[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"resection-margins\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:resection-margins":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100501112","cellvizio-to-evaluate-margins-in-crohns-ileal-disease-100501112",false,"NCT05805020","Cellvizio to Evaluate Margins in Crohn's Ileal Disease","Is There a Concordance Between the Cellvizio With an Intravenous Injection of Fluorescein and the Pathology to Determine the Microscopic Inflammation at the Ileal Resection Margins in Crohn's Ileal Disease","CELLVICROHN","Inclusion Criteria:\n\n* Patients who need a ileocaecal resection for a Crohn disease whatever is the phenotype of the Crohn's disease\n\nExclusion Criteria:\n\n* Patients\\\u003C18 years old,\n* pregnancy or breastfeeding,\n* patients who have an ileocolic resection for a surgical recurrence of the Crohn's disease.\n* Patients operated in emergency for a peritonitis,\n* patients who have a contra-indication for fluorescein injection or severe allergia to any drug","ALL","18 Years",{"count":20,"type":21},41,"ESTIMATED","INTERVENTIONAL",[24],"NA","Crohn disease is an inflammatory bowel disease. A surgical procedure is required in about 80% of cases. Surgery doesn't cure from Crohn's disease but the type of surgery remains important as there are several intraoperative risk factors for recurrence. Among these factors the microscopic inflammation at the resection margins. This is a crucial point, if the resection is too large there is a risk of short bowel syndrome, if the resection is too short (microscopic inflammation at resection site), there is a higher risk of postoperative recurrence (75% vs 46% at 18 months). Surgeons have to do a limited resection (2cm from macroscopic crohn disease). However this macroscopic non inflammatory resection margin can be microscopically inflammatory (up to 80%). Thus it is useful to evaluate if there is a microscopic inflammation at the resection margin. Moreover there is an increase interest for the role of the mesentery for recurrence but its role remains unclear. It is of interest to clarify the border between the inflammatory and non-inflammatory mesentery. Cellvizio is a confocal laser endomicroscopy providing the possibility of obtaining in vivo high-magnification images of the gut epithelium. This allows real-time examination of the gastrointestinal mucosa at the cellular and subcellular level. Cellvizio has never been used during surgery for Crohn disease.\n\nThe aim of this study is to evaluate the intraoperative use of Cellvizio (using the CelioFlex microsonde) with an intravenous injection of fluorescein to determine the best ileal resection margins in Crohn disease.",[27,28,29],"Crohn Disease","Resection Margins","Recurrence",[27,28,31],"recurrence","RECRUITING","2025-05-22",{"date":35,"type":36},"2025-05-28","ACTUAL",{"date":38,"type":36},"2022-03-03",{"date":40,"type":21},"2026-03",{"name":42,"class":43},"Centre Hospitalier Universitaire, Amiens","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":44},"100575924","phase-1-b7-h3-nir-imaging-for-osteosarcoma-surgery-100575924","NCT06778603","B7-H3 NIR Imaging for Osteosarcoma Surgery","Resection of Osteosarcoma in Limbs Navigated by B7H3-based NIR Lmaging: a Prospective, Single-center,Single-arm, Exploratory Trial","ROLN-B7-H3","Inclusion Criteria:\n\n* 1\\. Patients with histologically confirmed osteosarcoma of the limbs.\n* 2\\. the patients has not undergone tumor resection.\n* 3\\. Age between 18 and 60 years old.\n* 4\\. No prior systemic treatment for osteosarcoma.\n* 5\\. Measurable disease as assessed by imaging studies (e.g., MRI, CT).\n* 6\\. Adequate bone marrow, liver, and renal function.\n* 7\\. Written informed consent obtained from the patient.\n\nExclusion Criteria:\n\n* 1\\. History of other malignancies within the past 5 years.\n* 2\\. Pregnancy or lactation.\n* 3\\. Known hypersensitivity to any component of the B7H3-based NIR imaging agent.\n* 4\\. Uncontrolled intercurrent illness that would preclude safe study participation.\n* 5\\. Prior radiation therapy to the target lesion.\n* 6\\. Any medical condition that would compromise the patient's ability to undergo surgery or comply with study procedures.\n* 7.Patients not able to sign the Informed Consent.","60 Years",{"count":55,"type":21},32,[57,58],"PHASE1","PHASE2","Complete removal of all tumor tissue with a wide surgical margin is essential for the treatment of osteosarcoma (OS). However, it's difficult, sometimes impossible, to achieve due to the invisible small satellite lesions and blurry tumor boundaries. Besides, intraoperative frozen-section analysis of resection margins of OS is often restricted by the hard tissues around OS, which makes it impossible to know whether a negative margin is achieved. Herein, based on the high expression of B7-H3 in OS, a targeted probe B7H3-IRDye800CW is synthesized by conjugating anti-B7H3 antibody and IRDye800CW. This trial is aimed to investigate R0-resection rate and 2-y local recurrence rate after using this probe in Musculoskeletal tumor surgery for osteosarcoma as well as the safety parameters of this probe in human.",[61,28,62,63],"Osteosarcoma","B7-H3 Probe","Local Recurrence",[65,66,67,68],"osteosarcoma","resection margins","B7-H3 Targeted Probe","local recurrence rate","2025-01-11",{"date":71,"type":36},"2025-01-16",{"date":73,"type":36},"2024-01-01",{"date":75,"type":21},"2026-12-31",{"name":77,"class":43},"Peking University People's Hospital"]