[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"reperfusion-injury-myocardial\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:reperfusion-injury-myocardial":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100559498","phase-2-effect-of-l-carnitine-on-biomarkers-of-myocardial-reperfusion-injury-in-patients-with-stemi-100559498",false,"NCT06564909","Effect of L-Carnitine on Biomarkers of Myocardial Reperfusion Injury in Patients With STEMI","Effect of L-Carnitine on Biomarkers of Myocardial Reperfusion Injury in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention","Inclusion Criteria:\n\n* Female or male aged \\>18 and \\\u003C 75 years.\n* STEMI patients undergoing PCI.\n\nExclusion Criteria:\n\n* Patients with a recent history of myocardial infarction (MI), a previous PCI, a previous coronary artery bypass graft, or any cardiac surgery.\n* A late presentation (\\>12 h), unsuccessful primary PCI (residual stenosis \\>50% in the culprit lesion after procedure),\n* Pretreatment with thrombolytic or glycoprotein IIb\u002FIIIa inhibitor therapy before primary PCI,\n* Concurrent Infectious or active inflammatory disease,\n* Severe liver or renal disease, (aspartate aminotransferase (AST) or alanine transaminase (ALT) \\> 3x ULN or Total bilirubin \\> 3 x ULN), (CrCl \\\u003C 60 ml\u002Fmin (based on the Cockroft-Gault equation)\n* Neoplasm, or hematological disorders\n* Pregnant or breast-feeding patients\n* Active participation in another clinical study\n* Patients taking antioxidant drugs.\n* History of or known allergy or intolerability to the study medications","ALL","18 Years","75 Years",{"count":20,"type":21},76,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The study aims is to evaluate the efficacy and tolerability of L-Carnitine on biomarkers of myocardial reperfusion injury in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary PCI by the assessment of nitrotyrosine as an oxidative stress marker and Matrix metallopeptidase-2 (MMP-2) as a cardiac fibrosis marker",[27,28],"Reperfusion Injury, Myocardial","Myocardial Infarction","RECRUITING","2025-06-22",{"date":32,"type":33},"2025-06-26","ACTUAL",{"date":35,"type":33},"2025-06-01",{"date":37,"type":21},"2026-03",{"name":39,"class":40},"Ain Shams University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":41},"100525996","trans-coronary-cooling-and-dilution-for-cardioprotection-during-revascularisation-for-st-elevation-myocardial-infarction-100525996","NCT06128993","Trans-coronary Cooling and Dilution for Cardioprotection During Revascularisation for ST-elevation Myocardial Infarction","STEMI-Cool","Inclusion Criteria:\n\n* Clinical ST-elevation myocardial infarction or equivalent (e.g. new onset LBBB)\n* \\\u003C12 Hrs after symptom onset\n* Thrombolysis in myocardial infarction (TIMI) 0-1 coronary flow in a target vessel\n\nExclusion Criteria:\n\n* History of severe asthma\n* Pregnancy\n* Severe concomitant disease or conditions with a life expectancy of less than one year.",{"count":50,"type":21},60,[52],"NA","A heart attack (myocardial infarction) occurs when an artery supplying blood to the heart is suddenly blocked resulting in damage to the heart muscle.\n\nPatients presenting to hospital with a heart attack undergo an immediate angiogram (x-ray of the arteries in the heart) and are usually treated immediately with a balloon and stent to open their blocked artery. This procedure is called \"primary percutaneous coronary intervention\" (or primary PCI for short).\n\nAn angiogram is a routine procedure that involves insertion of fine plastic tube (catheter) into either the groin or wrist under local anaesthetic. The tube is passed into the artery in the heart and X-ray pictures are taken to find out if the arteries are blocked. Blocked arteries can usually be opened by passing a small balloon into the artery, via the fine plastic tube followed by placement of a stent (a fine metal coil) into the artery to prevent it from blocking again.\n\nAlthough this treatment is very successful, it can result in damage to the heart muscle when the artery is opened. Cooling the entire body has been shown to reduce heart muscle damage during heart attacks in some patients but not in others; however, it is uncomfortable due to the shivering, expensive and can result in delays in opening the blocked artery.\n\nThe investigators are conducting a series of research studies to find out if cooling the heart muscle directly through the catheter being used for the normal primary angioplasty treatment using room temperature may be effective in preserving heart muscle, without the shortcomings of entire body cooling.\n\nThe investigators have already published an initial series of ten cases in which this treatment appeared to be feasible without causing significant clinical problems.\n\nThe present study is a pilot study designed to assess the rate of patient recruitment and feasibility of this new treatment while exploring some detailed outcomes measuring the restoration of blood flow within the coronary artery at the end of the procedure.\n\nUltimately if the present pilot study is successful, the investigators plan to go on to undertake a much larger randomised outcome study to determine definitively whether this treatment can help reduce heart attack size.",[28,27],"2025-01-29",{"date":57,"type":33},"2025-01-31",{"date":59,"type":33},"2023-11-01",{"date":61,"type":21},"2026-01",{"name":63,"class":40},"Royal Brompton & Harefield NHS Foundation Trust"]