[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"regional-anesthesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:regional-anesthesia":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,26,0,25,[9,48,77,106,131,161,184,211,239,269,299,328,353,374,398,421,442,460,486,514,545,566,585,605,633],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":18,"sex":19,"minAge":4,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100644907","impact-of-communication-delays-on-anesthesia-response-to-medical-emergencies-and-ultrasound-guided-regional-anesthesia-100644907",false,"NCT07675863","Impact of Communication Delays on Anesthesia Response to Medical Emergencies and Ultrasound-Guided Regional Anesthesia","The Impact of Communication Delays on Anesthesia Response to Medical Emergencies and Ultrasound-Guided Regional Anesthesia: A Randomized Simulation Study","ICARUS","Inclusion Criteria:\n\n* Medical students from Dalhousie University and Canadian Armed Forces (CAF) medical technicians or nurses at a minimum of Rank Qualification Medical Technician Private\n\nExclusion Criteria:\n\n* prior experience and training in regional anesthesia techniques\n* visual\u002Fauditory impairments that make unmodified video chats difficult",true,"ALL",{"count":21,"type":22},42,"ESTIMATED","INTERVENTIONAL",[25],"NA","Hypotheses The investigators hypothesize that a communication delay of 80 seconds compared to no delay will be associated with longer procedural times and decreased quality during brachial plexus block scanning. Secondly, the communication delay will be associated with more errors in treatment and a delay of essential treatments in a medical emergency.\n\nBackground The near future will see crewed missions in deep space. As the number of people travelling to space increases, so will the chances of traumatic injury and other medical emergencies. Given many changes to body systems in microgravity and the scarcity of equipment and personnel in space, treating medical emergencies is already very difficult. Because most pain medications interfere with cognition, and general anesthesia would be very risky in these conditions, regional anesthesia ('nerve blocks') has been suggested as a less risky alternative. However, nerve blocks are highly specialized skills and responding to medical emergencies in general requires extensive medical training, it is likely that astronauts will require guidance from earth-based physicians.\n\nAs crews venture deeper into space, the ability of teams to communicate in real time with earth-based medical teams decreases. For missions to the moon, communication delays of 3 to 160 seconds in each direction are expected. In the event of a medical emergency, space crews may require consultation with ground teams. The investigators predict that this communication delay will impact task duration, create opportunities for miscommunication and potentially result in higher rates of complications.\n\nObjectives\n\n* Quantify the difference (communication delay versus no delay) in time to identify critical structures while scanning brachial plexus block sonoanatomy and time to essential treatment during a medical emergency.\n* Quantify the difference (communication delay versus no delay) in quality and ease of imaging while scanning brachial plexus block sonoanatomy.\n* Quantify the difference in completeness of emergency treatment using a composite measure (communication delay versus no delay).\n* Describe the challenges and solutions for team functioning and remote mentorship when a communication delay exists.\n\nMethods This is a within-subjects, mixed-methods, simulation-based randomized study. Regional anesthesia novices (medical students) and Canadian Armed Forces (CAF) medical technicians or CAF nurses will be recruited and given a 4-hour training session on the basics of brachial plexus blocks and their complications. Participants will be placed in teams of 3, participating in two simulation scenarios. Once the team enters the simulation space, they will be able to ask for assistance from a \"remote\" team of experts. Teams will be guided through identifying the sonoanatomy for brachial plexus blocks and responding to a complication from placing a peripheral nerve block. Every team will complete both the no communication delay and 80-second communication delay. Teams will be randomly assigned the order in which they perform each condition.\n\nTime to \"block\" (when the participant identifies where they would place the local anesthetic) and time to essential treatments during an emergency will be recorded. Participants will rate the ease of ultrasound image acquisition and ease of communication, while the expert team will rate the quality of the ultrasound images and the ease of communication. Quantitative outcomes will be analyzed using univariate statistics. After the scenario, teams will debrief the scenario with a focus on communication, safe identification of target nerves and their ability to respond to a complication. Transcriptions of the debriefing sessions will be analyzed for themes using qualitative analysis.",[28,29,30,31],"Regional Anesthesia","Regional Anesthesia Morbidity","Regional Anesthesia Success","Remote Consultation, Teleconsultation",[33,34],"Communication delay","Space Medicine","RECRUITING","2026-06-23",{"date":38,"type":39},"2026-06-30","ACTUAL",{"date":41,"type":22},"2026-07-11",{"date":43,"type":22},"2027-04-15",{"name":45,"class":46},"Nova Scotia Health Authority","OTHER",1,{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":12,"sex":19,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":73,"leadSponsor":75,"locationsCount":47},"100643353","efficacy-of-the-erector-spinae-plane-block-for-persistent-back-pain-in-patients-with-ankylosing-spondylitis-100643353","NCT07633730","Efficacy of the Erector Spinae Plane Block for Persistent Back Pain in Patients With Ankylosing Spondylitis","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Diagnosis of ankylosing spondylitis according to the Modified New York Criteria\n* Patients receiving ongoing treatment with controlled disease activity but persistent back pain\n* Willingness to participate in the study\n\nExclusion Criteria:\n\n* Body mass index (BMI) greater than 35 kg\u002Fm²\n* History of thoracic surgery\n* Intellectual disability or mental retardation\n* Presence of major psychiatric comorbidity\n* Congenital spinal anomaly\n* Pregnancy\n* History of bleeding diathesis\n* Presence of active local and\u002For systemic infection\n* Known allergy to the medications to be injected\n* Hemodynamic instability\n* Active phase of the disease (elevated acute phase reactants, active arthritis findings, etc.)","18 Years","65 Years",{"count":57,"type":22},15,[25],"Despite adequate control of disease activity with standard medical therapies, there remains an ongoing need for complementary and interventional approaches for the management of persistent back pain in patients with ankylosing spondylitis. Although the erector spinae plane block has been described in the literature as a safe and effective analgesic intervention for chronic back pain in various patient populations, to the best of our knowledge, no clinical study has specifically evaluated its use for persistent back pain in patients with ankylosing spondylitis receiving medical treatment. Therefore, the present study aims to evaluate the effects of erector spinae plane block on pain severity and clinical outcomes in patients with ankylosing spondylitis whose disease activity is controlled under treatment but who continue to experience persistent back pain.",[61,62,63,28],"Ankylosing Spondylitis (AS)","Back Pain","ESPB",[63,65,62,66,67,68],"Erector Spinae Plane Block","Ankylosing Spondylitis","Persistent back pain","Regional anesthesia","2026-06-02",{"date":71,"type":39},"2026-06-08",{"date":69,"type":39},{"date":74,"type":22},"2027-06-02",{"name":76,"class":46},"Marmara University",{"id":78,"slug":79,"hasResults":12,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":12,"sex":19,"minAge":54,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":47},"100639461","comparison-of-meta-peng-and-suprainguinal-fascia-iliaca-plane-block-in-hip-fractures-100639461","NCT07612761","Comparison of Meta-PENG and Suprainguinal Fascia Iliaca Plane Block in Hip Fractures","Comparison of the Effects of Ultrasound-Guided Meta-PENG Block and Suprainguinal Fascia Iliaca Plane Block in Patients Undergoing Hip Fracture Surgery Under Spinal Anesthesia","META-SIFI","Inclusion Criteria:\n\n* Age greater than 18 years\n* ASA physical status I-III\n* Scheduled to undergo hip fracture surgery under spinal anesthesia\n* Written informed consent obtained from the patient or the patient's legal representative\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* ASA physical status IV-V\n* Presence of central or autonomic nervous system disease\n* Known allergy to the drugs used in the study",{"count":86,"type":22},80,"OBSERVATIONAL","This prospective observational single-center study will compare the effects of ultrasound-guided meta-PENG block and suprainguinal fascia iliaca plane block in patients undergoing hip fracture surgery under spinal anesthesia.\n\nHip fracture surgery can cause significant pain before, during, and after the operation. Regional anesthesia techniques may help reduce pain, improve positioning for spinal anesthesia, decrease the need for additional analgesics, and support earlier mobilization.\n\nPatients included in the study will be adults scheduled for hip fracture surgery under spinal anesthesia. According to routine clinical practice and the anesthesiologist's decision, patients will receive either ultrasound-guided meta-PENG block or ultrasound-guided suprainguinal fascia iliaca plane block. The study will not assign patients to a treatment group by randomization.\n\nThe main outcome will be pain during positioning for spinal anesthesia, measured using the Numeric Rating Scale. Additional outcomes will include postoperative pain at rest and during activity, additional analgesic consumption, patient satisfaction, mobilization time, and length of hospital stay.",[90,91,28],"Hip Fracture","Postoperative Pain",[93,94,95,96,68],"Hip fracture","Meta-PENG block","Suprainguinal fascia iliaca plane block","Postoperative analgesia","2026-05-23",{"date":99,"type":39},"2026-05-29",{"date":101,"type":39},"2026-05-14",{"date":103,"type":22},"2026-12-31",{"name":105,"class":46},"Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital",{"id":107,"slug":108,"hasResults":12,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":18,"sex":19,"minAge":54,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":23,"phases":115,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":47},"100634131","ultrasound-guided-erector-spinae-plane-block-versus-thoracoscopically-guided-intercostal-nerve-block-in-video-assisted-thoracoscopic-surgery-100634131","NCT07535697","Ultrasound-Guided Erector Spinae Plane Block Versus Thoracoscopically-Guided Intercostal Nerve Block in Video-Assisted Thoracoscopic Surgery","Prospective, Randomized Comparative Study of an Anesthesiological, Ultrasound-Guided \"Erector Spinae Plane Block\" (ESPB) Versus a Surgical, Thoracoscopically-Guided \"Intercostal Nerve Block\" (ICNB) in \"Video-Assisted Thoracoscopic\" (VATS) Procedures, Evaluating Postoperative Analgesic Consumption, Postoperative Pain Perception, and Duration of the Procedure","Inclusion Criteria:\n\n* Provision of written informed consent\n* Adults (≥ 18 years of age)\n* Elective video-assisted thoracoscopic surgery (VATS) for pulmonary resection (e.g., lobectomy, segmentectomy, wedge resection)\n\nExclusion Criteria:\n\n* Lack of informed consent\n* Language barrier\n* Pregnancy or breastfeeding\n* Known allergy to local anesthetics used in the study\n* Infection at the injection site(s)\n* History of complex chest wall surgery\n* Revision surgery with a prior operation within the last 6 months\n* Intraoperative conversion to open thoracotomy\n* Chronic pain syndrome\n* Fibromyalgia\n* Chronic opioid use\n* Chronic alcohol abuse\n* Chronic substance abuse (e.g., THC, amphetamines, cocaine)\n* History of psychiatric disorders (e.g., depression, schizophrenia)\n* Impaired consciousness, cognition, or ability to communicate\n* Known coagulopathy (including platelet count \\\u003C 80,000\u002FµL or prolonged PTT\u002FaPTT \\>1.5× the upper limit of normal)\n* Ongoing therapeutic anticoagulation",{"count":114,"type":22},72,[25],"Effective postoperative pain management is essential after thoracic surgery. Insufficient pain control may impair breathing and coughing, increasing the risk of pulmonary complications such as collapsed lungs (atelectasis) or pneumonia.\n\nAlthough minimally invasive lung surgery (video-assisted thoracoscopic surgery, VATS) is less painful than open surgery, people can still have significant pain after the operation.\n\nThe goal of this randomized comparative study is to compare two commonly used regional anesthesia techniques for pain control after VATS in adults.\n\nResearchers will compare an ultrasound-guided erector spinae plane block (ESPB), performed by anesthesiologists, to a thoracoscopically-guided intercostal nerve block (ICNB), performed by surgeons.\n\nParticipants will:\n\n* Undergo elective VATS lung resection surgery\n* Receive either ESPB or ICNB, according to random assignment\n* Have the received amount of analgesics recorded during the first 24 hours\n* Have their pain levels assessed at predefined time points after surgery\n\nThe main questions this study aims to answer are:\n\n* Does ESPB result in similar analgesic consumption in the first 24 hours after surgery?\n* Does ESPB provide similar postoperative pain relief compared to ICNB?\n* Is the time needed to perform ESPB similar to ICNB?",[28,118,65,119],"Video-assisted Thoracoscopic Surgery (VATS)","Intercostal Nerve Block",[28,118,65,63,119,121],"ICNB","2026-04-27",{"date":124,"type":39},"2026-05-01",{"date":126,"type":22},"2026-05-04",{"date":128,"type":22},"2027-05-03",{"name":130,"class":46},"Sana Klinikum Offenbach",{"id":132,"slug":133,"hasResults":12,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":12,"sex":139,"minAge":54,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":143,"conditions":144,"keywords":147,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":47},"100618055","effect-of-gestational-weight-gain-on-spinal-anesthesia-in-elective-cesarean-delivery-100618055","NCT07326644","Effect of Gestational Weight Gain on Spinal Anesthesia in Elective Cesarean Delivery","Effect of Gestational Weight Gain on Regional Anesthesia in Cesarean Patients","GWG-CESA","Inclusion Criteria:\n\n* Pregnant women aged 18-45 years\n\n  * Single pregnancy\n  * Planned elective cesarean section\n  * Spinal anesthesia (regional anesthesia technique)\n  * Pre-pregnancy weight information available (maternal health record, e-Nabız or file record)\n  * Recorded pre-delivery weight information\n  * Gestational weight gain (GWG) calculable according to the IOM 2009 classification\n  * ASA I-II pregnant women\n  * Voluntary participation in the study and informed consent\n\nExclusion Criteria:\n\n* Pregnant women with preeclampsia, severe preeclampsia, eclampsia, or HELLP syndrome\n\n  * Pregnant women with a history of gestational diabetes or pregestational diabetes\n  * Multiple pregnancy (twins, triplets, etc.)\n  * Preterm pregnancy (\\\u003C37 weeks)\n  * Failure of spinal anesthesia or need for conversion to general anesthesia\n  * Lack of pre-pregnancy weight information or weight gain data during pregnancy\n  * Pregnancies with fetal anomalies\n  * Morbid obesity (BMI ≥ 45 kg\u002Fm²)","FEMALE","45 Years",{"count":142,"type":22},200,"This prospective, observational, non-interventional study aims to evaluate the effect of gestational weight gain on regional anesthesia characteristics in pregnant women undergoing elective cesarean delivery. No additional intervention, medication, or procedure beyond routine clinical care will be performed. Participants will be classified according to gestational weight gain categories based on the Institute of Medicine (IOM) 2009 guidelines, and spinal anesthesia block characteristics, hemodynamic responses, and perioperative outcomes will be assessed.",[145,28,146],"Gestational Weight Gain","Cesarean Delivery",[148,149,150,151],"Gestational weight gain","Spinal anesthesia","Cesarean delivery","Hemodynamic response","2026-04-20",{"date":154,"type":39},"2026-04-23",{"date":156,"type":39},"2025-12-05",{"date":158,"type":22},"2026-05-10",{"name":160,"class":46},"Elazıg Fethi Sekin Sehir Hastanesi",{"id":162,"slug":163,"hasResults":12,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":12,"sex":19,"minAge":54,"maxAge":55,"enrollmentInfo":168,"targetDuration":4,"studyType":23,"phases":170,"briefSummary":171,"conditions":172,"keywords":4,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":4},"100633945","erector-spinae-plane-block-versus-external-oblique-intercostal-plane-block-for-analgesia-in-open-cholecystectomy-100633945","NCT07533279","Erector Spinae Plane Block Versus External Oblique Intercostal Plane Block for Analgesia in Open Cholecystectomy","Efficacy of Bilateral Erector Spinae Plane Block Versus Bilateral External Oblique Intercostal Plane Block for Perioperative Analgesia in Open Cholecystectomy Surgeries: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients aged 18-65 years.\n* Patients scheduled for elective open cholecystectomy.\n* American Society of Anesthesiologists (ASA) physical status I-II.\n* Patients who provide informed consent.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Known allergy to local anesthetics.\n* Coagulopathy or anticoagulant therapy.\n* Infection at the site of injection.\n* Severe hepatic, renal, or cardiac disease.\n* Body mass index (BMI) \\> 35 kg\u002Fm².\n* Pregnancy.",{"count":169,"type":22},66,[25],"This randomized controlled trial aims to compare the analgesic efficacy of bilateral ultrasound-guided erector spinae plane block (ESPB) versus bilateral external oblique intercostal plane (EOI) block in patients undergoing open cholecystectomy.\n\nPatients will be randomly allocated into two groups to receive either ESPB or EOI block in addition to standard general anesthesia. The primary outcome is postoperative pain score assessed using the Numerical Rating Scale (NRS) at 2 hours after surgery. Secondary outcomes include intraoperative opioid consumption, postoperative nalbuphine requirements, time to first analgesic request, and hemodynamic changes.\n\nThis study seeks to determine the more effective regional anesthesia technique for improving perioperative analgesia in open cholecystectomy.",[173,91,65,28],"Cholecystectomy","NOT_YET_RECRUITING","2026-04-09",{"date":177,"type":39},"2026-04-16",{"date":179,"type":22},"2026-06",{"date":181,"type":22},"2027-05",{"name":183,"class":46},"Sohag University",{"id":185,"slug":186,"hasResults":12,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":18,"sex":19,"minAge":54,"maxAge":191,"enrollmentInfo":192,"targetDuration":4,"studyType":23,"phases":194,"briefSummary":195,"conditions":196,"keywords":199,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":207,"leadSponsor":209,"locationsCount":47},"100632187","artificial-intelligence-vs-automated-messaging-for-continuous-regional-analgesia-follow-up-100632187","NCT07510425","Artificial Intelligence vs. Automated Messaging for Continuous Regional Analgesia Follow-up","Postoperative Follow-up Via Artificial Intelligence-Based Application Versus Automated Messaging Application in Patients Receiving Continuous Regional Analgesia: A Comparative Study","Inclusion Criteria:\n\n* Patients aged between 18 and 75 years.\n* Physical status classification ASA I or II.\n* Scheduled for ambulatory surgical programs at UC Christus Health Network centers (Hospital Clínico, Clínica San Carlos de Apoquindo, or Centro Médico Santa Lucía).\n* Patients receiving postoperative pain management via continuous peripheral nerve block (CPNB) with a perineural catheter and disposable infusion pump.\n* Ownership and documented proficiency in operating a smartphone to access the mobile application.\n* Provision of written informed consent.\n\nExclusion Criteria:\n\n* Inability to understand or follow the digital monitoring protocol.\n* Patients not meeting the age or ASA physical status requirements.","75 Years",{"count":193,"type":22},166,[25],"Effective postoperative analgesia is critical for patient recovery, satisfaction, and the reduction of hospital stay duration. Continuous peripheral nerve blocks (CPNB) via catheter placement represent a cornerstone in achieving these objectives. Traditionally, follow-up for these patients has relied on standardized telephone protocols conducted by trained personnel. Original previous research in 2024 demonstrated that an automated text-messaging platform was feasible and maintained high patient satisfaction, it resulted in a significantly higher rate of unscheduled patient-initiated inquiries (28.3% vs. 6.4%) compared to traditional phone calls, likely due to a lack of adaptive response capabilities.\n\nObjective: This study aims to evaluate an enhanced technological iteration of our follow-up platform. By integrating an Artificial Intelligence (AI) interface trained on specialized clinical protocols, the new system is designed to provide automated, personalized and adaptive recommendations to patients.\n\nMethods and Intervention: The study will compare the effectiveness of this AI-driven platform against the previous version of the non-adaptive automated messaging system. The primary outcome is to compare the number of patient-initiated inquiries (re-consultations). Secondary outcomes include patient satisfaction, adherence to the follow-up protocol, and response rates from postoperative days one through three.\n\nImpact: The investigators hypothesize that the integration of AI will optimize human resources and improve patient autonomy without compromising safety or satisfaction, ultimately providing a scalable model for postoperative regional analgesia monitoring.",[197,198,28,30],"Anesthesia","Anesthesia , Analgesia",[197,28,200,201,202],"Continuous Nerve Block","Ambulatory","Outpatient follow-up","2026-04-01",{"date":205,"type":39},"2026-04-03",{"date":203,"type":22},{"date":208,"type":22},"2027-07-01",{"name":210,"class":46},"Pontificia Universidad Catolica de Chile",{"id":212,"slug":213,"hasResults":12,"nctId":214,"briefTitle":215,"officialTitle":216,"acronym":4,"eligibilityCriteria":217,"healthyVolunteers":12,"sex":19,"minAge":54,"maxAge":4,"enrollmentInfo":218,"targetDuration":4,"studyType":23,"phases":220,"briefSummary":221,"conditions":222,"keywords":225,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":235,"locationsCount":238},"100627706","dipb-vs-sifib-for-postoperative-analgesia-after-hip-surgery-100627706","NCT07452120","DIPB vs. SIFIB for Postoperative Analgesia After Hip Surgery","Comparison of the Effects of Deep Iliacus Plane Block (DIPB) and Suprainguinal Fascia Iliaca Block (SIFIB) on Postoperative Analgesia in Patients Undergoing Hip Surgery: A Randomized Controlled Study","Inclusion Criteria:\n\n* Patients aged ≥18 years\n* ASA physical status I-III\n* Scheduled for elective primary total hip arthroplasty under spinal anesthesia\n* Ability to understand the study procedures and provide informed consent\n\nExclusion Criteria:\n\n* Coagulation disorders or anticoagulant therapy contraindicating regional anesthesia\n* Infection at the block application site\n* Hemodynamic instability\n* Known allergy to local anesthetics\n* Pre-existing significant neurological or motor deficits in the lower extremities\n* Cognitive impairment preventing pain assessment\n* Refusal to participate or inability to provide informed consent",{"count":219,"type":22},70,[25],"This randomized, double-blind clinical trial aims to compare the effectiveness of the Deep Iliacus Plane Block (DIPB) and the Suprainguinal Fascia Iliaca Block (SIFIB) for postoperative pain control in patients undergoing primary total hip arthroplasty. Effective analgesia after hip surgery is essential for early mobilization, reduction of complications, and improved recovery outcomes.\n\nSeventy patients scheduled for elective hip arthroplasty under spinal anesthesia will be randomly assigned to receive either DIPB or SIFIB at the end of surgery. Postoperative pain scores, opioid consumption, motor block, and block-related complications will be evaluated over a 48-hour period.\n\nThe study aims to determine whether DIPB provides superior or comparable analgesia with reduced motor blockade compared to SIFIB, thereby contributing to safer and more comprehensive postoperative pain management in hip surgery patients.",[223,91,28,224],"Hip Arthroplasty","Acute Postoperative Pain",[226,227,223,91,28],"Deep Iliacus Plane Block","Suprainguinal Fascia Iliaca Block","2026-03-28",{"date":230,"type":39},"2026-04-02",{"date":232,"type":39},"2026-03-27",{"date":234,"type":22},"2026-11-01",{"name":236,"class":237},"Sivas Numune Hospital","OTHER_GOV",2,{"id":240,"slug":241,"hasResults":12,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":4,"eligibilityCriteria":245,"healthyVolunteers":12,"sex":19,"minAge":54,"maxAge":191,"enrollmentInfo":246,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":248,"conditions":249,"keywords":252,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":261,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":47},"100627224","sensory-analysis-and-cutaneous-mapping-of-different-regional-anesthesia-techniques-100627224","NCT07445854","Sensory Analysis and Cutaneous Mapping of Different Regional Anesthesia Techniques","Sensory Analysis and Cutaneous Mapping of Different Regional Anesthesia Techniques in Laparoscopic Cholecystectomy Surgery: A Prospective Observational Study","Inclusion Criteria:\n\n* Patients scheduled for elective laparoscopic cholecystectomy surgery and who have received a regional anesthesia technique for this purpose.\n* Aged between 18-75 years.\n* Belonging to ASA I-III group.\n* Having provided written informed consent.\n\nExclusion Criteria:\n\n* Patients who refuse to participate.\n* Patients who did not receive a block.\n* Patients classified as ASA IV.\n* History of previous abdominal surgery (affecting the laparoscopic approach).\n* Patients with cognitive dysfunction or inability to cooperate.\n* Patients diagnosed with psychiatric disorders (schizophrenia, mania, depression, etc.).\n* Patients who have been using antipsychotic medication for more than 4 weeks.",{"count":247,"type":22},40,"This prospective observational study aims to evaluate and compare the sensory block distribution and regression patterns of two regional anesthesia techniques - External Oblique Plane Block (EOPB) and Serratus Intercostal Plane Block (SIPB) - in patients undergoing laparoscopic cholecystectomy.\n\nThirty adult patients (ASA I-III, BMI ≤ 35 kg\u002Fm², ≥50 kg) scheduled for elective laparoscopic cholecystectomy procedures will be included, with 20 in each block group. Sensory block areas will be assessed using pinprick test, and dermatomal mapping will visualize the spread. The findings are expected to improve understanding of block behavior and guide multimodal analgesia strategies in laparoscopic cholecystectomy.",[250,251,28],"Laparoscopic Cholecystectomy","Postoperative Pain Management",[253,254,255,256,257,258,259],"regional anesthesia","Pain Management","Sensory Mapping","serratus intercostal plane block","external oblique plane block","eopb","sipb","2026-02-25",{"date":262,"type":39},"2026-03-03",{"date":264,"type":39},"2025-11-15",{"date":266,"type":22},"2026-06-01",{"name":268,"class":46},"Samsun University",{"id":270,"slug":271,"hasResults":12,"nctId":272,"briefTitle":273,"officialTitle":274,"acronym":4,"eligibilityCriteria":275,"healthyVolunteers":12,"sex":19,"minAge":276,"maxAge":277,"enrollmentInfo":278,"targetDuration":4,"studyType":23,"phases":280,"briefSummary":281,"conditions":282,"keywords":285,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":293,"completionDateStruct":295,"leadSponsor":297,"locationsCount":47},"100606510","revision-of-deep-brain-stimulator-in-patients-with-parkinsons-disease-100606510","NCT07176494","Revision of Deep Brain Stimulator in Patients With Parkinson's Disease","Revision of Deep Brain Stimulator in Patients With Parkinson's Disease: A Comparison of Perioperative Characteristics of Regional and General Anesthesia","Inclusion Criteria:\n\n* Those aged 40-85\n* Those with an ASA score of I-II-III\n* Those with a body mass index (BMI) between 18-30\n\nExclusion Criteria:\n\n* Those under 40 and over 85\n* Those with an ASA score of IV or higher\n* Those with a BMI of under 18 and over 30","40 Years","85 Years",{"count":279,"type":22},50,[25],"Parkinson's disease is a chronic and progressive neurodegenerative disease that affects the central nervous system, particularly impairing movement control. It is associated with the loss of dopamine-producing cells in the brain and typically occurs in middle age and beyond. Deep brain stimulation (DBS) is considered when symptoms of Parkinson's disease, such as tremors, slowed movements, and muscle rigidity, are not adequately controlled with medications. Selected patients with severe symptoms that do not respond to medical treatment are generally considered for this treatment.\n\nBattery revision surgeries can be performed under general anesthesia or regional anesthesia. Patients undergoing general anesthesia should be cautious about the potential complications of general anesthesia, while those undergoing regional anesthesia should be cautious about the local anesthetic systemic toxicity. Because each method has its own advantages, the choice of anesthesia may vary.\n\nThis study aimed to compare postoperative analgesic efficacy and patient satisfaction in patients who underwent surgery under general anesthesia or sedation-assisted battery replacement under regional anesthesia. Both anesthesia methods are routinely used in Parkinson's disease patients undergoing battery replacement.",[254,28,283,284],"Deep Brain Stimulation","Parkinsons Disease",[286,287,288,289],"Pectoserratus block","Interpektoral block","Deep brain stimulation","Awake surgery","2025-12-03",{"date":292,"type":39},"2025-12-10",{"date":294,"type":39},"2025-09-20",{"date":296,"type":22},"2026-07-20",{"name":298,"class":237},"Ankara Etlik City Hospital",{"id":300,"slug":301,"hasResults":12,"nctId":302,"briefTitle":303,"officialTitle":303,"acronym":304,"eligibilityCriteria":305,"healthyVolunteers":12,"sex":19,"minAge":54,"maxAge":4,"enrollmentInfo":306,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":308,"conditions":309,"keywords":311,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":319,"lastUpdatePostDateStruct":320,"startDateStruct":322,"completionDateStruct":324,"leadSponsor":326,"locationsCount":4},"100611311","neurological-events-and-unforeseen-risks-after-locoregional-anesthesia-100611311","NCT07238933","Neurological Events and Unforeseen Risks After Locoregional-anesthesia","NEURAL","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Scheduled to undergo a single-shot nerve or fascial plane block.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Performance of more than one single-shot nerve or fascial plane block within the same anatomical region or sensory distribution during the same procedure.\n* Use of continuous nerve or fascial plane catheter-based anesthesia.\n* Presence of a language barrier that, in the investigator's judgment, would prevent adequate follow-up.",{"count":307,"type":22},3396,"This is a multicenter, prospective, observational study aimed at determining the incidence of neurological and non-neurological complications following locoregional anesthesia procedures. The study will collect data on events such as nerve injury, hematoma, pneumothorax, and local anesthetic systemic toxicity.",[28,310],"Regional Anesthesia Block",[312,313,314,315,316,317,318],"Nerve Injury","Pneumothorax","Local Anesthetic Systemic","Toxicity","Upper limb block","Lower limb block","Fascial plane block","2025-11-18",{"date":321,"type":39},"2025-11-20",{"date":323,"type":22},"2025-12-01",{"date":325,"type":22},"2027-01-01",{"name":327,"class":46},"Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva",{"id":329,"slug":330,"hasResults":12,"nctId":331,"briefTitle":332,"officialTitle":333,"acronym":4,"eligibilityCriteria":334,"healthyVolunteers":12,"sex":139,"minAge":54,"maxAge":55,"enrollmentInfo":335,"targetDuration":4,"studyType":23,"phases":336,"briefSummary":337,"conditions":338,"keywords":341,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":347,"startDateStruct":349,"completionDateStruct":350,"leadSponsor":351,"locationsCount":47},"100611910","ipp-psp-block-vs-spsipb-in-breast-surgery-100611910","NCT07246720","IPP-PSP Block vs. SPSIPB in Breast Surgery","Interpectoral-pectoserratus Plane Block vs. Serratus Posterior Superior Intercostal Plane Block for Postoperative Analgesia in Patients Undergoing Breast Cancer Surgery","Inclusion Criteria:\n\n* 18-65 years of age\n* ASA I-II-III risk groups\n* Patients with informed consent\n* Patients undergoing breast cancer surgery\n\nExclusion Criteria: • Ages \\\u003C18 and \\>65\n\n* ASA ≥ IV\n* History of allergy to local anesthetics\n* Known coagulation disorders\n* Infection near the insertion site\n* Chronic analgesic use\n* Patients with diabetes mellitus and those receiving neoadjuvant chemotherapy (due to potential impairment of pain sensation)\n* Body mass index \\>30\n* Dementia or confusion\n* Lack of cooperation",{"count":219,"type":22},[25],"This prospective, randomized clinical study aims to compare the analgesic efficacy of the interpectoral-pectoserratus plane block and the serratus posterior superior intercostal plane block for postoperative pain management in patients undergoing breast cancer surgery. Both techniques are ultrasound-guided regional anesthesia methods targeting different interfascial planes of the thoracic wall. The study will evaluate postoperative pain scores, opioid consumption, Quality of recovery and potential complications. The findings are expected to contribute to optimizing regional anesthesia strategies for enhanced recovery and improved analgesia following breast cancer surgery.",[339,340,28],"Postoperative Acute Pain","Breast Cancer",[342,343,344,345,254],"Interpectoral-Pectoserratus Plane Block","Serratus Posterior Superior Intercostal Plane Block","Breast Cancer Surgery","Opioid Consumption","2025-11-17",{"date":348,"type":39},"2025-11-24",{"date":264,"type":22},{"date":38,"type":22},{"name":352,"class":46},"Zonguldak Bulent Ecevit University",{"id":354,"slug":355,"hasResults":12,"nctId":356,"briefTitle":357,"officialTitle":357,"acronym":358,"eligibilityCriteria":359,"healthyVolunteers":12,"sex":19,"minAge":54,"maxAge":4,"enrollmentInfo":360,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":362,"conditions":363,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":371,"leadSponsor":372,"locationsCount":47},"100610001","the-lateral-anterior-medial-lam-femoral-cutaneous-block-a-case-series-harborview-medical-center-seattle-wa-100610001","NCT07221903","The Lateral, Anterior, Medial (LAM) Femoral Cutaneous Block: A Case Series Harborview Medical Center, Seattle, WA","LAM","Inclusion Criteria:\n\n1. 18 years or older\n2. Scheduled surgery for STSG w\u002F donor site coming from thigh\n3. Care team requests LAM nerve block\n4. Anticipated postop pain in the cutaneous areas of anterior and lateral thigh\n\n   Exclusion Criteria:\n5. Inability to communicate sensation or motor changes in their body\n6. Preexisting sensory or motor deficits in the femoral nerve distribution\n7. Contraindication to the medication used or a peripheral nerve block, such as allergy to amide local anesthetics, severe liver dysfunction, injection site infection etc\n8. Pregnancy\n9. Prisoners\n10. Non-English Speaking\u002Freading\n11. Surgeries with anticipated or actual duration of 6 hours or longer\n12. TBSA 20% or greater\n13. Severe distracting injuries\u002Fpolytrauma (e.g., large or significant bone fractures)",{"count":361,"type":22},10,"Skin donor sites in patients undergoing split-thickness skin grafting surgeries can be very painful postoperatively. This site is most often the anterolateral thigh, the pain at which location can traditionally be covered by a fascia iliaca nerve block, although that comes with the disadvantage of losing motor functions in the femoral nerve distribution. The LAM nerve block, which is relatively new, aims to provide analgesia in the distribution of the lateral and anterior femoral cutaneous nerves. In short, this nerve block would decrease the sensation of the anterolateral thigh area without affecting the motor function of the leg. Investigators aim to study the consistency and coverage size of sensation changes by mapping out the area after the block in each patient.",[28,364,365],"Burn","Skin Grafting","2025-10-31",{"date":368,"type":39},"2025-11-04",{"date":370,"type":39},"2025-10-22",{"date":103,"type":22},{"name":373,"class":46},"University of Washington",{"id":375,"slug":376,"hasResults":12,"nctId":377,"briefTitle":378,"officialTitle":379,"acronym":380,"eligibilityCriteria":381,"healthyVolunteers":12,"sex":19,"minAge":54,"maxAge":4,"enrollmentInfo":382,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":384,"conditions":385,"keywords":387,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":389,"lastUpdatePostDateStruct":390,"startDateStruct":392,"completionDateStruct":394,"leadSponsor":396,"locationsCount":47},"100594281","the-sacral-erector-spinae-plane-block-in-total-knee-arthroplasty-100594281","NCT07017400","The Sacral Erector Spinae Plane Block in Total Knee Arthroplasty","Effectiveness of the Sacral Erector Spinae Plane (ESP) Block in Total Knee Arthroplasty: A Prospective Observational Study","sacral ESP","Inclusion Criteria:\n\n* Adults \\>18 years\n* ASA I-III\n* scheduled for unilateral TKA with expected hospitalization \\> 24 hours\n\nExclusion Criteria:\n\n* Refusal of consent\n* Local anesthetics allergies\n* contraindications to spinal or regional anesthesia\n* coagulation disorders\n* anticoagulation\u002Fantiaggregation medications\n* dementia\n* ASA-PS \\> III\n* ongoing infection\n* emergency surgeries",{"count":383,"type":22},126,"The goal of this observational study is to learn about the analgesic efficacy and postoperative recovery of two locoregional anesthesia combinations in patients \\> 18 years (ASA I-III), scheduled for unilateral TKA under spinal anesthesia with expected hospitalization \\> 24 hours:\n\n* ACB + sacral ESP block\n* ACB + iPACK block\n\nThe main question it aims to answer is: Does the ACB + sacral ESP block combination produce effective postoperative recovery and analgesic effect?\n\nParticipants already taking ACB + sacral ESP block as part of their regular peri-operative care for TKA will be followed in the postoperative period for 48 hours.",[386,28],"Total Knee Anthroplasty",[253,388],"total knee arthroplasty","2025-08-22",{"date":391,"type":39},"2025-08-28",{"date":393,"type":39},"2025-07-16",{"date":395,"type":22},"2027-12",{"name":397,"class":46},"San Giovanni di Dio Hospital",{"id":399,"slug":400,"hasResults":12,"nctId":401,"briefTitle":402,"officialTitle":403,"acronym":4,"eligibilityCriteria":404,"healthyVolunteers":12,"sex":19,"minAge":54,"maxAge":4,"enrollmentInfo":405,"targetDuration":4,"studyType":23,"phases":407,"briefSummary":408,"conditions":409,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":413,"lastUpdatePostDateStruct":414,"startDateStruct":415,"completionDateStruct":417,"leadSponsor":419,"locationsCount":47},"100602514","regional-anesthesia-in-tka-impact-on-postoperative-joint-motion-and-patient-satisfaction-100602514","NCT07124494","Regional Anesthesia in TKA: Impact on Postoperative Joint Motion and Patient Satisfaction","Evaluation of the Effects of Regional Anesthesia Methods Applied in Total Knee Arthroplasty on Joint Range of Motion in the Postoperative Period and Patient Satisfaction","* Minimum Age: 18 Years\n* Maximum Age: None\n* Sex: All\n* Gender Based: No\n* Accepts Healthy Volunteers: No\n* Inclusion Criteria:\n\n  * Scheduled for primary total knee arthroplasty\n  * Age ≥ 18 years\n  * American Society of Anesthesiologists (ASA) physical status I-III\n  * Accepting neuraxial anesthesia\n* Exclusion Criteria:\n\n  * Skin infection at the planned injection site\n  * Sepsis\n  * Coagulopathy\n  * Refusal of neuraxial anesthesia\n  * Severe hypovolemia\n  * Demyelinating central nervous system disease\n  * Age under 18 years\n  * Illiterate in Turkish\n  * Non-cooperative patients\n  * Known allergy or hypersensitivity to bupivacaine",{"count":406,"type":22},30,[25],"This is a single-center, prospective, randomized controlled trial aiming to evaluate the effects of different regional anesthesia\u002Fanalgesia techniques on postoperative knee range of motion (ROM) and patient satisfaction following total knee arthroplasty (TKA). Ninety patients undergoing elective TKA under spinal anesthesia will be randomly assigned to one of three groups: 1) spinal anesthesia with epidural catheter, 2) spinal anesthesia followed by adductor canal catheterization, and 3) spinal anesthesia with multimodal intravenous analgesia. The primary outcome is postoperative knee joint ROM measured on postoperative days 1, 2, and 3. Secondary outcomes include patient satisfaction, Oxford Knee Score, postoperative opioid consumption, and VAS scores. The study is conducted at Konya City Hospital and will be completed over a 6-month period.",[410,91,28,411,412],"Total Knee Arthroplasty","Knee Range of Motion","Patient Satisfaction","2025-08-21",{"date":391,"type":39},{"date":416,"type":39},"2025-08-05",{"date":418,"type":22},"2026-02-19",{"name":420,"class":46},"Konya City Hospital",{"id":422,"slug":423,"hasResults":12,"nctId":424,"briefTitle":425,"officialTitle":425,"acronym":4,"eligibilityCriteria":426,"healthyVolunteers":18,"sex":139,"minAge":54,"maxAge":4,"enrollmentInfo":427,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":429,"conditions":430,"keywords":432,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":435,"lastUpdatePostDateStruct":436,"startDateStruct":437,"completionDateStruct":439,"leadSponsor":440,"locationsCount":4},"100603258","insufficient-regional-anesthesia-for-cesarean-section-mothers-experiences-a-qualitative-study-100603258","NCT07134179","Insufficient Regional Anesthesia for Cesarean Section: Mothers' Experiences A Qualitative Study","Inclusion Criteria:\n\n* Women undergoing elective or emergency cesarean delivery within the last 2 years, with the experience of pain during surgery\n* Regional (spinal or epidural or combined epidural-spinal) anesthesia NOT converted to general anesthesia\n* Age ≥18 years\n\nExclusion Criteria:\n\n* Does not speak Danish or English\n* Does not wish to participate",{"count":428,"type":22},20,"In Denmark, approximately 20% of all children are born via cesarean section (C-section), making it the most common surgical procedure (also internationally). The recommended anesthesia for cesarean sections is regional anesthesia (spinal or epidural, \"spinal anesthesia\"), as it has several advantages: the woman is awake and experiences the delivery of her child, she maintains spontaneous breathing. Furthermore, regional anesthesia can contribute to early postoperative pain management to some extent.\n\nWith spinal anesthesia, most women feel pressure and touch but no pain during the cesarean section. However, some women do experience pain during the procedure, necessitating further intervention or ultimately a change in anesthetic form. If inadequate anesthesia is detected before the surgery begins, one may choose to administer renewed regional anesthesia (typically an epidural). However, if the woman first experiences pain after the surgery has commenced, it can be necessary to place her under general anesthesia for the remainder of the procedure. Experience shows that this process can be challenging, and there are frequent examples in clinical practice of inappropriate courses of action, where women have experienced unacceptable pain during their cesarean sections without being placed under general anesthesia.\n\nThe consequences of inadequate anesthesia for cesarean sections can be quite significant for women, including impaired bonding with the child, poorer establishment of breastfeeding, increased risk of postpartum reactions and post-traumatic stress.\n\nThe aim of this study is to investigate how women experience insufficient regional anesthesia during cesarean sections, in cases where the regional anesthesia was not converted to general anesthesia. The focus is on exploring the factors that contribute positively and negatively to the woman's experience in this situation, and investigate if any recommendations for how to handle the situation can be extrapolated from the women's experiences.\n\nMethod Qualitative study.\n\nInclusion criteria:\n\n* Adult women undergoing elective or emergency cesarean delivery within the last 2 years, with the experience of pain during surgery\n* Regional (spinal or epidural or combined epidural-spinal) anesthesia NOT converted to general anesthesia\n\nExclusion criteria:\n\n* Does not speak Danish or English\n* Does not wish to participate\n\nRelevant women will be invited to contact us through public post on social media. If a woman responds to the post, she will be offered further information about the project, both verbally via telephone and in writing sent by email.\n\nWomen can also be invited to participate if encountered by a project-group member during clinical work.\n\nParticipants will be invited to an interview via telephone. This will take place as a semi-structured interview, initiated with open questions and concluded with a few more specific questions. At the end of the interview, a screening for post-traumatic stress will be conducted using the PTSD-8 tool.\n\nInterviews will be recorded digitally and transcribed verbatim. The interview guide will be developed with input from the entire project group and with participation from three mothers who have previously experienced insufficient regional anesthesia during a cesarean section. The guide will be pilot-tested on 2-3 patients after cesarean section. The interview guide may be adjusted during the study, if necessary.\n\nThe number of women required to participate before a sufficient amount of information is obtained (as no new information is expected from subsequent interviews) is not known in advance; however, it is estimated that 20 women will need to participate. However, the sample size is also defined by convenience, as the investigators do not know how many women it will be possible to establish contact with via the Facebook post and through clinical work. If too few women (e.g. \\\u003C15) are included within the first two months, the investigators will make a new public posting and expand the period of inclusion to concern cesarean sections within the last 5 years instead of 2 years.\n\nBaseline data regarding the mother and the cesarean section will be collected by asking the women during the scheduled interview, and therefore access to medical records are not necessary. Qualitative data will also be gathered through the interview, conducted as a semi-structured interview based on an interview guide.\n\nData will be entered into SurveyXact software, where it will be securely stored. Data will be handled using descriptive statistics. Interview data will be analyzed using content analysis. Nvivo software will be used for managing and coding qualitative data.",[431,28],"Caesarean Section",[433,434],"pain during caesarean section","insufficient regional anesthesia","2025-08-20",{"date":413,"type":39},{"date":438,"type":22},"2025-08-15",{"date":203,"type":22},{"name":441,"class":46},"Sygehus Lillebaelt",{"id":443,"slug":444,"hasResults":12,"nctId":445,"briefTitle":446,"officialTitle":446,"acronym":4,"eligibilityCriteria":447,"healthyVolunteers":12,"sex":139,"minAge":54,"maxAge":4,"enrollmentInfo":448,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":449,"conditions":450,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":435,"lastUpdatePostDateStruct":453,"startDateStruct":455,"completionDateStruct":457,"leadSponsor":458,"locationsCount":459},"100567512","insufficient-regional-anesthesia-and-conversion-to-general-anesthesia-for-cesarean-section-a-qualitative-multicenter-study-100567512","NCT06669156","Insufficient Regional Anesthesia and Conversion to General Anesthesia for Cesarean Section A Qualitative Multicenter Study","Inclusion Criteria:\n\n* Women undergoing elective or emergency cesarean section, aged over 17 years\n* Regional (spinal or epidural or combined epidural-spinal) anesthesia converted to general anesthesia intraoperatively (i.e., after surgery has commenced) due to insufficient regional anesthesia (i.e., not for obstetric indications, such as in cases of difficult fetal extraction)\n\nExclusion Criteria:\n\n* Does not speak Danish or English\n* Does not wish to participate",{"count":406,"type":22},"Background In Denmark, approximately 20% of all children are born via cesarean section (C-section), making it the most common surgical procedure (also internationally). The recommended anesthesia for cesarean sections is regional anesthesia (spinal or epidural, \"spinal anesthesia\"), as it has several advantages: the woman is awake and experiences the delivery of her child, she maintains spontaneous breathing (the risk of difficult airway management is significantly higher in pregnant women), and the risk of aspiration of stomach contents into the lungs (which is clearly increased in pregnant women) is reduced. Furthermore, regional anesthesia can contribute to early postoperative pain management to some extent.\n\nWith spinal anesthesia, most women feel pressure and touch but no pain during the cesarean section. However, some women do experience pain during the procedure, necessitating a change in the plan. If inadequate anesthesia is detected before the surgery begins, one may choose (depending on, for example, the urgency of the cesarean) to administer renewed regional anesthesia (typically an epidural). However, if the woman first experiences pain after the surgery has commenced, it is necessary to place her under general anesthesia for the remainder of the procedure. Experience shows that this process can be challenging, and there are frequent examples in clinical practice of inappropriate courses of action, where women have experienced unacceptable pain during their cesarean sections without being placed under general anesthesia. It is difficult to obtain an exact figure on how many women experience inadequate anesthesia during cesarean sections under regional anesthesia, as not all cases are recognized or followed up on. Studies indicate that up to 12% experience pain during a cesarean section.\n\nThe consequences of inadequate anesthesia for cesarean sections can be quite significant for women, including impaired bonding with the child, poorer establishment of breastfeeding, increased risk of postpartum reactions and post-traumatic stress, as well as (anecdotally) the risk of women opting out of future pregnancies, as they may be reluctant to subject themselves to a similar situation again.\n\nAim The aim of this study is to investigate how women experience insufficient regional anesthesia during cesarean sections that require conversion to general anesthesia. The focus is on exploring the factors that contribute positively and negatively to the woman's experience in this situation.\n\nMethod Qualitative study in six Danish hospitals.\n\nInclusion criteria:\n\n* Women undergoing elective or emergency cesarean section, aged over 17 years\n* Regional (spinal or epidural or combined epidural-spinal) anesthesia converted to general anesthesia intraoperatively (i.e., after surgery has commenced) due to insufficient regional anesthesia (i.e., not for obstetric indications, such as in cases of difficult fetal extraction)\n\nExclusion criteria:\n\n* Does not speak Danish or English\n* Does not wish to participate\n\nThe woman will be contacted for the first time on day 1 or 2 after the cesarean section (before she is discharged from the hospital). She will be informed about the project and invited to participate. As a potential project participant, she is entitled to a 24-hour consideration period, and if desired, a new contact will be arranged for the following day. If she wishes to participate, she will be contacted again after 3 months. At this time, she will receive a call to schedule a follow-up telephone interview within a few days. This will take place as a semi-structured interview, initiated with open questions and concluded with a few more specific questions. At the end of the interview, a screening for post-traumatic stress will be conducted using the PTSD-8 tool. Follow-up interviews will be recorded digitally and transcribed verbatim.\n\nSample Size The project encompasses all women at the participating centers who experience insufficient regional anesthesia during a cesarean section and conversion to general anesthesia during 1 year.",[451,452,28],"Cesarean Section Complications","Cesarean Section Pain",{"date":454,"type":39},"2025-08-27",{"date":456,"type":39},"2025-02-01",{"date":325,"type":22},{"name":441,"class":46},7,{"id":461,"slug":462,"hasResults":12,"nctId":463,"briefTitle":464,"officialTitle":465,"acronym":4,"eligibilityCriteria":466,"healthyVolunteers":12,"sex":19,"minAge":54,"maxAge":55,"enrollmentInfo":467,"targetDuration":4,"studyType":23,"phases":469,"briefSummary":470,"conditions":471,"keywords":474,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":480,"startDateStruct":481,"completionDateStruct":482,"leadSponsor":484,"locationsCount":47},"100360872","erector-spinae-block-vs-placebo-block-study-100360872","NCT03978780","Erector Spinae Block vs. Placebo Block Study","Quality of Recovery Scores Following Erector Spinae Block vs. Sham Block in Ambulatory Breast Cancer Surgery: A Randomised Controlled Trial","Inclusion Criteria:\n\n* ASA classification: I-III\n* BMI \\\u003C 35 kg\u002Fm2\n* Day surgery procedure\n\nExclusion Criteria:\n\n* Prior ipsilateral breast surgery, excluding lumpectomy\n* Pre-existing neurological deficit or peripheral neuropathy involving the ipsilateral chest\n* Severe, poorly controlled cardiac conditions, significant arrhythmias, severe valvular heart diseases\n* Severe, poorly controlled respiratory conditions (severe COPD, severe interstitial lung disease, severe \u002F poorly controlled asthma)\n* Contraindication to regional anaesthesia (e.g. bleeding diathesis, coagulopathy, sepsis, infection at the site of potential needle puncture on the posterior chest)\n* Patient refusal\n* Chronic pain disorder\n* Chronic opioid use (≥30 mg oxycodone \u002F day)\n* Contraindication (or allergy) to a component of multi-modal analgesia protocol\n* Allergy to amide local anaesthetics used in nerve blocks\n* Contraindications to any of the components of the standardized general anaesthesia\n* Significant psychiatric disorder that would preclude objective study assessment\n* Pregnancy\u002F women with nursing infants\n* Unable to provide informed consent\n* Unable to speak and read English",{"count":468,"type":22},60,[25],"Regional anaesthesia combined with general anaesthesia has become common in the perioperative management of breast cancer surgery patients. Regional techniques have been recognised to provide excellent post-operative analgesia. It enhances multi-modal analgesia regimes while being opioid sparing, reducing incidence of post-operative nausea and vomiting and allowing earlier mobilisation\u002Fdischarge and improving treatment success. Therefore identifying the correct regional anaesthetic technique for this group of patients is important in providing optimum peri-operative care.",[340,472,28,473],"Nerve Block","Neuromuscular Blockade",[475,476,477,478],"Spinae fascial plane block","Breast surgery","interfascial plane block","erector spinae block","2025-07-14",{"date":393,"type":39},{"date":179,"type":22},{"date":483,"type":22},"2028-01",{"name":485,"class":46},"Women's College Hospital",{"id":487,"slug":488,"hasResults":12,"nctId":489,"briefTitle":490,"officialTitle":491,"acronym":4,"eligibilityCriteria":492,"healthyVolunteers":12,"sex":19,"minAge":54,"maxAge":493,"enrollmentInfo":494,"targetDuration":4,"studyType":23,"phases":495,"briefSummary":496,"conditions":497,"keywords":501,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":505,"lastUpdatePostDateStruct":506,"startDateStruct":508,"completionDateStruct":510,"leadSponsor":512,"locationsCount":47},"100596297","when-to-block-timing-of-scalp-block-in-craniotomy-100596297","NCT07043621","When to Block? Timing of Scalp Block in Craniotomy","Scalp Block Before Incision or Before Emergence in Craniotomy: A Randomized Controlled Evaluation of Effectiveness and Recovery Quality Via QoR-40","Inclusion Criteria:\n\n* Patients aged between 18 and 80 years.\n* Scheduled for craniotomy under general anesthesia.\n* ASA physical status classification I to III.\n* Glasgow Coma Scale (GCS) score of 15 at the time of emergence from anesthesia.\n* Provide informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Chronic use of analgesic medications prior to surgery.\n* Glasgow Coma Scale (GCS) score below 15 postoperatively.\n* Allergy or hypersensitivity to local anesthetics or opioids used in the study.\n* Contraindications for scalp block or patient-controlled analgesia.\n* Patients with severe hepatic, renal, or cardiac dysfunction.\n* Patients unable to comprehend or complete the QoR-40 questionnaire.","80 Years",{"count":468,"type":22},[25],"This study aims to evaluate the effect of scalp block timing-whether administered preoperatively or postoperatively-on postoperative recovery quality in patients undergoing craniotomy. The recovery quality will be assessed using the validated Quality of Recovery-40 (QoR-40) questionnaire. A total of 60 patients, aged 18-80 years, classified as ASA I-III and with a Glasgow Coma Scale (GCS) score of 15 upon admission to the recovery unit, will be enrolled. The primary outcome is the QoR-40 score. Secondary outcomes include hemodynamic changes and pain intensity measured by the Visual Analog Scale (VAS).",[498,28,499,500],"Scalp Block","Craniotomy Surgery","QoR-40",[498,502,503,504],"Craniotomy surgery","analgesia","postoperative pain","2025-06-27",{"date":507,"type":39},"2025-06-29",{"date":509,"type":22},"2025-06",{"date":511,"type":22},"2025-12",{"name":513,"class":46},"Sakarya University",{"id":515,"slug":516,"hasResults":12,"nctId":517,"briefTitle":518,"officialTitle":519,"acronym":4,"eligibilityCriteria":520,"healthyVolunteers":12,"sex":19,"minAge":54,"maxAge":521,"enrollmentInfo":522,"targetDuration":4,"studyType":23,"phases":524,"briefSummary":526,"conditions":527,"keywords":530,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":536,"lastUpdatePostDateStruct":537,"startDateStruct":539,"completionDateStruct":541,"leadSponsor":543,"locationsCount":47},"100595580","phase-4-lidocaine-vs-lidocaine-with-dexmedetomidine-for-intravenous-regional-anesthesia-ivra-in-upper-limb-surgery-100595580","NCT07034300","Lidocaine vs. Lidocaine With Dexmedetomidine for Intravenous Regional Anesthesia (IVRA) in Upper Limb Surgery","Comparison of Lidocaine Alone Versus Lidocaine With Dexmedetomidine for Intravenous Regional Anesthesia (IVRA)","Inclusion Criteria:\n\n* American Society of Anesthesiology Status I\n* American Society of Anesthesiology Status II\n* Elective surgery\n* Surgery duration \\\u003C45 minutes\n\nExclusion Criteria:\n\n* Sleep apnea\n* BMI \\>30\n* Heart block\n* uncontrolled hypertension","60 Years",{"count":523,"type":22},90,[525],"PHASE4","This study compares lidocaine alone vs. lidocaine with dexmedetomidine in Intravenous regional anesthesia (IVRA) for upper limb surgery in terms of pain scores and duration of analgesia",[528,529,28],"Post-operative Pain","Upper Limb Surgery",[531,532,533,534,529,535],"Intravenous Regional Anesthesia","Lidocaine","Dexmedetomidine","Pain","Bier Block","2025-06-15",{"date":538,"type":39},"2025-06-24",{"date":540,"type":39},"2025-05-21",{"date":542,"type":22},"2025-08-31",{"name":544,"class":46},"Fatima Memorial Hospital",{"id":546,"slug":547,"hasResults":12,"nctId":548,"briefTitle":549,"officialTitle":550,"acronym":4,"eligibilityCriteria":551,"healthyVolunteers":12,"sex":19,"minAge":54,"maxAge":4,"enrollmentInfo":552,"targetDuration":4,"studyType":23,"phases":554,"briefSummary":555,"conditions":556,"keywords":4,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":557,"lastUpdatePostDateStruct":558,"startDateStruct":560,"completionDateStruct":562,"leadSponsor":564,"locationsCount":47},"100594567","serratus-posterior-plane-block-vs-erector-spine-plane-block-100594567","NCT07021131","Serratus Posterior Plane Block vs Erector Spine Plane Block","Continuous Serratus Posterior Plane Block Versus Continuous Erector Spine Plane Block for Video-assisted Thoracoscopic Surgery: a Prospective Randomized Non-inferiority Trial","Inclusion Criteria:\n\n* Patiens undergoing VATS-surgery\n\nExclusion Criteria:\n\n* Age \\\u003C 20 years\n* Body Mass Index \\>35 kg\u002Fm2\n* Technical difficulties with the nerve block administration and\u002For subsequent bolus application\n* Abnormal course of the surgery (e.g. conversion to thoracotomy) or the postoperative phase (e.g. surgical revision of the chest)\n* Patient's refusal",{"count":553,"type":22},100,[25],"Analgesia related to the administration of local anesthetic solution into the fascia of erector spinae muscle is mediated by the effect of local anesthetic on the posterior and lateral branches of the anterior part of the spinal nerve. Comparable analgesic efficiency after the administration of both nerve blocks would reject the widespread theory of the paravertebral site of effect of the local anesthetic in ESPB.",[28],"2025-06-06",{"date":559,"type":39},"2025-06-13",{"date":561,"type":22},"2025-07-01",{"date":563,"type":22},"2026-07-01",{"name":565,"class":46},"Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.",{"id":567,"slug":568,"hasResults":12,"nctId":569,"briefTitle":570,"officialTitle":570,"acronym":4,"eligibilityCriteria":571,"healthyVolunteers":12,"sex":19,"minAge":54,"maxAge":55,"enrollmentInfo":572,"targetDuration":4,"studyType":23,"phases":573,"briefSummary":574,"conditions":575,"keywords":4,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":576,"lastUpdatePostDateStruct":577,"startDateStruct":579,"completionDateStruct":581,"leadSponsor":583,"locationsCount":4},"100574212","comparative-analysis-of-ultrasound-guided-versus-landmark-based-techniques-for-regional-anesthesia-in-egyptian-patients-100574212","NCT06756347","Comparative Analysis of Ultrasound-Guided Versus Landmark-Based Techniques for Regional Anesthesia in Egyptian Patients","Inclusion Criteria:\n\n* ● Adult patients aged 18-65 years undergoing upper limb surgery requiring brachial plexus block.\n\n  * Patients capable of providing informed consent\n\nExclusion Criteria:\n\n* ● Patients with contraindications to regional anesthesia (e.g., infection at the site, severe coagulopathy).\n\n  * History of severe allergic reactions to local anesthetics.\n  * Anatomical abnormalities affecting the brachial plexus block.\n  * Obesity (BMI \\> 35) or other conditions that might confound results.",{"count":553,"type":22},[25],"Regional anesthesia is a cornerstone in modern surgical practices due to its ability to provide effective pain management and reduce reliance on general anesthesia. Traditional landmark-based techniques, widely used due to their simplicity and cost-effectiveness, rely on surface anatomy and palpation to guide needle placement. However, these techniques are associated with a higher risk of complications, including failed blocks and nerve injuries.\n\nUltrasound-guided techniques have emerged as a safer, more precise alternative, offering real-time visualization of anatomical structures. Studies suggest that ultrasound guidance improves the success rate, reduces procedural time, and minimizes complications. Despite global advancements in ultrasound-guided regional anesthesia, limited research addresses its efficacy and safety specifically in Egyptian patients, whose unique anatomical and physiological characteristics may influence outcomes.\n\nThis study seeks to fill this knowledge gap and provide evidence-based guidance tailored to this population, focusing on brachial plexus blocks.",[28],"2025-01-02",{"date":578,"type":39},"2025-01-03",{"date":580,"type":22},"2025-01-01",{"date":582,"type":22},"2026-03-01",{"name":584,"class":46},"Assiut University",{"id":586,"slug":587,"hasResults":12,"nctId":588,"briefTitle":589,"officialTitle":590,"acronym":4,"eligibilityCriteria":591,"healthyVolunteers":12,"sex":19,"minAge":54,"maxAge":55,"enrollmentInfo":592,"targetDuration":593,"studyType":87,"phases":4,"briefSummary":594,"conditions":595,"keywords":4,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":597,"lastUpdatePostDateStruct":598,"startDateStruct":599,"completionDateStruct":601,"leadSponsor":603,"locationsCount":4},"100574126","impact-of-smoking-on-ultrasound-guided-infraclavicular-brachial-plexus-block-onset-and-duration-100574126","NCT06755229","Impact of Smoking on Ultrasound-Guided Infraclavicular Brachial Plexus Block Onset and Duration","Does Smoking Affect the Onset and Duration of Ultrasound-guided Infraclavicular Brachial Plexus Block?","Inclusion Criteria:\n\n* ASA physical status I and II\n* Scheduled for acute or elective hand or forearm surgery under the lateral infraclavicular block\n\nExclusion Criteria:\n\n* morbid obesity (body mass index \\> 40)\n* bleeding disorder\n* coagulopathy\n* medication with vitamin K antagonists\n* high-dose or fractionated heparin treatment\n* allergy to local anaesthetics\n* infection at the site of needle insertion\n* peripheral neurological disease\n* pregnancy",{"count":247,"type":22},"1 Day","The present study will be conducted involving 40 patients aged 18-65 years with ASA physical status I and II, scheduled for acute or elective hand or forearm surgery under the lateral infraclavicular block. Patients will be divided into two groups based on smoking status: Group I (non-smokers) and Group II (smokers who smoke ≥20 cigarettes\u002Fday for over 1 year).\n\nUsing a high-frequency linear ultrasound transducer, the axillary artery, vein, and the three nerve cords will be identified in the lateral infraclavicular region. After disinfection with ethanol-chlorhexidine, a sterile drape will be placed, and the attending anesthesiologist will perform the ultrasound-guided infraclavicular brachial plexus block with a triple injection technique. A total of 10 mL of bupivacaine 0.25% and prilocaine 0.05% will be injected at all three nerve cords.\n\nThe primary outcome will be the sensory blockade onset time, while secondary outcomes will include the duration of sensory and motor blockade, motor blockade onset time, time to first postoperative rescue analgesia, and total consumption of rescue analgesia. Postoperative pain will be assessed using the Visual Analogue Scale (VAS) within the first 24 hours at intervals of 2, 4, 8, 12, 16, and 24 hours. If VAS exceeds 30 cm, rescue analgesia with 0.05 mg\u002Fkg intravenous morphine sulfate will be administered.",[596,28],"Smoking, Cigarette","2024-12-24",{"date":580,"type":39},{"date":600,"type":22},"2025-01-15",{"date":602,"type":22},"2025-03-20",{"name":604,"class":46},"Selcuk University",{"id":606,"slug":607,"hasResults":12,"nctId":608,"briefTitle":609,"officialTitle":610,"acronym":611,"eligibilityCriteria":612,"healthyVolunteers":12,"sex":19,"minAge":54,"maxAge":4,"enrollmentInfo":613,"targetDuration":4,"studyType":23,"phases":614,"briefSummary":615,"conditions":616,"keywords":619,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":624,"lastUpdatePostDateStruct":625,"startDateStruct":627,"completionDateStruct":629,"leadSponsor":631,"locationsCount":47},"100570206","stress-reduction-using-video-googles-on-patients-undergoing-vascular-surgery-100570206","NCT06704230","Stress Reduction Using Video Googles on Patients Undergoing Vascular Surgery","Multimedia Patient Entertainment During Vascular Surgery Procedures in Regional Anesthesia","MEP-VASC","Inclusion Criteria:\n\n* Planed carotid endarterectomy in local anesthesia\n\nExclusion Criteria:\n\n* patients which are not able to communicate because of stroke or language barrier,\n* Dementia or neurological damage which impairs answering questionnaires or the understanding of the situation during surgery\n* medication with steroids",{"count":553,"type":22},[25],"One treatment option of internal carotid artery stenosis is open surgical endarterectomy. The operation is frequently carried out under regional plexus anesthesia, allowing the patient to remain awake during the procedure. This approach offers the advantage of monitoring for neurological changes during carotid artery clamping, allowing the surgical team to immediately respond by placing a shunt to ensure cerebral perfusion. As a result, performing surgery under regional anesthesia provides therefor a benefit. However, for patients, the procedure, which can last up to two hours or longer in some cases, may pose a significant burden. The fixed position, inability to move, sterile drapes over the face, manipulation by the surgical team, and anxiety about potential complications are just a few of the factors that may distress patients during the operation. Increased sweating and reports of substantial subjective distress are not uncommon if the procedure is performed under local anesthesia.\n\nIn many medical fields, devices and therapies are now being utilized to reduce patient stress in the perioperative setting. In procedures performed under local or regional anesthesia, such as in orthopedics or dentistry, efforts are being made to make operations more tolerable and less stressful for patients. For example, music and video goggles are employed to entertain and distract patients during the intervention. Newer approaches using video googles appear in more and more fields to reduce distress. Especially in vascular surgery and particularly in carotid surgery, the use of audiovisual distraction during the procedure has not been implemented to our knowledge, and its benefits remain undocumented. Because of the special setting and burden for the patients it is highly necessary to test these devices in carotid surgery and explore potential benefits for these patients.",[617,28,618],"Carotid Artery Diseases","Distress, Procedural",[620,621,622,623],"video googles","carotid endarterectomy","distress in patients","vascular surgery","2024-11-22",{"date":626,"type":39},"2024-11-26",{"date":628,"type":39},"2022-09-09",{"date":630,"type":22},"2025-04",{"name":632,"class":46},"University Hospital Augsburg",{"id":634,"slug":635,"hasResults":12,"nctId":636,"briefTitle":637,"officialTitle":638,"acronym":4,"eligibilityCriteria":639,"healthyVolunteers":12,"sex":19,"minAge":54,"maxAge":4,"enrollmentInfo":640,"targetDuration":4,"studyType":23,"phases":642,"briefSummary":643,"conditions":644,"keywords":4,"overallStatus":174,"whyStopped":4,"lastUpdateSubmitDate":646,"lastUpdatePostDateStruct":647,"startDateStruct":649,"completionDateStruct":650,"leadSponsor":651,"locationsCount":4},"100567656","mixed-local-for-sciatic-block-100567656","NCT06671028","Mixed Local for Sciatic Block","Ropivacaine Versus Ropivacaine With Lidocaine Mixture in Poplitial-Sciatic Nerve Block for Below Knee Surgeries- A Randomized, Single Center Study","Inclusion Criteria:\n\n* Adult patients (≥18 years old)\n* Scheduled for elective below-knee surgeries such as ankle arthroscopy, lower limb fracture fixation, toe surgeries, etc\n* Capable of providing informed consent\n\nExclusion Criteria:\n\n* History of allergic reaction to local anesthetics\n* Pre-existing neurological disorders affecting lower limbs\n* Significant renal or hepatic impairment\n* Pregnancy or breastfeeding\n* Less than 60kg\n* Inability to provide informed consent",{"count":641,"type":22},110,[25],"Choice of local anesthetics is the major determinant of the characteristics of a peripheral nerve block. Short acting local anesthetics while provides faster onset suffer from shorter duration. On the other hand, long acting local anesthetics while provides long duration suffered from long onset time. The ideal local anesthetics should provide faster nerve block onset while providing reasonable duration to provide sustained postoperative analgesia. Mixing short and long acting local anesthetics for nerve blocks may appear to be the solution however previous published studies have demonstrated similar onset time to long acting local anesthetics and with reduced duration. Recently, the London Health Sciences Centre established an ambulatory surgical centre. Fast onset peripheral nerve block is desirable. Previous studies have not looked at popliteal sciatic block and anecdotally we feel addition of short acting local anesthetics appear to speed up onset. We are therefore interested in conducting a randomize trial to determine whether mixing short and long acting local anesthetics can speed up onset of surgical quality block.",[28,645],"Local Anesthetic","2024-10-31",{"date":648,"type":39},"2024-11-04",{"date":580,"type":22},{"date":208,"type":22},{"name":652,"class":46},"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's"]