[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"residual-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:residual-disease":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100598292","phase-2-predict-rd-ctdna-surveillance-in-tnbc-with-residual-disease-100598292",false,"NCT07069595","PREDICT-RD: ctDNA Surveillance in TNBC With Residual Disease","PREDICT-RD: Postoperative Molecular Residual Disease by ctDNA Surveillance in TNBC With Residual Disease","PREDICT-RD","Inclusion Criteria:\n\nWritten informed consent was obtained to participate in the study, and HIPAA authorization for the release of personal health information.\n\n* Participant is willing and able to comply with study procedures based on the judgment of the investigator.\n* Age ≥ 18 years at the time of consent.\n* Histological confirmation of TNBC defined by ER\u002FPR \\\u003C10%, HER2 0-1+ by IHC or 2+ by IHC and fluorescence in situ hybridization (FISH) negative.\n* Stage II\u002FIII TNBC treated with neoadjuvant systemic therapy AND have residual disease defined as RCB II\u002FIII at time of surgery.\n* Baseline staging scans at the discretion of the treating physician and demonstrate no evidence of metastatic disease.\n* The participant must have archival diagnostic tissue and\u002For surgical resection tissue Available.\n* Participants are willing and able to comply with study procedures based on the judgment of the investigator.\n\nExclusion Criteria:\n\n• Participants are pregnant or breastfeeding.","ALL","18 Years",{"count":20,"type":21},78,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","This is a Phase II, interventional, prospective, single-arm, multi-center study that will enroll patients with stage II\u002FIII triple negative breast cancer (TNBC) who have residual cancer burden (RCB) II\u002FIII after conventional neoadjuvant chemo-immunotherapy followed by surgery. Technological advances in ctDNA assays have improved both the sensitivity and reliability of molecular residual disease (MRD) detection to enable real-time measurement with clinical-grade assays.\n\nThe primary objective of this study will be to evaluate ctDNA-based MRD status in high-risk, early-stage TNBC patients by defining the proportion of TNBC patients with MRD-only recurrence (ctDNA positive without radiographically measurable recurrence) during post-surgery surveillance. The secondary objectives will evaluate the safety, preliminary efficacy, and survival outcomes of using Dato-DXd in participants with MRD-only TNBC.\n\nDato-DXd is an investigational antibody-drug conjugate (monoclonal antibody specific for TROP2 and a topoisomerase I (Topo-1) inhibitor) that has demonstrated promising efficacy in TNBC patients with a manageable safety profile.",[27,28,29,30],"Breast Cancer","Residual Disease","Triple Negative Breast Cancer (TNBC)","Stage II\u002FIII",[32,33,34],"circulating tumor DNA (ctDNA)","surveillance","Dato-DXd","RECRUITING","2026-04-21",{"date":38,"type":39},"2026-04-22","ACTUAL",{"date":41,"type":39},"2026-02-26",{"date":43,"type":21},"2032-11-01",{"name":45,"class":46},"UNC Lineberger Comprehensive Cancer Center","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100526410","phase-1-a-study-of-tetrathiomolybdate-tm-plus-capecitabine-100526410","NCT06134375","A Study of Tetrathiomolybdate (TM) Plus Capecitabine","Novel Targeting of the Microenvironment to Decrease Metastatic Recurrence of High-Risk TNBC: A Randomized Phase II Study of Tetrathiomolybdate (TM) Plus Capecitabine in Patients With Breast Cancer at High Risk of Recurrence","Inclusion Criteria:\n\n1. Patients must have histologically confirmed breast malignancy that is Triple negative tumors as defined as ER and PR \\\u003C1% and HER2 negative as per ASCO\u002FCAP guidelines\n2. The patient must have completed standard neoadjuvant chemotherapy which constitutes at least 6 cycles of chemotherapy.\n3. Phase Ib: Patients must have residual invasive carcinoma, at minimum in one of the following capacities: (1) node positive disease after treatment without residual invasive carcinoma in the breast; (2) RCB 2 or RCB 3 MDAH Calculator; Standard therapy consists of the following: (1) Local therapy: (a) Lumpectomy or mastectomy to negative margins. (b) Sentinel lymph node biopsy or axillary node dissection; (c) Radiation therapy to breast if patient received a lumpectomy and per investigator choice if considering chest wall\u002Fextended field RT. (2) Systemic therapy: Prior chemotherapy is required for patients entered on the trial. Neoadjuvant treatment should consist of the following standard therapy: Anthracycline and taxane-based therapy (i.e. AC-\\>T, AC-\\>Tcarbo, Keynote 522 regimen) or a non-anthracycline based chemo and immunotherapy regimen (NeoPACT). Patients must have received neoadjuvant Pembrolizumab for the phase Ib only and plan to continue it in the adjuvant setting for at least the first cycle of treatment.\n\n   Randomized Phase 2: Patients must have residual invasive carcinoma, at minimum in one of the following capacities: (1) node positive disease after treatment without residual invasive carcinoma in the breast; (2) RCB 2 or RCB 3 MDAH Calculator; Standard therapy consists of the following: (1) Local therapy: (a) Lumpectomy or mastectomy to negative margins. (b) Sentinel lymph node biopsy or axillary node dissection; (c) Radiation therapy to breast if patient received a lumpectomy and per investigator choice if considering chest wall\u002Fextended field RT. (2) Systemic therapy: Prior chemotherapy is required for patients entered on the trial. Neoadjuvant treatment should consist of the following standard therapy: Anthracycline and taxane-based therapy (i.e. AC-\\>T, AC-\\>Tcarbo, Keynote 522 regimen) or a non-anthracycline based chemo and immunotherapy regimen (NeoPACT). Pembrolizumab is allowed. Patients will be stratified by: (1) Treatment (chemotherapy vs chemotherapy + immunotherapy); (2) Age (Age ≤ 40 yrs vs \\> 40 yrs); and (3) RCB 2 vs RCB 3. These important stratification factors represent variables that are known to affect outcome for patients with TNBC.\n4. At least two weeks must have elapsed from last chemotherapy or radiation therapy. At least 4 weeks must have elapsed from most recent surgery.\n5. No clinical or radiologic evidence of disease after surgery and\u002For systemic treatment (by CT scan of chest, abdomen and pelvis and bone scan or PET scan prior to enrollment).\n6. Previous treatment with capecitabine is not allowed.\n7. Because no dosing or adverse event data are currently available on the use of TM in patients \\\u003C18 years of age, children are excluded from this study.\n8. KPS 90 or 100.\n9. Life expectancy of greater than 3 months.\n10. Patients must have normal organ and marrow function as defined below:\n\n    * hemoglobin \\>10mg\u002FdL\n    * absolute neutrophil count \\>1,500\u002F µL\n    * platelets \\>100,000\u002FµL\n    * total bilirubin \\\u003C1.5 x normal institutional limits\n    * AST (SGOT)\u002FALT (SGPT) \\\u003C1.5 X institutional upper limit of normal\n11. Antiresorptive therapy and denosumab may be administered.\n12. Patients must be on stable medical therapy for at least 2 weeks if they are being treated medically for their chemotherapy induced peripheral neuropathy.\n13. The effects of TM on the developing human fetus are unknown. For this reason, women of childbearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately.\n14. Ability to understand and the willingness to sign a written informed consent document.\n15. Normal B12 levels.\n\nExclusion Criteria:\n\n1. Patients who have had chemotherapy or radiotherapy within 2 weeks prior to entering the study. Patients who have had surgery within 4 weeks.\n2. Patients who have received capecitabine or who are on warfarin\n3. Patients who had their final breast surgery more than 12 weeks prior to study start.\n4. Phase Ib: patients who have not received neoadjuvant immunotherapy and\u002For do not plan to continue treatment with immunotherapy for at least the first cycle of study treatment.\n5. Objective evidence of breast cancer.\n6. Metastatic disease\n7. Carcinomatous meningitis or active parenchymal brain metastases.\n8. Estimated creatinine clearance \\\u003C 60 ml\u002Fmin\n9. History of allergic reactions attributed to compounds of similar chemical or biologic composition to TM or capecitabine.\n10. Pregnant women are excluded from this study because TM has the potential to have teratogenic or abortifacient effects. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with TM, breastfeeding should be discontinued if the mother is treated with TM.\n11. Because patients with immune deficiency are at increased risk of lethal infections when treated with marrow-suppressive therapy, HIV-positive patients receiving combination anti- retroviral therapy are excluded from the study because of possible pharmacokinetic interactions with TM.","80 Years",{"count":57,"type":21},204,[59,24],"PHASE1","There are two parts to this study. It is a phase 1b followed by a randomized phase 2 study to assess whether adding 3 years of adjuvant tetrathiomolybdate (TM) to standard 6 months treatment of adjuvant capecitabine and pembrolizumab in high risk for relapse triple negative breast cancer.\n\nIn the phase 1b part of the study, TM is added to adjuvant capecitabine and pembrolizumab in high risk for relapse triple negative breast cancer (RCB 2, 3, risk for relapse \\>60% at 5 years) after completion of neoadjuvant chemo-immunotherapy and surgery to establish the safety of the combination. This will be followed by a randomized phase 2 clinical trial of adjuvant TM and capecitabine vs capecitabine alone.\n\nIf pembrolizumab was administered in the neoadjuvant setting, it may be continued in the adjuvant setting per investigator discretion.",[62,28],"Triple Negative Breast Cancer",[64,28],"Triple Negative Breast cancer","2026-04-15",{"date":67,"type":39},"2026-04-20",{"date":69,"type":39},"2024-11-26",{"date":71,"type":21},"2036-06-26",{"name":73,"class":46},"Dartmouth-Hitchcock Medical Center",3]