[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"relapsed-or-refractory-diffuse-large-b-cell-lymphoma-rr-dlbcl\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:relapsed-or-refractory-diffuse-large-b-cell-lymphoma-rr-dlbcl":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100637341","phase-1-lisaftoclax-plus-chidamide-and-rituximab-in-relapsed-or-refractory-diffuse-large-b-cell-lymphoma-100637341",false,"NCT07601607","Lisaftoclax Plus Chidamide and Rituximab in Relapsed or Refractory Diffuse Large B-cell Lymphoma","A Phase Ib\u002FIIa Clinical Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Lisaftoclax in Combination With Chidamide and Rituximab in Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) Patients（CLARITY Trial）","Inclusion Criteria:\n\n* Age ≥18 years.\n* Histologically confirmed diffuse large B-cell lymphoma (DLBCL) according to the 2016 WHO classification with BCL-2 positivity by immunohistochemistry (defined as BCL-2 expression ≥30%).\n* Relapsed or refractory DLBCL after prior treatment with an anthracycline-containing regimen and an anti-CD20 antibody-containing regimen.\n* Received at least one prior line of therapy and considered ineligible for autologous stem cell transplantation (ASCT).\n* Estimated life expectancy ≥3 months.\n* Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.\n* At least one measurable or evaluable lesion according to the Lugano 2014 lymphoma response criteria.\n* Adequate bone marrow, hepatic, and renal function.\n* Ability to understand and willingness to voluntarily sign a written informed consent form.\n\nExclusion Criteria:\n\n* Central nervous system (CNS) involvement by lymphoma, primary CNS lymphoma, or leukemic phase lymphoma.\n* Prior intolerance to BCL-2 inhibitors and chidamide, or disease refractory to or relapsed after treatment with both agents.\n* Known hypersensitivity to any component of the study drugs or their analogs.\n* Prior allogeneic hematopoietic stem cell transplantation within 6 months before the first dose, active graft-versus-host disease (GvHD), or requirement for immunosuppressive therapy within 28 days prior to study treatment.\n* Clinically significant active cardiovascular disease.\n* Uncontrolled or clinically unstable infection requiring parenteral antibacterial, antiviral, or antifungal therapy within 7 days before the first dose of study treatment.\n* Pregnant or breastfeeding women.\n* Active human immunodeficiency virus (HIV) infection and\u002For acquired immunodeficiency syndrome (AIDS).\n* Malabsorption syndrome or other conditions that may interfere with enteral administration or absorption of study drugs.\n* Any other medical, psychiatric, or social condition that, in the investigator's judgment, would make the subject inappropriate for participation in this study.","ALL","18 Years",{"count":19,"type":20},51,"ESTIMATED","INTERVENTIONAL",[23,24],"PHASE1","PHASE2","This is a phase 1b\u002F2a, open-label trial to evaluate the safety, pharmacokinetics, and preliminary efficacy of lisaftoclax in combination with chidamide and rituximab in patients with relapsed or refractory diffuse large B-cell lymphoma (R\u002FR DLBCL).",[27],"Relapsed or Refractory Diffuse Large B-Cell Lymphoma (R\u002FR DLBCL)","NOT_YET_RECRUITING","2026-05-16",{"date":31,"type":32},"2026-05-22","ACTUAL",{"date":34,"type":20},"2026-05-30",{"date":36,"type":20},"2028-11-30",{"name":38,"class":39},"Sun Yat-sen University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":51,"briefSummary":52,"conditions":53,"keywords":54,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":40},"100630616","phase-2-enhancing-car-t-cell-therapy-efficacy-in-b-cell-lymphoma-via-chidamide-and-pd-1-inhibitor-combination-100630616","NCT07489989","Enhancing CAR-T Cell Therapy Efficacy in B-cell Lymphoma Via Chidamide and PD-1 Inhibitor Combination.","Chidamide-based Combination With PD-1 Blockade: A Synergistic Strategy to Improve CAR-T Cell Therapy Outcomes for B-cell Lymphoma.","Inclusion Criteria\n\n\\-\n\nThe patient must meet all of the following inclusion criteria:\n\n1. Histologically or cytologically confirmed CD19 and\u002For CD22-positive large B-cell lymphoma (LBCL) according to the WHO 2016 classification, including diffuse large B-cell lymphoma (DLBCL), high-grade B-cell lymphoma (HGBL), and related entities, with one of the following:\n\n   1. Partial response (PR) after induction therapy with a standard first-line chemotherapy regimen (e.g., R-CHOP for 4-6 cycles); or\n   2. Complete response (CR) after standard first-line induction therapy, but with high-risk features present at initial diagnosis.\n2. Presence of high-risk features at initial diagnosis, defined as at least one of the following:\n\n   1. High-grade B-cell lymphoma with MYC and BCL2 and\u002For BCL6 rearrangements (\"double-hit\" or \"triple-hit\") confirmed by fluorescence in situ hybridization (FISH);\n   2. High-grade B-cell lymphoma with 11q aberration (Burkitt-like lymphoma with 11q aberration);\n   3. International Prognostic Index (IPI) score of 2-5; age-adjusted IPI (aa-IPI) score of 2-3; or National Comprehensive Cancer Network-IPI (NCCN-IPI) score of 4-8;\n   4. CD5 positivity by immunohistochemistry;\n   5. Dual expression of MYC and BCL2 by immunohistochemistry (recommended thresholds: MYC ≥ 40% and BCL2 ≥ 50%);\n   6. TP53 mutation detected by gene sequencing;\n   7. Molecular subtype MCD or N1 by next-generation sequencing (NGS);\n   8. Relapsed\u002Frefractory B-cell lymphoma, meeting one of criteria ①-④ plus criterion ⑤:\n\n      * Less than 50% tumor reduction or disease progression after ≥4 cycles of standardized chemotherapy;\n\n        * Relapse within 6 months after achieving CR with standard regimen;\n\n          * ≥2 relapses after CR;\n\n            * Relapse after hematopoietic stem cell transplantation;\n\n              * Must have received adequate prior therapy, including at least an anti-CD20 monoclonal antibody and anthracycline-containing combination chemotherapy.\n3. Age 18 to 85 years, male or female.\n4. Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.\n5. Expected survival of \\>3 months from the date of signing informed consent.\n6. Hemoglobin (HGB) ≥60 g\u002FL (transfusion permitted).\n7. Absolute neutrophil count (ANC) ≥1,000\u002FμL and platelet count ≥45,000\u002FμL.\n8. Adequate hepatic, renal, cardiac, and pulmonary function, meeting \\*\\*all\\*\\* of the following:\n\n   1. Total bilirubin (TBIL) ≤1.5 × upper limit of normal (ULN) (except for patients with Gilbert's syndrome);\n   2. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤2.5 × ULN;\n   3. Serum creatinine (Cr) ≤1.5 × ULN \\*\\*or\\*\\* creatinine clearance (CCr) ≥60 mL\u002Fmin (estimated by Cockcroft-Gault formula);\n   4. Left ventricular ejection fraction (LVEF) ≥50% by echocardiogram (ECHO), with no pericardial effusion and no clinically significant arrhythmias;\n   5. Baseline oxygen saturation by pulse oximetry \\>92% on room air;\n   6. No clinically significant pleural effusion.\n\nExclusion Criteria:\n\n* Patients eligible for CAR-T cell immunotherapy must \\*\\*NOT\\*\\* meet any of the following exclusion criteria:\n\n  1. Prior treatment with any form of chimeric antigen receptor (CAR) T-cell therapy or other genetically modified T-cell therapy.\n  2. History of severe immediate-type hypersensitivity reaction to aminoglycoside antibiotics or other drugs.\n  3. Known history of human immunodeficiency virus (HIV) infection, active hepatitis B virus (HBV) infection, or any uncontrolled active systemic infection requiring intravenous antibiotics.\n\n     (Active HBV infection is defined as meeting \\*\\*all\\*\\* of the following: a) HBV DNA ≥ 2000 IU\u002FmL; b) ALT ≥ 2 × upper limit of normal (ULN); c) hepatitis not attributable to other causes such as the underlying disease or medications. Patients with active HBV at initial diagnosis who achieve non-active HBV status after adequate anti-HBV treatment may be eligible under continued effective anti-HBV therapy.)\n  4. Non-hematologic malignancy-related hepatic or renal impairment, including any of the following: ALT \\> 3 × ULN, AST \\> 3 × ULN, total bilirubin (TBIL) \\> 2 × ULN, or creatinine clearance \\\u003C 30 mL\u002Fmin.\n  5. History of myocardial infarction, percutaneous coronary intervention (including coronary angioplasty or stenting), unstable angina, active arrhythmia, or other clinically significant cardiovascular disease within the past 12 months.\n  6. Any other serious medical condition that, in the opinion of the investigator, may interfere with the study treatment or increase risk to the patient (e.g., poorly controlled diabetes, active peptic ulcer disease, severe respiratory or circulatory disease, severe autoimmune disease, congenital immunodeficiency, uncontrolled severe infection, or other conditions with high risk of clinical deterioration).\n  7. History of severe immediate-type hypersensitivity reaction to any medication required during the treatment process, or history of severe allergy to biologics (including antibiotics).\n  8. Female patients who are pregnant or breastfeeding (preconditioning chemotherapy regimen poses potential risk to the fetus or infant).\n  9. In the opinion of the investigator, the patient is unlikely to comply with all required study visits, procedures, or long-term follow-up; has poor willingness or ability to participate and cooperate fully; or has insufficient compliance (as judged by the patient and\u002For family).\n  10. History of other malignancy, unless the patient has been disease-free and has received no antitumor therapy for at least 3 years (exceptions: non-melanoma skin cancer, and carcinoma in situ of the cervix, bladder, or breast).\n  11. Receipt of a live vaccine within 6 weeks prior to initiation of the preconditioning regimen.\n  12. Major surgery (excluding lymph node biopsy) within the past 14 days, or anticipated need for major surgery during the treatment period.\n  13. Any other serious physical or psychiatric illness, or clinically significant laboratory abnormality, that may increase the risk associated with study participation, interfere with the interpretation of study results, or render the patient unsuitable for participation in the opinion of the investigator.","85 Years",{"count":50,"type":20},30,[24],"B-cell non-Hodgkin lymphoma (B-NHL) is one of the most common malignancies in China, with approximately 100,000 new cases diagnosed annually. Although immunochemotherapy, novel small-molecule targeted agents, and hematopoietic stem cell transplantation have significantly improved outcomes for patients with B-cell malignancies, nearly half of patients still experience drug resistance and relapse. In high-risk aggressive B-cell lymphoma, the 5-year survival rate remains around 50%. Previous clinical guidelines recommended autologous hematopoietic stem cell transplantation as first-line consolidation therapy for high-risk patients; however, multiple studies have demonstrated that even after autologous transplantation, nearly half of these patients relapse and succumb to the disease.\n\nChimeric antigen receptor T (CAR-T) cell therapy has achieved objective response rates of approximately 50% in relapsed\u002Frefractory lymphoma, particularly in B-cell subtypes. Nevertheless, limitations such as tumor immune antigen escape, immunosuppressive effects of the tumor microenvironment (TME) on CAR-T cells, and T-cell exhaustion continue to restrict the durability and efficacy of CAR-T-mediated cytotoxicity.\n\nThis study evaluates the incorporation of chidamide (an HDAC inhibitor) combined with a PD-1 inhibitor as maintenance therapy following CAR-T cell immunotherapy in patients with relapsed\u002Frefractory high-risk aggressive B-cell lymphoma. By implementing an \"early intervention\" strategy-prompt administration of CAR-T cell therapy after induction treatment for relapsed\u002Frefractory high-risk aggressive B-cell lymphoma-and subsequent maintenance with chidamide plus a PD-1 inhibitor, the approach aims to reduce relapse rates and improve overall survival. These strategies are intended to address the current unmet clinical need for improved outcomes in relapsed\u002Frefractory high-risk aggressive B-cell lymphoma, where prognosis remains poor despite existing therapies.",[27],[27,55,56,57],"CAR-T therapy","Chidamide","PD-1 inhibitor","RECRUITING","2026-03-18",{"date":61,"type":32},"2026-03-24",{"date":63,"type":32},"2025-05-15",{"date":65,"type":20},"2027-05-15",{"name":67,"class":39},"Daihong Liu"]