[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"renal-protection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:renal-protection":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100556177","phase-4-effects-of-minimal-flow-sevoflurane-and-multimodal-analgesia-in-head-and-neck-cancer-surgery-100556177",false,"NCT06521697","Effects of Minimal-Flow Sevoflurane and Multimodal Analgesia in Head and Neck Cancer Surgery","Anesthetic-sparing and Renal Protection Effects of Minimal-flow Sevoflurane Anesthesia and Multimodal Analgesia Using a Mixture of Dexmedetomidine-ketamine-lidocaine in Head and Neck Cancer Patients With Free Flap Microvascular Surgery","Inclusion Criteria:\n\n* Age 18-99 years\n* Scheduled for head and neck cancer tumor resection and free flap reconstruction surgery\n\nExclusion Criteria:\n\n* Preoperative tracheostomy\n* History of previous head and neck cancer tumor resection\n* Anemia (hematocrit \\\u003C30% or recent transfusion)\n* Hypertension on ACEI\u002FARB medications\n* Significant medical conditions (e.g., NYHA class 3 or 4 heart failure, eGFR \\\u003C60 ml\u002Fmin\u002F1.73 m², Child B or C liver failure, severe respiratory disorders, pre-existing cognitive impairment)\n* ASA physical status 4 or 5\n* Allergies to sevoflurane, dexmedetomidine, ketamine, or lidocaine","ALL","18 Years","99 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","This study evaluates the anesthetic-sparing and renal protection effects of minimal-flow sevoflurane anesthesia combined with multimodal analgesia using dexmedetomidine, ketamine, and lidocaine in head and neck cancer patients undergoing free flap microvascular surgery. The 2x2 factorial randomized controlled trial aims to compare sevoflurane usage and renal function changes with different fresh gas flow rates and multimodal analgesia.",[27,28,29,30,31],"Head and Neck Cancer","Anesthesia","Renal Protection","Acute Kidney Injury","Multimodal Analgesia",[33,34,35,36,27],"Greenhouse gas","Carbon emissions","Acute kidney injury","Multimodal analgesia","NOT_YET_RECRUITING","2024-07-21",{"date":40,"type":41},"2024-07-26","ACTUAL",{"date":43,"type":21},"2024-08",{"date":45,"type":21},"2025-12",{"name":47,"class":48},"National Taiwan University Hospital","OTHER"]