[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"renal-transplant-failure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:renal-transplant-failure":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100606534","the-use-of-urinary-dickkopf-3-u-dkk3-as-a-new-biomarker-which-can-identify-patients-at-high-risk-of-renal-allograft-dysfunction-earlier-that-the-current-established-tests-100606534",false,"NCT07176806","The Use of Urinary Dickkopf 3 (u DKK3) as a New Biomarker Which Can Identify Patients at High Risk of Renal Allograft Dysfunction, Earlier That the Current Established Tests.","The Usefulness of Urinary Dickkopf 3 (u DKK3) as a Biomarker of Renal Allograft Dysfunction in Renal Transplant Recipients","Inclusion Criteria:\n\nkidney transplant recipients only Longitudinal data of graft function including serum creatinine, e GFR over 12 months at specific time-points; baseline (1 week after transplantation), 3, 6 and 12 months\n\nExclusion Criteria:\n\nCombined kidney pancreas transplant patients with missing graft function values including serum creatinine, e GFR at the specific time-points.","ALL","17 Years","75 Years",{"count":20,"type":21},258,"ESTIMATED","OBSERVATIONAL","Kidney function after a renal transplant is monitored closely, particularly in the first year, as the risk of deterioration in graft function is worrying. Graft dysfunction can lead to chronic kidney failure and graft loss. Currently, renal transplant function is mainly monitored using creatinine and estimated glomerular filtration rate (eGFR). However, these tests are not sensitive enough to detect small changes in graft function. A new test which can detect graft dysfunction in an early phase would be useful as this would help optimise treatment and prolong survival. Dickkopf -3 (DKK3) is a protein which is released by kidney cells in response to injury. High levels of the DKK3 protein in urine has been shown to have the potential to predict decline in graft function, earlier than the currently available tests, although the results show a mixed picture. Before this test is used routinely, further studies need to be carried out. We want to analyse this protein in multiple urine samples collected over 12 months in our cohort of renal transplant recipients. We will be comparing the urine DKK3 test with our currently available tests to investigate whether this test can identify patients who are at risk of graft dysfunction earlier.",[25],"Renal Transplant Failure",[27],"urinary DKK3, RENAL ALLOGRAFT DYSFUNCTION","NOT_YET_RECRUITING","2025-09-09",{"date":31,"type":32},"2025-09-16","ACTUAL",{"date":34,"type":21},"2026-01",{"date":36,"type":21},"2027-01",{"name":38,"class":39},"Guy's and St Thomas' NHS Foundation Trust","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":51,"conditions":52,"keywords":60,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":40},"100518030","expanding-the-scope-of-post-transplant-hla-specific-antibody-detection-and-monitoring-in-renal-transplant-recipients-100518030","NCT06025240","Expanding the Scope of Post-transplant HLA-specific Antibody Detection and Monitoring in Renal Transplant Recipients","HLA-AB","Inclusion Criteria:\n\n1. cf-DNA arm:\n\n   * Adult patients transplanted within 6-12 months (retrospective recruitment)\n   * Patients admitted for renal transplant or within the first 6 months following transplant (prospective recruitment)\n   * Patients must have capacity to provide informed consent\n   * Patients must have received a high-risk transplant defined as level 4 mismatch, cRF \\>20, second or subsequent transplant, ABO or HLA incompatible\n2. Older Age Immunological Events:\n\n   \\- Any adult patient with capacity undergoing, or within 72 hours of, a renal transplant\n3. Predictive models:\n\n   * Any adult patient with capacity undergoing, or within 72 hours of, a renal transplant\n   * Unsensitized pre-transplant\n\nExclusion Criteria:\n\n1. cf-DNA arm:\n\n   * Transplanted for longer than 12 months;\n   * Low risk transplants;\n   * Patients lacking capacity;\n2. Older Age Immunological Events:\n\n   * Patients lacking capacity\n   * Patients transplanted longer than 2 weeks\n3. Predictive models:\n\n   * Sensitised patients\n   * Patients lacking capacity\n   * Patients transplanted longer than 2 weeks","18 Years",{"count":50,"type":21},282,"The purpose of this study is to assess a new test to detect antibodies which may form following kidney transplant. These antibodies can be difficult to detect as they do not cause any symptoms but can lead to kidney damage. A new blood test will be performed alongside existing antibody tests to see how well the test functions in comparison and to see how well it is able to distinguish between inflammation caused by antibodies and other sorts of inflammation such as a urinary tract infection. The investigators also want to determine whether it is predictable whom will develop antibodies after a transplant and use these results to change the current way patients are monitored for antibodies after receiving a transplant. In addition to this, the investigators want to establish if patients over 60 years of age are relatively protected against immunological events such as rejection compared to patients who are under 60 years of age. The results could potentially lead to using a different immunosuppression regime based on which population age group patients belong to and lowering the risks associated with these drugs.",[53,25,54,55,56,57,58,59],"Kidney Transplant","Kidney Transplant Rejection","Frailty","Kidney Transplant; Complications","Transplant Dysfunction","Diagnosis","Renal Transplant",[61,62,63,64,65,66,67,68,69],"kidney transplant","novel biomarkers","post-transplant antibodies","HLA-specific antibodies","donor specific antibodies","transplant in older age","machine learning","predictive models","rejection","RECRUITING","2024-08-28",{"date":73,"type":32},"2024-08-30",{"date":75,"type":32},"2023-10-13",{"date":77,"type":21},"2026-10-13",{"name":79,"class":80},"Liverpool University Hospitals NHS Foundation Trust","OTHER_GOV"]