and continuous PVB demonstrated that continuous ESPB improves the quality of postoperative recovery in VATS patients. Previous studies have also confirmed that single-injection ESPB provides superior recovery quality and analgesic efficacy compared with single-injection PVB in VATS patients. However, single-dose nerve block only exert effects for 8-12 hours, while continuous nerve blocks may increase the risk of infection and compromise patient comfort. Moderate to severe postoperative pain in VATS patients predominantly occurs within the first 48 hours postoperatively, with the most intense pain typically observed on the first postoperative day. Therefore, there is an urgent need to explore analgesic techniques with prolonged duration and fewer complications for application in VATS.\n\nLiposomal bupivacaine, a novel extended-release local anesthetic approved by the FDA for clinical use, can prolong the duration of local anesthesia to 72 hours. Its clinical efficacy in procedures such as brachial plexus block has been validated. However, the application of liposomal bupivacaine in erector spinae plane block for VATS, and its impact on the quality of postoperative recovery, remains unreported.This study will test the hypothesis that erector spinae plane block with liposomal bupivacaine for VATS can enhance patients' quality of recovery-15 score (QoR-15) at 48 h.",[28,149],"Pain, Postoperative",[151,152,153,154],"quality of recovery","erector spinae plane block","liposomal bupivacaine","video-assisted thoracic surgery","NOT_YET_RECRUITING","2025-08-24",{"date":158,"type":39},"2025-08-26",{"date":160,"type":22},"2025-08",{"date":162,"type":22},"2028-03",{"name":164,"class":46},"RenJi Hospital",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":11,"sex":173,"minAge":84,"maxAge":174,"enrollmentInfo":175,"targetDuration":4,"studyType":23,"phases":177,"briefSummary":178,"conditions":179,"keywords":182,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":76},"100457197","height-adjusted-versus-standardized-dose-of-bupivacaine-for-spinal-anesthesia-100457197","NCT05233462","Height Adjusted Versus Standardized Dose of Bupivacaine for Spinal Anesthesia","Height Adjusted Versus Standardized Dose of Bupivacaine in Spinal Anesthesia for Caesarean Delivery - A Randomized Double-blind Interventional Study","RAMCES","Inclusion Criteria:\n\n* scheduled cesarean section with intrathecal anesthesia\n* term pregnancy \\> 35 weeks\n* signed informed consent\n\nExclusion Criteria:\n\n* unscheduled or emergent cesarean section\n* any contra indication to intrathecal anesthesia\n* any antihypertensive drug prescribed to control arterial pressure during pregnancy\n* pre-eclampsia and eclampsia\n* history of Marfan or Ehlers Danlos disease","FEMALE","45 Years",{"count":176,"type":22},250,[25],"General anesthesia during pregnancy is associated with several major risks including unanticipated difficult airway, pulmonary aspiration, and specific anesthetic effects on the newborn. Thus, intrathecal anesthesia is the technique of choice for cesarean section.\n\nNevertheless, the main side effect of intrathecal anesthesia is arterial hypotension which depend mainly on the dose of local anesthetic administered intrathecally.\n\nTo date there is no guidelines nor evidences whic help the anesthetist to precisely estimate the required dose. Most often a \"standardized dose\" of 8 to 10 mg of bupivacaine is administered. However, some data suggest that a lower dose may be administered resulting in less frequent arterial hypotension. Nevertheless, a well designed randomized study is lacking.",[28,180,181],"Cesarean Section Complications","Local Anesthetic Complication",[183,184,185,186],"cesarean section","intrathecal anesthesia","bupivacaine","morbidity","2025-07-22",{"date":189,"type":39},"2025-07-25",{"date":191,"type":39},"2022-02-23",{"date":193,"type":22},"2026-12-31",{"name":195,"class":46},"University Hospital, Caen",{"id":197,"slug":198,"hasResults":11,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":4,"eligibilityCriteria":202,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":85,"enrollmentInfo":203,"targetDuration":4,"studyType":23,"phases":205,"briefSummary":206,"conditions":207,"keywords":211,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":219,"leadSponsor":221,"locationsCount":76},"100548877","tpvb-or-spsipb-in-pain-management-after-vats-100548877","NCT06426706","TPVB or SPSIPB in Pain Management After VATS","Paravertebral Block or Serratus Posterior Superior Intercostal Plane Block in Pain Management After Video-Assisted Thoracoscopic Surgery: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients between the age of 18-80 undergoing video-assisted thoracoscopic surgery\n\nExclusion Criteria:\n\n* Allergy to local anaesthetics Chronic opioid use history Patients with psychiatric disorders Patients who are not open to communication Patients with chronic organ failure Patients that do not give consent Patients that need emergency surgery within the first 24 hours of the initial surgery",{"count":204,"type":22},44,[25],"The goal of this clinical trial is to compare the analgesic efficacy of thoracal paravertebral block (TPVB) and serratus posterior superior intercostal plane block (SPSIPB) in patients undergoing video-assisted thoracoscopic surgery (VATS). The main questions it aims to answer are:\n\nHow will the total perioperative opioid consumption of the patients receiving two different blocks change? How will TPVB and SPSIPB effect the patients' numeric rating scores for pain in the postoperative 24-hour period? How will TPVB and SPSIPB effect the incidence of opioid related side effects?\n\nParticipants will be divided in two groups:\n\nTPVB group will receive a TPVB before the surgery. SPSIPB group will receive a SPSIPB nerve block before the surgery. Researchers will compare the results between the groups to see the postoperative effects concerning opioid consumption as well as the pain scores, respiratory parameters and opioid associated side effects.\n\nThe hypothesis of this study is that participants receiving SPSIPB for VATS will have a less total opioid consumption 24 hours postoperatively.",[208,209,210,28],"Video-assisted Thoracoscopic Surgery","Paravertebral Block","Serratus Posterior Superior Intercostal Plane Block",[212,213,214],"video-assisted thoracoscopic surgery","paravertebral block","serratus posterior superior intercostal plane block","2025-01-02",{"date":217,"type":39},"2025-01-03",{"date":217,"type":22},{"date":220,"type":22},"2025-03-15",{"name":222,"class":46},"Koç University",{"id":224,"slug":225,"hasResults":11,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":4,"eligibilityCriteria":229,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":4,"enrollmentInfo":230,"targetDuration":4,"studyType":23,"phases":232,"briefSummary":233,"conditions":234,"keywords":236,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":76},"100562128","maxillary-and-mandibular-nerve-block-block-one-get-one-free-100562128","NCT06599138","Maxillary and Mandibular Nerve Block. Block One Get One Free.","Ultrasound-guided Maxillary Nerve Block: An Anatomical Cadaveric Study. Determination of Dispersion in Ultrasound-guided Suprazygomatic Maxillary Nerve Block in Cadavers.","Inclusion Criteria:\n\n\\- Embalmed cadaveric specimens without known maxillary disease\n\nExclusion Criteria:\n\n\\- Embalmed cadaveric specimens with known maxillary disease",{"count":231,"type":22},10,[25],"Ultrasound-guided maxillary nerve block is mandatory for perioperative pain management of surgeries involving the middle third of the face. The suprazygomatic approach to the maxillary nerve has proven to be the safest and most effective. The volume used for maxillary nerve block remains a matter of debate; and this study aims to compare and study the dispersion of 2 - 5ml injected into the ptergopalatine fossa, and to know the reach of the mandibular nerve with this block.",[235,28],"Postoperative Pain",[237,238,239],"Maxillary nerve","Nerve block","Ultrasound","2024-11-04",{"date":242,"type":39},"2024-11-06",{"date":244,"type":22},"2024-11-14",{"date":246,"type":22},"2024-12-16",{"name":248,"class":46},"Servei Central d'Anestesiologia",{"id":250,"slug":251,"hasResults":11,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":4,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":256,"enrollmentInfo":257,"targetDuration":4,"studyType":23,"phases":259,"briefSummary":260,"conditions":261,"keywords":267,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":76},"100556058","evaluation-of-the-effectiveness-of-two-methods-of-regional-anesthesia-during-s-icd-implantation-procedure-100556058","NCT06520150","Evaluation of the Effectiveness of Two Methods of Regional Anesthesia During S-ICD Implantation Procedure.","Evaluation of the Effectiveness of Two Methods of Regional Anesthesia During Subcutaneous Implantable Cardioverter-defibrillator (SICD) Implantation Procedure.","Inclusion Criteria:\n\n* patients aged 18-90 years requiring S-ICD implantation for cardiac indications,\n* high risk of anesthesia (ASA II or higher), patients giving informed consent to participate in the study.\n\nExclusion Criteria:\n\n* absolute contraindications to regional anesthesia such as generalized coagulation disorders, inflammation at the site of anesthesia, allergy to the drugs used for regional anesthesia\n* lack of consent of the patient for the conducted procedure,\n* inability to cooperate with the patient - such as severe mental retardation, unregulated mental illness with motor agitation, advanced neurodegenerative diseases such as Parkinson's disease\u002FAlzheimer's,\n* inability to give informed consent to participate in the study.","90 Years",{"count":258,"type":22},32,[25],"Our study consists of a combination of regional blockade ('local' anesthesia) of the anterior and lateral chest wall in the form of a thin needle prick and the supply of local anesthetic drugs to the area of the relevant chest wall structures to exclude all stimuli, including pain from the operative site. A short-acting analgesic and sedative drug will be administered intravenously throughout the procedure - in a dose that allows the required contact between the patient and the anesthetist. If necessary, the dose of the drug may be increased to maintain pain comfort throughout the procedure.\n\nThe anesthetic team will be with the patient throughout the procedure to ensure comfort and safety.",[262,263,149,264,28,265,266],"Chest Pain","Pain, Procedural","Analgesia","Anesthesia, Local","ICD",[268,269,270,271,272,273,274,275,276],"Superficial Serratus Anterior Plane Block (SSAP)","Superficial Parasternal Intercostal Plane Block (SPIP)","Pectoserratus Plane Blocks (PSP)","Regional anaesthesia","Subcutaneous implantable defibrillator (S-ICD)","thorax blockade","less invasive","implantation","pain treatment","2024-07-23",{"date":279,"type":39},"2024-07-25",{"date":281,"type":39},"2024-06-16",{"date":283,"type":22},"2025-12-01",{"name":285,"class":46},"4th Military Clinical Hospital with Polyclinic, Poland"]