[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"relaxation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:relaxation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,44,68,94,120,150,191,212,237,264,290],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100584757","virtual-reality-based-and-face-to-face-relaxation-programs-in-pregnant-women-with-preeclampsia-100584757",false,"NCT06893510","Virtual Reality-Based and Face-to-Face Relaxation Programs in Pregnant Women With Preeclampsia","The Effect of Virtual Reality-Based and Face-to-Face Relaxation Programs on Maternal and Fetal Outcomes in Pregnant Women With Preeclampsia","Inclusion Criteria:\n\n* Hospitalized with a diagnosis of preeclampsia.\n* Gestational age ≥26 weeks.\n* 18 years or older.\n* Singleton and viable pregnancy.\n* Willing to participate in the study voluntarily.\n\nExclusion Criteria:\n\n* Multiple pregnancy.\n* Pregnancy achieved through assisted reproductive technologies.\n* Hearing or vision impairment in the pregnant individual.\n* Fetal distress requiring emergency intervention.\n* HELLP Syndrome or Eclampsia.\n* History of vertigo.\n\nWithdrawal Criteria:\n\n* Cases where live birth does not occur.\n* Participants who voluntarily withdraw from the study.\n* Participants whose general health condition deteriorates during the intervention.\n* Participants experiencing side effects from virtual reality headset use (e.g., dizziness, nausea, headache).\n* Participants who do not practice progressive muscle relaxation at least once a week after the intervention.","FEMALE","18 Years",{"count":19,"type":20},96,"ESTIMATED","INTERVENTIONAL",[23],"NA","Preeclampsia, affecting 2-8% of pregnancies globally, is a leading hypertensive disorder in pregnancy. It is clinically characterized by elevated blood pressure (≥140\u002F90 mmHg) after the 20th gestational week, often accompanied by proteinuria and systemic complications such as thrombocytopenia, liver dysfunction, and cerebral symptoms. This condition poses significant risks for both maternal and fetal health, increasing the likelihood of organ damage, preterm birth, and long-term cardiovascular and neurodevelopmental complications. Non-pharmacological interventions, including relaxation techniques, have been explored for symptom management. Progressive muscle relaxation (PMR) has shown efficacy in reducing stress, anxiety, and blood pressure. Recently, virtual reality (VR)-based relaxation techniques have gained attention for enhancing stress relief and improving health outcomes. This study aims to compare the effects of VR-based PMR with in-person PMR on maternal and fetal outcomes in preeclamptic pregnancies.",[26,27,28,29,30],"Pre-Eclampsia","Maternal Health","Relaxation","Virtual Reality","Fetal Monitoring","RECRUITING","2026-06-07",{"date":34,"type":35},"2026-06-10","ACTUAL",{"date":37,"type":35},"2025-09-08",{"date":39,"type":20},"2026-09-01",{"name":41,"class":42},"Istanbul University - Cerrahpasa","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":51,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":43},"100638584","consciousness-studies-and-cardiovascular-health-100638584","NCT07620639","Consciousness Studies and Cardiovascular Health","Inclusion Criteria:\n\n* Age 18 and older\n* Able to provide informed consent (English only for pilot)\n* Chronic Selective Serotonin Reuptake Inhibitors\u002F Serotonin-norepinephrine reuptake inhibitors (SSRI\u002FSNRI) or Attention Deficit\u002F Hyperactivity Disorder (ADHD) meds allowed (recorded)\n* Normal vision and hearing\n* Stable vitals (HR 55-100 bpm, Systolic Blood Pressure (SBP) 90-160mmHg (millimeters of mercury, afebrile)\n* Willing to abstain 6 hours pre-session from caffeine, nicotine, heavy exercise\n* Willing to tolerate electroencephalogram (EEG) headband, Galvanic Skin Response (GSR) electrodes are small sensors placed on the skin (usually fingers or palm) and virtual reality (VR) headset\n\nExclusion Criteria:\n\n* History of seizure disorder or photosensitive epilepsy\n* Migraine with visual aura\n* Retinal disease sensitive to flicker\n* Unstable cardiac disease\n* Dysautonomia\n* Recent sedative use (benzodiazepines, opioids)\n* Beta blocker dose changes within last 7 days\n* Alcohol or recreational drugs within 12 hours\n* Active panic disorder\n* Severe motion sickness\n* Scalp conditions preventing EEG contact\n* Severe visual or hearing impairment Cognitive impairment\n* Non-English speakers (pilot in English only)",true,"ALL",{"count":53,"type":20},40,[23],"The objective of the study is to evaluate whether a virtual reality (VR) based intervention combining binaural beats, photic stimulation, and real-time biofeedback reduces stress and improves physiological markers compared to non-VR interventions and usual care in patients that go to cardiology clinic.",[57,28,29],"Blood Pressure","NOT_YET_RECRUITING","2026-05-26",{"date":61,"type":35},"2026-06-02",{"date":63,"type":20},"2026-10",{"date":65,"type":20},"2028-10",{"name":67,"class":42},"University of Miami",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":51,"minAge":17,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":21,"phases":77,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":43},"100635812","comparison-of-two-relaxation-strategies-between-glasses-virtual-reality-headset-and-without-relaxation-tool-in-the-anxiety-preoperative-of-orthopedic-adult-patients-100635812","NCT07557550","Comparison of Two Relaxation Strategies Between Glasses, Virtual Reality Headset, and Without Relaxation Tool, in the Anxiety Preoperative of Orthopedic Adult Patients","RELAXPREOP","Inclusion Criteria:\n\n* Patient treated at the UAC D0\n* Orthopedic patient (arthroplasty mainly)\n* Anesthesic procedure with general anesthesia\n* Patient \\>18 years old without cognitive impairment in the investigator's judgment\n* Patient who has signed a free and informed consent\n* Patient affiliated to a social security scheme\n\nExclusion Criteria:\n\n* Patient with deafness that does not allow him to perceive and understand sounds\n* Patient with a visual impairment who does not allow him to watch and understand a video\n* Patient who does not master the French language (spoken, written and read)\n* Patient with a history of epilepsy\n* Patient with a history of migraine\u002Fheadache when using a virtual reality headset\n* Patients with a history of dizziness triggered by images (film, video game...)\n* Patient with untreated dry eye disease\n* Patient with psychiatric diseases and disorders not compatible with the study in the investigator's judgment\n* Patient who is pregnant, parturient, or breastfeeding.\n* Patient under guardianship or curatorship, under judicial protection or deprived of public law",{"count":76,"type":20},632,[23],"In adults, the prevalence of preoperative anxiety related to surgery or anesthesia ranges from 60 to 80%, and context plays an important role. Patients with significant preoperative anxiety experience reduced sleep quality. In addition, high preoperative anxiety is linked to more severe postoperative pain and an increased need for painkillers. In addition, it is a source of dysfunction in care. Currently, there are no recommendations regarding the prevention of preoperative anxiety. New approaches have emerged that show some benefit: music, binaural auditory stimulation and hypnosis. In the UAC J0 unit of the Amiens-Picardie University Hospital, the caregivers offer the PSiO glasses, a tool combining three techniques: light therapy, relaxation and chromotherapy. This system has obtained CE and FCC markings and seems to be more or less effective on patients admitted to the CH . A pilot study evaluating the effects of virtual reality hypnosis on patients' preoperative anxiety has shown that this technology represents a non-invasive way to reduce preoperative stress levels without side effects and without the need for additional medical or paramedical staff. This study aims to improve the patient's well-being before their operation. Depending on the randomization, he will benefit from a relaxation session with the Psio glasses or a virtual reality hypnosis session with the Hypno VR headset. Follow-up of patients will be carried out on the basis of variation in an anxiety scale, physiological criteria, the amount of anesthetic products used, the time spent in the recovery room, and the evaluation of pain.",[28,29,80],"Anxiety Preoperative",[82,83,84],"relaxation","virtual reality","anxiety preoperative","2026-04-23",{"date":87,"type":35},"2026-04-29",{"date":89,"type":35},"2026-04-01",{"date":91,"type":20},"2027-04",{"name":93,"class":42},"Centre Hospitalier Universitaire, Amiens",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":51,"minAge":17,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":21,"phases":104,"briefSummary":105,"conditions":106,"keywords":110,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":43},"100587993","healing-hearts-of-hospitalized-patients-100587993","NCT06935604","Healing Hearts of Hospitalized Patients","Healing Hearts of Hospitalized Patients With Virtual Reality: A Pragmatic, Crossover Trial","Inclusion Criteria:\n\n* Adults aged 18 years and above\n* Able to provide informed consent\n* Able to follow verbal instructions\n* Adequate motor skills for upper extremities to operate VR equipment\n* Clinically stable\n* English speaking\n* Willing to participate in mindfulness activities\n\nExclusion Criteria:\n\n* Severe cognitive impairment\n* Clinically unstable\n* Facial trauma prohibiting headset use\n* Physical limitations in facial, neck, upper extremities that hinder use of VR equipment\n* History of seizures or other neurological conditions\n* Severe motion sickness\n* Active nausea\n* Severe visual impairment\n* Severe cognitive impairment","99 Years",{"count":103,"type":20},42,[23],"The study aims to evaluate the impact of a bedside-delivered virtual reality (VR) mindfulness experience on well-being and psychosocial outcomes among hospitalized adult patients compared to standard of care (SOC; no added mindfulness intervention).",[107,108,109,28],"Well-Being, Psychological","Anxiety","Affect",[29],"2026-04-21",{"date":113,"type":35},"2026-04-24",{"date":115,"type":20},"2026-06-01",{"date":117,"type":20},"2027-05-31",{"name":119,"class":42},"Stanford University",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":50,"sex":51,"minAge":17,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":21,"phases":130,"briefSummary":131,"conditions":132,"keywords":135,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":43},"100622706","decreasing-stress-via-virtual-reality-and-binaural-beats-in-non-clinical-adults-100622706","NCT07387107","Decreasing Stress Via Virtual Reality and Binaural Beats in Non-Clinical Adults","Decreasing Stress Via Virtual Reality and Binaural Beats in Non-Clinical Adults: A Randomized Controlled Study.","DESTUD","Inclusion Criteria:\n\n1\\. Adults aged 18 years or older 2. Ability to understand study procedures and provide written informed consent 3. Sufficient proficiency in the German language to complete questionnaires and follow study instructions 4. Willingness to participate in a single approximately 60-minute study session\n\nExclusion Criteria:\n\n1\\. Current or history of neurological or psychiatric disorders that may interfere with data collection (e.g., dementia, major depressive disorder, stroke, epilepsy) 2. Severe visual or hearing impairments that would limit the use of virtual reality equipment or headphones 3. History of adverse reactions to virtual reality",{"count":129,"type":20},52,[23],"This study is a non-clinical substudy conducted within the DESTRESS research program (NCT05036538), which investigates the effects of relaxation interventions on physiological and psychological parameters. While the main DESTRESS trial focuses on cardiac surgical patients, this additional study arm examines the same interventions in a non-clinical adult population under controlled conditions, independent of disease-, surgery-, or medication-related influences.\n\nParticipants are randomly assigned to one of several experimental conditions and take part in a single approximately 30-minute session. Depending on group allocation, the session may include exposure to natural soundscapes, natural soundscapes combined with binaural beats, virtual reality-based natural environments, virtual reality combined with binaural beats, or a control condition without a relaxation intervention.\n\nThe primary aim of the DESTUD-Study is to assess the feasibility and potential stress-reducing effects of these non-pharmacological relaxation approaches in a non-clinical setting and to support the interpretation of findings from the clinical DESTRESS trial. Physiological responses, including heart rate variability and electrodermal activity, as well as self-reported stress measures, are collected before, during and after the conditions.",[133,28,29,134],"Stress","Binaural Beats",[29,134,136,137,138,139,140],"Heart Rate Variability","Stress Reduction","Relaxation Intervention","Non-Clinical Population","Electrodermal Activity","2026-03-11",{"date":143,"type":35},"2026-03-13",{"date":145,"type":35},"2026-03-05",{"date":147,"type":20},"2026-07-15",{"name":149,"class":42},"Heart and Brain Research Group, Germany",{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":50,"sex":51,"minAge":157,"maxAge":4,"enrollmentInfo":158,"targetDuration":4,"studyType":21,"phases":160,"briefSummary":161,"conditions":162,"keywords":176,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":4},"100628685","feasibility-of-breathwork-intervention-with-older-adults-after-knee-surgery-100628685","NCT07464860","Feasibility of Breathwork Intervention With Older Adults After Knee Surgery","A Box Breathing Intervention and the Surgical Stress Response in Older Adults Undergoing Total Knee Arthroplasty: A Randomized Controlled Feasibility Trial","Adults aged 65 years or older of any sex, gender and ethnic background who meet the following criteria will be eligible to enroll in the present study:\n\nInclusion Criteria:\n\n* scheduled for elective TKA within the next week to two months (can be second knee, but cannot be a revision of the original knee)\n* self-reported good health, including denial of debilitating illness that may affect participation in or be potentially exacerbated by deep, controlled breathing (i.e., chronic obstructive pulmonary disorder \\[COPD\\], symptomatic or advanced heart failure, complete heart block, glaucoma, epilepsy)\n* denial of conditions that alter cortisol release or that require corticosteroid therapy (i.e., Cushing's syndrome, Addison's disease, pituitary tumors, adrenal gland tumors, asthma)\n* denial of severe psychiatric or cognitive conditions that warrant the need for a durable power of attorney (DPOA)\n* able to understand written and verbal English.\n\nExclusion Criteria:\n\n* currently taking oral, injectable, intranasal, topical, or inhaled corticosteroid medications (i.e., prednisone, hydrocortisone, dexamethasone, methylprednisolone, methylprednisolone acetate, triamcinolone, betamethasone, mometasone, fluticasone, budesonide, clobetasol)\n* do not have the technology requirements to complete data collection (i.e., participant does not have a smartphone, tablet, laptop, or desktop computer; lack of reliable internet)\n\nThe following exclusion criteria may affect participants' ability to remain in the study following enrollment:\n\n• Development of complications during surgery that require prolonged hospitalization into Postoperative Day (POD) 2 (e.g., postoperative intubation and ventilation requirements, intractable pain, intractable nausea\u002Fvomiting, signs of infection or sepsis)","65 Years",{"count":159,"type":20},32,[23],"Postoperative complications after surgical procedures, including following total knee arthroplasty (TKA), have a negative impact on the health and well-being of surgical patients. Older adults (≥65 years) are particularly vulnerable to postoperative complications and their associated morbidities due to the biological aging process. Older adults comprise nearly half of surgical patients worldwide, and this number is expected to increase in the next 10-20 years as the aging population continues to grow. TKA is the most common procedure undergone by older adults, and the rate of TKA procedures is also expected to rise. Despite perioperative guidelines and protocols to prevent postoperative complications, the prevalence of postoperative complications following TKA is approximately 12%. Given these statistics, millions of older adults undergoing TKA may be at risk for postoperative complications and their associated morbidities in the coming decades. Therefore, additional interventions are needed to combat postoperative complications in this population.\n\nThe body's natural response to surgery, also known as the surgical stress response (SSR), contributes to postoperative complications through complex mechanisms involving the autonomic nervous system (ANS). Increased sympathetic nervous system (SNS) activity, or the body's fight-or-flight response, causes dysregulation in feedback systems that regulate the stress response, potentially leading to poorer outcomes. Interventions, such as breathwork, that induce the parasympathetic nervous system (PNS), or the body's rest-and-digest response, have been shown to balance the ANS, regulate stress biology, and improve outcomes. This study will examine the feasibility of adding a breathwork intervention (Box Breathing), compared to an attention control, to standard perioperative care for older adults undergoing TKA. This study will also examine the proof of concept that Box Breathing, compared to an attention control, may help regulate the SSR by assessing an objective measure of stress-related biology, diurnal cortisol rhythm, and gathering self-report information on pain, anxiety, depression, and quality of recovery following TKA.",[163,164,165,166,167,168,169,28,170,171,172,173,174,175],"Surgical Stress Response","Stress Physiological","Stress Physiology","Stress Psychological","Breathing Techniques","Breathing Exercises","Hypothalamic Pituitary Adrenal","Relaxation Therapy","Cortisol","Postoperative Pain","Postoperative Anxiety","Postoperative Depression","Quality of Recovery (QoR-15)",[163,177,178,179,168,167,180,172,173,174,181,182],"Total Knee Arthroplasty","Hypothalamic-Pituitary-Adrenal Axis","Breathwork","Postoperative Complications","Quality of Recovery","Diurnal Cortisol Rhythm","2026-03-06",{"date":141,"type":35},{"date":186,"type":20},"2026-04-06",{"date":188,"type":20},"2026-09-30",{"name":190,"class":42},"University of Arizona",{"id":192,"slug":193,"hasResults":11,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":197,"eligibilityCriteria":198,"healthyVolunteers":50,"sex":51,"minAge":17,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":21,"phases":201,"briefSummary":202,"conditions":203,"keywords":204,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":209,"leadSponsor":211,"locationsCount":4},"100626152","effects-of-nature-based-virtual-reality-and-binaural-beats-on-heart-rate-variability-and-relaxation-100626152","NCT07431918","Effects of Nature-Based Virtual Reality and Binaural Beats on Heart Rate Variability and Relaxation","Effects of Nature-Based Virtual Reality and Binaural Beats on Heart Rate Variability and Relaxation: A Controlled Within-Subject Study","VRELAX","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Ability to understand study procedures and provide written informed consent\n* Sufficient proficiency in the German language to complete questionnaires and follow study instructions\n* Willingness to participate in a single approximately 60-minute study session\n\nExclusion Criteria:\n\n* Current or history of neurological or psychiatric disorders that may interfere with data collection (e.g., dementia, major depressive disorder, stroke, epilepsy)\n* Severe visual or hearing impairments that would limit the use of virtual reality equipment or headphones\n* History of adverse reactions to virtual reality",{"count":200,"type":20},18,[23],"The VRELAX study is a non-clinical sub-study within the \"Decreasing Preoperative Stress to Prevent Postoperative Delirium and Postoperative Cognitive Decline in Cardiac Surgical Patients\"- research program (DESTRESS; NCT05036538), which investigates non-pharmacological relaxation interventions using virtual reality and binaural auditory stimulation. In a randomized counterbalanced within-subject design, non-clinical adult participants complete two sessions separated by a 1 day intervention-free interval. A 30-minute immersive nature-based virtual reality exposure combined with gradually decreasing binaural beats (10-1 Hertz (Hz)), and a control condition without relaxation. Heart rate variability (HRV) is recorded continuously, and subjective stress is assessed before and after each condition. The primary outcome is parasympathetic activation operationalized as high-frequency (HF) power of heart rate variability. Secondary outcomes include additional HRV parameters and self-reported stress ratings. The study aims to characterize short-term relaxation effects and evaluate the feasibility of independent use in everyday settings, supporting interpretation of clinical findings of the DESTRESS trial.",[133,28,29,134],[29,134,136,137,138,139],"2026-02-18",{"date":207,"type":35},"2026-02-25",{"date":207,"type":20},{"date":210,"type":20},"2026-12-20",{"name":149,"class":42},{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":50,"sex":51,"minAge":219,"maxAge":220,"enrollmentInfo":221,"targetDuration":4,"studyType":21,"phases":223,"briefSummary":224,"conditions":225,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":234,"locationsCount":43},"100616886","sleep-and-morning-wellbeing-study-100616886","NCT07311434","Sleep and Morning Wellbeing Study","Evaluation of Perceived Outcomes With AGZ: A Randomized, Controlled, Consumer Perception Study","Inclusion Criteria:\n\n* Male or female.\n* Age 25-59 years.\n* BMI ≥18.5 and ≤29.9 kg\u002Fm².\n* Currently experiencing issues with sleep quality, falling asleep, staying asleep, or waking during the night.\n* RU-SATED score ≤17.\n* Willing and able to follow the study protocol.\n* Willing to discontinue any other supplements (including nootropics, adaptogens, calming herbs), medications, herbal remedies, or over-the-counter sleep medications (e.g., zolpidem, diphenhydramine, Benadryl, ZzzQuil, Unisom, magnesium or melatonin products) used to assist with sleep during the study.\n* Agree to limit alcohol intake within approximately 4 hours of bedtime throughout participation.\n* Agree to limit caffeine intake to ≤400 mg\u002Fday (about 3-4 cups of coffee) and avoid ingestion of caffeine-containing products after 2:00 PM during the study period.\n* Generally healthy and not living with any uncontrolled chronic disease.\n* Resides in the United States.\n* Willing to discontinue any restricted products and adhere to all required study assessments.\n\nExclusion Criteria:\n\n* Diagnosed chronic sleep conditions (e.g., insomnia, narcolepsy, REM Behavior Disorder, moderate to severe restless leg syndrome, sleep apnea).\n* Current use of sleep-tracking technology (e.g., wrist-worn trackers, rings, smartphone apps) that could influence sleep behavior or perception.\n\nWomen currently undergoing perimenopause or experiencing vasomotor symptoms (e.g., night sweats).\n\n* Use of hormone therapy (estrogen, progesterone, phytoestrogens) within the last 3 months.\n* Diagnosed psychiatric disorders including major depressive disorder with acute symptoms, bipolar disorder, generalized anxiety disorder with active symptoms, and PTSD with frequent nightmares.\n* Diagnosed neurodegenerative or chronic pain disorders, including Parkinson's disease, Alzheimer's disease, or uncontrolled fibromyalgia.\n* Regular prescribed stimulant use (e.g., amphetamines such as Adderall\u002FVyvanse; methylphenidate such as Ritalin\u002FConcerta; modafinil\u002Farmodafinil).\n* Current use of CNS-activating antidepressants (bupropion, fluoxetine, venlafaxine, sertraline).\n* Current or recent use of cannabis or THC-containing products (recreational or medicinal marijuana, CBD with measurable THC, synthetic cannabinoids) within the past 30 days.\n* Employment in jobs disrupting nighttime sleep (e.g., night shift, rotating shift, excessive travel).\n* Current use of prescription sleep aids.\n* Introduction of any new sleep-related supplements, medications, herbal remedies, or melatonin products during the study.\n* Use of any prescription or OTC products with sedative properties (e.g., melatonin, diphenhydramine, doxylamine, valerian, ZzzQuil, Advil PM) within 4 weeks prior to enrollment or habitual use ≥3 times per week prior to enrollment unless investigator-approved.\n* Allergy or sensitivity to any study product ingredients.\n* Pregnant, breastfeeding, or trying to conceive during the study period.\n* History of substance abuse.\n* Heavy alcohol use (≥8 drinks\u002Fweek for women or ≥15 drinks\u002Fweek for men).\n* Participation in another research study now or within the next 7 weeks.\n* Any condition or behavior that, in the investigator's judgment, may interfere with study participation or data integrity.","22 Years","59 Years",{"count":222,"type":20},300,[23],"The study will be a prospective randomized, controlled clinical study. There will be interventional treatment for a total of 30 days. The subjects will complete questionnaires throughout the study at pre-specified timepoints.",[226,28,133,227],"Sleep","Daytime Sleepiness","2026-02-10",{"date":230,"type":35},"2026-02-11",{"date":232,"type":35},"2026-01-20",{"date":115,"type":20},{"name":235,"class":236},"Athletic Greens International","INDUSTRY",{"id":238,"slug":239,"hasResults":11,"nctId":240,"briefTitle":241,"officialTitle":242,"acronym":4,"eligibilityCriteria":243,"healthyVolunteers":11,"sex":51,"minAge":17,"maxAge":244,"enrollmentInfo":245,"targetDuration":4,"studyType":21,"phases":247,"briefSummary":248,"conditions":249,"keywords":253,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":261,"leadSponsor":262,"locationsCount":4},"100609280","benson-relaxation-exercises-and-sleep-quality-in-lung-cancer-patients-100609280","NCT07212517","Benson Relaxation Exercises and Sleep Quality in Lung Cancer Patients","The Effect of Benson Relaxation Exercises on Sleep Quality in Patients With Lung Cancer","Inclusion Criteria:\n\n* Patients aged 18 years and over,\n* Have been diagnosed with lung cancer and be receiving inpatient treatment,\n* Be conscious and able to communicate,\n* Agree to participate in breathing exercises during the study,\n* Score above 5 on the PSQI,\n* Sign a written informed consent form.\n\nExclusion Criteria:\n\n* Patients under 18 years of age,\n* Those with additional mental or cognitive disorders,\n* Those with physiological barriers to performing breathing exercises,\n* Those unable to complete the programme during the study period,\n* Those with a PSQI score above 5,\n* Those who violated the study protocol,\n\n  •. Those with an oxygen saturation value below 90,\n* Those scoring above 5 on the Visual Pain Scale,\n* Those who have previously practised yoga or meditation,\n* Patients with haemoptysis,\n* Patients taking any anxiolytic or hypnotic medication.\n\n  * During the 15 days of Benson relaxation exercise, patients in both the intervention and control groups will not be allowed to perform the exercise if their O2 saturation and pain level changes meet the exclusion criteria.","80 Years",{"count":246,"type":20},60,[23],"The aim of this study is to investigate the effect of Benson Relaxation Exercises on sleep quality in hospitalized patients diagnosed with lung cancer. It is planned to be conducted as a randomized controlled trial.\n\nHypotheses of the Study H1: The sleep quality of lung cancer patients who undergo Benson relaxation exercises is statistically significantly better than that of patients who do not undergo such exercises.\n\nH2: There is no significant difference in sleep quality between patients who undergo Benson relaxation exercises and those who do not.",[250,28,251,252],"Sleep Quality","Canser","Benson Exercise",[254,255,256],"cancer patient","Benson relaxation","sleep Quality","2025-09-30",{"date":259,"type":35},"2025-10-08",{"date":257,"type":20},{"date":147,"type":20},{"name":263,"class":42},"Uskudar University",{"id":265,"slug":266,"hasResults":11,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":270,"eligibilityCriteria":271,"healthyVolunteers":11,"sex":51,"minAge":17,"maxAge":272,"enrollmentInfo":273,"targetDuration":4,"studyType":21,"phases":275,"briefSummary":276,"conditions":277,"keywords":280,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":289,"locationsCount":43},"100481231","interest-of-prior-relaxation-on-the-recordings-of-the-somatosensory-evoked-potentials-100481231","NCT05546307","Interest of Prior Relaxation on the Recordings of the SomatoSensory Evoked Potentials","Randomized, Single-blind Study Evaluating the Interest of Prior Relaxation on the Quality of the Recordings of the SomatoSensory Evoked Potentials","RELAXPE","Inclusion Criteria:\n\n* Any patient addressed for a study of the somatosensory evoked potentials in upper limbs\n* Patients between 18 to 70 years old.\n* Patients able to understand the instructions of the relaxation session and the examination.\n* Patient providing informed consent exclusion criteria\n\nExclusion Criteria:\n\n* No availability of a technician trained in relaxation\n* Patient's refusal to participate in the protocol","70 Years",{"count":274,"type":20},242,[23],"Many factors influence the quality and duration of SomatoSensory Evoked potentials (SSEP). Some are related to the technique : type of electrodes, intensity of stimulation, stimulation site ; others are related to the patient : poor state of relaxation of the patient generating muscle artefacts; hypersensitivity of the patient to electrical stimuli making the examination unpleasant; examination time considered too long. However, the patient's relaxed state is essential to the quality of the signal . Thus the duration of an examination is very variable : between 30 and 75 minutes for the upper limbs.... For several months, the investigators provide relaxation to some patients just before the examination. Results seem to be positive. The investigators aim to study the effect of relaxation session on the quality of the SSEP recordings. Fifteen-minutes relaxation session will be provided by a nurse trained to the relaxation.\n\nThe investigators will compare two groups : one group with one relaxation session before the examination and one group without relaxation session before the examination.\n\nThe investigators chose to study the influence of relaxation session on (i) the artifacts rejection rate by the machine for the recordings of SSEP by stimulation of the median nerve to the upper limbs (ii) the duration of the examination (iii) the patient experience",[28,278,279],"Somatosensory Evoked Potentials","Patient Experience",[28,278,281],"Patient experience","2025-06-03",{"date":284,"type":35},"2025-06-04",{"date":286,"type":35},"2022-09-15",{"date":288,"type":20},"2025-07",{"name":93,"class":42},{"id":291,"slug":292,"hasResults":11,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":296,"eligibilityCriteria":297,"healthyVolunteers":11,"sex":51,"minAge":17,"maxAge":298,"enrollmentInfo":299,"targetDuration":4,"studyType":21,"phases":301,"briefSummary":302,"conditions":303,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":307,"startDateStruct":309,"completionDateStruct":311,"leadSponsor":313,"locationsCount":43},"100475797","apa-and-relaxation-by-biofeedback-in-patients-with-haematological-malignancy-admitted-in-icu-100475797","NCT05475600","APA and Relaxation by Biofeedback in Patients With Haematological Malignancy Admitted in ICU","Adapted Physical Activity and Relaxation by Biofeedback in Patients With Haematological Malignancy Admitted in Intensive Care unit_APAER_H Protocol","APAER_H","Inclusion Criteria:\n\n* Subjects aged between 18 and 75 years old\n* Admitted in Intensive Care Unit\n* Informed consent\n\nExclusion Criteria:\n\n* Contraindication for physical exercise\n* Inability to understand the French language (written and\u002For oral)\n* Ongoing involvement in another proprietary research protocol\n* Lack of affiliation to social security","75 Years",{"count":300,"type":20},90,[23],"Adapted Physical Activity (APA) is accepted as an effective, recommended and beneficial supportive care for the health of people with cancer during the different phases of the disease. The objective of the project is to analyse the effect of APA programs (Classic, Exergaming and Relaxation) on the state anxiety of people with severe blood diseases admitted to Intensive Care Unit (ICU). Anxiety is a major affect in this context. The interest of the practice of APA for this public is to reduce the level of state anxiety and to limit the decline of functional capacities. The main objective of this work is to identify whether specific and\u002For complementary effects result from the use of biofeedback and\u002For Exergaming.",[304,305,108,28],"Adapted Physical Activity","Hematological Malignancies","2025-03-14",{"date":308,"type":35},"2025-03-17",{"date":310,"type":35},"2022-12-02",{"date":312,"type":20},"2027-01",{"name":314,"class":42},"Centre Hospitalier Régional Metz-Thionville"]