[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"rejection-transplant-liver\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:rejection-transplant-liver":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,40,66],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100426835","prospective-study-of-white-blood-cells-100426835",false,"NCT04838171","Prospective Study of White Blood Cells","Investigation of White Blood Cells to Support the Development of Engineered Regulatory T Cell (Treg) Therapies","No additional inclusion\u002F exclusion criteria will be applied by Quell other than those specified by the consenting institutions.",true,"ALL",{"count":19,"type":20},10,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to investigate white blood cells from volunteering donors to support the development of engineered regulatory T cell therapies.",[24,25,26],"Autoimmune Diseases","Inflammation","Rejection; Transplant, Liver","RECRUITING","2026-01-16",{"date":30,"type":31},"2026-01-21","ACTUAL",{"date":33,"type":31},"2021-03-24",{"date":35,"type":20},"2030-01",{"name":37,"class":38},"Quell Therapeutics Limited","INDUSTRY",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":17,"minAge":46,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":54,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":39},"100572495","transcriptomics-as-an-aid-in-the-histological-diagnosis-of-acute-rejection-after-liver-transplantation-100572495","NCT06734013","Transcriptomics as an Aid in the Histological Diagnosis of Acute Rejection After Liver Transplantation","Inclusion Criteria:\n\n* Patients with a diagnosis of post-OLT rejection prior to the visit at which they will be enrolled, with tissue available for RT-PCR investigations\n* Age ≥ 18 years\n* Informed consent\n\nExclusion Criteria:\n\n* Age \\\u003C18 years","18 Years",{"count":48,"type":20},40,"INTERVENTIONAL",[51],"NA","The primary objective of this exploratory study is to identify genes associated with acute rejection in liver transplant patients. To this end, a panel of acute rejection indicator genes (both humoral and cell-mediated) will be selected from results published in the literature and applied to biological material derived from biopsies. The secodnary objective is to identify genes associated with the diagnosis of humoral acute rejection and those associated with the diagnosis of cell-mediated acute rejection.",[26],[55],"Liver transplant","2024-12-10",{"date":58,"type":31},"2024-12-16",{"date":60,"type":31},"2024-10-17",{"date":62,"type":20},"2025-06",{"name":64,"class":65},"IRCCS Azienda Ospedaliero-Universitaria di Bologna","OTHER",{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":17,"minAge":46,"maxAge":4,"enrollmentInfo":73,"targetDuration":4,"studyType":49,"phases":75,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":39},"100571230","tissue-analysis-of-liver-grafts-as-a-predictor-of-transplant-outcome-100571230","NCT06717542","Tissue Analysis of Liver Grafts as a Predictor of Transplant Outcome.","Tissue Analysis (Histological, Ultrastructural and Molecular) of Liver Grafts as a Predictor of Transplant Outcome.","Inclusion Criteria:\n\n* For Donors:\n\nAvailability of enough tissue for histological, immunohistochemical and RT-PCR analysis.\n\n* HOPE performed on the liver graft prior to transplantation.\n* For Recipients:\n* Availability of enough tissue for histological, immunohistochemical and RT-PCR analysis.\n* Age greater than\u002Fequal to 18 years.\n\nExclusion Criteria:\n\n* None",{"count":74,"type":20},200,[51],"Despite the good clinical results in terms of outcome with the application of HOPE prior to liver transplantation, very little is still known about the phenotypic and molecular changes that occur during perfusion\u002Fpreservation during HOPE, particularly with regard to endothelial trophism and activation. Delving into these aspects would be very useful to allow personalised perfusion treatments in the future, thus improving the outcome of transplantation.",[78,26],"Hepatic Transplantation",[80,81],"Transplant","Liver","2024-12-01",{"date":84,"type":31},"2024-12-05",{"date":86,"type":31},"2023-01-17",{"date":88,"type":20},"2028-01",{"name":64,"class":65}]