[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"rehabilitation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:rehabilitation":39},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,102,0,25,[9,61,89,112,140,167,192,221,256,283,303,330,358,387,410,441,464,490,528,559,580,603,621,647,673],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":41,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":49,"lastUpdatePostDateStruct":50,"startDateStruct":53,"completionDateStruct":55,"leadSponsor":57,"locationsCount":60},"100644951","the-impact-of-enhanced-music--natural-visuals-on-emotional-health-100644951",false,"NCT07676110","The Impact of Enhanced Music & Natural Visuals on Emotional Health","Impacts of Music, Audio Enhancements, Audio Guidance, and Visuals on Physical and Emotional Well-being. (Emotional Health - Longitudinal 1 Randomized, Controlled Multi-center Study)","Inclusion Criteria:\n\n* You are 13 years of age or older\n* You can read, write, and speak English at a 5th-grade level or higher\n* You are legally capable of providing informed consent (adult participants) or capable of providing assent (child participants)\n* To the best of your knowledge, you are willing and able to commit to the session(s) and activities of this study\n* You are willing and able to use the sound-delivery and data-collection apparatus of this study\n* You are willing to use your own personal equipment. Depending on the study, you may need to have your own ear buds\u002Fheadphones and\u002For a \"smart\" device with internet and\u002For Bluetooth access (e.g., smartphone, iPad).\n* You have normal hearing in both ears.\n* You never experience ringing noises or buzzing sensations in your ears (tinnitus)\n* You do not use a heart\u002Fcardiac pacemaker and do not have any history of cardiac rhythm disturbances, such as cardiac conduction delays or blocks\n* You have no known history of fainting, fainting, spells or seizures, spinning sensations, or trouble with balance (medical terms include epilepsy, seizures, syncope, vertigo, nystagmus)\n* You do not use of any of the following medications: Beta blockers, steroids, ephedrine, acute anti-anxiety medication (e.g., benzodiazepines such as diazepam\u002FValium, lorazepam\u002FAtivan or clonazepam\u002FKlonopin), or acute or chronic pain medications (including narcotics and codeine)\n* For any study session, you will not be under the influence of any substances that could prevent safe participation and will not have consumed e.g., alcohol, THC, Psilocybin, or other mood-altering drugs in the 12 hours preceding the session.\n\nExclusion Criteria:\n\n\\-",true,"ALL","13 Years",{"count":21,"type":22},200,"ESTIMATED","INTERVENTIONAL",[25],"NA","The investigators are conducting research on factors related to the self-regulation of mood and arousal states across a range of everyday activities as well as different levels of stress. Behavioral interventions-such as meditation, listening to music, or visualizing art or nature-offer important alternatives and\u002For adjunctive strategies to pharmaceutical tools or other mechanisms supporting physical and emotional well-being. This research will expand on the knowledge base regarding the impact of biophysical stimulation and\u002For frame of mind on an individual's self-directed management of physical and emotional health. Motivation, confidence, and composure are critical aspects of self-efficacy, framing a person's mindset to make healthy choices across daily activities.\n\nThe research in this protocol is carried out across multiple sites and studies by means of digital tools and a consistent participant experience workflow. Together, these resources are intended to support individuals across multiple self-directed experiences utilized in the maintenance of their basic health. Before, during, and after session experiences, the participant provides objective (physiological) responses and\u002For subjective (self-report) responses and reflections; some studies also include interviews or focus groups. The combined set of responses can be summarized, connected to other measures, and input to machine learning models to improve personalization of stimuli. By studying the effects of soundBrilliance experiences across a variety of contexts and participant samples, the investigators can better refine each element of the stimulus to improve satisfaction, tolerance, and targeted outcomes.",[28,29,30,31,32,33,34,35,36,37,38,39,40],"Emotion Management Skills","Lifestyle, Healthy","Lifestyle Intervention","Recovery","Exercise and Recovery","Exercise Training","Anxiety and Mood Disorders","Sleep","Motivation","Comfort","Pain Management","Rehabilitation","Creativity and Mindfulness",[42,43,44,45,46,47],"Music","Visuals","Visual Imagery","Biophysical Stimuli","Emotional Health","Emotional Management","RECRUITING","2026-06-23",{"date":51,"type":52},"2026-06-30","ACTUAL",{"date":54,"type":52},"2026-05-25",{"date":56,"type":22},"2027-06",{"name":58,"class":59},"soundBrilliance LLC","INDUSTRY",3,{"id":62,"slug":63,"hasResults":12,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":12,"sex":18,"minAge":69,"maxAge":4,"enrollmentInfo":70,"targetDuration":4,"studyType":23,"phases":72,"briefSummary":73,"conditions":74,"keywords":4,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":88},"100644308","tele-pulmonary-rehabilitation-for-copd-patients-living-in-peripheral-areas-100644308","NCT07666854","Tele-Pulmonary Rehabilitation For COPD Patients Living in Peripheral Areas","Examining the Feasibility and Effectiveness of a Remote Group Respiratory Rehabilitation Program for Patients With Chronic Obstructive Pulmonary Disease Living in Peripheral Areas as a First Step to Policy Change","TELE-PR-PRPRL","Inclusion Criteria:\n\n* Male and females Patients with COPD based on accepted criteria who are eligible for reimbursement of pulmonary rehabilitation (PR) according to the Israeli \"health basket\" criteria including one of the following:\n\n  * FEV1 below 50%\n  * Severe exacerbation (hospitalization) in the previous year\n  * Two moderate exacerbations in the previous year\n* Willingness to initiate a PR or TPR programs.\n* Living in geographic peripheral area.\n* Ability to perform the TPR program or traditional PR activities as assessed by a member of the study team prior to enrollment.\n* Agree to participate, with signed informed consent.\n* Age \\> 18.\n\nExclusion Criteria:\n\n* Uncontrolled comorbidity (e.g uncontrolled congestive heart failure).\n* Inability to operate the mobile application.\n* Without a mobile device or computer.\n* An exacerbation in the 2-months prior to randomization.\n* Completed PR program in the last 12 months.\n* Pregnancy.\n* Patients with cognitive impairment.","40 Years",{"count":71,"type":22},110,[25],"Pulmonary rehabilitation (PR) is a key non-pharmacological intervention for patients with chronic obstructive pulmonary disease (COPD), yet it remains underutilized, particularly among patients living in peripheral areas due to limited access, travel distance, and logistical barriers. Tele-pulmonary rehabilitation (TPR) has the potential to improve access to care, but its feasibility and effectiveness as a group-based intervention have not been well established.\n\nThe aim of this study is to evaluate whether a group-based TPR program can improve treatment initiation and adherence compared to usual care, defined as referral to standard PR, among COPD patients living in peripheral areas. In addition, the study will assess the effect of the intervention on COPD exacerbations, symptom burden, quality of life, and patient satisfaction.\n\nThis is a prospective randomized controlled trial that will enroll patients with COPD who are eligible for PR according to the Israeli health basket criteria and have not participated in PR in the past year. Participants will be randomly assigned to one of two groups: (1) referral to standard PR (control group), or (2) participation in a 12-week, twice-weekly, group-based TPR program delivered remotely via a dedicated application and video sessions (intervention group).",[75,39,76],"COPD (Chronic Obstructive Pulmonary Disease)","Peripheral","NOT_YET_RECRUITING","2026-06-18",{"date":80,"type":52},"2026-06-24",{"date":82,"type":22},"2026-07-01",{"date":84,"type":22},"2028-08-01",{"name":86,"class":87},"Tel-Aviv Sourasky Medical Center","OTHER_GOV",1,{"id":90,"slug":91,"hasResults":12,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":12,"sex":18,"minAge":97,"maxAge":4,"enrollmentInfo":98,"targetDuration":4,"studyType":23,"phases":100,"briefSummary":101,"conditions":102,"keywords":4,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":106,"startDateStruct":107,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},"100644283","tele-pulmonary-rehabilitation-for-patients-with-chronic-lung-diseases-100644283","NCT07666841","Tele-Pulmonary Rehabilitation For Patients With Chronic Lung Diseases","Tele-Pulmonary Rehabilitation to Improve Adherence and Management of Patients With Chronic Lung Diseases","TELE-PRIME","Inclusion Criteria:\n\n1. Patients meeting the Israeli Health Basket criteria for reimbursement of pulmonary rehabilitation (PR), including one of the following conditions:\n\n   * COPD with an FEV1 below 50% or with severe exacerbation (hospitalization) in the previous year or two moderate exacerbations in the previous year.\n   * Interstitial lung disease with an FVC below 80% or a DLCO below 60%.\n   * Bronchiectasis with at least two exacerbations in the past year or at least one hospitalization, and an FEV1 below 80%.\n   * Pulmonary arterial hypertension.\n2. Willingness to initiate a PR or Tele-PR (TPR) programs.\n3. Ability to perform the TPR program or traditional PR activities as assessed by a member of the study team prior to enrollment.\n4. Agree to participate, with signed informed consent.\n\nExclusion Criteria:\n\n1. Uncontrolled comorbidity (e.g uncontrolled congestive heart failure)\n2. Inability to operate the mobile application.\n3. Without a mobile device or computer.\n4. A hospitalization in the 2-months prior to randomization.\n5. Completed PR program in the last 12 months.\n6. Inability to complete 10 repetitions in the 1-minute sit-to-stand test or 5-second single-leg stance\n7. Pregnancy\n8. Inability to provide informed consent due to impaired decision-making capacity, as determined by the study's capacity assessment.","18 Years",{"count":99,"type":22},90,[25],"Pulmonary rehabilitation is a key treatment for lung diseases, but many patients struggle to attend sessions due to travel distances, physical limitations, or logistical barriers. The purpose of this study is to evaluate whether a tele-pulmonary rehabilitation (TPR) program can improve the rates of treatment initiation and adherence among patients with chronic lung diseases compared to traditional, center-based pulmonary rehabilitation. Additionally, the study will assess improvements in quality of life, physical symptoms, and safety in both groups.\n\nThis study will enroll 90 patients from two medical centers in Israel (Tel Aviv and Barzilai). Participants will be randomly assigned to one of two groups:\n\n1. The control group will receive usual care with a referral by a pulmonologist to standard pulmonary rehabilitation at a medical center.\n2. The intervention group will participate in a supervised remote tele-rehabilitation program using a dedicated application and remote monitoring.",[75,39,103,104,105],"Bronchiectasis Adult","Pulmonary Arterial Hypertension (PAH)","Interstitial Lung Disease (ILD)",{"date":80,"type":52},{"date":82,"type":22},{"date":109,"type":22},"2028-12-31",{"name":86,"class":87},2,{"id":113,"slug":114,"hasResults":12,"nctId":115,"briefTitle":116,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":17,"sex":18,"minAge":97,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":23,"phases":121,"briefSummary":122,"conditions":123,"keywords":125,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":88},"100641401","use-of-football-in-programs-to-reduce-stigma-toward-mental-illness-a-comparison-of-the-effectiveness-of-contact-interaction-and-video-based-approaches-100641401","NCT07658066","Use of Football in Programs to Reduce Stigma Toward Mental Illness: A Comparison of the Effectiveness of Contact Interaction and Video-Based Approaches","Inclusion Criteria:\n\n* University students currently enrolled, aged between 18 and 30 years.\n* In good physical condition with no contraindications to exercise (i.e., not diagnosed by a physician or advised to avoid physical activity, and with no items selected on the PAR-Q+ \\[Physical Activity Readiness Questionnaire for Everyone\\]).\n* Able to follow the study procedures and provide signed informed consent.\n\nExclusion Criteria:\n\n* Individuals who are unable to safely participate in football activities due to intellectual disability, pregnancy, head injury, cardiovascular disease, or other neuromuscular or musculoskeletal disorders.\n* Individuals who are unable to effectively participate in the intervention program or complete assessments due to significant emotional disturbances, personality disorders, substance (alcohol) abuse, or severe mental illness.","30 Years",{"count":120,"type":22},210,[25],"The goal of this clinical trial is to evaluate the effectiveness of football-based interventions in reducing stigma toward mental illness among university students. The main questions it aims to answer are:\n\n* Does participating in a contact-based education program involving football help reduce stigma toward mental illness among university students?\n* What are the effects of three different intervention methods on reducing stigma toward mental illness?\n\nResearchers will compare the traditional contact-based education program with the other two interventions to evaluate their differences in effectiveness.\n\nParticipants will:\n\n* Be randomly assigned to one of the three intervention groups.\n* Complete online assessments to measure attitudes toward mental illness before and after the intervention.\n* Participate in qualitative interviews to provide in-depth feedback on their experiences and perceptions.",[124,39],"Psychiatry",[126,127,128,129,130],"mental illness","Psychiatric disorders","physical activity","stigma","exercise","2026-06-16",{"date":78,"type":52},{"date":134,"type":52},"2026-03-02",{"date":136,"type":22},"2027-10-31",{"name":138,"class":139},"Kaohsiung Medical University Chung-Ho Memorial Hospital","OTHER",{"id":141,"slug":142,"hasResults":12,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":17,"sex":18,"minAge":147,"maxAge":148,"enrollmentInfo":149,"targetDuration":4,"studyType":23,"phases":151,"briefSummary":152,"conditions":153,"keywords":4,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":88},"100633363","virtual-reality-mirror-therapy-with-focused-object-directed-attention-system-100633363","NCT07525713","Virtual Reality Mirror Therapy With Focused Object-Directed Attention System","Virtual Reality Mirror Therapy With Focused Object-Directed Attention for Neuro-Rehabilitation","Inclusion Criteria:\n\n* Clinical diagnosis of stroke with unilateral side involved;\n* A score of Mini-mental state examination greater than 24 for proving higher mental function;\n* Time of onset \\> 6 months before treatment begins;\n* Premorbid right-handedness.\n\nExclusion Criteria:\n\n* Severe vision impairment;\n* Major cognitive-perceptual deficit;\n* Other brain disease.","20 Years","80 Years",{"count":150,"type":22},54,[25],"In this study, the investigators hypothesized that Virtual Reality Mirror Therapy with Focused Object-Directed Attention (VRMTFOA) would yield superior therapeutic effects compared to conventional Virtual Reality Mirror Therapy (VRMT) in individuals with unilateral stroke.\n\nThe aim of this study is to compare the immediate effects of a single session of VRMT, VRMTFOA, and VRMTFOA with auditory feedback on upper extremity function and brain activity in stroke patients.",[154,39,155,156,157,158],"Stroke","Virtual Reality","Mirror Movement Therapy","Attention","Task Performance","2026-06-14",{"date":131,"type":52},{"date":162,"type":52},"2026-04-20",{"date":164,"type":22},"2027-12-31",{"name":166,"class":139},"National Cheng-Kung University Hospital",{"id":168,"slug":169,"hasResults":12,"nctId":170,"briefTitle":171,"officialTitle":171,"acronym":172,"eligibilityCriteria":173,"healthyVolunteers":12,"sex":18,"minAge":97,"maxAge":4,"enrollmentInfo":174,"targetDuration":4,"studyType":23,"phases":176,"briefSummary":177,"conditions":178,"keywords":180,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":88},"100481296","evaluation-of-the-effectiveness-of-virtual-reality-self-rehabilitation-in-the-treatment-of-facial-paralysis-and-synkinesis-100481296","NCT05547152","Evaluation of the Effectiveness of Virtual Reality Self-rehabilitation in the Treatment of Facial Paralysis and Synkinesis","RéMiFaSy","Inclusion Criteria:\n\n* Patient with recent onset peripheral facial palsy (≤ 12 months).\n* Patient with peripheral facial palsy of grade ≥ III on the House \\& Brackmann score\n* Patient of legal age (≥ 18 years)\n* Patient with appropriate information and informed consent\n\nExclusion Criteria:\n\n* Patient with central facial palsy\n* Patient with peripheral facial palsy of \\> 12 months onset\n* Patient with peripheral facial palsy of grade \\\u003C III House \\& Brackmann score\n* Patient who has previously undergone palliative surgery\n* Patient undergoing a botulinum toxin injection protocol\n* Patients benefiting from enhanced protection, i.e. minors, persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social institution, adults under legal protection, pregnant or breast-feeding women and patients in emergency situations\n* Patients who have not provided informed consent\n* Patients with cognitive disorders that do not allow them to follow the proposed self-education protocol\n* Blind or visually impaired patients (visual acuity of the better eye after correction ≤ 4\u002F10)",{"count":175,"type":22},100,[25],"Peripheral facial palsy affects 15 to 40 people per 100,000 inhabitants and induces important functional and social repercussions. Synkinesis is a frequent after-effect of facial palsy recovery, consisting of involuntary facial spasms that disturb the gestural harmony and can go as far as a painful hypertonic spasm. More than 55% of patients recovering from facial palsy will develop transient or permanent synkinesis. These facial hypertonias have two main causes: imperfect axonal regeneration, which is all the more important as the damage is proximal, and hyperexcitability of the facial nerve nucleus due to a lack of central control. Management is therefore essential for the functional restoration of the face, especially since synkinesis do not evolve spontaneously. The main treatments are currently botulinum toxin injection, acting on the motor plate, and functional rehabilitation, consisting on local muscle relaxation and central motor control work. In recent years, therapies based on biofeedback and acting on central motor control have shown interesting results, and technological advances in virtual reality have made it possible to deepen this treatment in patients suffering from stroke, limb trauma or Parkinson's disease. In this project, the investigators evaluate the contribution of virtual reality to the management of facial palsy, and hypothesize that self-rehabilitation using this technology will improve motor control of the skin muscles and reduce complications related to their hypertonia such as synkinesis.",[179,39,155],"Peripheral Facial Palsy",[179,181,182],"rehabilitation","virtual reality","2026-06-12",{"date":185,"type":52},"2026-06-15",{"date":187,"type":52},"2022-08-02",{"date":189,"type":22},"2029-08",{"name":191,"class":139},"Centre Hospitalier Universitaire, Amiens",{"id":193,"slug":194,"hasResults":12,"nctId":195,"briefTitle":196,"officialTitle":196,"acronym":197,"eligibilityCriteria":198,"healthyVolunteers":12,"sex":18,"minAge":97,"maxAge":199,"enrollmentInfo":200,"targetDuration":4,"studyType":23,"phases":202,"briefSummary":203,"conditions":204,"keywords":209,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":4},"100641741","stroke-rehabilitation-through-intensive-exercise-100641741","NCT07650500","Stroke Rehabilitation Through Intensive Exercise","S-THRIVE","Inclusion Criteria:\n\n* Age between 18 and 70 years.\n* History of a first-ever stroke occurring at least 6 months before enrollment.\n* Independence in personal activities of daily living (e.g., dressing, undressing, and using the toilet).\n* Ability to take a few steps indoors without a walking aid and without supervision; use of an orthosis is permitted.\n\nExclusion Criteria:\n\n* Unstable cardiovascular disease or exercise-induced epilepsy.\n* Insufficient cognitive ability to participate in group-based training, including the capacity to understand, follow, and maintain verbal instructions during exercise tasks.\n* Blood pressure \\>140\u002F90 mmHg at the first visit.","70 Years",{"count":201,"type":22},50,[25],"The goal of this clinical trial is to learn whether combining moderate to high intensity aerobic exercise with constraint-induced movement therapy (CI therapy) can improve walking ability in adults who have had a stroke. The study will also learn if telerehabilitation at home can support long-term recovery after intensive rehabilitation.\n\nThe main questions this study aims to answer are:\n\n* Does moderate to high intensity aerobic exercise before CI therapy improve walking ability, balance and lower extremity function in people with long-lasting gait difficulties after stroke?\n* Does CI therapy alone lead to similar or different improvements in walking ability, balance or lower extremity function?\n* Does telerehabilitation help participants maintain or further improve their function after the intensive rehabilitation period?\n\nResearchers will compare two groups. One group will receive 4 weeks of CI therapy, 5 days per week, plus 20 minutes of moderate-to-high-intensity aerobic exercise before the rehabilitation session on 3 of these days, and the other group will receive 4 weeks of CI therapy, 5 days per week, without preparatory aerobic exercise.\n\nAfter the completion of CI therapy, all participants will be offered an individualized 8-week telerehabilitation program to follow at home. They will use a mobile application to report physical activity and follow instructions for telerehabilitation.\n\nAll participants will complete two assessment visits (about 3 hours each), 1-2 weeks before and 1-2 weeks after CI therapy. They will also complete questionnaires electronically after the telerehabilitation program.\n\nDaily activity will be measured twice during the study: once during a week after the intensive rehabilitation and once during a week after the telerehabilitation program. A small movement sensor worn on the thigh will be used. The sensor is attached with a soft strap or an adhesive patch and is comfortable to wear all day. The sensor shows how much a person walks, stands, or sits in everyday life. It is light, does not disturb normal activities, and only collects movement information for the study. An instruction sheet will be included to make it easy to use.",[154,39,205,206,207,208],"Rehabilitation Outcome","Aerobic Exercise","Telerehabilitation","Gait Impairment in Stroke Patients",[210,211,212],"Aerobic exercise, stroke rehabilitation, constraint-induced movement therapy","telerehabilitation","gait impairment","2026-06-11",{"date":131,"type":52},{"date":216,"type":22},"2026-08-01",{"date":218,"type":22},"2029-06-30",{"name":220,"class":139},"The Swedish School of Sport and Health Sciences",{"id":222,"slug":223,"hasResults":12,"nctId":224,"briefTitle":225,"officialTitle":226,"acronym":227,"eligibilityCriteria":228,"healthyVolunteers":17,"sex":18,"minAge":229,"maxAge":230,"enrollmentInfo":231,"targetDuration":4,"studyType":23,"phases":233,"briefSummary":234,"conditions":235,"keywords":242,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":248,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":88},"100643382","the-act-on-a-geriatric-5-ms-guided-physical-therapy-intervention-for-knee-osteo-arthritis-in-older-adults-100643382","NCT07640529","The ACT-ON: A Geriatric 5-Ms-Guided Physical Therapy Intervention for Knee Osteo-Arthritis in Older Adults.","The ACT-ON: A Geriatric 5-Ms-Guided Physical Therapy Intervention for Knee Osteo-Arthritis in Older Adults: A Randomised Control Trial","5Ms\u002FPT\u002FKOA\u002FOA","Inclusion Criteria:\n\n* Prospective participants will be Saudi Nationals\n* aged 60 years or older\n* with a clinical diagnosis of knee osteoarthritis.\n* individuals must be capable of walking 10 meters independently or with an assistive device\n* self-report the ability to tolerate a one-hour assessment session.\n\nExclusion Criteria:\n\n* severe cognitive impairment\n* knee surgery within the past 6 months.\n* diagnosis of rheumatoid arthritis\n* the presence of unstable comorbidities (e.g., uncontrolled hypertension, heart failure, arrhythmia, severe pulmonary disease requiring oxygen, or a cardiac event in the past 6 months).\n* severe joint instability or deformity.\n* unmanaged severe osteoporosis.\n* a recent intra-articular corticosteroid injection (\\\u003C3 months).\n* active cancer treatment within the past 6 months.\n* non-elective hospitalization for a major illness.\n* surgery within the past 6 months.","55 Years","90 Years",{"count":232,"type":22},40,[25],"The study is a Random control trail study conducted at King Khalid University Hospital in Riyadh, Saudi Arabia, focusing on Application of 5 framework in rehabilitation program of knee arthritis. The study will involve a in each group sample of 20 KOA patients, with a 12-month duration. The sample size was estimated using G\\*Power 3.1 software, and the initial power analysis indicated that 40 participants would be required to achieve 80.0% statistical power. The study's participants will be aged between 55 and 80 years, diagnosed with Knee osteoarthritis, without cognitive impairment, knee surgery in the past 6 months, or unstable comorbidities. The study will involve in-person 16 sessions, with the first two lasting approximately one hour and the remaining session 30-45 minutes. The main outcome measures that will be used in this study are Stay Independent Brochure, Iconographical Falls Efficacy Scale (icon-FES), Timed Up and Go, 2-Minute Walk Test, 5 Time Set to Stand Test AND Arthritis Self-Efficacy Scale 8 Item (ASES-8), Patient-Specific Functional Scale (PSFS), and Patient satisfaction level with Physical Therapy service MedRisk. Data will be taken from direct questions to patients, by filling out the questionnaire via Google Form, and through some tests and SPSS will be used for data analysis, with ANOVA Test intervention scores of the outcome measures.",[39,236,237,238,239,205,240,241],"Excercise","Geriatric","Physical Therapy","Rehabilitation Exercise","Knee Osteoarthristis","Knee Osteoarthritis",[243,244,245,246],"5Ms","PT","KOA","OA","2026-06-06",{"date":249,"type":52},"2026-06-10",{"date":251,"type":22},"2026-05-15",{"date":253,"type":22},"2026-10-15",{"name":255,"class":139},"King Saud University",{"id":257,"slug":258,"hasResults":12,"nctId":259,"briefTitle":260,"officialTitle":260,"acronym":261,"eligibilityCriteria":262,"healthyVolunteers":12,"sex":18,"minAge":97,"maxAge":4,"enrollmentInfo":263,"targetDuration":4,"studyType":23,"phases":265,"briefSummary":266,"conditions":267,"keywords":271,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":88},"100452889","efficacy-of-a-personalized-rehabilitation-program-of-facial-involvement-in-systemic-sclerosis-100452889","NCT05177380","Efficacy of a Personalized Rehabilitation Program of Facial Involvement in Systemic Sclerosis","PREVISS","Inclusion Criteria:\n\n* Age ≥ 18 yo\n* Systemic sclerosis according to the 2013 ACR\u002FEULAR (American College of Rheumatology) classification criteria\n* Systemic sclerosis with facial involvement defined by a MHISS score \\> 6\n* Immunosuppressive and\u002For anti-fibrosis treatment stable for at least 1 month\n* Subject able to understand the objectives and risks of research and to give informed consent\n* Subject enrolment in the health insurance scheme\n\nExclusion Criteria:\n\n* Pregnancy\n* Previous participation in a rehabilitation program of facial involvement\n* Patient under legal protection\n* Impossibility to give clear information of subject",{"count":264,"type":22},60,[25],"Systemic sclerosis is a rare autoimmune disorder characterized by microangiopathy, activation of the immune system, and sclerosis of tissues including the skin. Facial involvement is frequent and disabling. It causes significant functional and aesthetic discomfort, and a major deterioration in quality of life. It results in a loss of suppleness of the skin and subcutaneous tissues, dysfunction of the temporomandibular joint, peribuccal rhagades, microstomia, and dry mouth causing difficulties in mouth opening, feeding, dental care, and weight loss.\n\nFacial involvement in systemic sclerosis can be assessed using the Mouth Handicap in Systemic Sclerosis (MHISS) score, a validated patient questionnaire assessing the functional and aesthetic consequences of systemic sclerosis on the face.\n\nAlthough common and disabling, facial involvement is underestimated and poorly managed. Immunosuppressive and\u002For anti-fibrosis drugs are not very effective. Facial rehabilitation could significantly improve the mouth handicap but facial rehabilitation is not currently performed in standard care in systemic sclerosis patients.\n\nThe aim of the study is to evaluate the efficacy of a personalized rehabilitation program vs standard care in facial involvement of systemic sclerosis patients.",[268,269,270,39],"Systemic Sclerosis","Face","Facial Involvement",[269,272,39,273],"Facial involvement","Systemic sclerosis","2026-06-05",{"date":276,"type":52},"2026-06-08",{"date":278,"type":52},"2022-10-13",{"date":280,"type":22},"2029-12",{"name":282,"class":139},"University Hospital, Strasbourg, France",{"id":284,"slug":285,"hasResults":12,"nctId":286,"briefTitle":287,"officialTitle":287,"acronym":4,"eligibilityCriteria":288,"healthyVolunteers":12,"sex":18,"minAge":97,"maxAge":148,"enrollmentInfo":289,"targetDuration":4,"studyType":23,"phases":290,"briefSummary":291,"conditions":292,"keywords":4,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":301,"locationsCount":88},"100595597","the-feasibility-and-therapeutic-effect-of-hybrid-end-effector-robot-assisted-gait-training-with-an-active-assisted-module-in-chronic-stroke-survivors-100595597","NCT07034521","The Feasibility and Therapeutic Effect of Hybrid End-effector Robot-assisted Gait Training With an Active-assisted Module in Chronic Stroke Survivors","Inclusion Criteria:\n\n* Aged between 18 and 80 years old.\n* First-ever stroke, confirmed by brain CT or MRI, with onset between 6 months and 3 years prior to enrollment.\n* Walking ability classified as Functional Ambulation Category (FAC) level 1 to level 3.\n* Prior to the current stroke, the participant was an independent community ambulator without mobility impairments.\n\nExclusion Criteria:\n\n* Presence of lower limb joint contractures, deformities, or severe spasticity (Modified Ashworth Scale score of 4).\n* Lower limb musculoskeletal conditions causing wounds, pain, inability to bear weight, or significant leg length discrepancy (\\>2 cm after orthotic correction).\n* Known history of osteoporotic fractures in the thoracolumbar spine or hip joints.\n* Inability to use the exoskeleton device due to body size, including:\n\nBody weight \\> 135 kg; Thigh length \\\u003C 36 cm or \\> 48 cm; Calf length \\\u003C 42 cm or \\> 58 cm\n\n* Cognitive or communication impairments that prevent understanding of study instructions or completion of questionnaires.\n* Acute infections or unstable vital signs.\n* Significant orthostatic hypotension or inability to maintain upright posture for more than 30 minutes.\n* Use of indwelling urinary catheter or tracheostomy.\n* Pregnant women.\n* Terminal illness with life expectancy less than six months.\n* Inability to attend 15 rehabilitation sessions and follow-up assessment at 3 months.",{"count":264,"type":22},[25],"Walking rehabilitation after stroke is most effective during the first three months of recovery, but even in the chronic phase-beyond six months post-stroke-a significant number of patients still show potential for gait improvement. Robot-assisted rehabilitation is becoming increasingly common in clinical settings, with various design modes available. However, the effectiveness of new products in improving gait or motor function still requires further investigation.\n\nThis study aims to evaluate the usability and therapeutic effects of a new end-effector exoskeleton robot system, HIWIN MRG-P110, for gait training in chronic stroke patients. The system uses foot pedal mechanisms to drive hip and knee movements for lower-limb training. Unlike its predecessor, this device allows adjustment of the active assistance ratio, encouraging users to engage in voluntary movement. It is designed for gait training in stroke patients and others with neurological impairments, but the usability and efficacy of this new training model remain to be verified.\n\nThis clinical trial is a randomized, single-blind, prospective study enrolling 60 stroke patients who are 6 months to 3 years post-onset and have a Functional Ambulation Category (FAC) level of 0 to 3. The study will explore how patients with varying degrees of motor weakness learn to adapt to the \"active-assistive mode\" in terms of speed and perception. Participants will be randomly assigned to either the active-assistive mode group or the fully passive mode group. Both groups will receive 15 treatment sessions over 5 weeks.\n\nThe study will compare the two groups in terms of:\n\n1. Improvements in gait and balance immediately post-treatment and at 3-month follow-up\n2. Changes in brain activity, as measured by functional near-infrared spectroscopy (fNIRS)",[154,39,293],"Robotic Rehabilitation","2026-05-18",{"date":296,"type":52},"2026-05-19",{"date":298,"type":52},"2025-08-12",{"date":300,"type":22},"2028-05",{"name":302,"class":139},"National Taiwan University Hospital",{"id":304,"slug":305,"hasResults":12,"nctId":306,"briefTitle":307,"officialTitle":307,"acronym":308,"eligibilityCriteria":309,"healthyVolunteers":12,"sex":18,"minAge":97,"maxAge":4,"enrollmentInfo":310,"targetDuration":4,"studyType":23,"phases":312,"briefSummary":313,"conditions":314,"keywords":318,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":323,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":4},"100639040","personalized-robotic-telerehabilitation-for-upper-limb-functional-recovery-after-stroke-in-a-home-based-setting-100639040","NCT07590349","Personalized Robotic Telerehabilitation for Upper Limb Functional Recovery After Stroke in a Home-Based Setting","ROBOHOME","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Diagnosis of stroke with residual upper-limb motor impairment\n* Upper-limb functional impairment defined by a Fugl-Meyer Assessment for Upper Extremity (FMA-UE) score between 20 and 50\n* Ability to understand study procedures and provide written informed consent\n* Availability of a home environment suitable for telerehabilitation\n\nExclusion Criteria:\n\n* Presence of severe neurological or musculoskeletal disorders affecting the upper limb\n* Severe spasticity (Modified Ashworth Scale ≥3)\n* Severe upper-limb pain (Numerical Rating Scale \\>4)\n* Skin lesions, infections, or conditions preventing safe use of wearable devices\n* Participation in another interventional clinical trial\n* Any medical or cognitive condition that may interfere with compliance or safe participation in the study",{"count":311,"type":22},70,[25],"Stroke is a leading cause of long-term disability worldwide, with upper-limb impairment representing a major determinant of functional limitation and reduced independence. Conventional rehabilitation approaches are often limited by accessibility, intensity, and long-term adherence, highlighting the need for innovative, home-based solutions.\n\nThis study aims to evaluate the effectiveness of a personalized robotic telerehabilitation program for upper-limb recovery in individuals with post-stroke motor impairment. The intervention combines a wearable robotic device with a virtual reality-based platform, enabling patients to perform structured, task-oriented exercises in a home environment under remote supervision.\n\nParticipants will be allocated to either a robotic-assisted telerehabilitation program or a control condition based on virtual reality-based rehabilitation alone. Motor recovery will be assessed using standardized clinical scales, including the Fugl-Meyer Assessment for Upper Extremity (FMA-UE), along with measures of functional performance, patient-reported outcomes, and treatment adherence.\n\nBy integrating robotic assistance with telemedicine, this study seeks to enhance rehabilitation intensity, improve patient engagement, and facilitate continuity of care beyond traditional clinical settings. The results are expected to support the development of accessible, personalized rehabilitation pathways for individuals with stroke-related upper-limb disability.",[154,315,316,317,39],"Hemiparesis","Upper Extremity Paresis","Motor Impairment",[319,320,207,321],"stroke","Robotics","Hemiplegia","2026-05-14",{"date":251,"type":52},{"date":325,"type":22},"2026-06-01",{"date":327,"type":22},"2027-05-30",{"name":329,"class":139},"University of Campania Luigi Vanvitelli",{"id":331,"slug":332,"hasResults":12,"nctId":333,"briefTitle":334,"officialTitle":335,"acronym":4,"eligibilityCriteria":336,"healthyVolunteers":12,"sex":18,"minAge":337,"maxAge":338,"enrollmentInfo":339,"targetDuration":4,"studyType":23,"phases":341,"briefSummary":342,"conditions":343,"keywords":345,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":352,"startDateStruct":353,"completionDateStruct":355,"leadSponsor":356,"locationsCount":88},"100638892","telerehabilitation-based-dance-therapy-in-pediatric-cancer-100638892","NCT07596745","Telerehabilitation-Based Dance Therapy in Pediatric Cancer","Effects of Telerehabilitation-Based Dance Therapy on Motor Proficiency, Quality of Life, Participation, and Motivation in Pediatric Cancer: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Children aged 6-14 years diagnosed with a hematological malignancy or solid tumor by a pediatric oncology specialist.\n* Currently undergoing treatment or within 6 months after completion of treatment (for hematological malignancies: during maintenance therapy or ≤6 months post-treatment; for solid tumors: during treatment or ≤6 months post-treatment).\n* Medically stable and cleared by the treating clinical team to participate in moderate physical activity\u002Fdance therapy.\n* Able to stand independently and perform movements without assistive devices.\n* Access to a digital device (smartphone, tablet, or computer) equipped with a camera, audio capability, and a stable internet connection.\n* Parent\u002Fguardian able to read and write in Turkish.\n* Written informed consent from the parent\u002Fguardian and assent from the child (as appropriate for age).\n\nExclusion Criteria:\n\n* Pre-existing genetic, neurological, developmental, or motor disorders diagnosed prior to cancer diagnosis that may affect motor performance.\n* Medical contraindications to exercise (e.g., unresolved fractures, severe avascular necrosis, recent bone marrow transplantation, or other conditions restricting physical activity as determined by the treating physician).\n* Inability to maintain stable internet connectivity required for telerehabilitation sessions.\n* Previous structured dance therapy participation within the last 6 months.","6 Years","14 Years",{"count":340,"type":22},30,[25],"Childhood cancer requires prolonged and intensive treatment, resulting in significant biopsychosocial challenges for affected children and their families. During and following treatment, children frequently experience impairments in fine and gross motor skills, reduced physical capacity, emotional difficulties, and decreased participation in daily activities. Within the framework of the International Classification of Functioning, Disability and Health for Children and Youth (ICF-CY), these impairments in body structure and function may negatively influence activity, participation, and overall quality of life.\n\nDance therapy is a holistic rehabilitation approach that integrates rhythm, structured movement, and emotional expression to enhance motor performance, body awareness, and psychosocial well-being. Emerging evidence suggests that dance-based interventions may contribute to improved pain management, psychological resilience, and emotional health in pediatric oncology populations. However, access to structured physical activity programs remains limited due to treatment-related fatigue, infection risk, travel burden, time constraints, and financial costs.\n\nTelerehabilitation may overcome these barriers by delivering therapy remotely, thereby improving accessibility, reducing logistical constraints, and ensuring continuity of care.\n\nThe aim of this randomized controlled trial is to evaluate the effects of an 8-week telerehabilitation-based dance therapy program (twice weekly, 35-40 minutes per session) on fine and gross motor skills, health-related quality of life, participation in home, school, and community settings, and motivation in children undergoing or recently completing cancer treatment.",[344,39],"Pediatric Cancer",[344,346,207,347,348,349,350,36],"Dance Therapy","Physiotherapy","Motor Proficiency","Quality of Life","Participation","2026-05-13",{"date":296,"type":52},{"date":354,"type":22},"2026-05-16",{"date":51,"type":22},{"name":357,"class":139},"Akdeniz University",{"id":359,"slug":360,"hasResults":12,"nctId":361,"briefTitle":362,"officialTitle":363,"acronym":364,"eligibilityCriteria":365,"healthyVolunteers":12,"sex":18,"minAge":97,"maxAge":148,"enrollmentInfo":366,"targetDuration":4,"studyType":23,"phases":368,"briefSummary":369,"conditions":370,"keywords":374,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":379,"lastUpdatePostDateStruct":380,"startDateStruct":381,"completionDateStruct":383,"leadSponsor":385,"locationsCount":88},"100638496","multimodal-ai-guided-recovery-management-after-lung-cancer-surgery-100638496","NCT07588737","Multimodal AI-Guided Recovery Management After Lung Cancer Surgery","Multimodal Artificial Intelligence-Guided Symptom Monitoring and Recovery Management After Lung Cancer Surgery: A 20-Center Prospective Randomized Controlled Trial","AI-LungRecover","Inclusion Criteria:\n\n1. Age 18 years or older.\n2. Clinically or pathologically diagnosed with lung cancer.\n3. Undergoing lung cancer-related thoracic surgery.\n4. Surgical procedures may include video-assisted thoracoscopic surgery, robot-assisted thoracic surgery, or open thoracic surgery.\n5. Surgical extent may include wedge resection, segmentectomy, lobectomy, sleeve resection, combined resection, bilobectomy, or pneumonectomy.\n6. Clinically stable after surgery and able to participate in symptom assessment and postoperative recovery management.\n7. Able to use a smartphone or study device, or has a caregiver who can assist with use.\n8. Able to complete patient-reported symptom assessments and postoperative recovery information reporting.\n9. Provides written informed consent.\n\nExclusion Criteria:\n\n1. Patients receiving non-surgical treatment only.\n2. Patients undergoing bronchoscopy, percutaneous biopsy, or other non-surgical diagnostic or therapeutic procedures only.\n3. Clinically unstable after surgery and unable to participate in symptom assessment or recovery management.\n4. Requiring prolonged intensive care unit treatment, continuous advanced life support, or continuous intensive medical management.\n5. Severe cognitive impairment, psychiatric disorder, language communication disorder, or other conditions that preclude completion of study assessments.\n6. Unable to use a smartphone or study device and without a caregiver who can assist with use.\n7. Currently participating in another interventional clinical study that may affect the primary outcome of this trial.\n8. Any other condition judged by the investigator to make the patient unsuitable for participation in this study.",{"count":367,"type":22},868,[25],"This study is a multicenter, prospective, randomized controlled trial designed to evaluate the effectiveness and safety of a multimodal artificial intelligence (AI)-guided postoperative recovery management system in patients after lung cancer surgery. Eligible patients will be enrolled after surgery when their clinical condition is stable and will be randomly assigned to either an AI-guided recovery management group or a usual postoperative care group.\n\nPatients in the AI-guided group will receive usual postoperative care plus a multimodal AI-based recovery management system. The system will collect patient-reported symptoms, vital signs, physical activity, respiratory rehabilitation information, recovery-related data, and, when needed, wound or chest-related images or short videos. Based on these data, the system will provide recovery feedback, general nursing advice, respiratory rehabilitation reminders, activity guidance, and risk stratification alerts. For red-flag symptoms or high-risk conditions, the system will advise patients to contact the clinical team or seek medical care.\n\nPatients in the usual-care group will receive standard postoperative management after lung cancer surgery and will complete symptom assessments at the same prespecified time points, but they will not receive AI-generated individualized recovery feedback or AI-generated risk alerts.\n\nThe primary outcome is the number of MDASI-LC-derived target symptom threshold events within 30 days after surgery. Target symptoms include pain, fatigue, disturbed sleep, shortness of breath, and cough. Secondary outcomes include overall target symptom burden, quality of recovery, time to recovery to a mild-symptom state, functional interference, respiratory rehabilitation adherence, physical activity adherence, unplanned healthcare utilization, pulmonary complications, and unplanned readmission.",[371,39,372,373],"Postoperative Care","Artificial Intelligence (Al)","Randomized Controlled Trial (RCT)",[375,376,377,378],"Artificial Intelligence","Large Language Model","Postoperative Rehabilitation","Thoracic Surgery","2026-05-09",{"date":251,"type":52},{"date":382,"type":52},"2025-03-01",{"date":384,"type":22},"2026-12-31",{"name":386,"class":139},"The First Affiliated Hospital of Guangzhou Medical University",{"id":388,"slug":389,"hasResults":12,"nctId":390,"briefTitle":391,"officialTitle":392,"acronym":4,"eligibilityCriteria":393,"healthyVolunteers":12,"sex":18,"minAge":147,"maxAge":394,"enrollmentInfo":395,"targetDuration":4,"studyType":23,"phases":396,"briefSummary":397,"conditions":398,"keywords":4,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":401,"lastUpdatePostDateStruct":402,"startDateStruct":404,"completionDateStruct":406,"leadSponsor":408,"locationsCount":4},"100636679","effectiveness-of-vr-rehabilitation-for-people-with-asymmetrical-gait-patterns-100636679","NCT07568821","Effectiveness of VR Rehabilitation for People With Asymmetrical Gait Patterns","Evaluation of the Effectiveness of Rehabilitation in Patients With Gait Pattern Asymmetry Using a Virtual Reality","Inclusion Criteria:\n\n* Diagnosed and clinically confirmed gait pattern asymmetry in the course of neurological diseases\n* Informed consent to participate in the study and willingness to comply with rehabilitation recommendations\n\nExclusion Criteria:\n\n* Active rheumatic diseases, cancer, advanced diabetes, cardiovascular diseases, and other conditions that may affect the safety and effectiveness of rehabilitation\n* Contraindications to VR therapy (epilepsy, motion sickness, dizziness, nausea)\n* Lower limb injuries or surgeries within the last 6 months\n* Severe mental disorders preventing understanding of instructions\n* Lack of informed consent to participate in the study","65 Years",{"count":232,"type":22},[25],"A randomized comparative study will be conducted to evaluate the rehabilitation process using a VR-based application versus conventional therapy in 40 patients (sample size determined using a sample size calculator). After meeting the eligibility criteria, participants will be randomly assigned to two groups: the experimental group (20 patients with gait pattern asymmetry), performing a gait training program using a VR rehabilitation application, and the control group (20 patients with gait pattern asymmetry), performing only a conventional gait training program.\n\nParticipants in both groups will take part in a 2-week rehabilitation program (Monday to Friday), with daily training sessions lasting up to 2 hours. Patient assessment will be conducted twice: an initial evaluation before the start of the intervention (Assessment I) and a follow-up evaluation after completion of the 2-week program (Assessment II), at the same time of day, under the same conditions, and using the same measurement tools.",[399,400,39],"Disability Evaluation","Recovery of Function","2026-05-05",{"date":403,"type":52},"2026-05-11",{"date":405,"type":22},"2027-03-01",{"date":407,"type":22},"2027-08-01",{"name":409,"class":139},"University of Rzeszow",{"id":411,"slug":412,"hasResults":12,"nctId":413,"briefTitle":414,"officialTitle":415,"acronym":416,"eligibilityCriteria":417,"healthyVolunteers":12,"sex":18,"minAge":97,"maxAge":4,"enrollmentInfo":418,"targetDuration":4,"studyType":23,"phases":420,"briefSummary":421,"conditions":422,"keywords":424,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":431,"lastUpdatePostDateStruct":432,"startDateStruct":434,"completionDateStruct":436,"leadSponsor":438,"locationsCount":440},"100605482","bracing-after-ankle-fracture-100605482","NCT07163091","Bracing After Ankle Fracture","Bracing After Ankle Fracture (BAF): a Randomised Multicenter Non-inferiority Trial Comparing Ankle Stirrups to Walkers on Pain, Function and Social Interaction for Adults After Ankle Fracture - Study Protocol","BAF","Inclusion Criteria:\n\n* 18 years or older\n* Surgically or non-surgically treated ankle fracture\n\nExclusion Criteria:\n\n* Pathological fractures\n* Inadequacy to read or speak danish\n* Open fractures\n* Prolonged need for immobilisation (e.g. non-union or insufficient wound healing)\n* Inability to adhere to trial procedures (e.g. neuropathy or severe psychiatric disorder)\n* Restricted weightbearing\n* Uninterest in participating",{"count":419,"type":22},1400,[25],"Ankle fractures are common, debilitating and usually treated with immobilisation using a foot-ankle brace (walker). Emerging evidence suggests that a less restrictive brace may reduce recovery time without increasing the risk of complications, and patients tend to prefer ankle stirrups. However, evidence supporting their non-inferiority remains limited and inconclusive. Thus, the aim is assess if an ankle stirrup is non-inferior to a standard walker in reducing pain and function measured by the Manchester-Oxford Foot Questionnaire (MOXFQ) three months after ankle fracture. The hypothesis is that ankel stirrups align better with patients preferenes for less immobilising braces and offer sufficient stability while the fracture heals. Secondarily it may lead to faster recovery of function, return to work and reduced cost. The sample size of a maximum of 1400 patients allow us to assess non-inferiority in age and sex specific subgroups and treatment (surgical or non-sugical). Non-inferiority will be assessed in a pragmatic, multicenter, randomised controlled trial involving Scandinavian orthopedic departments.",[423,39,31],"Ankle Fracture",[425,426,427,428,429,430],"ankle fracture","Brace","walker","ankle stirrup","intervention","RCT","2026-04-28",{"date":433,"type":52},"2026-04-29",{"date":435,"type":52},"2026-04-23",{"date":437,"type":22},"2029-09-30",{"name":439,"class":139},"Odense University Hospital",16,{"id":442,"slug":443,"hasResults":12,"nctId":444,"briefTitle":445,"officialTitle":445,"acronym":4,"eligibilityCriteria":446,"healthyVolunteers":12,"sex":18,"minAge":97,"maxAge":4,"enrollmentInfo":447,"targetDuration":4,"studyType":23,"phases":449,"briefSummary":450,"conditions":451,"keywords":455,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":431,"lastUpdatePostDateStruct":458,"startDateStruct":459,"completionDateStruct":461,"leadSponsor":462,"locationsCount":88},"100590009","the-effect-of-inspiratory-muscle-training-with-substance-use-disorder-100590009","NCT06961838","The Effect of Inspiratory Muscle Training With Substance Use Disorder","Inclusion Criteria:\n\n* Being older than 18 years\n\n  * Meeting the current Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) criteria for Substance Use Disorder\n  * Receiving inpatient treatment\n  * Substance use for more than one year\n  * Being able to follow simple instructions\n  * Not having any visual and auditory pathology\n  * Being able to cooperate with the devices used.\n\nExclusion Criteria:\n\n* Failure to comply with the treatment and assessment program\n* Participation in a structured physiotherapy\u002Fexercise program in the last 6 months\n* Presence of current psychotic symptoms\n* Presence of any physical disability or medical problem\n* Presence of respiratory system problems such as asthma and tuberculosis and infectious health problems (e.g. HIV, hepatitis B).",{"count":448,"type":22},34,[25],"The aim was to investigate the effectiveness of inspiratory muscle training on dyspnoea, pulmonary function, respiratory muscle strength, cough capacity, functional exercise capacity, substance craving, depression, anxiety and quality of life in individuals with substance use disorder.",[452,453,454,39],"Substance Abuse Disorder","Exercise","Pulmonary Function",[456,453,39,454,457],"Substance Use Disorder","Muscle Training",{"date":401,"type":52},{"date":460,"type":52},"2025-07-03",{"date":82,"type":22},{"name":463,"class":139},"Uskudar University",{"id":465,"slug":466,"hasResults":12,"nctId":467,"briefTitle":468,"officialTitle":469,"acronym":4,"eligibilityCriteria":470,"healthyVolunteers":12,"sex":18,"minAge":97,"maxAge":471,"enrollmentInfo":472,"targetDuration":4,"studyType":23,"phases":474,"briefSummary":475,"conditions":476,"keywords":478,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":483,"lastUpdatePostDateStruct":484,"startDateStruct":486,"completionDateStruct":487,"leadSponsor":488,"locationsCount":4},"100574724","intensive-music-therapy-on-cognitive-function-in-subacute-stroke-rehabilitation-in-malaysia-100574724","NCT06763003","Intensive Music Therapy on Cognitive Function in Subacute Stroke Rehabilitation in Malaysia","Feasibility Randomised Controlled Trial of Intensive Music Therapy on Cognitive Function in Subacute Stroke Rehabilitation in Malaysia","Inclusion Criteria:\n\n* Diagnosed with ischemic or haemorrhagic stroke confirmed by CT scan\n* Duration of stroke within the first 3 months\n* Aged 18 - 75 years old\n* Ability to provide informed consent\n* Understands Bahasa Melayu or English with basic communication abilities to follow instructions during therapy sessions\n* Mild to moderate cognitive impairments with MoCA score of 10-25.\n\nExclusion Criteria:\n\n* Severe aphasia\n* Significant uncorrected hearing or visual impairments preventing engagement in music therapy.\n* Severe or unstable medical conditions (e.g., uncontrolled hypertension or diabetes).\n* Medications that significantly impair cognition or motor function (e.g., high dose sedatives).\n* History of neurological diseases other than stroke (eg, Parkinson's disease).","75 Years",{"count":473,"type":22},36,[25],"The purpose of this study is to explore whether intensive music therapy can help improve cognitive functions like memory, attention, and decision-making skills in stroke patients who are undergoing rehabilitation.\n\nThis is a feasibility study, meaning it's also designed to see how practical it is to include music therapy as part of stroke rehabilitation. The investigators want to learn how well patients can participate in and stick with this type of therapy, and whether it fits well with other treatments that stroke patients usually receive. By understanding this, the investigators can assess the resources, staff training, and planning needed for music therapy to be part of stroke recovery in the future.\n\nThe study will also help the investigators estimate the effects of music therapy, which will be used to design a larger, more detailed study in the future.",[39,477,154,157],"Cognition",[479,480,181,319,481,482],"Music therapy","randomised controlled trial","cognition","attention","2026-04-27",{"date":485,"type":52},"2026-05-01",{"date":485,"type":22},{"date":384,"type":22},{"name":489,"class":139},"University of Malaya",{"id":491,"slug":492,"hasResults":12,"nctId":493,"briefTitle":494,"officialTitle":494,"acronym":4,"eligibilityCriteria":495,"healthyVolunteers":17,"sex":18,"minAge":147,"maxAge":199,"enrollmentInfo":496,"targetDuration":4,"studyType":23,"phases":498,"briefSummary":499,"conditions":500,"keywords":512,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":519,"lastUpdatePostDateStruct":520,"startDateStruct":521,"completionDateStruct":523,"leadSponsor":525,"locationsCount":527},"100636162","develop-and-evaluate-an-artificial-intelligence-assisted-prehabilitation-program-for-returning-to-work-and-cost-effectiveness-analysis-in-patients-with-oral-cancer-100636162","NCT07562100","Develop and Evaluate An Artificial Intelligence Assisted Prehabilitation Program for Returning to Work and Cost-effectiveness Analysis in Patients With Oral Cancer","Inclusion Criteria:\n\n* Adult (\\> 20 years old and younger than 70 years old)\n* Newly diagnosed as OC and scheduled to receive cancer-related treatment\n* Able to use Mobile phone\n* Willing to sign an informed consent form after receiving a detailed explanation of the study's aims and procedures\n* Healthcare professionals involved in patients' care, including doctors, nurses, case managers, dietitians, rehabilitation therapists, and psychologists\n* Family members who are primary caregivers of the participating patients, engaged in different stages of medical care\n\nExclusion Criteria:\n\n* Risk populations for walking or performing exercise\n* Patients with cognitive impairment or psychiatric diseases",{"count":497,"type":22},650,[25],"The goal of this clinical trial is to develop and evaluate an Artificial Intelligence Assisted Prehabilitation Program (AI APP) for returning to work and cost-effectiveness analysis in patients with oral cancer (OC). The main questions it aims to answer are:\n\n* What kinds of needs are related to returning to work (RTW) in patients with OC from diagnosis to survival that we can incorporate into the development of AI APP to assist this population ?\n* How is the effect of the AI APP that based on findings from the first question for patients with OC on physical and psychological distress, fear of recurrence, self-efficacy in coping with cancer, communication, motor function, quality of life, and RTW?\n* How is the effect of the RTW AI prediction model to identify high-risk groups ? And how is the comprehensive cost effectiveness of benefits and quality of life of the AI APP for OC population?\n\nResearchers will compare patients without using AI APP to see if the AI APP works to assist with coping physical and psychological distress, communication, motor function, quality of life, and RTW issues for individuals with OC?\n\nParticipants will:\n\n* Be asked to fulfill a structural questionnaire, or engage in a semi-structured one-by-one interview or a focus group to assess their physical, psychological, and social support needs in the first stage.\n* Be invited to participant the pilot testing of AI APP in the second stage.\n* Be provided and trained by 3-month AI APP for 3 months or cared as usual in the third stage.\n* Complete a structural questionnaire and follow up one year, including the baseline (before using the AI app) and at 1-2 weeks, 3 months, 6 months, 9 months, and 12 months after the baseline.\n* Engage in one-by-one interview or a focus group to assess user experiences of the AI APP.",[501,502,503,347,504,505,506,507,39,349,508,509,510,511],"Oral Cancer","Psychological Distress","Communication Aids for Disabled","Return to Work","Prehabilitation","Physical Symptom Distress","Motor Function","Cost Effectiveness","Artifical Intelligence","Prediction Model","Case Management, APP(Application)",[375,504,501,502,503,347,505,513,514,39,515,516,517,518],"Physical symptom distress","motor function","Quality of life","Cost effectiveness","prediction model","case management, APP(Application)","2026-04-24",{"date":485,"type":52},{"date":522,"type":52},"2024-09-27",{"date":524,"type":22},"2029-12-01",{"name":526,"class":87},"Taipei Veterans General Hospital, Taiwan",5,{"id":529,"slug":530,"hasResults":12,"nctId":531,"briefTitle":532,"officialTitle":533,"acronym":534,"eligibilityCriteria":535,"healthyVolunteers":12,"sex":18,"minAge":97,"maxAge":4,"enrollmentInfo":536,"targetDuration":4,"studyType":23,"phases":538,"briefSummary":539,"conditions":540,"keywords":543,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":552,"lastUpdatePostDateStruct":553,"startDateStruct":554,"completionDateStruct":555,"leadSponsor":557,"locationsCount":88},"100627588","virtual-activities-of-living-for-occupational-rehabilitation-100627588","NCT07450586","Virtual Activities of Living for Occupational Rehabilitation","Virtual Activities of Living for Occupational Rehabilitation (VALOR)","VALOR","Criteria for inclusion:\n\n1. Participant has had a right or left hemispheric stroke affecting normal hand function.\n2. At least 3 months have passed since the last stroke.\n3. Participant has sufficient active finger flexion at the MCP joint in at least one finger to be detected by visual observation by a study therapist.\n4. Participant has visual acuity with corrective lenses of 20\u002F50 or better.\n5. Participant must have active movement against gravity of at least 30 degrees shoulder flexion, 45 degrees elbow flexion, elbow extension to within 30 degrees of full extension, and 15 degrees shoulder internal and external rotation.\n6. In the opinion of a study therapist, participant can independently and safely use the system at home or has an at-home caregiver who is willing and able to assist.\n7. In the opinion of a study therapist, participant has a suitable and safe space in their home for using the VALOR system.\n8. Participant is willing and able to provide informed consent.\n\nCriteria for exclusion:\n\n1. Withholding or withdrawal of consent by the participant.\n2. Inability to understand and follow verbal directions.\n3. Determination by the Principal Investigator that participation would result in overexertion or significant discomfort or pain.\n4. A psychological diagnosis that in the determination of the Principal Investigator could significantly impact subject's participation or that could be aggravated by study participation (Principal Investigator will consult with candidate's personal physician as appropriate).\n5. Determination by the Principal Investigator that participation would result in significant agitation or elevated stress.\n6. Visual field deficit in either eye that impairs the ability to view the VR display.\n7. Significant contractures of the muscles, joints, tendons, ligaments, or skin that restrict normal upper extremity movement.\n8. More than mild tone\u002Fspasticity (measured on modified Ashworth, 5-point scale);\n9. Severe pre-stroke co-morbidities, such as cardiovascular, neurological, orthopedic, or rheumatoid impairments before stroke that may interfere with task performance.\n10. Severe sensory deficits from the involved UE; or\n11. Hemispatial neglect that impairs the ability to process and perceive visual stimuli provided through the VR display.\n\nAs the system will be adaptable to a wide range of hand dexterity, no restriction will be made for fine control of digits. Patients will not be excluded due to inability to use the VR headset. If at any time the study therapist, in consultation with the Duke PI, determines the patient is not tolerating VR headset use, the patient will be given the option to use a non-immersive version of the VALOR system which employs a TV monitor and depth sensor in lieu of the headset. Please see Potential Risks section for additional details on controls and mitigations for potential cyber sickness.",{"count":537,"type":22},48,[25],"Duke University will serve as the clinical research site for the Phase II RCT of the VALOR system, which enables telehealth delivery of evidence-based upper extremity (UE) stroke therapy in a patient's home using immersive VR headset technology for guided practice of activities of daily living (ADLs) and instrumental ADLs (IADLs). The study compares VALOR Home Exercise Program (HEP) to Usual Care Treatment (UCT) in adults with stroke-related UE impairment.",[154,541,542,39,155],"Occupational Therapy","Activities of Daily Living",[544,155,545,546,547,542,548,549,550,551,321,541],"Stroke Rehabilitation","Upper Extremity","Telehealth","Home Exercise Program","Fugl-Meyer Assessment","Wolf Motor Function Test","Motor Activity Log","Hand Function","2026-04-22",{"date":483,"type":52},{"date":185,"type":22},{"date":556,"type":22},"2027-07-29",{"name":558,"class":59},"Barron Associates, Inc.",{"id":560,"slug":561,"hasResults":12,"nctId":562,"briefTitle":563,"officialTitle":563,"acronym":4,"eligibilityCriteria":564,"healthyVolunteers":12,"sex":18,"minAge":565,"maxAge":148,"enrollmentInfo":566,"targetDuration":4,"studyType":23,"phases":567,"briefSummary":568,"conditions":569,"keywords":4,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":573,"lastUpdatePostDateStruct":574,"startDateStruct":575,"completionDateStruct":577,"leadSponsor":578,"locationsCount":88},"100574162","comparative-efficacy-of-intra-articular-vs-mri-guided-extra-articular-dextrose-injections-in-knee-osteoarthritis-management-100574162","NCT06755697","Comparative Efficacy of Intra-articular vs. MRI-guided Extra-articular Dextrose Injections in Knee Osteoarthritis Management","Inclusion Criteria:\n\n1. . age between 45 to 80 years old;\n2. . meet at least three of the six American College of Rheumatology (ACR) criteria, including age over 50 years, morning stiffness less than 30 minutes, crepitus in passive knee movements, bony tenderness, bony enlargement, and no palpable warmth;\n3. . radiologic grading of 2 or 3 according to Kellgren-Lawrence criteria;\n4. showing willingness to receive prolotherapy.\n\nExclusion Criteria:\n\n1. . severe systemic disorders including cancer, uncontrolled diabetes mellitus, sepsis, or cardiopulmonary diseases;\n2. . history of anticoagulation therapy, knee injection over the past three months;\n3. . history of knee surgery or candidates for knee arthroplasty;\n4. . history of drug abuse;\n5. . a history of intolerance to prolotherapy;\n6. . pregnancy;\n7. . infectious arthritis, inflammatory joint diseases, joint dysplasia;\n8. Body Mass Index (BMI) greater than 35 kg\u002Fm2;\n9. . not suitable or no willing to received MRI examination of the knee.","45 Years",{"count":264,"type":22},[25],"Osteoarthritis (OA) is a serious worldwide public health concern, causing increased disability-adjusted life years (DALY), the reasons of which include rising prevalence of obesity and increasing older populations. The knee is one of the most easily injured joint in the body, and knee OA can become a chronic and disabling condition that pose a threat to not only the patient but also his or her caretakers and healthcare resources. The prevalence of knee OA is 5% - 15% in men over 60 years, and 10% - 25% in women aged more than 60.\n\nKnee OA can result from injuries, diseases, or wear and tear from overuse. It refers to structural changes that affect subchondral bone, articular cartilage, menisci, ligaments, synovium, and other joint structures. Currently, there are several conservative management of knee OA, including physiotherapy (therapeutic exercise, diathermy, electrotherapy), oral or topical medications, intra-articular and extra-articular injections, and radiofrequency.\n\nThere are various substances used in injections for knee OA, among which are corticosteroid, platelet-rich plasma (PRP), AmnioFix, exosome, dextrose, and hyaluronic acid (HA). Compared with PRP, AmnioFix, exosome, and HA, which are not covered by the health insurance system, dextrose is a readily available and cost-effective substance. The principle of hypertonic dextrose injection, \"prolotherapy\", is injection of small volumes of the irritant solution at or around the lesion in order to stimulate fibroblast and vascular proliferation, local tissue healing, reduction of joint instability, thus resulting in pain relief. Previous studies have demonstrated that prolotherapy resulted in clinically meaningful sustained improvement of function and pain in knee OA, and there were no severe adverse events related to hypertonic dextrose injection. A study in 2023 showed that among various dextrose concentrations, higher concentrations demonstrated greater improvement of knee OA, thus 20% dextrose is recommended.\n\nRegarding the site of dextrose injection in knee OA, previous studies demonstrated comparable effects of intra-articular and extra-articular injections. The periarticular injections include points around the knee where periarticular nerves exit the joint capsule, and acupuncture points at upper medial and lateral parts of knee joint. A study in 2024 revealed that prolotherapy combining intra-articular with peri-articular perineural injection resulted in better pain alleviation and improvement in knee joint function in knee OA. There are several choices of imaging modality for recognizing the sites of lesion in knee OA, such as X-ray, ultrasound (US), and magnetic resonance imaging (MRI). Radiography is used to assess osteophytes, joint space narrowing, and subchondral sclerosis, but it has limited ability to detect synovial inflammation, joint effusion, soft tissue abnormalities, and early cartilage damage. US can be used to evaluate synovial fluid and cartilage thickness, but not deep structures (e.g. subchondral bone change, meniscus tear, and ACL tear, etc.). On the other hand, MRI is an optimal and accurate imaging choice for visualizing soft tissue as well as deep structures (e.g. ACL, meniscus, etc) in knee OA. The MRI findings of knee OA includes cartilage damage, meniscus tear, bone marrow lesions, synovitis, ligamentous laxity, and osteophytes. The detection of bony lesions can aid intraosseous Infiltrations, and signs of ligamentous laxity also provides target for ligaments injection. However, there is no current evidence on the effectiveness of prolotherapy targeting knee OA lesion sites according to MRI findings.\n\nBecause the effectiveness of prolotherapy targeting lesion sites according to MRI findings has not been well established, the investigators aim to investigate whether injecting dextrose into MRI-positive lesion sites is more beneficial for knee OA comparing to intra-articular injections. The investigators hypothesize that MRI could be a good choice for the guidance of prolotherapy targets.",[241,570,571,572,238,39],"Glucose","Prolotherapy","MRI","2026-04-21",{"date":519,"type":52},{"date":576,"type":52},"2025-01-23",{"date":109,"type":22},{"name":579,"class":139},"Shin Kong Wu Ho-Su Memorial Hospital",{"id":581,"slug":582,"hasResults":12,"nctId":583,"briefTitle":584,"officialTitle":585,"acronym":4,"eligibilityCriteria":586,"healthyVolunteers":12,"sex":18,"minAge":97,"maxAge":230,"enrollmentInfo":587,"targetDuration":4,"studyType":589,"phases":4,"briefSummary":590,"conditions":591,"keywords":4,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":595,"lastUpdatePostDateStruct":596,"startDateStruct":597,"completionDateStruct":599,"leadSponsor":601,"locationsCount":88},"100557044","predictive-algorithms-for-critical-rehabilitation-outcomes-100557044","NCT06532994","Predictive Algorithms for Critical Rehabilitation Outcomes","Development and Validation of a Prediction Algorithms to Estimate the Clinical Effect of Early Rehabilitation on ICU Survivors Received Mechanical Ventilation in the ICU","Inclusion Criteria:\n\n1. Age older than 18 years;\n2. Received mechanical ventilation, including endotracheal intubation and tracheostomy, during ICU admission;\n3. Met the rehabilitation intervention indications outlined in the \"Chinese Expert Consensus on Neurocritical Rehabilitation\" during ICU admission and underwent corresponding early rehabilitation interventions, including but not limited to arousal therapy for consciousness disorders, early active\u002Fpassive mobilization, comprehensive pulmonary rehabilitation, etc.;\n4. No mortality events occurred during ICU admission;\n5. Informed consent form signed by family members or the patient.\n\nExclusion Criteria:\n\n1. Pediatric patients under 18 years of age;\n2. Hospitalized patients in the ICU who did not receive mechanical ventilation;\n3. Patients in the ICU who did not undergo early rehabilitation interventions;\n4. mortality events occurred during ICU admission;\n5. Patients transferred out of the ICU due to treatment abandonment by family members;\n6. Family refusal to sign the informed consent form or patient refusal to sign the informed consent form when conscious and competent.",{"count":588,"type":22},250,"OBSERVATIONAL","An increasing amount of evidence from evidence-based medicine indicates that early rehabilitation intervention for patients receiving mechanical ventilation is safe and feasible, and can promote functional recovery and reduce hospital stay. However, the conscious state, respiratory function, and daily living activities of these patients after being discharged from the ICU vary greatly, and some patients do not show obvious benefits. How to identify which patients may have benefit from early rehabilitation is a key issue that needs to be addressed in critical care rehabilitation. This study aims to investigate the clinical data related to the disease of the ICU survivors who received mechanical ventilation as the research object, by collecting their clinical data when receiving early rehabilitation intervention, and constructing a clinical prediction model for the efficacy of early rehabilitation intervention in the ICU through the selection of optimal regression equation or machine learning algorithm. The application of this model can effectively determine whether ICU inpatients need early rehabilitation intervention, thereby reducing complication rates and improving their quality of life.",[592,593,39,594],"Intensive Care","Mechanical Ventilation","Algorithms","2026-04-15",{"date":573,"type":52},{"date":598,"type":52},"2024-08-01",{"date":600,"type":22},"2026-12-30",{"name":602,"class":139},"Wuhan University",{"id":604,"slug":605,"hasResults":12,"nctId":606,"briefTitle":607,"officialTitle":608,"acronym":4,"eligibilityCriteria":609,"healthyVolunteers":17,"sex":18,"minAge":97,"maxAge":148,"enrollmentInfo":610,"targetDuration":4,"studyType":23,"phases":612,"briefSummary":613,"conditions":614,"keywords":4,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":615,"lastUpdatePostDateStruct":616,"startDateStruct":617,"completionDateStruct":619,"leadSponsor":620,"locationsCount":88},"100603658","effects-of-virtual-reality-multisensory-cooperative-task-oriented-mirror-therapy-100603658","NCT07139379","Effects of Virtual Reality Multisensory Cooperative Task-Oriented Mirror Therapy","Virtual Reality Multisensory Cooperative Task-Oriented Mirror Therapy for Neuro-Rehabilitation","Inclusion Criteria:\n\n* Clinical diagnosis of stroke with unilateral side involved;\n* A score of Mini-mental state examination greater than 24 for proving higher mental function\n* Time of onset \\> 6 months before treatment begins; and\n* Premorbid right-handedness.\n\nExclusion Criteria:\n\n* Severe vision impairment;\n* Major cognitive-perceptual deficit;\n* Other brain disease.",{"count":611,"type":22},44,[25],"In the proposed study, the investigators assumed that Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Therapy (VRMCTOMT) will provide a better treatment effects than traditional virtual reality mirror therapy (VRMT) for the patients with unilateral stroke. The aim of the study is to examine the difference in the treatment effects among the combination of task-oriented training with either VRMCTOMT, or VRMT on the upper extremity function and brain activity of the stroke patients.",[154,39,155,156,158],"2026-04-12",{"date":595,"type":52},{"date":618,"type":52},"2025-06-24",{"date":384,"type":22},{"name":166,"class":139},{"id":622,"slug":623,"hasResults":12,"nctId":624,"briefTitle":625,"officialTitle":626,"acronym":627,"eligibilityCriteria":628,"healthyVolunteers":12,"sex":18,"minAge":97,"maxAge":4,"enrollmentInfo":629,"targetDuration":4,"studyType":23,"phases":631,"briefSummary":632,"conditions":633,"keywords":635,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":640,"lastUpdatePostDateStruct":641,"startDateStruct":643,"completionDateStruct":645,"leadSponsor":646,"locationsCount":88},"100633054","physical-recovery-during-bracing-after-ankle-fracture-re-baf-100633054","NCT07521696","Physical Recovery During Bracing After Ankle Fracture (Re-BAF)","Physical Recovery During Bracing After Ankle Fracture (Re-BAF): A Multi-Center Superiority Analysis Nested Within a Non-inferiority Randomised Controlled Trial (BAF; NCT07163091)","Re-BAF","Inclusion Criteria:\n\n* 18 years or older\n* Surgically or non-surgically treated ankle fracture\n\nExclusion Criteria:\n\n* Pathological fractures\n* Open fractures (skin perforation)\n* Prolonged need for immobilisation (e.g. non-union or insufficient wound healing)\n* Non-weight bearing treatment\n* Inability to adhere to trial procedures (e.g. neuropathy or severe psychiatric disorder)\n* Allergy to SENS Motion adhesive patches\n* Inability to read or speak Danish\n* Uninterest in participating",{"count":630,"type":22},280,[25],"Ankle fractures are among the most common fractures and represent the second most frequent fracture type requiring surgery. Many patients experience long-term pain, stiffness, and reduced ankle function, which substantially limits their physical activity. Even five years after injury, more than a third of patients have not regained their pre-injury activity levels.\n\nStandard treatment typically involves immobilisation using a rigid foot-ankle brace (walker). Although effective in protecting fracture healing, these braces may be overly restrictive, contributing to ankle stiffness, swelling, delayed physical recovery and return to daily activities, and reduced quality of life. Patients increasingly express a preference for lighter, movement-permitting ankle supports, such as minimal ankle stirrups. Recent evidence suggests that braces and elastic bands that allow more ankle movement than walkers may enhance faster recovery without increasing complications.\n\nHowever, high quality evidence is necessary for more robust conclusions. The Scandinavian Bracing after Ankle Fracture (BAF) multicentre randomised controlled trial (NCT07163091) therefore investigates whether an ankle stirrup is non-inferior to a standard walker with respect to patient-reported ankle pain and function, measured by the Manchester-Oxford Foot Questionnaire (MOXFQ) three months after ankle fracture. The primary hypothesis is that ankle stirrups better align with patients' preferences for less restrictive bracing while providing sufficient stability during fracture healing. Secondarily, ankle stirrups may promote faster recovery and physical activity.\n\nThe Re-BAF trial is nested within a larger multicentre non-inferiority trial (Bracing after Ankle Fracture \\[BAF\\], ClinicalTrials.gov ID: NCT07163091), aiming to investigate whether an ankle stirrup is non-inferior to a standard foot-ankle brace in improving patient-reported foot and ankle function, as measured by the Manchester-Oxford Foot Questionnaire (\\[MOXFQ\\], primary BAF outcome) after ankle fracture.\n\nThe aim of the Re-BAF trial is to investigate whether ankle stirrups are superior to standard foot-ankle braces in improving physical activity, assessed using objectively measured thigh-worn accelerometry from baseline (i.e. randomisation) to 12-week follow-up. We hypothesize that early and continuous movement during rehabilitation, enabled by an ankle stirrup, is superior in improving physical activity compared with a foot-ankle brace, without compromising fracture healing.",[423,31,634,39],"Physical Activity",[636,31,39,637,638,639],"Ankle Fractures","Braces","Physical activity","Randomized Controlled Trial","2026-04-07",{"date":642,"type":52},"2026-04-13",{"date":644,"type":22},"2026-04-01",{"date":437,"type":22},{"name":439,"class":139},{"id":648,"slug":649,"hasResults":12,"nctId":650,"briefTitle":651,"officialTitle":652,"acronym":4,"eligibilityCriteria":653,"healthyVolunteers":12,"sex":18,"minAge":97,"maxAge":654,"enrollmentInfo":655,"targetDuration":4,"studyType":23,"phases":656,"briefSummary":657,"conditions":658,"keywords":660,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":664,"lastUpdatePostDateStruct":665,"startDateStruct":667,"completionDateStruct":669,"leadSponsor":671,"locationsCount":88},"100484668","biofeedback-as-an-adjunctive-treatment-for-post-stroke-dysphagia-100484668","NCT05591040","Biofeedback as an Adjunctive Treatment for Post-stroke Dysphagia","Biofeedback as an Adjunctive Treatment for Post-stroke Dysphagia: A Multicentric Randomized Controlled Trial","Inclusion Criteria:\n\n* first stroke injury\n* onset from more than six weeks\n* presence of dysphagia\n* good comprehension ( not below PT 53 in Token Test)\n* good eyesight and hearing, or adequately corrected\n\nExclusion Criteria:\n\n* All the elements that hinder a good recording of the electromyographic signal (for instance a cutaneous infection, a wound or a dermatitis in the submandibular area);\n* Severe concomitant illnesses (fever, infections, metabolic problems, serious cardiac insufficiency) that can influence patient's collaboration;\n* Serious dystonia or unintentional movements\n* presence of disorders of consciousness;\n* encephalopathy due to multiple infarcts;\n* inability to sustain the experimental treatment;\n* other neurological diseases (for example Parkinson disease)","89 Years",{"count":175,"type":22},[25],"The aim of the study is to evaluate whether the effect of biofeedback treatment is more effective than a control treatment in the recovery of dysphagia.\n\nThis study will be a multicentric randomized, single-blind controlled study. The investigators intend to recruit 100 patients who have suffered a stroke and have dysphagia. Fifty patients will undergo training with bio-feedback (experimental group) and the other fifty patients will undergo standard training, using only verbal feedback rather than visual feedback (control group). Our hypothesis, based on the results obtained in some previous studies, is that in the control group the efficacy of the treatment will be lower in the absence of immediate visual feedback of strength, timing, coordination and efficacy of the swallowing act.",[659,39,154],"Dysphagia",[661,319,662,181,663],"dysphagia","biofeedback","randomized controlled study","2026-03-25",{"date":666,"type":52},"2026-03-27",{"date":668,"type":52},"2022-10-30",{"date":670,"type":22},"2027-12-03",{"name":672,"class":139},"IRCCS San Camillo, Venezia, Italy",{"id":674,"slug":675,"hasResults":12,"nctId":676,"briefTitle":677,"officialTitle":678,"acronym":679,"eligibilityCriteria":680,"healthyVolunteers":12,"sex":18,"minAge":681,"maxAge":682,"enrollmentInfo":683,"targetDuration":4,"studyType":589,"phases":4,"briefSummary":685,"conditions":686,"keywords":690,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":697,"lastUpdatePostDateStruct":698,"startDateStruct":699,"completionDateStruct":701,"leadSponsor":702,"locationsCount":704},"100621281","real-world-pediatric-oncology-rehabilitation-in-italy--rewori--100621281","NCT07368582","Real World Pediatric Oncology Rehabilitation in Italy ( ReWori )","Real World Pediatric Oncology Rehabilitation in Italy (ReWori) Study Protocol: Prognostic Factors of Functional Abilities in Children, Adolescents and Young Adults With Cancer Undergoing Rehabilitation","REWORI","Inclusion Criteria:\n\n* Diagnosis of cancer,\n* Children, adolescents and young adults aged between 0 and 24 years old,\n* Children, adolescents and young adults at any stage of treatment and off therapy,\n* Children, adolescents and young adults referred to the Rehabilitation Service of AIEOP centres and Rehabilitation Centres that provide rehabilitation care for paediatric and young adult cancer patients involved in the study.\n\nExclusion Criteria:\n\n* Failure to sign the consent\u002Fassent form for participation in the study by the subject and\u002For by the person exercising parental authority.","0 Months","24 Years",{"count":684,"type":22},249,"This observational study aims to describe changes in the functional abilities of children, adolescents and young adults with cancer who are undergoing physiotherapy or neuropsychomotor rehabilitation. This is real-world study aiming to describe normal rehabilitation pathways in many different hospitals or rehabilitation centres in Italy.\n\nThe primary research question is:\n\n1\\) What are the longitudinal changes in functional abilities among these patients receiving physiotherapy or neuropsychomotor rehabilitation?\n\nThe secondary research questions are:\n\n1. What types of rehabilitation practices are implemented across AIEOP centres?\n2. What are the rehabilitation needs among patients undergoing physiotherapy or neuropsychomotor rehabilitation?\n3. How does health-related quality of life differ across the various stages of the rehabilitation pathway? Participants undergoing usual rehabilitation treatment are evaluated on their functional abilities on a monthly basis. If they agree to participate in this study, the main characteristics of the rehabilitation treatment and the monthly evaluation are collected.",[344,687,688,39,689,238],"Pediatric Cancer Patients","Pediatric Oncology","Motor Outcomes",[691,181,692,693,694,695,696,130],"pediatric oncology","motor performance","physical therapy","children","adolescents","young adults","2026-03-24",{"date":664,"type":52},{"date":700,"type":52},"2024-07-19",{"date":437,"type":22},{"name":703,"class":139},"Associazione Italiana Ematologia Oncologia Pediatrica",13]