[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"renal-function-abnormal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:renal-function-abnormal":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100640414","effect-of-lsd-on-renal-function-in-cirrhosis-patients-with-portal-hypertension-bleeding-2-year-follow-up-100640414",false,"NCT07585786","Effect of LSD on Renal Function in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up)","A Prospective, Single-Center, Observational Cohort Study to Evaluate the Long-Term (2-Year) Effects of Laparoscopic Splenectomy and Azygoportal Disconnection on Renal Function in Patients With Liver Cirrhosis, Portal Hypertension Bleeding","LSD-RFPH","Inclusion Criteria:\n\n1. Confirmed diagnosis of liver cirrhosis (clinical, laboratory, imaging)\n2. Splenomegaly and hypersplenism\n3. History of portal hypertension bleeding (esophageal and gastric variceal bleeding )\n4. Age 18-80 years, male or female\n5. Child-Pugh Class A or B liver function\n6. No history of primary renal disease or acute kidney injury (AKI)\n7. Signed written informed consent\n8. Ability to complete 24-month follow-up\n\nExclusion Criteria:\n\n1. Child-Pugh Class C liver cirrhosis\n2. Primary renal diseases (glomerulonephritis, polycystic kidney disease, chronic pyelonephritis, etc.)\n3. Previous abdominal surgery precluding safe laparoscopic splenectomy and azygoportal disconnection\n4. Severe cardiac, pulmonary, cerebrovascular dysfunction; malignant tumors; primary hematological disorders\n5. Hepatic encephalopathy or refractory ascites within 1 month before surgery\n6. Pregnancy or lactation\n7. Poor compliance, inability to complete follow-up","ALL","18 Years","80 Years",{"count":21,"type":22},30,"ESTIMATED","2 Years","OBSERVATIONAL","Patients with liver cirrhosis often have impaired or at-risk kidney function due to the close link between liver and kidney (hepatorenal syndrome). Laparoscopic Splenectomy and Azygoportal Disconnection (LSD) is commonly used to treat Cirrhosis with Portal Hypertension Bleeding in these patients, but its impact on kidney function over 2 years is unclear. This study will follow patients undergoing laparoscopic splenectomy to measure changes in kidney function before and after surgery, identify risk factors for kidney damage and whether LSD can improve kidney function in the long term, and help improve care to protect kidney function in cirrhotic patients .",[27,28,29,30],"Cirrhosis, Liver","Splenectomy; Status","Renal Function Abnormal","Portal Hypertension",[32,33,34,35,36,37],"Cirrhosis","Splenectomy","Laparoscopy","azygoportal disconnection","Renal function","Portal hypertension bleeding","NOT_YET_RECRUITING","2026-05-14",{"date":41,"type":42},"2026-05-18","ACTUAL",{"date":44,"type":22},"2026-05-01",{"date":46,"type":22},"2029-02-28",{"name":48,"class":49},"Northern Jiangsu People's Hospital","OTHER",{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100631229","ischemic-preconditioning-reduces-the-severity-of-acute-kidney-injury-after-partial-nephrectomy-100631229","NCT07497958","Ischemic Preconditioning Reduces the Severity of Acute Kidney Injury After Partial Nephrectomy","Ischemic Preconditioning Reduces the Severity of Acute Kidney Injury After Partial Nephrectomy: a Randomized Controlled Clinical Study","Inclusion Criteria:\n\n* Patients who are scheduled to undergo partial nephrectomy, with no specific surgical procedure limitation, including laparoscopic surgery, robot-assisted surgery, and open surgery\n* Aged 18 to 80\n* Possess good organ function status: sufficient organ function (based on the normal values of the clinical trial center)\n\n  1. Blood routine test: WBC≥3.5×10\\^9\u002FL, absolute neutrophil count ≥1.5×10\\^9\u002FL, PLT≥75.0×10\\^9\u002FL, HGB≥80g\u002FL;\n  2. Liver function: Total bilirubin ≤1.5×upper limit of normal (ULN), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5×ULN;\n\nExclusion Criteria:\n\n* The anesthesiologist assesses that the patient cannot tolerate general anesthesia surgery\n* Individuals with severe cardiovascular and cerebrovascular diseases, uncontrolled hypertension, and diabetes\n* Estimated glomerular filtration rate (eGFR) \\\u003C 30 ml\u002Fmin\u002F1.73m²\n* Horseshoe kidney\n* Solitary kidney\n* Pregnant women",{"count":58,"type":22},174,"INTERVENTIONAL",[61],"NA","It is demonstrated that remote ischemic preconditioning can alleviate the degree of acute renal injury on the operated side in patients undergoing partial nephrectomy.",[64,29],"Renal Cell Carcinoma (RCC)",[29,66,67,68],"Acute kidney injury","Partial nephrectomy","Ischemic preconditioning","2026-03-23",{"date":71,"type":42},"2026-03-27",{"date":73,"type":22},"2026-04-01",{"date":75,"type":22},"2028-12-31",{"name":77,"class":49},"Sun Yat-sen University",1,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":86,"targetDuration":4,"studyType":59,"phases":88,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":78},"100618027","the-cold-ischemia-robot-assisted-partial-nephrectomy-100618027","NCT07326280","The Cold Ischemia Robot-assisted Partial Nephrectomy","The Impact of Cold Ischemia on Recovery From Ischemia After Robot-assisted Partial Nephrectomy: A Randomized Controlled Clinical Study","Inclusion Criteria:\n\n\\- 18 to 80 years old; 2. Intending to perform robot-assisted partial nephrectomy\n\nExclusion Criteria:\n\n* Anesthesiologist assessment: Patient unsuitable for general anesthesia;\n* Having severe cardiovascular and cerebrovascular diseases;\n* horseshoe kidney;\n* pregnant women",{"count":87,"type":22},310,[61],"To establish evidence that cold ischemia, achieved through the use of ice slush, can improve the recovery from ischemia on the operated kidney in patients undergoing robot-assisted partial nephrectomy.",[91,29],"Renal Cell Carcinoma","RECRUITING","2026-01-07",{"date":95,"type":42},"2026-01-08",{"date":97,"type":42},"2024-01-01",{"date":99,"type":22},"2026-12-31",{"name":77,"class":49}]