[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"renal-colic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:renal-colic":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,44,68,98,124,149,178,204],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100498953","phase-4-evaluation-of-the-effects-of-ketorolac-dose-on-duration-of-analgesia-in-emergency-department-ed-renal-colic-patients-100498953",false,"NCT05776953","Evaluation of the Effects of Ketorolac Dose on Duration of Analgesia in Emergency Department (ED) Renal Colic Patients","Evaluation of the Effects of Ketorolac 15mg IV Versus 30mg IV on Duration of Analgesia in Patients Who Present to the Emergency Department With Renal Colic","Inclusion Criteria:\n\nPatients will be included if they present to the Emergency Department with (all of the following):\n\n* Adult emergency department patients \\\u003C 65 years old\n* One or more of the following common ED chief complaints associated with the suspected diagnosis of renal colic. These chief complaints include but are not limited to: flank pain, back pain, abdominal pain, left and\u002For right lower quadrant pain, and\u002For pelvic pain\n* Pain score of 4 or greater on the 0-10 NRS\n* Determination of treatment with IV ketorolac\n\nExclusion Criteria:\n\nPatients will be excluded if any of the following apply:\n\n* Allergy to ketorolac\n* Pregnant patients\n* Previously received analgesic medications within 4 hours prior to administration of ketorolac in our ED\n* Known or stated history of renal insufficiency\n* Body weight \\\u003C 50 kg\n* Age greater than 65 years\n* Patients that do no read\u002Fwrite Spanish or English","ALL","18 Years","65 Years",{"count":20,"type":21},86,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","This is a prospective interventional study examining the effect of ketorolac at doses of 15mg versus 30 mg for duration of analgesia in emergency department patients with suspected renal colic.",[27,28,29,30],"Renal Colic","Flank Pain","Emergencies","Analgesia","RECRUITING","2026-05-20",{"date":34,"type":35},"2026-05-22","ACTUAL",{"date":37,"type":35},"2023-12-21",{"date":39,"type":21},"2026-09-01",{"name":41,"class":42},"Hackensack Meridian Health","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":43},"100591461","phase-3-comparative-efficacy-of-iv-dexamethasone-vs-nebulized-terbutaline-for-renal-colic-pain-in-the-ed-100591461","NCT06980727","Comparative Efficacy of IV Dexamethasone vs. Nebulized Terbutaline for Renal Colic Pain in the ED","Increment Value of Intravenous Dexametasone Versus Nebulized Terbutaline for Renal Colic Pain Management in the Emergency Department: A Randomized Clinical Trial","Inclusion criteria:\n\n* Adults aged 18-65 years\n* Clinical diagnosis of acute renal colic (defined as sudden sharp colicky flank pain with or without radiation to the genitalia or groin, and with or without urinary symptoms)\n* Pain score of 5 or more measured using the 10-cm NRS scale\n\nExclusion Criteria:\n\n* History of cardiovascular, hepatic, renal, or metabolic diseases\n* Evidence of sepsis or clinical suspicion of urinary tract infection\n* Hemodynamically unstable (systolic blood pressure \\\u003C 90 mmHg)\n* Uncontrolled diabetes\n* Pregnancy or breastfeeding\n* Inability to understand verbal and\u002For written information\n* Received any analgesics within 6 hours prior to presentation\n* Serum potassium \\\u003C 3.7 mmol\u002FL\n* Concomitant use of:\n\nAny beta-blockers (including beta-blocker-containing eye drops)\n\nProlonged-release long-acting β-agonists\n\nShort-acting β2-agonists within 6 hours prior to presentation\n\n* Contraindication to terbutaline use\n* Known allergy to paracetamol or terbutaline\n* Abdominal tenderness suggestive of peritoneal inflammation\n* Clinical suspicion of conditions other than urolithiasis, including:\n* Abdominal aortic aneurysm\n* Aortic dissection\n* History of drug dependence or chronic alcohol consumption",{"count":52,"type":21},300,[54],"PHASE3","Adult patients (18-55 years of age) with clinical diagnosis of acute renal colic (sudden sharp colic flank pain with or without radiation to genitalia or groin and with or without urinary symptoms) who had pain score of 5 or more measured by 10-cm visual analogue scale (VAS), will be included. Will be excluded those who had history of cardiovascular, hepatic, renal or metabolic diseases, patients with evidence of sepsis or clinical suspicion of urinary tract infection, hemodynamically unstable patients (systolic blood pressure \\<90 mmHg), patients with uncontrolled diabetes, pregnancy, breastfeeding, patients unable to understand verbal and\u002For written information, patients receiving analgesics within 6 hours before presentation, serum potassium less than 3.7 mmol\u002Fl, concomitant use of any beta blockers (including beta-blocker containing eye drops), prolonged-release long-acting β-agonists, use of short-acting β2-agonists within the 6 h preceding presentation to the emergency department, any contraindication to the use of terbutaline, history of drug dependence or chronic consumption of alcohol. Will be also excluded patients with known allergy to paracetamol or terbutaline, patients with abdominal tenderness as a sign of peritoneal inflammation and those with any clinical suspicion for diseases other than urolithiasis, including abdominal aortic aneurysm or dissection.",[27],[27,58],"Dexamethasone","NOT_YET_RECRUITING","2026-05-18",{"date":32,"type":35},{"date":63,"type":21},"2026-08-08",{"date":65,"type":21},"2028-03-01",{"name":67,"class":42},"University of Monastir",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":22,"phases":78,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":4},"100634200","relief-efficacy-of-lidocaine-versus-morphine-for-acute-renal-colic-in-the-emergency-department-100634200","NCT07536594","Relief Efficacy of Lidocaine Versus Morphine for Acute Renal Colic in the Emergency Department","RELIEF-RC: Relief Efficacy of LIdocaine Versus morphinE For Acute Renal Colic in the Emergency Department","RELIEF-RC","Inclusion Criteria:\n\nIn order to be eligible for inclusion in the study, an individual must meet all of the following criteria:\n\n* Age ≥ 18 years at time of visit\n* Able and willing to consent for participation in study\n* Documentation of suspected renal colic as primary complaint as evidenced by reported flank pain, back pain, abdominal pain, or groin pain, or as determined by the treating clinician\n* Requires additional treatment due to inadequate analgesia or clinical suspicion of unsafe discharge secondary to pain after initial treatment with parenteral ketorolac\n\nExclusion Criteria:\n\nAny individual who meets any of the following criteria will be excluded from participation in this study:\n\n* Age \\\u003C 18 years\n* Use of analgesia for renal colic within 6 hours prior to clinician evaluation\n* Inability or unwillingness to consent for participation in study\n* Experienced a severe adverse event that required clinician intervention after initial treatment with parenteral ketorolac\n* Documented history of allergic or anaphylactic reaction to NSAIDs, lidocaine, or morphine\n* Documented history of cardiac arrhythmias\n* Documented history of chronic use of opioid medications for unrelated diagnoses\n* Currently pregnant\n* Documented history of end-stage renal or hepatic dysfunction\n* Clinical contraindications to NSAIDs, lidocaine, or morphine per clinician discretion",{"count":77,"type":21},250,[79],"NA","The opioid epidemic continues to be a major public health crisis in the United States. According to the Center for Disease Control, approximately 8 million Americans reported misusing prescription opioids in 2023, with over 5 million Americans reporting that they suffer from opioid use disorder. The United States government estimates that 105,000 people died from drug overdose in 2023, and approximately 80,000 of those deaths can be attributed to opioids (\\~76%). In acknowledgement of the opioid crisis, we wish to contribute to ongoing efforts to reduce unnecessary and excessive opioid prescription.\n\nIn 2012, researchers in Iran published a randomized controlled trial comparing intravenous (IV) lidocaine to IV morphine for acute renal colic, reporting that 90% patients responded \"successfully\" in the lidocaine group versus 70% in the morphine group. They also concluded that there was a statistically significant difference between pain scores between the two groups at all time points, favoring the lidocaine group. However, the study was conducted at a single emergency department in Tabriz, Iran, with a relatively homogenous patient population, and the researchers did not explicitly define their primary outcome variable for what constituted a \"successful\" response in the treatment groups. The investigators of this study aim to build upon this preliminary evidence by recruiting a more diverse population to improve generalizability and by predefining pain-reduction thresholds to allow for more meaningful comparison between the interventions.",[27,82,83],"Kidney Stones, Urolithiasis, Hypocitraturia","Opioid Use During Medical Care",[85,86,87,88],"renal colic","kidney stones","lidocaine","opioid use","2026-04-15",{"date":91,"type":35},"2026-04-17",{"date":93,"type":21},"2026-06",{"date":95,"type":21},"2028-06",{"name":97,"class":42},"Loma Linda University",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":22,"phases":108,"briefSummary":109,"conditions":110,"keywords":112,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":43},"100591314","ear-pressure-points-plus-pain-meds-for-faster-kidney-stone-pain-relief-100591314","NCT06978816","Ear Pressure Points Plus Pain Meds for Faster Kidney Stone Pain Relief","Auricular Acupoint Embedding as Adjunctive Therapy to NSAIDs for Accelerated Relief of Renal Colic in Urolithiasis: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age between 15 and 75 years (inclusive)\n2. Diagnosis of urinary tract stones confirmed by CT or ultrasound\n3. Visual Analog Scale (VAS) score ≥ 4 (indicating moderate to severe renal colic)\n4. No severe cardiac, hepatic, or pulmonary dysfunction, and no coagulation disorders.\n5. No psychiatric disorders\n\nExclusion Criteria:\n\n1. Use of any analgesic medication within the past 6 hours.\n2. Allergy to NSAIDs, morphine, or anisodamine (scopolamine derivatives)\n3. History of asthma, urticaria, congestive heart failure, acute ischemic heart disease, acute cerebrovascular disease, or increased intracranial pressure\n4. Active peptic ulcer, pyloric obstruction, or intestinal obstruction\n5. Severe adverse reactions to acupuncture in the past\n6. Pregnancy or lactation\n7. Unwillingness to sign informed consent","75 Years",{"count":107,"type":21},116,[79],"Title: Can Ear Acupressure Help Relieve Kidney Stone Pain Faster When Combined with Painkillers?\n\nPurpose:\n\nThis study tests whether adding ear acupressure to standard painkillers (NSAIDs) helps adults with kidney stone pain feel better faster. The investigators also want to know if this combination causes any side effects.\n\nKey Questions:\n\nDoes ear acupressure + NSAIDs reduce pain more quickly than NSAIDs alone? Are there any safety concerns with this treatment? How does real ear acupressure compare to a fake (placebo) procedure? Who Can Join? Adults aged 18-75 Experiencing moderate-to-severe kidney stone pain (confirmed by CT or ultrasound) No recent painkiller use or allergies to NSAIDs\n\nWhat Participants Will Do:\n\nReceive in the emergency room:\n\nReal treatment: Tiny needles placed on 3 ear points + NSAIDs (ketorolac injection) OR Placebo treatment: Fake tape on ear points + NSAIDs (same injection) Rate their pain on a 0-10 scale over 60 minutes. Have their heart rate and blood pressure checked.\n\nStudy Details:\n\nDuration: Single ER visit (no long-term follow-up) Participants Needed: 116 Safety: Rescue pain medication (like morphine) is available if needed.\n\nWhy This Matters:\n\nKidney stones cause severe pain, and current painkillers may not work fast enough. Ear acupressure is a low-risk method from traditional Chinese medicine that could provide quicker relief.\n\nEthics:\n\nApproved by Changhai Hospital's Ethics Committee. Participants can leave the study anytime.",[27,111],"Acupuncture, Ear",[113,27,114],"Kidney Calculi","acupuncture, ear","2026-03-16",{"date":117,"type":35},"2026-03-18",{"date":119,"type":35},"2025-06-01",{"date":121,"type":21},"2026-12-01",{"name":123,"class":42},"Gao Xiaofeng",{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":131,"targetDuration":4,"studyType":22,"phases":133,"briefSummary":134,"conditions":135,"keywords":136,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":43},"100606516","phase-4-analgesic-efficacy-of-transcutaneous-electrical-nerve-stimulation-and-dexketoprofen-in-renal-colic-100606516","NCT07176572","Analgesic Efficacy of Transcutaneous Electrical Nerve Stimulation and Dexketoprofen in Renal Colic","Comparison of Analgesic Efficacy of Transcutaneous Electrical Nerve Stimulation and Dexketoprofen Trometamol in Patients Presenting to the Emergency Department With Renal Colic: A Randomized Controlled Trial","Inclusion Criteria:\n\n\\- Aged 18 years or over with a definite diagnosis of renal colic\n\nExclusion Criteria:\n\n* Patients who refuse to participate in the study\n* Pregnant women\n* Breastfeeding women\n* Haemodynamically unstable\n* Evidence of peritoneal inflammation\n* Patients who were taking analgesics at the time of initial presentation\n* Unconsciousness or inability to communicate\n* Contraindications to applying TENS or using the drug in the study.",{"count":132,"type":21},128,[24],"The aim of this study was to compare the analgesic efficacy of transcutaneous electrical nerve stimulation (TENS) and dexketoprofen trometamol in patients presenting to the emergency department due to renal colic.",[27],[137,138,139],"Transcutaneous electrical nerve stimulation","emergency medicine","Dexketoprofen Trometamol","2025-09-29",{"date":142,"type":35},"2025-10-02",{"date":144,"type":21},"2026-03-01",{"date":146,"type":21},"2026-12-31",{"name":148,"class":42},"Adiyaman University Research Hospital",{"id":150,"slug":151,"hasResults":11,"nctId":152,"briefTitle":153,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":155,"targetDuration":4,"studyType":22,"phases":157,"briefSummary":158,"conditions":159,"keywords":160,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":43},"100598354","the-use-of-ar--vr-in-patients-presenting-to-the-ed-with-renal-colic-100598354","NCT07070401","The Use of AR \u002F VR in Patients Presenting to the ED With Renal Colic","Inclusion Criteria:\n\n* Patient self-reported history of nephrolithiasis\n* Subjective history suggesting that current presentation is similar to past presentations of nephrolithiasis (character, quality, location, intensity of pain; previous surgical intervention or lithotripsy)\n* Patients with self-reported moderate to severe pain on the visual pain scale determined as greater than 5\u002F10\n* Normal vital signs (afebrile)\n* Agreeable to informed consent as dictated by IRB and local practice\n* No contraindications to standard therapy (ie fluids, NSAIDs, opioids, etc.)\n* Compliance with the virtual reality treatment\n* Keeps the headset on for the duration of the experience\n* Understands the instructions\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Pregnant\n* Individuals with chronic pain conditions such as fibromyalgia (chronic pain may confound results, as patients may have higher than baseline pain levels affecting their response to medications)\n* Individuals with severe anxiety or claustrophobia\n* Individuals with severe motion sickness or previous episodes of motion sickness due to VR (those who may not react well to the VR experience)\n* Individuals with GFR\\\u003C60 or previous documented diagnosis of CKD as they may not be suitable candidate for traditional analgesia\n* Individuals with previous opioid dependence\n* Requirement of immediate surgery (obstructing calculi with concomitant urinary tract infection)\n* Patients with diagnoses meeting admission criteria (sepsis, MI)\n* Audio\u002Fvisual impairment (unable to appreciate stimuli provided by the headset)\n* Patients administered opiates as the first line pain control medication will not be included in final data collection, as opioid administration may result in difficulty consenting and understanding the study protocol \u002F design",{"count":156,"type":21},92,[79],"Utilization of VR \u002F AR Calming as an adjunct to pharmacologic pain management for Renal Colic in Emergency Department Patients",[27,82],[27,161,162,163,164,165,166,167,168],"Nephrolithiasis","Urolithiasis","Emergency Department","Pain Management","Virtual Reality","Augmented Reality","Audiovisual Stimulation","Patient Anxiety","2025-07-08",{"date":171,"type":35},"2025-07-17",{"date":173,"type":35},"2025-04-01",{"date":175,"type":21},"2026-03-31",{"name":177,"class":42},"Community Medical Center, Toms River, NJ",{"id":179,"slug":180,"hasResults":11,"nctId":181,"briefTitle":182,"officialTitle":182,"acronym":183,"eligibilityCriteria":184,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":185,"enrollmentInfo":186,"targetDuration":4,"studyType":22,"phases":188,"briefSummary":190,"conditions":191,"keywords":192,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":43},"100542657","phase-2-paracetamol-tramadol-and-paracetamol-caffeine-versus-placebo-in-the-emergency-discharge-treatment-of-renal-colic-100542657","NCT06345716","Paracetamol-Tramadol and Paracetamol-caffeine Versus Placebo in the Emergency Discharge Treatment of Renal Colic","RC","Inclusion Criteria:\n\n* -Age \\> 18 years old.\n* Consent to participate in the study.\n* Pain in the flank\u002Flumbar fossa of sudden onset with urine strips and\u002For imaging corresponding to the diagnosis of renal colic.\n* Pain score at discharge \\\u003C 30 (visual analog scale - VAS or verbal numerical scale - VAS from 0 to 100).\n\nExclusion Criteria:\n\n* -Inability to appreciate pain according to the VAS.\n* Pregnant or breastfeeding woman.\n* Renal insufficiency with creatinine clearance \\\u003C 60 ml\u002Fmin.","99 Years",{"count":187,"type":21},1500,[189],"PHASE2","This is a prospective, randomized, single-blind study. Patients included in the study after successful treatment of the acute attack were randomized upon discharge from the Emergency Department into three groups: oral paracetamol-tramadol group, oral paracetamol-caffeine group and oral placebo group.",[27],[85,193,194,195],"paracetamol-tramadol","paracetamol-cafeine","placebo","2024-09-11",{"date":198,"type":35},"2024-09-19",{"date":200,"type":35},"2024-04-10",{"date":202,"type":21},"2025-11-30",{"name":67,"class":42},{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":210,"eligibilityCriteria":211,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":212,"targetDuration":4,"studyType":22,"phases":214,"briefSummary":215,"conditions":216,"keywords":217,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":220,"lastUpdatePostDateStruct":221,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":43},"100494792","phase-2-oral-nsai-versus-acetaminophen-or-placebo-as-a-discharge-treatment-of-non-complicated-renal-colics-100494792","NCT05722782","Oral NSAI Versus Acetaminophen or Placebo as a Discharge Treatment of Non Complicated Renal Colics","The Investigation of the Efficacity and Safety of Oral Non Steroidal Anti Inflammatory (NSAI) Drugs Such as Piroxicam as a Second Line Treatment of Patients Consulting the Emergency Department for Renal Colics","NAP-RC","Inclusion Criteria:\n\n* Over 18 years old\n* Consenting to participate in the study\n* Patients treated in the ED for RC\n* No contraindications of NSAI or paracetamol treatment\n\nExclusion Criteria:\n\n* Contraindication of NSAI treatment\n* Patients non reachable by telephone call\n* Patients that did not receive or use the treatment",{"count":213,"type":21},500,[189],"Treatment with NSAI in renal colics has not been well investigated and there is no clear recommendations regarding this subject.\n\nThe aim of this study is to determine if an oral NSAI treatment is beneficial in patients discharged for the emergency department after the first line treatment of a renal colic investigating the reccurence of pain, the reconsultation rates and the admissions.",[27],[27,218,219],"NSAI","Acetaminophen","2023-11-13",{"date":222,"type":35},"2023-11-14",{"date":224,"type":35},"2023-07-01",{"date":226,"type":21},"2027-12",{"name":67,"class":42}]