[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"rescue-stenting\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:rescue-stenting":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100571957","rescue-stenting-and-intravenous-thrombolysis-in-patients-with-large-vessel-ischemic-stroke-100571957",false,"NCT06727006","Rescue Stenting and Intravenous Thrombolysis In Patients With Large Vessel Ischemic Stroke","Stroke, Thrombolysis and Rescue Stenting","STARS","Inclusion Criteria:\n\n* Patients with large vessel occlusion strokes undergoing thrombectomy and rescue stenting within 24 hours of stroke onset\n* Patients ≥ 18 years of age\n\nExclusion Criteria:\n\n* Patients \\\u003C 18 years\n* Refusal to give informed consent","ALL","18 Years",{"count":20,"type":21},400,"ESTIMATED","OBSERVATIONAL","Intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) are the standard of care for treating selected patients with acute large-vessel occlusion stroke (LVOS). Successful revascularization is strongly correlated with favorable outcomes. Nevertheless, recanalization failure with stent retrieval and contact aspiration has been observed in up to 29% of patients. If primary thrombectomy fails to achieve recanalization, rescue stenting (RS) has proven to be a feasible rescue therapy. Currently, approved evidence-based alternatives for LVOS patients who have failed MT are lacking, but permanent stenting is suggested as a rescue treatment in expert consensus statements.\n\nDual antiplatelet therapy (DAPT), typically consisting of clopidogrel and aspirin, is recommended after stent implantation to reduce the risk of stent thrombosis; however, these medications are not suitable in the acute setting, and optimal platelet inhibition strategies remain unclear. Glycoprotein (GP) IIb\u002FIIIa receptor inhibitors have intravenous administration, a rapid onset of action, and their effects subside within a few hours after discontinuation. For these reasons, an increasing number of studies have investigated their use in conjunction with primary stenting for acute stroke. Currently, there is no evidence supporting the superiority of any particular antithrombotic strategy, so decisions are guided by clinical judgment.\n\nAn additional challenge for clinicians arises when IVT is combined with stenting. Stroke guidelines recommend starting antiplatelets 24 hours after IVT and the risk associated with antithrombotic therapy within the first 24 hours after IVT remains uncertain.\n\nThis is multicenter, prospective, observational study of patients with LVOS undergoing mechanical thrombectomy and rescue stenting. The aim of this study is to evaluate real-world antithrombotic strategies in emergency stenting, particularly in patients treated with IVT, and to assess the safety of emergent stenting following intravenous thrombolysis.",[25,26,27,28],"Large Vessel Occlusion","Stroke Acute","Thrombolysis","Rescue Stenting",[30,27],"Rescue stenting","RECRUITING","2024-12-14",{"date":34,"type":35},"2024-12-17","ACTUAL",{"date":37,"type":35},"2023-10-21",{"date":39,"type":21},"2027-03",{"name":41,"class":42},"ASST Santi Paolo e Carlo","OTHER",7,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":65},"100465804","rescue-stenting-with-credo-heal-for-recanalisation-after-unsuccessful-thrombectomy-rechrut-100465804","NCT05345483","REscue Stenting With CREDO® Heal for Recanalisation After Unsuccessful Thrombectomy (RECHRUT)","RECHRUT","Inclusion Criteria:\n\n* Patients, treated with CREDO® heal according to IFU\n* Over 18 years old\n* With acute persistent vascular occlusion due to high grade intracranial artery stenosis in the anterior or posterior circulation for which alternative therapy concepts are not considered or fail\n* With suspected underlying stenosis of the occluded artery, which is suitable for PTA and stenting according to the treating physician's assessment and\u002For persistent occlusion after failed recanalization by mechanical thrombectomy of the target region\n* With small to moderate infarct core prior to initiation of thrombectomy (CT ASPECTS 6-10, DWI lesion \\\u003C 70 ml)\n* With symptoms onset less than 24 hours before start of the procedure\n* Treated with study device following at least one futile mechanical recanalization attempt with a stent retriever, direct aspiration or combination of both\n* With pre-stroke disability mRS 0-2\n\nExclusion Criteria:\n\n* Any contraindication according to IFU and patients:\n* With atherosclerotic (probable according to clinical, anamnestic or laboratory chemical testing) vessel constrictions (high-grade intracranial stenoses \\> 70 %) with significant circulatory disturbance (haemodynamic infarct pattern and signs of restricted collaterals) and recurrent symptoms in spite of medical therapy\n* With contraindication against treatment with anti-platelet medication\n* Participating in another trial",{"count":52,"type":21},153,"Goal of the study is to evaluate the efficacy and safety of acute permanent stenting of symptomatic intracranial stenosis following unsuccessful recanalization by thrombectomy in acute ischemic stroke with large vessel occlusion using the self-expandable CREDO® heal Stent.",[28],"2024-12-04",{"date":57,"type":35},"2024-12-05",{"date":59,"type":35},"2023-01-25",{"date":61,"type":21},"2027-01",{"name":63,"class":64},"Acandis GmbH","INDUSTRY",17]