[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"relaxation-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:relaxation-therapy":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,56,100],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100633150","ai-guided-relaxation-for-hemodialysis-anxiety-100633150",false,"NCT07522944","AI-Guided Relaxation for Hemodialysis Anxiety","Artificial Intelligence-Guided Relaxation Interventions for Reducing Anxiety and Enhancing Coping Strategies in Patients Undergoing Hemodialysis","Inclusion Criteria:\n\nAdult patients aged 18 years or older Confirmed diagnosis of end-stage renal disease (ESRD) receiving maintenance hemodialysis for at least 3 months to ensure treatment stability Conscious, oriented, and able to communicate effectively Documented baseline anxiety at a mild-to-moderate level confirmed on initial screening using the GAD-7 or HADS prior to enrollment Adequate visual and auditory functions sufficient to interact with the AI-guided relaxation platform Willing to participate and provide written informed consent prior to enrollment\n\nExclusion Criteria:\n\nHistory of epilepsy, chronic vertigo, or seizure disorders, as AI or VR visual stimuli may trigger adverse episodes Severe cognitive impairment or diagnosed psychiatric disorders such as dementia or schizophrenia that prevent comprehension of or adherence to study instructions Acute medical complications or hemodynamic instability occurring during the dialysis session Severe visual impairment or blindness precluding use of the digital relaxation interface Skin infections or injuries on the face or head preventing comfortable use of a headset where applicable Currently enrolled in any other psychological or relaxation intervention study","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to evaluate whether a relaxation program guided by Artificial Intelligence (AI) can help reduce anxiety and improve coping mechanisms for patients receiving maintenance hemodialysis. Patients undergoing dialysis often face significant psychological stress and physical discomfort. This research uses a randomized controlled trial (RCT) with a parallel-group, pretest-posttest controlled design to compare patient well-being before and after using the AI-guided intervention.\n\nParticipants will engage with an AI system designed to provide personalized relaxation techniques during their dialysis sessions. The study uses a mixed-methods approach. Quantitative: Researchers will use standardized scales to measure changes in anxiety levels, depression, coping strategies, and perceived relaxation. Qualitative: Researchers will conduct interviews with participants to understand their personal experiences, how they engaged with the AI technology, and how it influenced their ability to manage the stress of their treatment.",[26,27,28,29,30],"Renal Insufficiency, Chronic","Anxiety","Relaxation Therapy","Maintenance Hemodialysis","Stress, Psychological",[32,33,34,35,27,36,37,28,38,39,40,41,42],"Hemodialysis, Hospital","Renal Dialysis","End-Stage Renal Disease (ESRD)","Psychological Distress","Artificial Intelligence","Digital Health","Mindfulness-Based Interventions","Coping Skills","AI-Guided Intervention","Virtual Reality (VR)","Immersive Technology","RECRUITING","2026-05-07",{"date":46,"type":47},"2026-05-12","ACTUAL",{"date":49,"type":47},"2026-03-29",{"date":51,"type":20},"2026-05-30",{"name":53,"class":54},"Alexandria University","OTHER",2,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":4,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":16,"minAge":64,"maxAge":4,"enrollmentInfo":65,"targetDuration":4,"studyType":21,"phases":67,"briefSummary":68,"conditions":69,"keywords":83,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":4},"100628685","feasibility-of-breathwork-intervention-with-older-adults-after-knee-surgery-100628685","NCT07464860","Feasibility of Breathwork Intervention With Older Adults After Knee Surgery","A Box Breathing Intervention and the Surgical Stress Response in Older Adults Undergoing Total Knee Arthroplasty: A Randomized Controlled Feasibility Trial","Adults aged 65 years or older of any sex, gender and ethnic background who meet the following criteria will be eligible to enroll in the present study:\n\nInclusion Criteria:\n\n* scheduled for elective TKA within the next week to two months (can be second knee, but cannot be a revision of the original knee)\n* self-reported good health, including denial of debilitating illness that may affect participation in or be potentially exacerbated by deep, controlled breathing (i.e., chronic obstructive pulmonary disorder \\[COPD\\], symptomatic or advanced heart failure, complete heart block, glaucoma, epilepsy)\n* denial of conditions that alter cortisol release or that require corticosteroid therapy (i.e., Cushing's syndrome, Addison's disease, pituitary tumors, adrenal gland tumors, asthma)\n* denial of severe psychiatric or cognitive conditions that warrant the need for a durable power of attorney (DPOA)\n* able to understand written and verbal English.\n\nExclusion Criteria:\n\n* currently taking oral, injectable, intranasal, topical, or inhaled corticosteroid medications (i.e., prednisone, hydrocortisone, dexamethasone, methylprednisolone, methylprednisolone acetate, triamcinolone, betamethasone, mometasone, fluticasone, budesonide, clobetasol)\n* do not have the technology requirements to complete data collection (i.e., participant does not have a smartphone, tablet, laptop, or desktop computer; lack of reliable internet)\n\nThe following exclusion criteria may affect participants' ability to remain in the study following enrollment:\n\n• Development of complications during surgery that require prolonged hospitalization into Postoperative Day (POD) 2 (e.g., postoperative intubation and ventilation requirements, intractable pain, intractable nausea\u002Fvomiting, signs of infection or sepsis)",true,"65 Years",{"count":66,"type":20},32,[23],"Postoperative complications after surgical procedures, including following total knee arthroplasty (TKA), have a negative impact on the health and well-being of surgical patients. Older adults (≥65 years) are particularly vulnerable to postoperative complications and their associated morbidities due to the biological aging process. Older adults comprise nearly half of surgical patients worldwide, and this number is expected to increase in the next 10-20 years as the aging population continues to grow. TKA is the most common procedure undergone by older adults, and the rate of TKA procedures is also expected to rise. Despite perioperative guidelines and protocols to prevent postoperative complications, the prevalence of postoperative complications following TKA is approximately 12%. Given these statistics, millions of older adults undergoing TKA may be at risk for postoperative complications and their associated morbidities in the coming decades. Therefore, additional interventions are needed to combat postoperative complications in this population.\n\nThe body's natural response to surgery, also known as the surgical stress response (SSR), contributes to postoperative complications through complex mechanisms involving the autonomic nervous system (ANS). Increased sympathetic nervous system (SNS) activity, or the body's fight-or-flight response, causes dysregulation in feedback systems that regulate the stress response, potentially leading to poorer outcomes. Interventions, such as breathwork, that induce the parasympathetic nervous system (PNS), or the body's rest-and-digest response, have been shown to balance the ANS, regulate stress biology, and improve outcomes. This study will examine the feasibility of adding a breathwork intervention (Box Breathing), compared to an attention control, to standard perioperative care for older adults undergoing TKA. This study will also examine the proof of concept that Box Breathing, compared to an attention control, may help regulate the SSR by assessing an objective measure of stress-related biology, diurnal cortisol rhythm, and gathering self-report information on pain, anxiety, depression, and quality of recovery following TKA.",[70,71,72,73,74,75,76,77,28,78,79,80,81,82],"Surgical Stress Response","Stress Physiological","Stress Physiology","Stress Psychological","Breathing Techniques","Breathing Exercises","Hypothalamic Pituitary Adrenal","Relaxation","Cortisol","Postoperative Pain","Postoperative Anxiety","Postoperative Depression","Quality of Recovery (QoR-15)",[70,84,85,86,75,74,87,79,80,81,88,89],"Total Knee Arthroplasty","Hypothalamic-Pituitary-Adrenal Axis","Breathwork","Postoperative Complications","Quality of Recovery","Diurnal Cortisol Rhythm","NOT_YET_RECRUITING","2026-03-06",{"date":93,"type":47},"2026-03-11",{"date":95,"type":20},"2026-04-06",{"date":97,"type":20},"2026-09-30",{"name":99,"class":54},"University of Arizona",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":64,"enrollmentInfo":106,"targetDuration":4,"studyType":21,"phases":108,"briefSummary":109,"conditions":110,"keywords":113,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":4},"100588423","the-effect-of-virtual-reality-based-video-and-benson-relaxation-exercise-applied-to-palliative-care-providers-on-sleep-quality-fitness-and-general-well-being-100588423","NCT06941207","The Effect of Virtual Reality-Based Video and Benson Relaxation Exercise Applied to Palliative Care Providers on Sleep Quality, Fitness and General Well-Being","Inclusion Criteria:\n\n1. Being literate,\n2. Being over the age of 18,\n3. Having sufficient communication skills to answer oral and written questions and follow instructions,\n4. Being a palliative care provider for at least 6 months\n5. Does not have visual\u002Fverbal\u002Fauditory communication difficulties that would prevent understanding the information presented and expressing the answers correctly,\n6. Being a caregiver who can communicate in Turkish\n7. Not having severe vision problems\n\nExclusion Criteria:\n\n1. Sleep Quality Index score of 4 or less\n2. Being over 65 years old\n3. Palliative care providers who leave the study voluntarily\n4. Presence of chronic disease",{"count":107,"type":20},90,[23],"The research will be conducted to evaluate the effects of Virtual Reality-Based Video and Benson Relaxation Exercise Applied to Palliative Care Providers on Sleep Quality, Fitness and General Well-Being. In the Palliative Care Center; The palliative patient group will be comprised of individuals aged 18 and over who provide care. The population of the research consists of 210 people. Individuals will be distributed to the virtual reality video experimental group (30), Benson relaxation exercise experimental group (30) and control (30) groups by simple randomization method. Personal Information Form, Sleep Quality Index, Subjective Wellness Scale and General Well-Being Scale will be used to collect research data. Personal information form, Sleep Quality Index, Subjective Well-Being Scale and General Well-Being Scale will be administered to the caregivers in both the experimental group and the control group by the researcher using face-to-face interview technique (pre-test).\n\nThe caregivers, the first group in the experimental group, will be shown a total of 8 sessions of virtual reality-based videos (nature, forest walks and city tours, etc.) for an average of 30 minutes, twice a week for 4 weeks.\n\nThe caregivers, who are the second group in the experimental group, will have a total of 8 sessions of Benson relaxation exercises for 20-25 minutes, twice a week for 4 weeks.\n\nNo intervention will be made to the caregivers in the control group. At the end of the sessions, Sleep Quality Index, Subjective Well-Being Scale and General Well-Being Scale (post-test) will be applied to the experimental and control groups.\n\nThe basic question it aims to answer is:\n\nDo virtual reality-based video and BENSON relaxation exercises applied to palliative care givers affect sleep quality, vitality and general well-being?",[111,28,112],"Palliative Care","Caregiver",[114,115,116,117],"palliative care","benson relaxation exercise","virtual reality","sleep quality","2025-04-19",{"date":120,"type":47},"2025-04-23",{"date":122,"type":20},"2025-05",{"date":124,"type":20},"2026-01",{"name":126,"class":54},"Ataturk University"]