[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"remote-ischaemic-preconditioning\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:remote-ischaemic-preconditioning":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100611204","effect-of-remote-ischemic-preconditioning-on-early-neurological-deterioration-in-acute-perforating-artery-infarction-100611204",false,"NCT07237542","Effect of Remote Ischemic Preconditioning on Early Neurological Deterioration in Acute Perforating Artery Infarction","Effect of Remote Ischemic Preconditioning on Early Neurological Deterioration in Acute Perforating Artery Infarction (RIC-END): A Randomised Multicentre Trial","RIC-END","Inclusion Criteria:\n\n1. Age 18 years or older;\n2. Diagnosed with acute ischemic stroke;\n3. Clinical symptoms consistent with perforating artery infarction (NIHSS score ≤5, with consciousness item 1a ≤1);\n4. Time from onset to randomization within 48 hours;\n5. Diffusion-weighted imaging (DWI) showing a single infarct in the perforating artery territory with a maximum diameter ≤30 mm, meeting at least one of the following:\n\n(1) Diameter ≤15 mm and involving two or more axial slices; (2) Maximum diameter ≥15 mm; (3) Connected to the ventral surface of the pons but not crossing the midline; 6) Stenosis of parent artery \\\u003C70%; 7) Signed informed consent obtained from the patient or their legally authorized representative.\n\nExclusion Criteria:\n\n1. Received intravenous thrombolysis or endovascular treatment prior to randomization;\n2. Secondary stroke caused by brain tumor, traumatic brain injury, hematologic disorders, or other conditions;\n3. History of intracranial hemorrhage;\n4. Presence of RIC contraindications, such as severe upper limb soft tissue injury, fracture, subclavian artery stenosis, or peripheral vascular disease;\n5. Uncontrolled severe hypertension (systolic blood pressure \\[BP\\] ≥180 mmHg or diastolic BP ≥110 mmHg);\n6. Severe hepatic or renal dysfunction (Alanine Aminotransferase or Aspartate Aminotransferase \\> 3 × upper limit of normal; creatine kinase \\>3 × upper limit of normal; estimated Glomerular Filtration Rate \\\u003C 30 mL \u002F min \u002F 1.73 m²);\n7. Patients with thrombocytopenic purpura, coagulation disorders, or active visceral bleeding;\n8. Patients in the acute phase of fundus hemorrhage;\n9. History of severe aphasia or psychiatric disorders affecting clinical assessment;\n10. Life expectancy \\\u003C90 days;\n11. Pregnancy;\n12. Inability to comply with follow-up;\n13. Participation in other clinical trials.","ALL","18 Years",{"count":20,"type":21},910,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to conduct a prospective, randomized, double-blind, multicenter, parallel-controlled, group-sequential trialto scientifically evaluate the safety and efficacy of remote ischemic preconditioning (RIC) in preventing early neurological deterioration (END) in patients with acute perforating artery infarction (PAI).",[27,28],"Ischemic Stroke","Remote Ischaemic Preconditioning",[30,31,32,33],"perforating artery stroke","remote ischemic preconditioning","early neurological deterioration","randomized controlled trial","RECRUITING","2026-01-30",{"date":37,"type":38},"2026-02-03","ACTUAL",{"date":40,"type":38},"2025-12-11",{"date":42,"type":21},"2027-11-20",{"name":44,"class":45},"Jinling Hospital, China","OTHER"]