[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"relative-energy-deficiency-in-sport\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:relative-energy-deficiency-in-sport":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,44,74,102,132,157],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100638662","effects-of-resistance-training-on-women-with-functional-hypothalamic-amenorrhea-100638662",false,"NCT07612735","Effects of Resistance Training on Women With Functional Hypothalamic Amenorrhea","Impact of Strength Training on Mental Health and Physical Fitness in Women With Functional Hypothalamic Amenorrhea","Inclusion Criteria:\n\n* General Profile: Active women aged 18 to 35 years.\n* FHA Group: Clinical diagnosis of Functional Hypothalamic Amenorrhea, defined as the absence of menstruation for at least three consecutive months not attributable to other endocrine disorders.\n* Control Group (EU): Eumenorrheic women with regular ovulatory cycles lasting between 24 and 35 days during the previous six months.\n* Commitment: Agreement to participate in a supervised 8-week resistance training program and provision of medical documentation confirming menstrual status.\n\nExclusion Criteria:\n\n* Hormonal Status: Current use of any hormonal contraceptives.\n* Medical Conditions: Diagnosed endocrine disorders such as Polycystic Ovary Syndrome (PCOS), hyperandrogenism, or thyroid dysfunction.\n\nPregnancy: Current pregnancy.\n\n* Physical Activity History: Engagement in any structured resistance training program during the three months prior to the start of the intervention.\n* General Health: Any medical condition that could interfere with the study protocol or the ability to perform physical exercise.",true,"FEMALE","18 Years",{"count":20,"type":21},28,"ESTIMATED","INTERVENTIONAL",[24],"NA","Functional hypothalamic amenorrhea (FHA) is a condition where women lose their menstrual periods, typically due to a combination of stress and insufficient calorie intake to fuel their daily physical activity (low energy availability). Standard medical advice often requires these women to completely stop exercising to recover their energy balance and hormones. However, this \"complete rest\" approach can cause severe anxiety for active individuals and removes the necessary mechanical loading that keeps bones strong.\n\nThis study evaluates the safety and effectiveness of an 8-week supervised resistance training (weightlifting) program as a realistic alternative treatment for active women with FHA. The researchers compare a group of women experiencing FHA to a control group of women with regular menstrual cycles. Over the 8 weeks, participants complete three moderate-intensity, full-body weightlifting sessions per week.\n\nThe primary goal is to determine if women with FHA can successfully recover their menstrual cycles while continuing to lift weights. Additionally, the study monitors changes in muscle strength, jumping performance, body composition, resting heart rate, and psychological well-being. Ultimately, this study aims to provide healthcare providers and coaches with evidence-based strategies that allow female athletes to safely maintain their athletic identity and physical health during recovery.",[27,28,29,30],"Amenorrhea","Functional Hypothalamic Amenorrhea (FHA)","Low Energy Availability","Relative Energy Deficiency in Sport","NOT_YET_RECRUITING","2026-05-22",{"date":34,"type":35},"2026-05-29","ACTUAL",{"date":37,"type":21},"2026-05-15",{"date":39,"type":21},"2026-07-25",{"name":41,"class":42},"Catholic University of Murcia","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":16,"sex":52,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":43},"100603401","preventing-athlete-under-fueling-through-nutrition-100603401","NCT07136038","Preventing Athlete Under-fueling Through Nutrition.","Prevention and Education for RED-S Through Fueling Outcomes and Research in Metabolic Health","PERFORM","Inclusion Criteria:\n\n1. Age range: from 18 years of age and up\n2. Currently active and NCAA-eligible (including academic standing) member of any Case Western Reserve University (CWRU) Athletic Team\n3. Signed Informed Consent\n\nExclusion Criteria:\n\n1. Under 18 years of age\n2. Pregnant women or women who are nursing\n3. Unwilling to provide anthropometrics, questionnaires or other collection needs\n4. History of a diagnosed disordered eating","ALL",{"count":54,"type":21},300,[24],"The goal is to improve nutrition screening and support for Division III athletes.\n\nThe study will use standard, low-risk nutrition screening methods, such as measuring height, weight, grip strength, and body composition, as well as having athletes complete questionnaires. Dietitians trained in sports nutrition will provide nutrition advice based on these screenings.\n\nData will be collected at three points during the season: before the season starts, mid-season, and after the season ends. This study builds on earlier research conducted at Case Western Reserve University that showed nutrition support can improve athletes' health and performance.",[58,30,29],"Athlete",[60,61,62,63],"collegiate","sport","lean body mass","fat mass","RECRUITING","2026-03-02",{"date":67,"type":35},"2026-03-04",{"date":69,"type":35},"2025-08-19",{"date":71,"type":21},"2026-12-31",{"name":73,"class":42},"Case Western Reserve University",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":16,"sex":52,"minAge":18,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":85,"conditions":86,"keywords":87,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":43},"100610826","energy-availability-and-its-impact-in-elite-triathletes-100610826","NCT07232628","Energy Availability and Its Impact in Elite Triathletes","Energy Availability in Elite Triathletes: Impact on Performance and Injury Risk","TriatLEA","Inclusion Criteria:\n\n* Age ≥18 years\n* Healthy individuals\n* Training ≥15 hours\u002Fweek in triathlon\n\nExclusion Criteria:\n\n* Smokers\n* Use of prohibited substances (WADA list) without medical justification\n* Existing injuries or illnesses that could worsen due to participation",{"count":83,"type":21},40,"OBSERVATIONAL","This study investigates how energy availability affects performance, injury risk, and training outcomes in elite triathletes. Over two competitive seasons (2026-2027), 40 elite and sub-elite triathletes will be monitored through physiological tests, blood samples, and questionnaires. The goal is to identify markers of low energy availability and understand its impact on health and athletic performance. The study is observational and does not involve experimental treatments. Participants continue their regular training and diet while undergoing periodic assessments.",[29,30],[88,89,90,91,92],"RED-S","injury risk","performance","triathlon","biomarker","2025-11-14",{"date":95,"type":35},"2025-11-18",{"date":97,"type":35},"2025-10-01",{"date":99,"type":21},"2028-06",{"name":101,"class":42},"Bispebjerg Hospital",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":16,"sex":52,"minAge":18,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":22,"phases":113,"briefSummary":114,"conditions":115,"keywords":118,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":43},"100602382","impact-of-diet-induced-change-in-energy-balance-on-metabolism-in-endurance-athletes-100602382","NCT07122778","Impact of Diet-induced Change in Energy Balance on Metabolism in Endurance Athletes","Impact of Diet-induced Change in Energy Balance on Metabolism in Endurance Athletes: the Carpe DIEM Study","Carpe DIEM","Inclusion Criteria:\n\n* Self-identified endurance-trained sport participants\n* Training volume: \\>7 hours per week endurance training\n* Training frequency: at least 5 days per week\n\nExclusion Criteria:\n\n* Diagnosis of Relative Energy Deficiency in Sport (REDs)\n* Active eating disorder (EDE-Q)\n* Active flare of a chronic disease (e.g. inflammatory bowel disease)\n* Type 1 or 2 diabetes mellitus\n* Untreated or undergoing active treatment of anaemia (any cause)\n* Current injury which precludes undertaking high volume endurance training\n* Individuals following a habitual low-carbohydrate, high-fat diet\n* Any medical diagnosis which precludes intense exercise (e.g. untreated cardiac arrhythmia)\n* Allergy or intolerance to study foods\n* Blood donation within preceding 8 weeks of study start date\n* Use of medications that affect substrate utilisation (e.g. statins, corticosteroids, thyroxine, HRT)\n* For females: current pregnancy, breastfeeding within past 6 months or post-menopausal\n* Unable to undertake a treadmill running test\n* Participation in any research study in the past 8 weeks\n* Participation in a research study within the past year involving more than one DEXA scan\n* Unable to provide informed consent due to impaired cognitive capacity or decision-making ability","49 Years",{"count":112,"type":21},20,[24],"Recent research has suggested that increasing levels of physical activity are associated with a reduction in the independent components that contribute to total energy expenditure (such as resting metabolic rate and non-exercise movement) - this occurs to conserve energy required for physical activity where energy provision becomes scarce. There are potential deleterious health and performance consequences of a reduced energy supply to fundamental metabolic processes, putting individuals regularly undertaking high levels of physical activity, such as endurance athletes, at risk. However, this association is largely based on observational data in only moderately active populations, and it is currently unclear what role energy balance status and biological sex has on this relationship.\n\nThis research intends to address these unknowns by assessing the impact of diet-induced manipulation of energy balance (conditions of energy deficit and energy surplus) in individuals undertaking habitually high levels of physical activity on independent components of total energy expenditure (resting metabolism, exercise and non-exercise movement).\n\nMale and female athletes conducting regular moderate-to-high training volumes will undertake a randomised crossover study with a 7-day state of energy deficit and a 7-day state of energy surplus. Participants will continue to live and train as normal, but their diet will be controlled by specific food provision over the intervention periods in order to facilitate both conditions. Independent components of energy expenditure, markers of health, metabolism and performance will be measured to allow for comparison of conditions.",[116,117,29,30],"Energy Balance","Energy Deficit",[119,120,121,122],"energy deficit","energy balance","energy availability","physical activity","2025-08-11",{"date":125,"type":35},"2025-08-14",{"date":127,"type":21},"2025-08",{"date":129,"type":21},"2027-05",{"name":131,"class":42},"University of Bath",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":16,"sex":52,"minAge":18,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":22,"phases":140,"briefSummary":141,"conditions":142,"keywords":143,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":43},"100594955","unravelling-energy-issues-underpinning-low-energy-availability-in-high-performance-athletes-100594955","NCT07026175","Unravelling Energy Issues Underpinning Low Energy Availability in High Performance Athletes","Inclusion Criteria:\n\n* 18-45 years old\n* Well trained weight-bearing athlete (tier 2-4 1)\n* Perform \\~45km per week of weight-bearing endurance training, and able to undertake the prescribed exercise in each trial condition\n* Pass the ESSA pre-exercise screening tool and\u002For obtain GP clearance to exercise\n\nExclusion Criteria:\n\n* Assessment of red status on the REDs Clinical Assessment Tool\n* Unable to attend ACU in Fitzroy, Victoria, for the 6 study visits for completion of the study protocol\n* Pregnancy\n* Use of hormonal contraceptive with the previous 3 months\n* Onset of peri\u002Fmenopause","45 Years",{"count":112,"type":21},[24],"The goal of this clinical trial is to understand how the body responds to short-term, severe low energy availability (LEA) in healthy, weight-bearing endurance athletes aged 18-45 years old. LEA describes a mismatch between an individual's dietary energy intake and the energy cost of their commitments for training and competition. The main questions this trial aims to answer are:\n\n1. What effect does short-term, severe LEA have on sleeping metabolic rate?\n2. What effect does short-term, severe LEA have on other body systems identified within the Relative Energy Deficiency in Sport (REDs) Health and Performance Conceptual models?\n\nResearchers will compare a control trial with both a LEA trial achieved through diet restriction and a LEA trial achieved through increased exercise to see if there are differences in the body's response.\n\nParticipants will complete three 6-day trials, a minimum of 3-weeks apart, involving:\n\n* Prescribed diet (all food provided)\n* Prescribed running and\u002For cycling exercise\n* Two visits to ACU Fitzroy campus for blood tests and exercise testing\n* 50 hour stay (two nights and two days) in the ACU metabolic chamber",[30],[144,145,58,146,147],"Relative Energy Deficiency in Sport (REDs)","Endurance","Sleeping Metabolic Rate","Problematic Low Energy Availability","2025-06-10",{"date":150,"type":35},"2025-06-18",{"date":152,"type":21},"2025-06",{"date":154,"type":21},"2027-06",{"name":156,"class":42},"Australian Catholic University",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":16,"sex":52,"minAge":164,"maxAge":138,"enrollmentInfo":165,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":167,"conditions":168,"keywords":170,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":43},"100553022","relative-energy-deficiency-in-sport-and-dance-100553022","NCT06480682","Relative Energy Deficiency in Sport and Dance","Prevalence of Relative Energy Deficiency in Sport and Dance","Inclusion Criteria:\n\n* Full-time training at either a NGB centre, dance company, vocational dance school or academy\n* Engaged in full-time training at start of project\n\nExclusion Criteria\n\n* Not engaged in full-time training\n* Injury preventing engagement in training","16 Years",{"count":166,"type":21},200,"The International Olympic Committee recently published its consensus statement on relative energy deficiency syndrome (REDs) in sport which was followed by a similar version for dance by clinicians and researchers in dance. REDs is a complex multisystem syndrome with low energy availability as its foundation. Dancers and gymnasts, particularly in ballet, have long been reported to have body weight issues with an increase prevalence of eating disorders which has been associated with early onset osteoporosis. Combat sports have a similar issue, with athletes needing to \"make weight\" to compete in their ideal weight category that has lead to similar eating disorder and associated issues to dance. Currently there are no data on REDs prevalence in dance, gymnastics or combat sports and therefore understanding the underlying prevalence of REDs in both these populations will provide important information for both clinicians and coaches to help develop a safe and healthy environment for their dancers and athletes to compete\u002Fperform and to be able to retire from sport\u002Fdance without an increased risk of osteoporosis. In a few sports and dance genres, some participants might be more prone to a negative health effect referred to as relative energy deficiency syndrome (REDs). This is an energy deficiency relative to the balance between dietary energy intake and energy availability required to support homeostasis, health and activities of daily living, growth and sporting activities that can result in multiple systems being affected including decreases in bone health, energy metabolism, reproductive function, musculoskeletal health, immunity, glycogen synthesis and cardiovascular and haematological health. The purpose of this study is to examine the prevalence of REDs in specific sports (combat sports and gymnastics) and dance genres (ballet and musical theatre). Voluntary participants will be tested three times a year over a 5-year period. This will include an annual dual-energy x-ray absorptiometry and blood tests plus resting energy expenditure and questionnaires three times a year.",[30,169],"Bone Stress Reaction",[171,172,173,174,175,176,177],"Judo","Ballet","Gymnastics","Male","Female","Dance","weight category sport","2024-06-24",{"date":180,"type":35},"2024-06-28",{"date":182,"type":21},"2024-09-10",{"date":184,"type":21},"2029-07-30",{"name":186,"class":42},"University of Wolverhampton"]