[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"remineralization\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:remineralization":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100639820","phase-3-clinical-study-to-evaluate-remineralization-using-an-in-situ-model-100639820",false,"NCT07625670","Clinical Study to Evaluate Remineralization Using an in Situ Model.","Clinical Study to Evaluate Enamel Remineralization Using Three Dentifrices in an in Situ Model.","REMINSITU","Inclusion Criteria:\n\n* Males and females, between 18-70 years of age (inclusive);\n* Informed Consent Form signed and availability for the duration of the study;\n* Good general health (absence of any condition that, in the opinion of the Principal Investigator, might constitute a risk to the subject while participating in the study. Examples include heart problems, valve\u002Fhip replacements, etc);\n* Willingness to provide information related to their medical history;\n* Minimum of 20 uncrowned permanent natural teeth (excluding third molars);\n* Normal salivary flow;\n* Willingness to wear an intra-oral appliance all day as instructed except when eating and drinking.\n\nExclusion Criteria:\n\n* Oral pathology, chronic disease, or a history of allergy to testing products;\n* Subject using anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory medication or daily analgesics within one month prior to the start of the study or scheduled to start such intake during the course of the study;\n* Subject participating in any other clinical study;\n* Subject pregnant or breastfeeding;\n* Subject allergic to oral care products, personal care consumer products, or their ingredients;\n* Extended use of antibiotics or therapeutic mouthwash any time during the three months prior to entry into the study;\n* A medical history reporting that the subject has a current systemic or autoimmune disease, such as diabetes, lupus, etc.;\n* Ongoing use of medications known to affect the gingival tissues (i.e. calcium channel blockers, phenytoin, cyclosporine);\n* Advanced periodontal disease (purulent exudate, tooth mobility, and\u002For extensive loss of periodontal attachment or alveolar bone). Pocket depth equal or greater than 4 mm;\n* Five or more decayed, untreated dental sites (cavities);\n* Current smokers and subjects with a history of alcohol or drug abuse;\n* Dental work prevents wearing of the appliance or a reported need to wear a night guard.",true,"ALL","18 Years","70 Years",{"count":22,"type":23},30,"ESTIMATED","INTERVENTIONAL",[26],"PHASE3","This is a phase III clinical trial that aims to evaluate the enamel remineralization efficacy of three dentifrices on artificial caries lesions using an in situ model. The study involves 30 healthy volunteers, aged 18 to 70, who will participate in a randomized, triple-blind, three-period crossover design. Researchers will compare a 750 ppm MFP dentifrice against a 1450 ppm MFP positive control and a fluoride-free negative control to measure variations in mineral gain. Participants will wear a removable intraoral appliance containing human enamel blocks for three 14-day experimental phases. A 7-day washout period using will be implemented before and between each treatment phase.",[29,30,31],"Remineralization","Enamel Lesions","Enamel Subsurface Lesion",[33,34],"enamel remineralization","transverse micro-radiography","NOT_YET_RECRUITING","2026-06-02",{"date":38,"type":39},"2026-06-04","ACTUAL",{"date":41,"type":23},"2026-06",{"date":43,"type":23},"2026-10",{"name":45,"class":46},"Colgate Palmolive","INDUSTRY"]